Research Explorer

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Researcher

Siebe Loontiens

Awards & Distinctions

40 Results

2025

A nationwide comprehensive genomic profiling and molecular tumor board platform for patients with advanced cancer

Pieter-Jan VoldersPhilippe AftimosFranceska DedeurwaerdereGeert MartensJean-Luc CanonGabriela BeniugaGuy FroyenJacques Van HuysseRebecca De PauwHans Prenen et al.

A1 Journal Article in NPJ PRECISION ONCOLOGY

Atypical spindle cell/pleomorphic lipomatous tumour : a clinicopathologic, immunohistochemical and molecular study of 55 cases, highlighting TP53 gene alterations as a genetic hallmark of atypical pleomorphic lipomatous tumour

Fleur CordierTony G KleijnThomas MentzelUta FluckeJoost van GorpLiesbeth FerdinandeSarah Van BelleSiebe LoontiensJoni Van der MeulenJo Van Dorpe et al.

A1 Journal Article in HISTOPATHOLOGY

Prospective, multicenter validation of a platform for rapid molecular profiling of central nervous system tumors

Areeba PatelKirsten GöbelSebastian IlleFelix HinzNatalie SchoebeHenri BogumilJochen MeyerMichelle BrehmHelin KardoDaniel Schrimpf et al.

A1 Journal Article in NATURE MEDICINE

Revealing RB1 loss in an emerging entity : report of two cases of PRRX1-rearranged mesenchymal tumours

Fleur CordierSharareh FadaeiLiesbeth FerdinandeFrederick DochyLieve VanwalleghemKarolien Van Den BosscheSiebe LoontiensJoni Van der MeulenNadine Van RoyJo Van Dorpe et al.

A1 Journal Article in JOURNAL OF CLINICAL PATHOLOGY

2024

A case of a lipoblastoma with EEF1A1::PLAG1 fusion and metaplastic ossification

Ellen DeoletFleur CordierLiesbeth FerdinandeSiebe LoontiensJoni Van der MeulenJo Van DorpeDavid Creytens

A1 Journal Article in GENES CHROMOSOMES & CANCER

A challenging case of an intraosseous composite hemangioendothelioma of the occipital bone with YAP1::FOXR1 fusion

Fleur CordierLiesbeth FerdinandeSiebe LoontiensJoni Van der MeulenJo Van DorpeDavid Creytens

A1 Journal Article in GENES CHROMOSOMES & CANCER

Identification of potentially actionable genetic variants in epithelial ovarian cancer : a retrospective cohort study

Charlotte FieuwsJoni Van der MeulenKristiaan ProesmansEmiel De JaeghereSiebe LoontiensJo Van DorpePhilippe TummersHannelore DenysKoen Van de VijverKathleen Claes

A1 Journal Article in NPJ PRECISION ONCOLOGY

MOXD1 is a lineage-specific gene and a tumor suppressor in neuroblastoma

Elina FredlundStina AnderssonElien HilgertEzequiel MonferrerGuadalupe Álvarez-HernánSinan KarakayaSiebe LoontiensJan Willem BekTomas GregorEstelle Lecomte et al.

A1 Journal Article in SCIENCE ADVANCES

RAF1-rearranged spindle cell mesenchymal tumor with calcification and heterotopic ossification : a case report and review of literature

Fleur CordierSiebe LoontiensJoni Van der MeulenLore LapeireGabriëlle van RamshorstGwen SysJo Van DorpeDavid Creytens

A1 Journal Article in INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY

2023

High-grade endometrial stromal sarcoma-like sarcoma in male : does it exist? A case report and review of the literature

Fleur CordierJoni Van der MeulenSiebe LoontiensNadine Van RoyLore LapeireWouter WillaertLiesbeth FerdinandeKoen Van de VijverJo Van DorpeDavid Creytens

A1 Journal Article in PATHOLOGY RESEARCH AND PRACTICE

SOX11 regulates SWI/SNF complex components as member of the adrenergic neuroblastoma core regulatory circuitry

Bieke DecaestekerAmber LouwagieSiebe LoontiensFanny De VloedSarah-Lee BekaertJuliette RoelsSuzanne VanhauwaertSara De BrouwerEllen SandersA Berezovskaya et al.

A1 Journal Article in NATURE COMMUNICATIONS

2022

RRM2 enhances MYCN driven neuroblastoma formation and acts as a synergistic target with CHK1 inhibition

Lisa DepestelCarolina de Carvalho NunesLiselot MusIris NelenLouis DelhayeKaylee KellerVolodimir OlexioukFanny De VloedEllen SandersAline Eggermont et al.

RRM2 enhances MYCN-driven neuroblastoma formation and acts as a synergistic target with CHK1 inhibition

Carolina de Carvalho NunesLisa DepestelLiselot MusKaylee M. KellerLouis DelhayeAmber LouwagieMuhammad RishfiAlex WhaleNeesha KaraSimon R. Andrews et al.

A1 Journal Article in SCIENCE ADVANCES

2021

SOX11 as guardian of epigenetic plasticity in neuroblastoma

Bieke DecaestekerAmber LouwagieSiebe LoontiensSara De BrouwerCarolina de Carvalho NunesGeertrui DeneckerFanny De VloedLisa DepestelJuliette RoelsKaren Verboom et al.

2020

A novel TLX1-driven T-ALL zebrafish model : comparative genomic analysis with other leukemia models

Siebe LoontiensSuzanne VanhauwaertLisa DepestelGivani DewynWouter Van LoockeFinola E. MooreElaine G. GarciaLance BatchelorChiara BorgaBarbara Squiban et al.

A1 Journal Article in LEUKEMIA

Exploring the role of PHF6 in malignant and normal hematopoiesis through zebrafish modeling

Siebe LoontiensFranki SpelemanPieter Van VlierbergheKaat Durinck

PHF6 expression levels impact human hematopoietic stem cell differentiation

Siebe LoontiensAnne-Catherine DolensSteven StrubbeInge Van de WalleFinola E. MooreLisa DepestelSuzanne VanhauwaertFilip MatthijssensDavid M. LangenauFranki Speleman et al.

A1 Journal Article in FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY

SOX11 as guardian of epigenetic plasticity in neuroblastoma

Bieke DecaestekerAmber LouwagieSiebe LoontiensCarolina de Carvalho NunesKaren VerboomJuliette RoelsEva D'haeneRogier VersteegKaat DurinckAnton Henssen et al.

2019

ALK positively regulates MYCN activity through repression of HBP1 expression

Shana ClaeysGeertrui DeneckerKaat DurinckBieke DecaestekerLiselot MusSiebe LoontiensSuzanne VanhauwaertKristina AlthoffCaroline WigerupDaniel Bexell et al.

A1 Journal Article in ONCOGENE

PHF6loss drives IL7R oncogene addiction in TLX1 driven T-ALL

Siebe LoontiensKaat DurinckSuzanne VanhauwaertLisa DepestelMariana L OliveiraGivani DewynCharles De BockJoao T BarataDavid LangenauJan Cools et al.

Purification of high-quality RNA from a small number of fluorescence activated cell sorted zebrafish cells for RNA sequencing purposes

Siebe LoontiensLisa DepestelSuzanne VanhauwaertGivani DewynCharlotte GistelinckKaren VerboomWouter Van LoockeFilip MatthijssensAndy WillaertJo Vandesompele et al.

A1 Journal Article in BMC GENOMICS

SOX11 as mediator of the adrenergic cell state in NB

Bieke DecaestekerAmber LouwagieSara De BrouwerVolodimir OlexioukGeertrui DeneckerCarolina de Carvalho NunesKaren VerboomMoritz GartlgruberWouter Van LoockeElena Afanasyeva et al.

SOX11 is a key epigenetic regulator in the adrenergic MYCN amplified neuroblastoma

Amber LouwagieBieke DecaestekerSara De BrouwerGeertrui DeneckerCarolina de Carvalho NunesVolodimir OlexioukKaren VerboomMoritz GartlgruberWouter Van LoockeElena Afanasyeva et al.

SOX11 is a key epigenetic regulator in the adrenergic MYCN amplified neuroblastoma

Amber LouwagieBieke DecaestekerCarolina de Carvalho NunesGeertrui DeneckerVolodimir OlexioukKaren VerboomMoritz GartlgruberWouter Van LoockeElena AfanasyevaPauline Depuydt et al.

Zebravis als in-vivo model voor de studie van acute lymfatische leukemie

Siebe LoontiensSuzanne VanhauwaertLisa DepestelKaat DurinckFranki Speleman

A2 Journal Article in ONCOHEMATO

2018

Cell of origin dictates aggression and stem cell number in acute lymphoblastic leukemia

Elaine G GarciaSowmya IyerSara P GarciaSiebe LoontiensRuslan I SadreyevFranki SpelemanDavid M Langenau

A1 Journal Article in LEUKEMIA

Isolation of high-quality RNA from fluorescent activated cell sorted (FACS) zebrafish cells for RNA sequencing purposes

Siebe LoontiensSuzanne VanhauwaertLisa DepestelGivani DewynCharlotte GistelinckKaren VerboomEls JanssensFilip MatthijssensAndy WillaertJo Vandesompele et al.

Scrutinizing PHF6 regulatory networks in T-ALL and normal hematopoiesis using zebrafish

Siebe LoontiensKaat DurinckInge Van de WalleFinola MooreSuzanne VanhauwaertEls JanssensGivani DewynLisa DepestelChristophe Van NesteDavid Langenau et al.

TBX2 is a neuroblastoma core regulatory circuitry component enhancing MYCN/FOXM1 reactivation of DREAM targets

Bieke DecaestekerGeertrui DeneckerChristophe Van NesteEmmy M DolmanWouter Van LoockeMoritz GartlgruberCarolina de Carvalho NunesFanny De VloedPauline DepuydtKaren Verboom et al.

A1 Journal Article in NATURE COMMUNICATIONS

TBX2 is implicated in cell cycle control and proliferation in neuroblastoma

Bieke DecaestekerGeertrui DeneckerChristophe Van NesteFanny De VloedMoritz GartlgruberPauline DepuydtWouter Van LoockeShana ClaeysDries RombautSiebe Loontiens et al.

The RRM2-PHF6 complex protects neuroblastoma cells from DNA damage accumulation to install a replication stress resistance phenotype

Carolina de Carvalho NunesKaat DurinckLisa DepestelSiebe LoontiensLouis DelhayeSofia ZanottiEmmy DolmanAline EggermontBieke DecaestekerPauline Depuydt et al.

The core regulatory circuit component TBX2 is implicated in cell cycle control and proliferation in neuroblastoma

Bieke DecaestekerGeertrui DeneckerWouter Van LoockeMoritz GartlgruberPauline DepuydtFanny De VloedShana ClaeysDries RombautSiebe LoontiensAnton Henssen et al.

The core regulatory circuit component TBX2 is implicated in cell cycle control and proliferation in neuroblastoma

Bieke DecaestekerGeertrui DeneckerChristophe Van NesteFanny De VloedMoritz GartlgruberPauline DepuydtWouter Van LoockeShana ClaeysDries RombautSiebe Loontiens et al.

2017

BRD3 as a specific vulnerable therapeutic target in neuroblastoma

Jolien De WynKaat DurinckAnneleen BeckersSiebe LoontiensSuzanne VanhauwaertDaniel CarterBelamy ChuengGlenn MarshallKatleen De PreterFrank Westermann et al.

RRM2 is an essential and druggable component of the FOXM1 driven replicative stress DNA damage response in neuroblastoma

Carolina de Carvalho NunesSiebe LoontiensPauline DepuydtSuzanne VanhauwaertBieke DecaestekerBram De WildeKatleen De PreterGeertrui DeneckerChristophe Van NesteKaat Durinck et al.

RRM2 is an essential and druggable component of the FOXM1 driven replicative stress DNA damage response in neuroblastoma

Carolina de Carvalho NunesSiebe LoontiensPauline DepuydtSuzanne VanhauwaertBieke DecaestekerBram De WildeKatleen De PreterGeertrui DeneckerChristophe Van NesteKaat Durinck et al.

The core regulatory circuit component TBX2 is implicated in cell cycle control and proliferation in neuroblastoma

Bieke DecaestekerGeertrui DeneckerWouter Van LoockeMoritz GartlgruberPauline DepuydtFanny De VloedShana ClaeysDries RombautSiebe LoontiensAnton Henssen et al.

2016

CRISPR-Cas9 modeling of cell lines and zebrafish to study the TLX1-PHF6 cooperative interrelationship in T-cell acute lymphoblastic leukemia

Siebe LoontiensKaat DurinckNina De RockerAnnekatrien BoelEls JanssensSuzanne VanhauwaertPieter RondouCharles De BockInge Van de WalleFinola Moore et al.

The TBX2 super-enhancer marked transcription factor on 17q is overexpressed in neuroblastoma and infers poor prognosis

Bieke DecaestekerFanny De VloedSiebe LoontiensGeertrui DeneckerWouter Van LoockeMoritz GartlgruberDries RombautAnneleen BeckersShana ClaeysAnton Henssen et al.

The TBX2 super-enhancer marked transcription factor on 17q is overexpressed in neuroblastoma and infers poor prognosis

Bieke DecaestekerAnton HenssenWouter Van LoockeAnneleen BeckersSiebe LoontiensJohannes SchulteKatleen De PreterFranki Speleman