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Researcher
Siebe Loontiens
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1 to 5
of 5
Profile
Projects
Publications
Activities
Awards & Distinctions
36
Results
2024
A case of a lipoblastoma with EEF1A1::PLAG1 fusion and metaplastic ossification
Ellen Deolet
Fleur Cordier
Liesbeth Ferdinande
Siebe Loontiens
Joni Van der Meulen
Jo Van Dorpe
David Creytens
A1
Journal Article
in
GENES CHROMOSOMES & CANCER
2024
A challenging case of an intraosseous composite hemangioendothelioma of the occipital bone with YAP1::FOXR1 fusion
Fleur Cordier
Liesbeth Ferdinande
Siebe Loontiens
Joni Van der Meulen
Jo Van Dorpe
David Creytens
A1
Journal Article
in
GENES CHROMOSOMES & CANCER
2024
Identification of potentially actionable genetic variants in epithelial ovarian cancer : a retrospective cohort study
Charlotte Fieuws
Joni Van der Meulen
Kristiaan Proesmans
Emiel De Jaeghere
Siebe Loontiens
Jo Van Dorpe
Philippe Tummers
Hannelore Denys
Koen Van de Vijver
Kathleen Claes
A1
Journal Article
in
NPJ PRECISION ONCOLOGY
2024
RAF1-rearranged spindle cell mesenchymal tumor with calcification and heterotopic ossification : a case report and review of literature
Fleur Cordier
Siebe Loontiens
Joni Van der Meulen
Lore Lapeire
Gabriƫlle van Ramshorst
Gwen Sys
Jo Van Dorpe
David Creytens
A1
Journal Article
in
INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY
2024
Revealing RB1 loss in an emerging entity : report of two cases of PRRX1-rearranged mesenchymal tumours
Fleur Cordier
Sharareh Fadaei
Liesbeth Ferdinande
Frederick Dochy
Lieve Vanwalleghem
Karolien Van Den Bossche
Siebe Loontiens
Joni Van der Meulen
Nadine Van Roy
Jo Van Dorpe
et al.
A1
Journal Article
in
JOURNAL OF CLINICAL PATHOLOGY
2024
2023
High-grade endometrial stromal sarcoma-like sarcoma in male : does it exist? A case report and review of the literature
Fleur Cordier
Joni Van der Meulen
Siebe Loontiens
Nadine Van Roy
Lore Lapeire
Wouter Willaert
Liesbeth Ferdinande
Koen Van de Vijver
Jo Van Dorpe
David Creytens
A1
Journal Article
in
PATHOLOGY RESEARCH AND PRACTICE
2023
SOX11 regulates SWI/SNF complex components as member of the adrenergic neuroblastoma core regulatory circuitry
Bieke Decaesteker
Amber Louwagie
Siebe Loontiens
Fanny De Vloed
Sarah-Lee Bekaert
Juliette Roels
Suzanne Vanhauwaert
Sara De Brouwer
Ellen Sanders
A Berezovskaya
et al.
A1
Journal Article
in
NATURE COMMUNICATIONS
2023
2022
RRM2 enhances MYCN driven neuroblastoma formation and acts as a synergistic target with CHK1 inhibition
Lisa Depestel
Carolina de Carvalho Nunes
Liselot Mus
Iris Nelen
Louis Delhaye
Kaylee Keller
Volodimir Olexiouk
Fanny De Vloed
Ellen Sanders
Aline Eggermont
et al.
C3
Conference
2022
RRM2 enhances MYCN-driven neuroblastoma formation and acts as a synergistic target with CHK1 inhibition
Carolina de Carvalho Nunes
Lisa Depestel
Liselot Mus
Kaylee M. Keller
Louis Delhaye
Amber Louwagie
Muhammad Rishfi
Alex Whale
Neesha Kara
Simon R. Andrews
et al.
A1
Journal Article
in
SCIENCE ADVANCES
2022
2021
SOX11 as guardian of epigenetic plasticity in neuroblastoma
Bieke Decaesteker
Amber Louwagie
Siebe Loontiens
Sara De Brouwer
Carolina de Carvalho Nunes
Geertrui Denecker
Fanny De Vloed
Lisa Depestel
Juliette Roels
Karen Verboom
et al.
C3
Conference
2021
2020
A novel TLX1-driven T-ALL zebrafish model : comparative genomic analysis with other leukemia models
Siebe Loontiens
Suzanne Vanhauwaert
Lisa Depestel
Givani Dewyn
Wouter Van Loocke
Finola E. Moore
Elaine G. Garcia
Lance Batchelor
Chiara Borga
Barbara Squiban
et al.
A1
Journal Article
in
LEUKEMIA
2020
Exploring the role of PHF6 in malignant and normal hematopoiesis through zebrafish modeling
Siebe Loontiens
Franki Speleman
Pieter Van Vlierberghe
Kaat Durinck
Dissertation
2020
PHF6 expression levels impact human hematopoietic stem cell differentiation
Siebe Loontiens
Anne-Catherine Dolens
Steven Strubbe
Inge Van de Walle
Finola E. Moore
Lisa Depestel
Suzanne Vanhauwaert
Filip Matthijssens
David M. Langenau
Franki Speleman
et al.
A1
Journal Article
in
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
2020
SOX11 as guardian of epigenetic plasticity in neuroblastoma
Bieke Decaesteker
Amber Louwagie
Siebe Loontiens
Carolina de Carvalho Nunes
Karen Verboom
Juliette Roels
Eva D'haene
Rogier Versteeg
Kaat Durinck
Anton Henssen
et al.
C3
Conference
2020
2019
ALK positively regulates MYCN activity through repression of HBP1 expression
Shana Claeys
Geertrui Denecker
Kaat Durinck
Bieke Decaesteker
Liselot Mus
Siebe Loontiens
Suzanne Vanhauwaert
Kristina Althoff
Caroline Wigerup
Daniel Bexell
et al.
A1
Journal Article
in
ONCOGENE
2019
PHF6loss drives IL7R oncogene addiction in TLX1 driven T-ALL
Siebe Loontiens
Kaat Durinck
Suzanne Vanhauwaert
Lisa Depestel
Mariana L Oliveira
Givani Dewyn
Charles De Bock
Joao T Barata
David Langenau
Jan Cools
et al.
C3
Conference
2019
Purification of high-quality RNA from a small number of fluorescence activated cell sorted zebrafish cells for RNA sequencing purposes
Siebe Loontiens
Lisa Depestel
Suzanne Vanhauwaert
Givani Dewyn
Charlotte Gistelinck
Karen Verboom
Wouter Van Loocke
Filip Matthijssens
Andy Willaert
Jo Vandesompele
et al.
A1
Journal Article
in
BMC GENOMICS
2019
SOX11 as mediator of the adrenergic cell state in NB
Bieke Decaesteker
Amber Louwagie
Sara De Brouwer
Volodimir Olexiouk
Geertrui Denecker
Carolina de Carvalho Nunes
Karen Verboom
Moritz Gartlgruber
Wouter Van Loocke
Elena Afanasyeva
et al.
C3
Conference
2019
SOX11 is a key epigenetic regulator in the adrenergic MYCN amplified neuroblastoma
Amber Louwagie
Bieke Decaesteker
Sara De Brouwer
Geertrui Denecker
Carolina de Carvalho Nunes
Volodimir Olexiouk
Karen Verboom
Moritz Gartlgruber
Wouter Van Loocke
Elena Afanasyeva
et al.
C3
Conference
2019
SOX11 is a key epigenetic regulator in the adrenergic MYCN amplified neuroblastoma
Amber Louwagie
Bieke Decaesteker
Carolina de Carvalho Nunes
Geertrui Denecker
Volodimir Olexiouk
Karen Verboom
Moritz Gartlgruber
Wouter Van Loocke
Elena Afanasyeva
Pauline Depuydt
et al.
C3
Conference
2019
Zebravis als in-vivo model voor de studie van acute lymfatische leukemie
Siebe Loontiens
Suzanne Vanhauwaert
Lisa Depestel
Kaat Durinck
Franki Speleman
A2
Journal Article
in
ONCOHEMATO
2019
2018
Cell of origin dictates aggression and stem cell number in acute lymphoblastic leukemia
Elaine G Garcia
Sowmya Iyer
Sara P Garcia
Siebe Loontiens
Ruslan I Sadreyev
Franki Speleman
David M Langenau
A1
Journal Article
in
LEUKEMIA
2018
Isolation of high-quality RNA from fluorescent activated cell sorted (FACS) zebrafish cells for RNA sequencing purposes
Siebe Loontiens
Suzanne Vanhauwaert
Lisa Depestel
Givani Dewyn
Charlotte Gistelinck
Karen Verboom
Els Janssens
Filip Matthijssens
Andy Willaert
Jo Vandesompele
et al.
C3
Conference
2018
Scrutinizing PHF6 regulatory networks in T-ALL and normal hematopoiesis using zebrafish
Siebe Loontiens
Kaat Durinck
Inge Van de Walle
Finola Moore
Suzanne Vanhauwaert
Els Janssens
Givani Dewyn
Lisa Depestel
Christophe Van Neste
David Langenau
et al.
C3
Conference
2018
TBX2 is a neuroblastoma core regulatory circuitry component enhancing MYCN/FOXM1 reactivation of DREAM targets
Bieke Decaesteker
Geertrui Denecker
Christophe Van Neste
Emmy M Dolman
Wouter Van Loocke
Moritz Gartlgruber
Carolina de Carvalho Nunes
Fanny De Vloed
Pauline Depuydt
Karen Verboom
et al.
A1
Journal Article
in
NATURE COMMUNICATIONS
2018
TBX2 is implicated in cell cycle control and proliferation in neuroblastoma
Bieke Decaesteker
Geertrui Denecker
Christophe Van Neste
Fanny De Vloed
Moritz Gartlgruber
Pauline Depuydt
Wouter Van Loocke
Shana Claeys
Dries Rombaut
Siebe Loontiens
et al.
C3
Conference
2018
The RRM2-PHF6 complex protects neuroblastoma cells from DNA damage accumulation to install a replication stress resistance phenotype
Carolina de Carvalho Nunes
Kaat Durinck
Lisa Depestel
Siebe Loontiens
Louis Delhaye
Sofia Zanotti
Emmy Dolman
Aline Eggermont
Bieke Decaesteker
Pauline Depuydt
et al.
C3
Conference
2018
The core regulatory circuit component TBX2 is implicated in cell cycle control and proliferation in neuroblastoma
Bieke Decaesteker
Geertrui Denecker
Wouter Van Loocke
Moritz Gartlgruber
Pauline Depuydt
Fanny De Vloed
Shana Claeys
Dries Rombaut
Siebe Loontiens
Anton Henssen
et al.
C3
Conference
2018
The core regulatory circuit component TBX2 is implicated in cell cycle control and proliferation in neuroblastoma
Bieke Decaesteker
Geertrui Denecker
Christophe Van Neste
Fanny De Vloed
Moritz Gartlgruber
Pauline Depuydt
Wouter Van Loocke
Shana Claeys
Dries Rombaut
Siebe Loontiens
et al.
C3
Conference
2018
2017
BRD3 as a specific vulnerable therapeutic target in neuroblastoma
Jolien De Wyn
Kaat Durinck
Anneleen Beckers
Siebe Loontiens
Suzanne Vanhauwaert
Daniel Carter
Belamy Chueng
Glenn Marshall
Katleen De Preter
Frank Westermann
et al.
C3
Conference
2017
RRM2 is an essential and druggable component of the FOXM1 driven replicative stress DNA damage response in neuroblastoma
Carolina de Carvalho Nunes
Siebe Loontiens
Pauline Depuydt
Suzanne Vanhauwaert
Bieke Decaesteker
Bram De Wilde
Katleen De Preter
Geertrui Denecker
Christophe Van Neste
Kaat Durinck
et al.
C3
Conference
2017
RRM2 is an essential and druggable component of the FOXM1 driven replicative stress DNA damage response in neuroblastoma
Carolina de Carvalho Nunes
Siebe Loontiens
Pauline Depuydt
Suzanne Vanhauwaert
Bieke Decaesteker
Bram De Wilde
Katleen De Preter
Geertrui Denecker
Christophe Van Neste
Kaat Durinck
et al.
C3
Conference
2017
The core regulatory circuit component TBX2 is implicated in cell cycle control and proliferation in neuroblastoma
Bieke Decaesteker
Geertrui Denecker
Wouter Van Loocke
Moritz Gartlgruber
Pauline Depuydt
Fanny De Vloed
Shana Claeys
Dries Rombaut
Siebe Loontiens
Anton Henssen
et al.
C3
Conference
2017
2016
CRISPR-Cas9 modeling of cell lines and zebrafish to study the TLX1-PHF6 cooperative interrelationship in T-cell acute lymphoblastic leukemia
Siebe Loontiens
Kaat Durinck
Nina De Rocker
Annekatrien Boel
Els Janssens
Suzanne Vanhauwaert
Pieter Rondou
Charles De Bock
Inge Van de Walle
Finola Moore
et al.
C3
Conference
2016
The TBX2 super-enhancer marked transcription factor on 17q is overexpressed in neuroblastoma and infers poor prognosis
Bieke Decaesteker
Fanny De Vloed
Siebe Loontiens
Geertrui Denecker
Wouter Van Loocke
Moritz Gartlgruber
Dries Rombaut
Anneleen Beckers
Shana Claeys
Anton Henssen
et al.
C3
Conference
2016
The TBX2 super-enhancer marked transcription factor on 17q is overexpressed in neuroblastoma and infers poor prognosis
Bieke Decaesteker
Anton Henssen
Wouter Van Loocke
Anneleen Beckers
Siebe Loontiens
Johannes Schulte
Katleen De Preter
Franki Speleman
C3
Conference
2016