Research Explorer

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Researcher

Serge Van Calenbergh

Publications & Research Data

Awards & Distinctions

337 Results

2025

<i>Breaking Bad<i> Development of Aurora Kinase A degraders for the treatment of Neuroblastoma

Simon KrolsSerge Van Calenbergh

Photopharmacological activation of adenosine A1 receptor signaling suppresses seizures in a mouse model for temporal lobe epilepsy

Jeroen SpanogheEvelien WynendaeleMarijke VergaelenMaren De ColvenaerTina MarimanKristl VonckEvelien CarretteWytse WadmanErine CraeyLars Emil Larsen et al.

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Preclinical toxicological assessment of an α-galactosylceramide-adjuvanted mRNA cancer vaccine in Wistar Han rats and domestic pigs

Sofie MeulewaeterMargo De VelderDiethard ReckelbusKevin MwangiThomas EhouarneIlke AernoutYanou EngelenFëllanza HalimiIsis Van herteryckLobke De Bels et al.

A1 Journal Article in MOLECULAR THERAPY METHODS & CLINICAL DEVELOPMENT

Second-generation AURKA-targeting PROTACs : structural optimization toward in vivo degradation in neuroblastoma

Simon KrolsMuhammad RishfiFien MartensAnouk Van HauwermeirenEllen SandersPieter-Jan De SutterAn VermeulenKaat De WeverSarah-Lee BekaertM. Emmy M. Dolman et al.

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

Synergistic inhibition of CHK1 and MUS81 to combat replication stress resistance in high-risk neuroblastoma

Elien HilgertChristophe Van NesteSarah-Lee BekaertFien MartensSuzanne VanhauwaertEllen SandersPeter VerstraelenMartijn RisseeuwEllen M. WesterhoutMark A. Grannetia et al.

A1 Journal Article in SCIENTIFIC REPORTS

2024

Alpha-galactosylceramide improves the potency of mRNA LNP vaccines against cancer and intracellular bacteria

Sofie MeulewaeterIlke AernoutJoke DeprezYanou EngelenMargo De VelderLorenzo FranceschiniKarine BreckpotSerge Van CalenberghCaroline AsselmanKatie Boucher et al.

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Mapping the transporter-substrate interactions of the Trypanosoma cruzi NB1 nucleobase transporter reveals the basis for its high affinity and selectivity for hypoxanthine and guanine and lack of nucleoside uptake

Mustafa M. AldferFabian HulpiaSerge Van CalenberghHarry P. De Koning

A1 Journal Article in MOLECULAR AND BIOCHEMICAL PARASITOLOGY

N6-methyltubercidin gives sterile cure in a cutaneous Leishmania amazonensis mouse model

Cassandra PresentRoberson Donola GirãoCai LinGuy CaljonSerge Van CalenberghOtacilio MoreiraLeonardo Alexandre de Souza RuivoMarcos Meuser BatistaRaquel AzevedoDenise da Gama Jaen Batista et al.

A1 Journal Article in PARASITOLOGY

Photopharmacology in the spotlight : spatially selective adenosinergic modulation of hippocampal excitability in the pursuit of therapeutic innovation in temporal lobe epilepsy

Marijke VergaelenJeroen SpanogheJeroen MissinneSerge Van CalenberghPaul BoonKristl VonckRobrecht Raedt

Practical and divergent synthesis of carbocyclic pyrazolo[3,4‐d]pyrimidine nucleoside analogues

Ewout Van de VeldeAnouk Van HauwermeirenNatascha Van PeltAn MatheeussenGuy CaljonSerge Van Calenbergh

A1 Journal Article in EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Studying target-engagement of anti-infectives by solvent-induced protein precipitation and quantitative mass spectrometry

Lorenzo BizzarriDominik SteinbrunnThibaut QuennessonAntoine LacourGabriella Ines BianchinoPatricia BravoPhilippe ChaignonJonas LohsePascal MäserMyriam Seemann et al.

A1 Journal Article in ACS INFECTIOUS DISEASES

Towards therapeutic innovation in temporal lobe epilepsy : focal adenosinergic modulation of hippocampal excitability

Marijke VergaelenJeroen SpanogheJeroen MissinneSerge Van CalenberghKristl VonckPaul BoonRobrecht Raedt

2023

3D-printed wound dressings containing a fosmidomycin-derivative prevent Acinetobacter baumannii biofilm formation

Frits van CharanteDavid Martínez-PérezClara Guarch-PérezCharlotte CourtensAndrea SassEmilia ChoińskaJoanna IdaszekSerge Van CalenberghMartijn RioolSebastian A. J. Zaat et al.

A1 Journal Article in ISCIENCE

Acyloxymethyl and alkoxycarbonyloxymethyl prodrugs of a fosmidomycin surrogate as antimalarial and antibacterial agents

Charlotte CourtensFrits van CharanteThibaut QuennessonMartijn RisseeuwPaul CosGuy CaljonTom CoenyeSerge Van Calenbergh

A1 Journal Article in EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Cloning and characterization of Trypanosoma congolense and T. vivax nucleoside transporters reveal the potential of P1-type carriers for the discovery of broad-spectrum nucleoside-based therapeutics against animal African trypanosomiasis

Marzuq A. UngogoMustafa M. AldferManal J. NattoHainan ZhuangRobyn ChisholmKaty WalshMarieClaire McGeeKayhan IlbeigiJamal Ibrahim AsseriRichard J. S. Burchmore et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dual N6/C7-substituted 7-deazapurine and tricyclic ribonucleosides with affinity for G protein-coupled receptors

Simon KrolsFederica MatteucciKristof Van HeckeGuy CaljonKenneth A. JacobsonSerge Van Calenbergh

A1 Journal Article in ACS MEDICINAL CHEMISTRY LETTERS

Focal adenosine A1 receptor activation through photopharmacology as a potential treatment for drug-resistant epilepsy

Jeroen SpanogheLars Emil LarsenErine CraeySimona ManzellaKristl VonckSerge Van CalenberghPaul BoonR. Raedt

Nanobody-mediated SPECT/CT imaging reveals the spatiotemporal expression of programmed death-ligand 1 in response to a CD8+ T cell and iNKT cell activating mRNA vaccine

Thomas ErtveldtSofie MeulewaeterYannick De VlaeminckOscar OlarteKatrijn BroosSerge Van CalenberghStephanie BourgeoisJoke DeprezYves HeremansCleo Goyvaerts et al.

A1 Journal Article in THERANOSTICS

Study of G protein-coupled receptors dimerization : from bivalent ligands to drug-like small molecules

Mingcheng QianZhengyang SunXin ChenSerge Van Calenbergh

A1 Journal Article in BIOORGANIC CHEMISTRY

Targeted AURKA degradation : towards new therapeutic agents for neuroblastoma

Muhammad RishfiSimon KrolsFien MartensSarah-Lee BekaertEllen SandersAline EggermontFanny De VloedJoshua Robert GouldingMartijn RisseeuwJan Molenaar et al.

A1 Journal Article in EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

2022

A Toxoplasma gondii oxopurine transporter binds nucleobases and nucleosides using different binding modes

Gustavo D. CampagnaroHamza A. A. ElatiSofia BalaskaMaria Esther Martin AbrilManal J. NattoFabian HulpiaKelly LeeLilach SheinerSerge Van CalenberghHarry P. de Koning

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Enrichment of a purine nucleoside analog library towards activity against Leishmania and Trypanosoma cruzi species

Cai LinSerge Van CalenberghMartijn Risseeuw

Ex vivo feedback control of neurotransmission using a photocaged adenosine A1 receptor agonist

Erine CraeyFabian HulpiaJeroen SpanogheSimona ManzellaLars Emil LarsenMathieu SprengersDimitri De BundelIlse SmoldersEvelien CarretteJean Delbeke et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Exploration of 6-methyl-7-(hetero)aryl-7-deazapurine ribonucleosides as antileishmanial agents

Cai LinIzet KaralicAn MatheeussenPim-Bart FeijensFabian HulpiaLouis MaesGuy CaljonSerge Van Calenbergh

A1 Journal Article in EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

N6-modification of 7-deazapurine nucleoside analogues as anti-Trypanosoma cruzi and anti-Leishmania agents : structure-activity relationship exploration and in vivo evaluation

Cai LinDenise da Gama Jaén BatistaAna Lia MazzetiRoberson Donola GirãoGabriel Melo de OliveiraIzet KaralicFabian HulpiaMaria de Nazaré C. SoeiroLouis MaesGuy Caljon et al.

A1 Journal Article in EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Nucleoside analogues for the treatment of animal trypanosomiasis

Dorien MabilleKayhan IlbeigiSarah HendrickxMarzuq A. UngogoFabian HulpiaCai LinLouis MaesHarry P. de KoningSerge Van CalenberghGuy Caljon

A1 Journal Article in INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE

Phenethyl-4-ANPP : a marginally active byproduct suggesting a switch in illicit fentanyl synthesis routes

Marthe VandeputteAlex J. KrotulskiFabian HulpiaSerge Van CalenberghChristophe Stove

A1 Journal Article in JOURNAL OF ANALYTICAL TOXICOLOGY

Phenotypic evaluation of nucleoside analogues against Trypanosoma cruzi infection : in vitro and in vivo approaches

Ludmila F. de A. FiuzaDenise G. J. BatistaRoberson D. GirãoFabian HulpiaPaula Finamore-AraújoMustafa M. AldferEhab Kotb ElmahallawyHarry P. De KoningOtacílio MoreiraSerge Van Calenbergh et al.

A1 Journal Article in MOLECULES

2021

2-((3,5-Dinitrobenzyl)thio)quinazolinones : potent antimycobacterial agents activated by deazaflavin (F420)-dependent nitroreductase (Ddn)

Yanlin JianHe Eun ForbesFabian HulpiaMartijn RisseeuwGuy CaljonHélène Munier-LehmannHelena I. M. BoshoffSerge Van Calenbergh

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

4E interacting protein as a potential novel drug target for nucleoside analogues in Trypanosoma brucei

Dorien MabilleCamila Cardoso SantosRik HendrickxMathieu ClaesPeter TakacChristine ClaytonSarah HendrickxFabian HulpiaLouis MaesSerge Van Calenbergh et al.

A1 Journal Article in MICROORGANISMS

6-Methyl-7-deazapurine nucleoside analogues as broad-spectrum antikinetoplastid agents

Cai LinFabian HulpiaIzet KaralicLaurens De SchepperLouis MaesGuy CaljonSerge Van Calenbergh

A1 Journal Article in INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE

6‐methyl‐7‐aryl‐7‐deazapurine nucleosides as anti‐trypanosoma cruzi agents : structure‐activity relationship and in vivo efficacy

Cai LinLudmila Ferreira de Almeida FiuzaCamila Cardoso SantosDaniela Ferreira NunesOtacílio Cruz MoreiraJakob BoutonIzet KaralicLouis MaesGuy CaljonFabian Hulpia et al.

A1 Journal Article in CHEMMEDCHEM

7-Aryl-7-deazapurine 3 '-deoxyribonucleoside derivative as a novel lead for Chagas' disease therapy : in vitro and in vivo pharmacology

Camila Cardoso-SantosLudmila Ferreira de Almeida FiuzaCristiane Franca da SilvaAna Lia MazzetiRoberson Donola GiraoGabriel Melo de OliveiraDenise da Gama Jaen BatistaOtacilio Cruz MoreiraNatalia Lins da Silva GomesLouis Maes et al.

A2 Journal Article in JAC-ANTIMICROBIAL RESISTANCE

Analytical characterization of 'etonitazepyne', a new pyrrolidinyl‐containing 2‐benzylbenzimidazole opioid sold online

Peter BlanckaertMargot BalcaenCéline VanheeMartijn RisseeuwMichaël CanfynBart DesmedtSerge Van CalenberghEric Deconinck

A1 Journal Article in DRUG TESTING AND ANALYSIS

Deazapurine nucleoside analogues for the treatment of Trichomonas vaginalis

Manal J. NattoFabian HulpiaEric R. KalkmanSusan BaillieAmani AlhejeliYukiko MiyamotoLars EckmannSerge Van CalenberghHarry P. de Koning

A1 Journal Article in ACS INFECTIOUS DISEASES

Discovery of a true bivalent dopamine D2 receptor agonist

Mingcheng QianAdrián RicarteElise WoutersJames A.R. DaltonMartijn RisseeuwJesús GiraldoSerge Van Calenbergh

A1 Journal Article in EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Feedback control of CA1 excitability in hippocampal slices with a photoactive adenosine A1 receptor agonist

Erine CraeyJeroen SpanogheSerge Van CalenberghLars Emil LarsenEvelien CarretteJean DelbekeKristl VonckPaul BoonWytse WadmanRobrecht Raedt

Homoazanucleoside, purine nucleoside and hamamelitannin analogues : towards new therapeutics for infectious diseases

Jakob BoutonSerge Van Calenbergh

Optical control of excitatory transmission in hippocampal slices with photoactive adenosine A1 receptor agonist

Erine CraeyFabian HulpiaSerge Van CalenberghLars Emil LarsenCharlotte MathysInge Van ColenJean DelbekeKristl VonckPaul BoonWytse Wadman et al.

Optical control of excitatory transmission in hippocampal slices with photoactive adenosine A1 receptor agonist

Erine CraeyFabian HulpiaSerge Van CalenberghLars Emil LarsenCharlotte MathysInge Van ColenJean DelbekeKristl VonckPaul BoonWytse Wadman et al.

Report on a new opioid NPS : chemical and in vitro functional characterization of a structural isomer of the MT-45 derivative diphenpipenol

Annelies CannaertFabian HulpiaMartijn RisseeuwKatleen Van UytfangheEric DeconinckSerge Van CalenberghPeter BlanckaertChristophe Stove

A1 Journal Article in JOURNAL OF ANALYTICAL TOXICOLOGY

Revisiting pyrazolo[3,4-d]pyrimidine nucleosides as anti-trypanosoma cruzi and antileishmanial agents

Jakob BoutonLudmila Ferreira de Almeida FiuzaCamila Cardoso SantosMaria Angela MazzarellaMaria de Nazaré Correia SoeiroLouis MaesIzet KaralicGuy CaljonSerge Van Calenbergh

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

RUNX2 regulates leukemic cell metabolism and chemotaxis in high-risk T cell acute lymphoblastic leukemia

Filip MatthijssensNitesh D. SharmaMonique NysusChristian K. NicklHuining KangDominique R. PerezBéatrice LintermansWouter Van LoockeJuliette RoelsSofie Peirs et al.

A1 Journal Article in JOURNAL OF CLINICAL INVESTIGATION

Structure-aided optimization of non-nucleoside M. tuberculosis thymidylate kinase inhibitors

Lijun SongRomain MerceronFabian HulpiaAinhoa LuciaBegona GraciaYanlin JianMartijn RisseeuwToon VerstraelenPaul CosJose A. Ainsa et al.

A1 Journal Article in EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Sustainability in drug discovery

Evelien WynendaeleChristophe FurmanBartosz WielgomasPer LarssonEelko HakThomas BlockSerge Van CalenberghNicolas WillandMichal MarkuszewskiLuke R. Odell et al.

A2 Journal Article in MEDICINE IN DRUG DISCOVERY

Synthesis and evaluation of 3′-fluorinated 7-deazapurine nucleosides as antikinetoplastid agents

Jakob BoutonArno Furquim d'AlmeidaLouis MaesGuy CaljonSerge Van CalenberghFabian Hulpia

A1 Journal Article in EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and evaluation of a collection of purine-like C-nucleosides as antikinetoplastid agents

Jakob BoutonLouis MaesIzet KaralicGuy CaljonSerge Van Calenbergh

A1 Journal Article in EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

2020

1-(1-Arylethylpiperidin-4-yl)thymine analogs as antimycobacterial TMPK inhibitors

Yanlin JianFabian HulpiaMartijn RisseeuwHe Eun ForbesGuy CaljonHélène Munier-LehmannHelena I. M. BoshoffSerge Van Calenbergh

A1 Journal Article in MOLECULES

3'-Deoxyribofuranosyl 7-deazapurine nucleoside analogues : a new class of highly potent antitrypanosomal agents

Fabian HulpiaDorien MabilleGustavo Daniel CampagnaroLouis MaesHarry P de KoningGuy CaljonSerge Van Calenbergh

6-O-alkylated 7-deazainosine nucleoside analogues : discovery of potent and selective anti-sleeping sickness agents

Fabian HulpiaJakob BoutonGustavo D. CampagnaroIbrahim A. AlfayezDorien MabilleLouis MaesHarry P. de KoningGuy CaljonSerge Van Calenbergh

A1 Journal Article in EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Cationic amphiphilic drugs boost the lysosomal escape of small nucleic acid therapeutics in a nanocarrier-dependent manner

Thijs Van de VyverBram BogaertLynn De BackerFreya JorisRoberta GuagliardoJelter Van HoeckPieterjan MerckxSerge Van CalenberghSrinivas RamishettiDan Peer et al.

A1 Journal Article in ACS NANO

Deazapurine nucleoside analogues as potent anti-Trypanosoma cruzi agents

Fabian HulpiaCai LinChristiane França da SilvaDenise da Gama Jean BatistaCamilla Cardoso-SantosLouis MaesGuy CaljonMaria de Nazaré C. SoeiroSerge Van Calenbergh

Design and synthesis of M. tuberculosis thymidylate kinase inhibitors towards active whole-cell antimycobacterial agents

Yanlin JianSerge Van CalenberghMartijn Risseeuw

Design, synthesis and characterization of a new series of fluorescent metabotropic glutamate receptor type 5 negative allosteric modulators

Víctor Fernández-DueñasMingcheng QianJosep ArgerichCarolina AmaralMartijn RisseeuwSerge Van CalenberghFrancisco Ciruela

A1 Journal Article in MOLECULES

Endeavors towards transformation of M. tuberculosis thymidylate kinase (MtbTMPK) inhibitors into potential antimycobacterial agents

Yanlin JianRomain MerceronSteven De MunckHe Eun ForbesFabian HulpiaMartijn RisseeuwKristof Van HeckeSavvas SavvidesHélène Munier-LehmannHelena I. M. Boshoff et al.

A1 Journal Article in EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

First report on brorphine : the next opioid on the deadly new psychoactive substance horizon?

Nick VerougstraeteMarthe VandeputteCathelijne LyphoutAnnelies CannaertFabian HulpiaSerge Van CalenberghAlain VerstraeteChristophe Stove

A1 Journal Article in JOURNAL OF ANALYTICAL TOXICOLOGY

Radiosynthesis, in vitro and preliminary biological evaluation of [F-18]2-amino-4-((2-((3-fluorobenzyl)oxy)benzyl)(2-((3-(fluoromethyl)benzyl)oxy)benzyl)amino) butanoic acid, a novel alanine serine cysteine transporter 2 inhibitor-based positron emission tomography tracer

Tristan BaguetJakob BoutonJonas JanssensGlenn PauwelynJeroen VerhoevenBenedicte DescampsSerge Van CalenberghChristian VanhoveFilip De Vos

A1 Journal Article in JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Report on a novel emerging class of highly potent benzimidazole NPS opioids : chemical and in vitro functional characterization of isotonitazene

Peter BlanckaertAnnelies CannaertKatleen Van UytfangheFabian HulpiaEric DeconinckSerge Van CalenberghChristophe Stove

A1 Journal Article in DRUG TESTING AND ANALYSIS

Structure-activity relationship exploration of 3’-deoxy-7-deazapurine nucleoside analogues as anti-Trypanosoma brucei agents

Fabian HulpiaGustavo Daniel CampagnaroKhalid J. AlzahraniIbrahim A. AlfayezMarzuq A. UngogoDorien MabilleLouis MaesHarry P. de KoningGuy CaljonSerge Van Calenbergh

A1 Journal Article in ACS INFECTIOUS DISEASES

Sydnone ribosides as a platform for the synthesis of pyrazole C-nucleosides : a unified synthesis of formycin B and pyrazofurin

Jakob BoutonSerge Van CalenberghJan Hullaert

A1 Journal Article in ORGANIC LETTERS

Synthesis and structure activity relationships of cyanopyridone based anti-tuberculosis agents

Yanlin JianFabian HulpiaMartijn RisseeuwHe Eun ForbesHélène Munier-LehmannGuy CaljonHelena I. M. BoshoffSerge Van Calenbergh

A1 Journal Article in EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and structure-activity relationships of cerebroside analogues as substrates of cerebroside sulphotransferase and discovery of a competitive inhibitor

Wenjin LiJoren GuillaumeYounis BaqiIsabell WachsmannVolkmar GieselmannSerge Van CalenberghChrista E. Müller

A1 Journal Article in JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Synthetic rhamnose glycopolymer cell-surface receptor for endogenous antibody recruitment

Ruben De CoenLutz NuhnChamani PereraMaria Arista-RomeroMartijn RisseeuwAlec FreynRaffael NachbagauerLorenzo AlbertazziSerge Van CalenberghDavid A. Spiegel et al.

A1 Journal Article in BIOMACROMOLECULES

2019

3’-Deoxy-3’-fluoro-7-deazapurine nucleosides : synthesis and evaluation against kinetoplastid parasites

Jakob BoutonFabian HulpiaLouis MaesGuy CaljonSerge Van Calenbergh

4''-O-Alkylated α-galactosylceramide analogues as iNKT-cell antigens : synthetic, biological, and structural studies

Jonas JanssensAruna BitraJing WangTine DecruyKoen VenkenJohan Van der EyckenDirk ElewautDirk ZajoncSerge Van Calenbergh

A1 Journal Article in CHEMMEDCHEM

A molecular switch in mouse CD1d modulates natural killer T cell activation by α-galactosylsphingamides

Jing WangJoren GuillaumeJonas JanssensSoumya G. RemeshGe YingAruna BitraSerge Van CalenberghDirk Zajonc

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Amino acid based prodrugs of a fosmidomycin surrogate as antimalarial and antitubercular agents

Charlotte CourtensMartijn RisseeuwGuy CaljonLouis MaesAnandi MartinSerge Van Calenbergh

A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY

Broadening the message : a nanovaccine co-loaded with messenger RNA and α-GalCer induces antitumor immunity through conventional and natural killer T cells

Rein VerbekeIne LentackerKarine BreckpotJonas JanssensSerge Van CalenberghStefaan De SmedtHeleen Dewitte

A1 Journal Article in ACS NANO

Ceramide-templated macrolactams : total synthesis and biological evaluation of macrocyclic α-galactosylceramide analogues and their aglycons

Jonas JanssensJohan Van der EyckenSerge Van Calenbergh

A1 Journal Article in EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Combining tubercidin and cordycepin scaffolds results in highly active candidates to treat late-stage sleeping sickness

Fabian HulpiaDorien MabilleGustavo Daniel CampagnaroGabriela SchumanLouis MaesIsabel RoditiAnders HoferHarry P de KoningGuy CaljonSerge Van Calenbergh

A1 Journal Article in NATURE COMMUNICATIONS

Design and synthesis of trypanocidal purine nucleoside analogues : discovery of lead compounds for the treatment of sleeping sickness

Fabian HulpiaSerge Van Calenbergh

Discovery of 7-aryl-7-deazapurine 3'-deoxyribofuranosyl nucleoside analogues as anti-Trypanosoma cruzi agents

Fabian HulpiaLouis MaesGuy CaljonMaria de Nazaré SoeiroSerge Van Calenbergh

Discovery of pyrrolo[2,3-b]pyridine (1,7-dideazapurine) nucleoside analogues as anti-Trypanosoma cruzi agents

Cai LinFabian HulpiaCristiane França da SilvaDenise da Gama Jaén BatistaKristof Van HeckeLouis MaesGuy CaljonMaria de Nazaré Correia SoeiroSerge Van Calenbergh

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

Discovery of pyrrolo[2,3-b]pyridine nucleoside analogues as anti-Trypanosoma cruzi agents

Cai LinFabian HulpiaKristof Van HeckeLouis MaesGuy CaljonMaria de Nazaré C. SoeiroSerge Van Calenbergh

Double prodrugs of a fosmidomycin surrogate as antimalarial and antitubercular agents

Charlotte CourtensMartijn RisseeuwGuy CaljonLouis MaesPaul CosAnandi MartinSerge Van Calenbergh

A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Host metabolites stimulate the bacterial proton motive force to enhance the activity of aminoglycoside antibiotics

Aurélie CrabbéLisa OstynSorien StaelensCharlotte RigautsMartijn RisseeuwMaarten DhaenensSimon DaledHeleen Van AckerDieter DeforceSerge Van Calenbergh et al.

A1 Journal Article in PLOS PATHOGENS

New fluoroethyl phenylalanine analogues as potential LAT1-targeting PET tracers for glioblastoma

Jeroen VerhoevenFabian HulpiaKen KersemansJulie BolcaenStef De LombaerdeJan GoemanBenedicte DescampsGiorgio HallaertCaroline Van den BroeckeKarel Deblaere et al.

A1 Journal Article in SCIENTIFIC REPORTS

Novel pyrazolo[3,4-d]pyrimidine nucleosides : promising hits for Chagas disease and Leishmaniasis

Jakob BoutonFabian HulpiaSerge Van CalenberghGuy CaljonLouis Maes

Phosphonodiamidate prodrugs of N-alkoxy analogs of a fosmidomycin surrogate as antimalarial and antitubercular agents

Charlotte CourtensMartijn RisseeuwGuy CaljonPaul CosAnandi MartinSerge Van Calenbergh

A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Purine nucleoside analogs as highly potent leads for the treatment of human African trypanosomiasis

Fabian HulpiaLouis MaesHarry P de KoningGuy CaljonSerge Van Calenbergh

Purine nucleoside analogs as highly potent leads for the treatment of human African trypanosomiasis

Fabian HulpiaLouis MaesHarry P. de KoningGuy CaljonSerge Van Calenbergh

Revisiting tubercidin against kinetoplastid parasites : aromatic substitutions at position 7 improve activity and reduce toxicity

Fabian HulpiaGustavo Daniel CampagnaroMirko ScortichiniKristof Van HeckeLouis MaesHarry P de KoningGuy CaljonSerge Van Calenbergh

A1 Journal Article in EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

RORγt inhibition selectively targets IL-17 producing iNKT and γδ-T cells enriched in Spondyloarthritis patients

Koen VenkenPeggy JacquesCéline MortierMark E. LabadiaTine DecruyJulie CoudenysKathleen HoytAnita L. WayneRobert HughesMichael Turner et al.

A1 Journal Article in NATURE COMMUNICATIONS

Structural basis of NKT cell inhibition using the T-cell receptor-blocking anti-CD1d antibody 1B1

Ge YingJing WangThierry MallevaeySerge Van CalenberghDirk Zajonc

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Synthesis and biological evaluation of 1’-N-homoazanucleosides : discovery of a 5’-methylthioadenosine analogue with antitrypanosomal activity

Jakob BoutonSerge Van Calenbergh

Synthesis and evaluation of 3’-deoxy-3’-fluoro-7-deazapurine nucleosides as antikinetoplastid agents

Jakob BoutonFabian HulpiaGuy CaljonLouis MaesSerge Van Calenbergh

Synthesis of prodrugs of a fosmidomycin surrogate as antimalarial and antitubercular agents

Charlotte CourtensSerge Van CalenberghMartijn Risseeuw

Zwitterionic-hydrophilic interaction liquid chromatography for L-ascorbic acid 2-phosphate magnesium, a raw material in cell therapy

Xiaolong XuJonas UrlaubMagdalena WoźniczkaEvelien WynendaeleKaren HermanCurd SchollmayerBernd DiehlSerge Van CalenberghUlrike HolzgrabeBart De Spiegeleer

A1 Journal Article in JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

α-Galactosylceramide analogues as iNKT-cell antigens : synthesis, biological evaluation and structural analysis

Jonas JanssensJohan Van der EyckenSerge Van Calenbergh

2018

4"-O-alkylated α-galactosylceramide analogues as iNKT cell antigens : synthetic, biological and structural studies

Jonas JanssensJing WangAruna BitraTine DecruyKoen VenkenJohan Van der EyckenDirk ElewautDirk ZajoncSerge Van Calenbergh

Acyloxybenzyl and alkoxyalkyl prodrugs of a fosmidomycin surrogate as antimalarial and antitubercular agents

Charlotte CourtensMartijn RisseeuwGuy CaljonPaul CosSerge Van Calenbergh

A1 Journal Article in ACS MEDICINAL CHEMISTRY LETTERS

C7 substituted 7-deaza adenosines : design and synthesis of nucleosides with potent antitrypanosomal activity

Fabian HulpiaSerge Van Calenbergh

Design and synthesis of a purine nucleoside library : phenotypic discovery of antikinetoplastid agents

Fabian HulpiaSerge Van Calenbergh

Design and synthesis of non-nucleoside M. tuberculosis thymidylate kinase Inhibitors as antimycobacterial agents

Lijun SongSerge Van Calenbergh

Design, synthesis, and biological evaluation of bivalent ligands targeting dopamine D2-like receptors and the μ-opioid receptor

Mingcheng QianLakshmi VasudevanJelle HuysentruytMartijn RisseeuwChristophe StovePatrick ML VanderheydenKathleen Van CraenenbroeckSerge Van Calenbergh

A1 Journal Article in CHEMMEDCHEM

Discovery of novel 7-aryl 7-deazapurine 3'-deoxy-ribofuranosyl nucleosides with potent activity against Trypanosoma cruzi

Fabian HulpiaKristof Van HeckeCristiane Franca da SilvaDenise da Gama Jaen BatistaLouis MaesGuy CaljonMaria de Nazare C SoeiroSerge Van Calenbergh

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

Identification and characterization of 4-chloromethamphetamine (4-CMA) in seized ecstacy : a risk to public health

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A1 Journal Article in FORENSIC SCIENCE INTERNATIONAL

Optimized messenger RNA immunolipoplexes for cancer immunotherapy : balancing immunogenicity and adjuvancy

Rein VerbekeIne LentackerKarine BreckpotSerge Van CalenberghStefaan De SmedtHeleen Dewitte

Regioselective ring opening of 1,3-dioxane-type acetals in carbohydrates

Jonas JanssensMartijn RisseeuwJohan Van der EyckenSerge Van Calenbergh

A1 Journal Article in EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Structure guided lead generation toward nonchiral M. tuberculosis thymidylate kinase inhibitors

Lijun SongRomain MerceronBegoña GraciaAinhoa Lucía QuintanaMartijn RisseeuwFabian HulpiaPaul CosJosé A AínsaHélène Munier-LehmannSavvas Savvides et al.

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and biological evaluation of new bivalent GPCR ligands

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Synthesis of a 3'-C-ethynyl-β-D-ribofuranose purine nucleoside library : discovery of C7-deazapurine analogs as potent antiproliferative nucleosides

Fabian HulpiaSam NoppenDominique ScholsGraciela AndreiRobert SnoeckSandra LiekensPeter VervaekeSerge Van Calenbergh

A1 Journal Article in EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of pyrrolidine-based hamamelitannin analogues as quorum sensing inhibitors in Staphylococcus aureus

Jakob BoutonKristof Van HeckeReuven RasoolySerge Van Calenbergh

A1 Journal Article in BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY

Synthesis of pyrrolidine-based hamamelitannin analogues in the search for potentiators for antibiotics against Staphylococcus aureus

Jakob BoutonSerge Van Calenbergh

Synthesis toward bivalent ligands for the dopamine D2 and metabotropic glutamate 5 receptors

Mingcheng QianElise WoutersJames AR DaltonMartijn RisseeuwRené CransChristophe StoveJesús GiraldoKathleen Van CraenenbroeckSerge Van Calenbergh

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

Tailored design of sugar-modified a-GalCer analogues for Th1-polarized immune responses

Serge Van Calenbergh

2017

Autoreactivity to sulfatide by human invariant NKT cells

Annelein M StaxJessica TuengelEnrico GirardiNaoki KitanoLenka L AllanVictor LiuDongjun ZhengWilliam J PanenkaJoren GuillaumeChi-Huey Wong et al.

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Efficient diastereoselective synthesis of a new class of azanucleosides : 2'-homoazanucleosides

Jakob BoutonKristof Van HeckeSerge Van Calenbergh

A1 Journal Article in TETRAHEDRON

Efficient divergent synthesis of new immunostimulant 4″-modified α-galactosylceramide analogues

Jonas JanssensTine DecruyKoen VenkenToshiyuki SekiSimon KrolsJohan Van der EyckenMoriya TsujiDirk ElewautSerge Van Calenbergh

A1 Journal Article in ACS MEDICINAL CHEMISTRY LETTERS

Galactosylsphingamides : new α-GalCer analogues to probe the F’-pocket of CD1d

Joren GuillaumeJing WangJonas JanssensSoumya G RemeshMartijn RisseeuwTine DecruyMathy FroeyenDirk ElewautDirk M ZajoncSerge Van Calenbergh

A1 Journal Article in SCIENTIFIC REPORTS

Identification of a new tert -leucinate class synthetic cannabinoid in powder and 'spice-like' herbal incenses : methyl 2-[[1-(5-fluoropentyl)indole-3-carbonyl]amino]-3,3-dimethyl-butanoate (5F-MDMB-PICA)

Martijn RisseeuwPeter BlanckaertVera CoopmanStijn Van QuekelbergheSerge Van CalenberghJan Cordonnier

A1 Journal Article in FORENSIC SCIENCE INTERNATIONAL

Leptin receptor antagonism of iNKT cell function : a novel strategy to combat multiple myeloma

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A1 Journal Article in LEUKEMIA

Micellar paclitaxel-initiated RAFT polymer conjugates with acid-sensitive behavior

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A1 Journal Article in ACS MACRO LETTERS

Novel 3'-deoxy purine nucleoside analogs as highly potent leads for human African trypanosomiasis

Fabian HulpiaSerge Van Calenbergh

Novel hamamelitannin analogues for the treatment of biofilm related MRSA infections : a scaffold hopping approach

Arno VermoteGilles BrackmanMartijn RisseeuwTom CoenyeSerge Van Calenbergh

A1 Journal Article in EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel potentiators for vancomycin in the treatment of biofilm-related MRSA infections via a mix and match approach

Arno VermoteGilles BrackmanMartijn RisseeuwDavie CappoenPaul CosTom CoenyeSerge Van Calenbergh

A1 Journal Article in ACS MEDICINAL CHEMISTRY LETTERS

Small-molecule potentiators for conventional antibiotics against Staphylococcus aureus

Arno VermoteSerge Van Calenbergh

A1 Journal Article in ACS INFECTIOUS DISEASES

Synthesis of C6′′-modified α-C-GalCer analogues as mouse and human iNKT cell agonists

Joren GuillaumeToshiyuki SekiTine DecruyKoen VenkenDirk ElewautMoriya TsujiSerge Van Calenbergh

A1 Journal Article in ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis of new glycosphingolipids as NKT cell ligands

Joren GuillaumeSerge Van Calenbergh

2016

A case of acute intoxication due to combined use of fentanyl and 3,4-dichloro-N-[2-(dimethylamino)cyclohexyl]-N-methylbenzamide (U-47700)

Vera CoopmanPeter BlanckaertGeert Van ParysSerge Van CalenberghJan Cordonnier

A1 Journal Article in FORENSIC SCIENCE INTERNATIONAL

A PMB-protecting group strategy for the divergent synthesis of 4”-modified alpha-galactosylceramide analogues

Jonas JanssensJohan Van der EyckenSerge Van Calenbergh

A practical approach to the synthesis of new 4”-modified α-galactosylceramide analogues

Jonas JanssensJohan Van der EyckenSerge Van Calenbergh

C-3’-ethynylnucleosides: an old modification going viral

Fabian HulpiaJan BalzariniDominique ScholsSerge Van Calenbergh

Chemical dimerizers in three-hybrid systems for small molecule-target protein profiling

Dries De ClercqJan TavernierSam LievensSerge Van Calenbergh

A1 Journal Article in ACS CHEMICAL BIOLOGY

Design, synthesis and biological evaluation of novel hamamelitannin analogues as potentiators for vancomycin in the treatment of biofilm related Staphylococcus aureus infections

Arno VermoteGilles BrackmanMartijn RisseeuwTom CoenyeSerge Van Calenbergh

A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY

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Arno VermoteGilles BrackmanMartijn RisseeuwKoen BreyneEvelyne MeyerP CosTom CoenyeSerge Van Calenbergh

Elaboration of a proprietary thymidylate kinase inhibitor motif towards anti-tuberculosis agents

Lijun SongMartijn RisseeuwMatheus FroeyenIzet KaralicJan GoemanDavie CappoenJohan Van der EyckenPaul CosHélène Munier-LehmannSerge Van Calenbergh

A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY

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Fabian HulpiaJan BalzariniDominique ScholsGraciela AndreiRobert SnoeckSerge Van Calenbergh

A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Getting fosmidomycin inside mycobacterial cells : a prodrug approach

Charlotte CourtensMartijn RisseeuwSerge Van Calenbergh

Hamamelitannin analogues potentiate antibiotics in the fight against biofilm-related Staphylococcus aureus infections

Arno VermoteGilles BrackmanMartijn RisseeuwKristof Van HeckePaul CosEvelyne MeyerTom CoenyeSerge Van Calenbergh

Hamamelitannin analogues that modulate quorum sensing as potentiators of antibiotics against Staphylococcus aureus

Arno VermoteGilles BrackmanMartijn RisseeuwBieke VanhouttePaul CosKristof Van HeckeKoen BreyneEvelyne MeyerTom CoenyeSerge Van Calenbergh

A1 Journal Article in ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

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Fabian HulpiaSerge Van Calenbergh

pH-Degradable mannosylated nanogels for dendritic cell targeting

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A1 Journal Article in BIOMACROMOLECULES

Phenotypic screening of a focused nucleoside library

Fabian HulpiaSerge Van Calenbergh

Proteome-scale binary interactomics in human cells

Sam LievensJosé Van Der HeydenDelphine MasschaeleLeentje De CeuninckIoanna PettaSurya GuptaVeronic De PuysseleyrVirginie VauthierIrma LemmensDries De Clercq et al.

A1 Journal Article in MOLECULAR & CELLULAR PROTEOMICS

Purine-mimicking 3'-ethynylribofuranose nucleosides: new opportunities for an old sugar modification

Fabian HulpiaJan BalzariniDominique ScholsSerge Van Calenbergh

Purine-mimicking 3’-ethynylribofuranose nucleosides : new opportunities for an old sugar modification

Fabian HulpiaJan BalzariniDominique ScholsSerge Van Calenbergh

Quorum sensing modulating hamamelitannin analogues as potentiators for antibiotics against Staphylococcus aureus

Arno VermoteSerge Van Calenbergh

Study of the cross-talk between the dopamine D2-like receptors and the μ opioid receptor

Mingcheng QianKathleen Van CraenenbroeckSerge Van Calenbergh

Synthesis and biological evaluation of phytosphingosine modified α-GalCer analogues as potential immunomodulating agents

Jonas JanssensJohan Van der EyckenSerge Van Calenbergh

Synthesis and evaluation of 1-deoxy-D-xylulose 5-phosphate reductoisomerase inhibitors as antimalarial and antituberculosis agents

René ChoforSerge Van Calenbergh

Synthesis of 1’-N-homoazanucleosides as potential transition state analogues and antiviral agents

Jakob BoutonSerge Van Calenbergh

Synthesis of chemical dimerizers for the optimization of MASPIT

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Synthesis, in vitro and in vivo small-animal SPECT evaluation of novel technetium labeled bile acid analogues to study (altered) hepatic transporter function

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A1 Journal Article in CHEMMEDCHEM

The design and synthesis of inhibitors of Mycobacterium tuberculosis thymidylate kinase (MtTMPK)

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The design and synthesis of inhibitors of Mycobacterium tuberculosis thymidylate kinase (MtTMPK)

Lijun SongMartijn RisseeuwFabian HulpiaHélène Munier-LehmannSerge Van Calenbergh

The quorum sensing inhibitor hamamelitannin increases antibiotic susceptibility of Staphylococcus aureus biofilms by affecting peptidoglycan biosynthesis and eDNA release

Gilles BrackmanKoen BreyneRiet De RyckeArno VermoteFilip Van NieuwerburghEvelyne MeyerSerge Van CalenberghTom Coenye

A1 Journal Article in SCIENTIFIC REPORTS

Transiently responsive block copolymer micelles based on N-(2-hydroxypropyl)methacrylamide engineered with hydrolyzable ethylcarbonate side chains

Sabah KasmiBenoit LouageLutz NuhnAlexandra Van DriesscheJan Van DeunIzet KaralicMartijn RisseeuwSerge Van CalenberghRichard HoogenboomRiet De Rycke et al.

A1 Journal Article in BIOMACROMOLECULES

Trapping mammalian protein complexes in viral particles

Sven EyckermanKevin TitecaEmmy Van QuickelbergheEva ClootsAnnick VerheeNoortje SamynLeentje De CeuninckEvy TimmermanDelphine De SutterSam Lievens et al.

A1 Journal Article in NATURE COMMUNICATIONS

Uitgelezen gereedschap en gezelschap voor een taalminnende collega

Mieke AdriaensJean BourgeoisAnn BuysseLieven DanneelsIgnace De BeeldeGert de CoomanPiet DeprezYves JorensLuc TirrySerge Van Calenbergh et al.

Bookchapter in Great teachers : essays over hoger onderwijs voor Kristiaan Versluys

Well-defined polymer-paclitaxel prodrugs by a grafting-from-drug approach

Benoit LouageLutz NuhnMartijn RisseeuwNane VanparijsRuben De CoenIzet KaralicSerge Van CalenberghBruno De Geest

A1 Journal Article in ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

2015

Alternative reagents for methotrexate as immobilizing anchor moieties in the optimization of MASPIT: synthesis and biological evaluation

Dries De ClercqMartijn RisseeuwIzet KaralicAnne-Sophie De SmetDieter DefeverJan TavernierSam LievensSerge Van Calenbergh

A1 Journal Article in CHEMBIOCHEM

Design, synthesis and evaluation of novel hamamelitannin analogues that increase the susceptibility of Staphylococcus aureus to vancomycin

Arno VermoteSerge Van Calenbergh

Hamametitannin based adjuvants in the Vancomycin treatment of Staphylococcus Aureus infections: from a natural product towards a more druglike lead compound

Martijn RisseeuwSerge Van Calenbergh

In search of novel nucleoside therapeutics: exploring the purine core of 3'-C-ethynyladenosine

Fabian HulpiaJan BalzariniDominique ScholsSerge Van Calenbergh

Lipid and carbohydrate modifications of α-galactosylcer-amide differently influence mouse and human type I natural killer T cell activation

Alysia BirkholzMarek NemčovičEsther Dawen YuEnrico GirardiJing WangArchana KhuranaNora PauwelsElisa FarberSampada ChitaleRichard W Franck et al.

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Nucleosides with transposed base or 4'-hydroxymethyl moieties and their corresponding oligonucleotides

Kiran TotiMarleen RendersElisabetta GroazPiet HerdewijnSerge Van Calenbergh

A1 Journal Article in CHEMICAL REVIEWS

Small molecule fusion compounds for the optimization of MASPIT, a high throughput three-hybrid target deconvolution assay

Dries De ClercqSam LievensMartijn RisseeuwJan TavernierSerge Van Calenbergh

Synthesis and bioactivity of β-substituted fosmidomycin analogues targeting 1-deoxy-D-xylulose-5-phosphate reductoisomerase

René ChoforSanjeewani SooriyaarachchiMartijn RisseeuwTerese BergforsJenny PouyezChinchu JohnyAmanda HaymondAnnelien EveraertCynthia S DowdLouis Maes et al.

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and biological evaluation of small-molecule fusion compounds for the optimization of MASPIT, a three-hybrid target deconvolution assay

Dries De ClercqSam LievensMartijn RisseeuwJan TavernierSerge Van Calenbergh

Synthesis and evaluation of β-substituted fosmidomycin analogues as inhibitors of 1-deoxy-D-xylulose 5-phosphate reductoisomerase

René ChoforSanjeewani SooriyaarachchiMartijn RisseeuwTerese BergforsT Alwyn JonesSherry L MowbraySerge Van Calenbergh

Synthesis of C-5" and C-6"-modified α-GalCer analogues as iNKT-cell agonists

Joren GuillaumeNora PauwelsSANDRINE ASPESLAGHDirk ZajoncDirk ElewautSerge Van Calenbergh

A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY

The design and synthesis of inhibitors of Mycobacterium tuberculosis thymidylate kinase (MtTMPK)

Lijun SongMartijn RisseeuwFabian HulpiaHélène Munier-LehmannSerge Van Calenbergh

The influence of the acyl chain on the transdermal penetration-enhancing effect of synthetic phytoceramides

Lieselotte VeryserJente BoonenLien TaevernierJoren GuillaumeMartijn RisseeuwSyed Nisar Hussain ShahNathalie RocheSerge Van CalenberghBart De Spiegeleer

A1 Journal Article in SKIN PHARMACOLOGY AND PHYSIOLOGY

2014

A bidirectional crosstalk between iNKT cells and adipocytes mediated by leptin modulates susceptibility for T cell mediated hepatitis

Koen VenkenSylvie SeeuwsLennart ZabeauPeggy JacquesTine DecruyJulie CoudenysEveline VerheugenFien WindelsDominiek CatteeuwMichael Drennan et al.

A1 Journal Article in JOURNAL OF HEPATOLOGY

An immunogen synthesis strategy for the development of specific anti-deoxynivalenol monoclonal antibodies

Melanie SandersYirong GuoAbhishek IyerYara Ruiz GarciaAnastasia GalvitaArne HeyerickDieter DeforceMartijn RisseeuwSerge Van CalenberghMarc Bracke et al.

A1 Journal Article in FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT

An in silico approach for modelling T-helper polarizing iNKT cell agonists

Anton De SpiegeleerEvelien WynendaeleMatthias VandekerckhoveSofie StalmansMaxime BoucartNele Van Den NoortgateKoen VenkenSerge Van CalenberghSANDRINE ASPESLAGHDirk Elewaut

A1 Journal Article in PLOS ONE

C5/C6-fused or C5/C6-separated uridine phosphonates

Lijun SongMartijn RisseeuwSerge Van Calenbergh

Design, synthesis and biological evaluation of tamoxifen-fusion compounds for the optimization of MASPIT, a three-hybrid target deconvolution assay

Dries De ClercqMartijn RisseeuwSam LievensJan TavernierSerge Van Calenbergh

Kinase Substrate Sensor (KISS), a mammalian in situ protein interaction sensor

Sam LievensSarah GerloIrma LemmensDries De ClercqMartijn RisseeuwNele VanderroostAnne-Sophie De SmetElien RuyssinckEric ChevetSerge Van Calenbergh et al.

A1 Journal Article in MOLECULAR & CELLULAR PROTEOMICS

Synthesis and biological evaluation of 4'-hydroxymethyl deleted, transposed and modified nucleosides

Kiran TotiSerge Van Calenbergh

Synthesis and biological evaluation of tamoxifen fusion compounds for the optimization of MASPIT, a three-hybrid target deconvolution assay

Dries De ClercqMartijn RisseeuwSam LievensJan TavernierSerge Van Calenbergh

Synthesis and evaluation of N⁶-substituted apioadenosines as potential adenosine A₃ receptor modulators

Kiran TotiSteven M MossSilvia PaolettaZhan-Guo GaoKenneth A JacobsonSerge Van Calenbergh

A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis of an apionucleoside family and discovery of a prodrug with anti-HIV activity

Kiran TotiMarco DerudasDavy SinnaeveFreya Van den BroeckLia MargamuljanaJosé MartinsPiet HerdewijnJan BalzariniChristopher McGuiganSerge Van Calenbergh

A1 Journal Article in JOURNAL OF ORGANIC CHEMISTRY

Synthesis of extended uridine phosphonates derived from an allosteric P2Y2 receptor ligand

Lijun SongMartijn RisseeuwIzet KaralicMatthew O BarrettKyle A BrownT Kendall HardenSerge Van Calenbergh

A1 Journal Article in MOLECULES

Synthetic fosmidomycin analogues with altered chelating moieties do not inhibit 1-deoxy-D-xylulose 5-phosphate reductoisomerase or Plasmodium falciparum growth in vitro

René ChoforMartijn RisseeuwJenny PouyezChinchu JohnyJohan WoutersCynthia S DowdRobin D CouchSerge Van Calenbergh

A1 Journal Article in MOLECULES

2013

A 'clickable' MTX-reagent as a practical tool for profiling small molecule-intracellular target interactions via MASPIT

Martijn RisseeuwDries De ClercqSam LievensUlrik HillaertDavy SinnaeveFreya Van den BroeckJosé MartinsJan TavernierSerge Van Calenbergh

A1 Journal Article in CHEMMEDCHEM

A computational high-throughput screening approach of iNKT-agonists: a novel tool to find optimized iNKT cell ligands

Anton De SpiegeleerEvelien WynendaeleSofie StalmansNele Van Den NoortgateMatthias VandekerckhoveSerge Van CalenberghSANDRINE ASPESLAGHKoen VenkenDirk Elewaut

Alpha-O- or N-derivatized analogues of 3-(acetylhydroxyamino)propyl phosphonic acid (FR900098) as antimalarials

Thomas VerbrugghenPierre VandurmJenny PouyezLouis MaesJohan WoutersSerge Van Calenbergh

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

Bacterial CD1d-restricted glycolipids induce IL-10 production by human regulatory T cells upon cross-talk with invariant NKT cells

Koen VenkenTine DecruySANDRINE ASPESLAGHSerge Van CalenberghBart LambrechtDirk Elewaut

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Cytotoxic activity of Laserpitium latifolium L. extract and its daucane and phenylpropanoid constituents

Višnja PopovićArne HeyerickSilvana PetrovićSerge Van CalenberghIzet KaralicMarjan NiketićDieter Deforce

A1 Journal Article in RECORDS OF NATURAL PRODUCTS

Development of nanomedicines for the treatment of pulmonary biofilm infections: Insights from advanced fluorescence microscopy studies

Katrien ForierAnne-Sophie MessiaenMartijn RisseeuwSerge Van CalenberghHendrik DeschoutKoen RaemdonckHans NelisFabienne DanhierVéronique PréatFrans De Baets et al.

Enhanced TCR footprint by a novel glycolipid increases NKT-dependent tumor protection

SANDRINE ASPESLAGHMarek NemčovičNora PauwelsKoen VenkenJing WangSerge Van CalenberghDirk M ZajoncDirk Elewaut

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Sesquiterpene lactones from the extracts of two Balkan endemic Laserpitium species and their cytotoxic activity

Visnja PopovicArne HeyerickSilvana PetrovićSerge Van CalenberghIzet KaralićMarjan NiketićDieter Deforce

A1 Journal Article in PHYTOCHEMISTRY

Syntheses of MTX-fusion compounds for target profiling of small molecules with MASPIT

Dries De ClercqMartijn RisseeuwSam LievensJan TavernierSerge Van Calenbergh

Synthesis and evaluation of 5'-modified thymidines and 5-hydroxymethyl-2'-deoxyuridines as Mycobacterium tuberculosis thymidylate kinase inhibitors

Kiran TotiFrederick VerbekeMartijn RisseeuwVladimir FrecerHélène Munier-LehmannSerge Van Calenbergh

A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and evaluation of thiazolidinedione and dioxazaborocane analogues as inhibitors of AI-2 quorum sensing in Vibrio harveyi

Gilles BrackmanAbed Al Aziz Al QuntarClaes D EnkIzet KaralicHans NelisSerge Van CalenberghMorris SrebnikTom Coenye

A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis of new α-GalCer analogues as iNKT cell targeting agents

Nora PauwelsSerge Van Calenbergh

The bovine CD1D gene has an unusual gene structure and is expressed but cannot present α-galactosylceramide with a C26 fatty acid

Kim Anh Nguyen ThiAd P KoetsMartin VordermeierPeter J JervisLiam R CoxSimon P GrahamWiebren J SantemaD Branch MoodySerge Van CalenberghDirk M Zajonc et al.

A1 Journal Article in INTERNATIONAL IMMUNOLOGY

2012

5,5'-Bis-substituted 2'-deoxyuridines as possible M. tuberculosis thymidylate kinase inhibitors

Kiran TotiFrederick VerbekeMartijn RisseeuwHélène Munier-LehmannSerge Van Calenbergh

A dissociated glucocorticoid receptor modulator reduces airway hyperresponsiveness and inflammation in a mouse model of asthma

Laurent L ReberFrançois DaubeufMaud PlantingaLode De CauwerSarah GerloWim WaelputSerge Van CalenberghJan TavernierGuy HaegemanBart Lambrecht et al.

A1 Journal Article in JOURNAL OF IMMUNOLOGY

A divergent synthesis of α-galactosylceramide analogues

Joren GuillaumeSerge Van Calenbergh

A divergent synthesis of α-galactosylceramide analogues

Joren GuillaumeSerge Van Calenbergh

Crystal structures of bovine CD1d reveal altered αGalCer presentation and a restricted A' pocket unable to bind long-chain glycolipids

Jing WangJoren GuillaumeNora PauwelsSerge Van CalenberghIldiko Van RhijnDirk M Zajonc

A1 Journal Article in PLOS ONE

Dancing on coke: smuggling cocaine dispersed in polyvinyl alcohol

Alexander LN van NuijsKristof E MaudensWilly LambertSerge Van CalenberghMartijn RisseeuwPaul Van HeeAdrian CovaciHugo Neels

A1 Journal Article in JOURNAL OF FORENSIC SCIENCES

Drug design and identification of potent leads against Mycobacterium tuberculosis thymidine monophosphate kinase

Serge Van CalenberghS PocetH Munier-Lehmann

A1 Journal Article in CURRENT TOPICS IN MEDICINAL CHEMISTRY

Electrospun cellulose acetate phthalate fibers for semen induced anti-HIV vaginal drug delivery

Chaobo HuangStefaan SoenenEllen van GulckGuido VanhamJoanna RejmanSerge Van CalenberghChris VervaetTom CoenyeHans VerstraelenMarleen Temmerman et al.

A1 Journal Article in BIOMATERIALS

MASPIT: a high throughput assay for the identification of cytosolic targets of small molecules : proof of principle

Martijn RisseeuwSam LievensDries De ClercqUlrik HillaertJan TavernierSerge Van Calenbergh

Penetration enhancing effect of phytoceramides

Lieselotte VeryserJente BoonenJoren GuillaumeMartijn RisseeuwSerge Van CalenberghBart De Spiegeleer

Structural basis for the recognition of C20:2-αGalCer by the invariant natural killer T-cell receptor-like antibody L363

Esther Dawen YuEnrico GirardiJing WangThien-Thi Mac MacKarl OA YuSerge Van CalenberghSteven A PorcelliDirk M Zajonc

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Syntheses of methotrexate-hybrid compounds for target profiling of small molecules with MASPIT

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Syntheses of methotrexate-hybrid compounds for target profiling of small molecules with MASPIT

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Syntheses of methotrexate-hybrid compounds for target profiling of small molecules with MASPIT

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Synthesis and biological evaluation of apionucleosides and their protides

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A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY

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Synthesis of 1-deoxy-D-xylulose 5-phosphate reductoisomerase inhibitors as antimalarials

Thomas VerbrugghenSerge Van Calenbergh

Synthesis of 5-substituted 2'-deoxyuridine-5'-phosphonate analogues and evaluation of their antiviral activity

Sara Van PoeckeDavy SinnaeveJosé MartinsJan BalzariniSerge Van Calenbergh

A1 Journal Article in NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

Synthesis of 6”-triazole-substituted α-GalCer analogues as potent iNKT cell stimulating ligands

Nora PauwelsSANDRINE ASPESLAGHDirk ElewautSerge Van Calenbergh

A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis of β-analogues of FR900098 as antimalarials

René ChoforMartijn RisseeuwThomas VerbrugghenSerge Van Calenbergh

Versatile synthesis of C-5" and C-6"-modified α-GalCer analogues as new iNKT cell ligands

Nora PauwelsSANDRINE ASPESLAGHDirk ElewautSerge Van Calenbergh

2011

6''-Modified alpha-GalCer analogs capable of establishing an extra interaction with Cd1d leading to a polarized Th1 response and superior tumor protection

Serge Van CalenberghNora PauwelsSANDRINE ASPESLAGHYaLi LiMatthias TrappeniersDirk ZajoncDirk Elewaut

Dideoxyapiose nucleosides revisited : syntheses and protide derivatives

Kiran TotiJan BalzariniSerge Van Calenbergh

Divergent synthetic approach to 6''-modified α-GalCer analogues

Nora PauwelsSANDRINE ASPESLAGHGerd VanhoenackerKoen SandraEsther D. YuDirk M. ZajoncDirk ElewautBruno LinclauSerge Van Calenbergh

A1 Journal Article in ORGANIC & BIOMOLECULAR CHEMISTRY

Galactose modified iNKT cell agonists stabilised by a novel structural modification of CD1D lead to marked TH1 polarisation in vivo

SANDRINE ASPESLAGHYaLi LiEsther Dawen YuNora PauwelsMatthias TrappeniersEnrico GirardiTine DecruyKatrien Van BenedenKoen VenkenMichael Drennan et al.

Galactose-modified iNKT cell agonists stabilized by an induced fit of CD1d prevent tumour metastasis

SANDRINE ASPESLAGHYali LiEsther Dawen YuNora PauwelsMatthias TrappeniersEnrico GirardTine DecruyKatrien Van BenedenKoen VenkenMichael Drennan et al.

A1 Journal Article in EMBO JOURNAL

Resistance of the Burkholderia cepacia complex to fosmidomycin and fosmidomycin derivatives

Anne-Sophie MessiaenThomas VerbrugghenCharlotte DeclerckRegina OrtmannMartin SchlitzerHans NelisSerge Van CalenberghTom Coenye

A1 Journal Article in INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Structure-activity relationship of cinnamaldehyde analogs as inhibitors of AI-2 based quorum sensing and their effect on virulence of vibrio spp

Gilles BrackmanShari CelenUlrik HillaertSerge Van CalenberghPaul CosLouis MaesHans NelisTom Coenye

A1 Journal Article in PLOS ONE

Synthesis and antiviral evaluation of α-L-2'-deoxythreofuranosyl nucleosides

Kiran TotiMarco DerudasChristopher McGuiganJan BalzariniSerge Van Calenbergh

A1 Journal Article in EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and biological evaluation of pyrimidine nucleosides and nucleoside phosphonates

Sara Van PoeckeSerge Van Calenbergh

Synthesis and inhibitory activity of thymidine analogues targeting Mycobacterium tuberculosis thymidine monophosphate kinase

Sara Van PoeckeHélène Munier-LehmannOlivier HelynckMatheus FroeyenSerge Van Calenbergh

A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis of base-substituted uridine 5'-phosphonate analogues as potential P2Y2 receptor ligands

Sara Van PoeckeMatt BarrettKenneth A JacobsonT Kendall HardenSerge Van Calenbergh

Synthesis, modeling and evaluation of 3'-(1-aryl-1H-tetrazol-5-ylamino)-substituted 3'-deoxythymidine derivatives as potent and selective human mitochondrial thymidine kinase inhibitors

Sara Van PoeckeAna NegriJolien JanssensNicola SolaroliAnna KarlssonFederico GagoJan BalzariniiSerge Van Calenbergh

A1 Journal Article in ORGANIC & BIOMOLECULAR CHEMISTRY

2010

3'-[4-Aryl-(1,2,3-triazol-1-yl)]-3'-deoxythymidine analogues as potent and selective inhibitors of human mitochondrial thymidine kinase

Sara Van PoeckeAna NegriFederico GagoIneke Van DaeleNicola SolaroliAnna KarlssonJan BalzariniSerge Van Calenbergh

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

Antioxidant flavone glycosides from the leaves of Fargesia robusta

Laura Van HoyweghenIzet KaralicSerge Van CalenberghDieter DeforceArne Heyerick

A1 Journal Article in JOURNAL OF NATURAL PRODUCTS

L-2-deoxythreose nucleosides: synthesis and screening against viral strains

Kiran TotiJan BalzariniSerge Van Calenbergh

Optimizing the iNKT cell dependent antitumor effect using an altered glycolipid

SANDRINE ASPESLAGHYali LiTine DecruyKatrien Van BenedenKoen VenkenMatthias TrappeniersSerge Van CalenberghDirk ZajoncDirk Elewaut

Optimizing the iNKT cell dependent antitumor effect using an altered glycolipid

SANDRINE ASPESLAGHYali LiTine DecruyKatrien Van BenedenMichael DrennanKoen VenkenMatthias TrappeniersSerge Van CalenberghDirk ZajoncDirk Elewaut

Suppression of human natural killer T cell function by CD4(+)CD25(+)FOXP3(+) regulatory T cells

Koen VenkenTine DecruyKim DeswarteSANDRINE ASPESLAGHSerge Van CalenberghBart LambrechtDirk Elewaut

Synthesis and evaluation of amino-modified α-GalCer analogues

Matthias TrappeniersRené ChoforSANDRINE ASPESLAGHYali LiBruno LinclauDirk M ZajoncDirk ElewautSerge Van Calenbergh

A1 Journal Article in ORGANIC LETTERS

Synthesis and evaluation of α-halogenated analogues of 3-(acetylhydroxyamino)propylphosphonic acid (FR900098) as antimalarials

Thomas VerbrugghenPaul CosLouis MaesSerge Van Calenbergh

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of C-6-substituted uridine phosphonates through aerobic ligand-free Suzuki-Miyaura cross-coupling

Radim NenckaDavy SinnaeveIzet KaralicJosé MartinsSerge Van Calenbergh

A1 Journal Article in ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis of L-2-deoxythreose nucleosides as potential antiviral agents

Kiran TotiSerge Van Calenbergh

Synthesis of sphingosine- and sugar modified α-GalCer analogues : towards new immunomodulatory agents

Matthias TrappeniersSerge Van Calenbergh

Transport and delivery of antimicrobial agents in Burkholderia biofilms

Katrien ForierAnne-Sophie MessiaenTom CoenyeHans NelisShari CelenSerge Van CalenberghStefaan De SmedtJo DemeesterKevin Braeckmans

Unbreakable codes in electrospun fibers : digitally encoded polymers to stop medicine counterfeiting

Chaobo HuangBart LucasChris VervaetKevin BraeckmansSerge Van CalenberghIzet KaralicMado VandewoestyneDieter DeforceJo DemeesterStefaan De Smedt

A1 Journal Article in ADVANCED MATERIALS

Unbreakable codes in electrospun fibers to stop medicine counterfeiting

Chaobo HuangBart LucasChris VervaetKevin BraeckmansSerge Van CalenberghIzet KaralicMado VandewoestyneDieter DeforceJo DemeesterStefaan De Smedt

2009

AI-2 quorum sensing inhibitors affect the starvation response and reduce virulence in several Vibrio species, most likely by interfering with LuxPQ

Gilles BrackmanShari CelenSri Kartik BaruahPeter BossierSerge Van CalenberghHans NelisTom Coenye

A1 Journal Article in MICROBIOLOGY-SGM

Differential mechanism of NF-κB inhibition by two glucocorticoid receptor modulators in rheumatoid arthritis synovial fibroblasts

Valerie GossyeDirk ElewautNadia BougarneDebby BrackeSerge Van CalenberghGuy HaegemanKarolien De Bosscher

A1 Journal Article in ARTHRITIS AND RHEUMATISM

Human mitochondrial thymidine kinase is selectively inhibited by 3'-thiourea derivatives of beta-thymidine: identification of residues crucial for both inhibition and catalytic activity

Jan BalzariniIneke Van DaeleAna NegriNicola SolaroliAnna KarlssonSandra LiekensFrederico GagoSerge Van Calenbergh

A1 Journal Article in MOLECULAR PHARMACOLOGY

Receptor-mediated targeting of cathepsins in professional antigen presenting cells

Wrik HillaertMartijn VerdoesBogdan I FloreaAthanasios SaragliadisKim LL HabetsJohan KuiperSerge Van CalenberghFerry OssendorpGijsbrecht A van der MarelChristoph Driessen et al.

A1 Journal Article in ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis and P2Y receptor activity of nucleoside 5'-phosphonate derivatives

Liesbet CosynSerge Van CalenberghBhalchandra V JoshiHyojin KoRhonda L CarterT Kendall HardenKenneth A Jacobson

A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of L-2-deoxythreose nucleosides as potential antiviral agents

Kiran TotiSerge Van Calenbergh

The synthesis and in vivo evaluation of 2',2'-difluoro KRN7000

Leo LeungCyrille TomassiKatrien Van BenedenTine DecruyMatthias TrappeniersDirk ElewautYifang GaoTim ElliottAymen Al-ShamkhaniChristian Ottensmeier et al.

A1 Journal Article in CHEMMEDCHEM

Use of quorum sensing inhibitors to interfere with biofilm formation and development in Burkholderia multivorans and Burkholderia cenocepacia

Gilles BrackmanUlrik HillaertSerge Van CalenberghHans NelisTom Coenye

A1 Journal Article in RESEARCH IN MICROBIOLOGY

2008

6'-Derivatised α-GalCer analogues capable of inducing strong CD1d-mediated Th1-biased NKT cell responses in mice

Matthias TrappeniersKatrien Van BenedenTine DecruyBruno LinclauDirk ElewautSerge Van Calenbergh

A1 Journal Article in JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A plant-derived ligand favoring monomeric glucocorticoid receptor conformation with impaired transactivation potential attenuates collagen-induced arthritis

Pieter DewintValerie GossyeKarolien De BosscherWim Vanden BergheKatrien Van BenedenDieter DeforceSerge Van CalenberghU MULLER-LADNERBert Vander CruyssenAugust Verbruggen et al.

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Cinnamaldehyde and cinnamaldehyde derivatives reduce virulence in Vibrio spp. by decreasing the DNA-binding activity of the quorum sensing response regulator LuxR

Gilles BrackmanTom DefoirdtCarol MiyamotoPeter BossierSerge Van CalenberghHans NelisTom Coenye

A1 Journal Article in BMC MICROBIOLOGY

From M-tuberculosis thymidine monophosphate kinase (TMPKmt) inhibitors towards mitochondrial thymidine kinase (TK-2) inhibitors

Serge Van CalenberghI Van DaeleSara Van PoeckeM FroeyenH Munier LehmannJ Balzarini

Fungicidal activity of truncated analogues of dihydrosphingosine

Karin ThevissenUlrik HillaertEls MK MeertKuen K ChowBruno PA CammueSerge Van CalenberghIsabelle EJA François

A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Invariant NKT cells promote CD8(+) cytotoxic T cell responses by inducing CD70 expression on dendritic cells

Vadim Y. TarabanSonya MartinKathrine E. AttfieldMartin J. GlennieTim ElliottDirk ElewautSerge Van CalenberghBruno LinclauAymen Al-Shamkhani

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Synthesis and biological evaluation of purine and pyrimidine based ligands for the A3 and P2Y2 purinergic receptors

Liesbet CosynSerge Van Calenbergh

Synthesis and in vitro evaluation of α-GalCer epimers

Matthias TrappeniersStijn GoormansKatrien Van BenedenTine DecruyBruno LinclauAymen Al-ShamkhaniTim ElliottChristian OttensmeierJoern M. WernerDirk Elewaut et al.

A1 Journal Article in CHEMMEDCHEM

Synthesis and in vivo evaluation of 4-Deoxy-4,4-difluoro-KRN7000

L LeungC TomassiKatrien Van BenedenTine DecruyDirk ElewautT ElliottA Al-ShamkhaniC OttensmeierSerge Van CalenberghJ Werner et al.

A1 Journal Article in ORGANIC LETTERS

Synthesis and potency of novel uracil nucleotides and derivatives as P2Y(2) and P2Y(6) receptor agonists

HJ KoRL CarterLiesbet CosynR PetrelliS de CastroP BesadaYX ZhouL CappellacciP FranchettiM Grifantini et al.

A1 Journal Article in Bioorganic & Medicinal Chemistry

Synthesis of analogues of (E)-1-hydroxy-2-methylbut-2-enyl 4-diphosphate, an isoprenoid precursor and human γδ T cell activator

Steven Van HoofCarl Jeffrey LaceyRene C RöhrichJochen WiesnerHassan JomaaSerge Van Calenbergh

A1 Journal Article in JOURNAL OF ORGANIC CHEMISTRY

Synthesis of β- and γ-oxa isosteres of fosmidomycin and FR900098 as antimalarial candidates

Timothy HaemersJochen WiesnerDirk GiessmannThomas VerbrugghenUlrik HillaertRegina OrtmannHassan JomaaAndreas LinkMartin SchlitzerSerge Van Calenbergh

A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY

Towards new antimalarial drugs: Synthesis of non-hydrolyzable phosphate mimics as feed for a predictive QSAR study on 1-deoxy-D-xylulose-5-phosphate reductoisomerase inhibitors

D GiessmannP HeidlerTimothy HaemersSerge Van CalenberghA ReichenbergH JomaaC WeidemeyerS SanderbrandJ WiesnerA Link

A1 Journal Article in CHEMISTRY & BIODIVERSITY

Triplex formation by pyrene-labelled probes for nucleic acid detection in fluorescence assays

Ineke Van DaeleN BomholtVV FilichevSerge Van CalenberghE Pedersen

A1 Journal Article in CHEMBIOCHEM

2007

A single early activation of invariant NK T cells confers long-term protection against collagen-induced arthritis in a ligand-specific manner

Ken CoppietersKatrien Van BenedenPeggy JacquesPieter DewintAnn VervloetBert Vander CruyssenSerge Van CalenberghGuangwu ChenRichard FranckAugust Verbruggen et al.

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Abnormal first trimester screen in partial deletion of chromosome 6p21: A case-report

MH HULSBERGENSerge Van CalenberghJP FRYNS

A1 Journal Article in GENETIC COUNSELING

Design of thymidine-based inhibitors of Mycobacterium tuberculosis thymidylate kinase

Ineke Van DaeleSerge Van Calenbergh

Divergent strategy for the synthesis of α-aryl-substituted fosmidomycin analogues

Vincent DevreuxJochen WiesnerHassan JomaaJef RozenskiJohan Van der EyckenSerge Van Calenbergh

A1 Journal Article in JOURNAL OF ORGANIC CHEMISTRY

Molecular modeling of the human P2Y(2) receptor and design of a selective agonist, 2 '-amino-2 '-deoxy-2-thiouridine 5 '-triphosphate

AA IVANOVH KOLiesbet CosynS MADDILETIP BESADAI FRICKSS COSTANZITK HARDENSerge Van CalenberghKA JACOBSON

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

Rational design of 5'-thiourea-substituted α-thymidine analogues as thymidine monophosphate kinase inhibitors capable of inhibiting mycobacterial growth

Ineke Van DaeleHélène Munier-LehmannMatheus FroeyenJan BalzariniSerge Van Calenbergh

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and evaluation of α,β-unsaturated α-aryl-substituted fosmidomycin analogues as DXR inhibitors

Vincent DevreuxJochen WiesnerHassan JomaaJohan Van der EyckenSerge Van Calenbergh

A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

2006

2-Triazole-substituted adenosines: a new class of selective A₃ adenosine receptor agonists, partial agonists, and antagonists

Liesbet CosynKrishnan K PalaniappanSoo-Kyung KimHeng T DuongZhan-Guo GaoKenneth A JacobsonSerge Van Calenbergh

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

Orthogonal activation of the reengineered A(3) adenosine receptor (neoceptor) using tailored nucleoside agonists

ZG GAOHT DUONGT SONINASK KIMPhilippe Van RompaeySerge Van CalenberghL MAMEDOVAHO KIMMJ KIMAY KIM et al.

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and biological evaluation of bicyclic nucleosides as inhibitors of M-tuberculosis thymidylate kinase

Ineke Van DaeleHélène Munier-LehmannPieter HendrickxGilles MarchalPierre ChavarotMatheus FroeyenLi QingJosé MartinsSerge Van Calenbergh

A1 Journal Article in CHEMMEDCHEM

Synthesis and biological evaluation of cyclopropyl analogues of fosmidomycin as potent Plasmodium falciparum growth inhibitors

Vincent DevreuxJochen WiesnerJan GoemanJohan Van der EyckenHassan JomaaSerge Van Calenbergh

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and biological evaluation of novel PDMP analogues

Ulrik HillaertSwetlana Boldin-AdamskyJef RozenskiRoger BussonAnthony H FutermanSerge Van Calenbergh

A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis of hypermodified adenosine derivatives as selective adenosine A(3) receptor ligands

Liesbet CosynZG GAOP VAN ROMPAEYCR LUKA JACOBSONSerge Van Calenbergh

A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis of α-aryl-substituted and conformationally restricted fosmidomycin analogues as promising antimalarials

Timothy HaemersJochen WiesnerRoger BussonHassan JomaaSerge Van Calenbergh

A1 Journal Article in EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Synthesis of α-substituted fosmidomycin analogues as highly potent Plasmodium falciparum growth inhibitors

Timothy HaemersJochen WiesnerSara Van PoeckeJan GoemanDajana HenschkerEwald BeckHassan JomaaSerge Van Calenbergh

A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

2005

2-(1,2,3-triazol-1-yl) N-6-CH3-substituted adenosine derivatives: Highly potent and selective A(3) receptor ligands

Liesbet CosynK JACOBSONSerge Van Calenbergh

Chemical and biological effects on food irradiation

Oswald Van CleemputSerge Van CalenberghPascal Boeckx

A4 Journal Article in ANNALEN VAN DE BELGISCHE VERENIGING VOOR STRALINGSBESCHERMING

Development of a liquid chromatography/tandem mass spectrometry method for the quantification of fumonisin B-1, B-2 and B-3 in cornflakes

C PAEPENSSarah De SaegerChristof Van PouckeFrédéric DumoulinSerge Van CalenberghCarlos Van Peteghem

A1 Journal Article in RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Exploring high affinity inhibitors of M-tuberculosis thymidiylate kinase

Ineke Van DaeleH MUNIER-LEHMANNSerge Van Calenbergh

Exploring human adenosine A₃ receptor complementarity and activity for adenosine analogues modified in the ribose and purine moiety

Philippe Van RompaeyKenneth A JacobsonAriel S GrossZhan-Guo GaoSerge Van Calenbergh

A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY

Patent developments in antimycobacterial small-molecule therapeutics

Ineke Van DaeleSerge Van Calenbergh

A1 Journal Article in EXPERT OPINION ON THERAPEUTIC PATENTS

Synthesis of a versatile (S)-3-(hydroxymethyl)butane-1,2,4-triol building block and its application for the stereoselective synthesis of N-homoceramides

Ulrik HillaertSerge Van Calenbergh

A1 Journal Article in ORGANIC LETTERS

Synthesis of biologically relevant sphingolipid analogues

Ulrik HillaertSerge Van Calenbergh

2004

Antimalarial activity of N-6-substituted adenosine derivatives. Part 3

C HERFORTHJ WIESNERP HEIDLERS SANDERBRANDSerge Van CalenberghH JOMAAA LINK

A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY

Comparative metabolic excretion profile of sodium salicylate in broiler chickens and homing pigeons

Kris BaertSiska CroubelsA MAESUlrik HillaertSerge Van CalenberghPatrick De Backer

A1 Journal Article in JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS

Discovery of bicyclic thymidine analogues as selective and high-affinity inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase

Veerle VanheusdenHélène Munier-LehmannMatheus FroeyenRoger BussonJef RozenskiPiet HerdewijnSerge Van Calenbergh

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

Modulation of adenosine receptor affinity and intrinsic efficacy in adenine nucleosides substituted at the 2-position

M OHNOZG GAOPhilippe Van RompaeyS TCHILIBONSK KIMBA HARRISAS GROSSHT DUONGSerge Van CalenberghKA JACOBSON

A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY

Neoceptor concept applied to human A2A and A3 adenosine receptors.

KA JACOBSONSK KIMM OHNOHT DUONGPhilippe Van RompaeySerge Van CalenberghZG GAO

Synthesis and conformational analysis of 1-[2,4-dideoxy-4-C-hydroxymethyl-alpha-L-lyxopyranosyl]thymine

Veerle VanheusdenRoger BussonPiet HerdewijnSerge Van Calenbergh

A1 Journal Article in JOURNAL OF ORGANIC CHEMISTRY

2003

2,5-bis-(2-hydroxybenzoylamino)pentanoic acid, a salicylic acid-metabolite isolated from chicken: Characterization and independent synthesis

Ulrik HillaertKris BaertJ ROZENSKISiska CroubelsDenis De KeukeleirePatrick De BackerSerge Van Calenbergh

A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

3'-C-branched-chain-substituted nucleosides and nucleotides as potent inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase

Veerle VanheusdenHélène Munier-LehmannMatheus FroeyenLaurence DuguéArne HeyerickDenis De KeukeleireSylvie PochetRoger BussonPiet HerdewijnSerge Van Calenbergh

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

Color Doppler imaging is a valuable tool for the diagnosis and management of uterine vascular malformations

D TIMMERMANJ WAUTERSSerge Van CalenberghD VAN SCHOUBROECKG MALEUXT VAN DEN BOSCHB SPITZ

A1 Journal Article in ULTRASOUND IN OBSTETRICS & GYNECOLOGY

Design of a neoceptor and complementary neoligand derived from the A2A adenosine receptor.

SK KIMZG GAOPhilippe Van RompaeyAS GROSSAS CHENSerge Van CalenberghKA JACOBSON

Enzymatic and structural analysis of inhibitors designed against Mycobacterium tuberculosis thymidylate kinase - New insights into the phosphoryl transfer mechanism

A HAOUZVeerle VanheusdenH MUNIER-LEHMANNM FROEYENP HERDEWIJNSerge Van CalenberghM DELARUE

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Fatality due to combined use of the designer drugs MDMA and PMA : a distribution study

R DamsEls De LetterKjell MortierJan CordonnierWilly LambertMichel PietteSerge Van CalenberghAndreas De Leenheer

A1 Journal Article in JOURNAL OF ANALYTICAL TOXICOLOGY

Modeling the adenosine receptors: Comparison of the binding domains of A(2A) agonists and antagonists

SK KIMZG GAOPhilippe Van RompaeyAS GROSSA CHENSerge Van CalenberghKA JACOBSON

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

Mycobacterium tuberculosis thymidine monophosphate kinase inhibitors: Biological evaluation and conformational analysis of 2 '- and 3 '-modified thymidine analogues

Philippe Van RompaeyK NAUWELAERTSVeerle VanheusdenJ ROZENSKIH MUNIER-LEHMANNP HERDEWIJNSerge Van Calenbergh

A1 Journal Article in EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Structural and mechanistic basis of pre- and posttransfer editing by leucyl-tRNA synthetase

TL LINCECUMM TUKALOA YAREMCHUKRS MURSINNAAM WILLIAMSBS SPROATW VAN DEN EYNDEA LINKSerge Van CalenberghM GROTLI et al.

A1 Journal Article in MOLECULAR CELL

Thymidine and thymidine-5 '-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase

Veerle VanheusdenPhilippe Van RompaeyH MUNIER-LEHMANNS POCHETP HERDEWIJNSerge Van Calenbergh

A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

2002

5 '-Deoxy congeners of 9-(3-amido-3-deoxy-beta-D-xylofuranosyl)-N-6-cyclopentyladenine: New adenosine A(1) receptor antagonists and inverse agonists.

Serge Van CalenberghA LINKS FUJIKAWAR DE LIGTVeerle VanheusdenA GOLISADENM BLATONJ ROZENSKIAP IJZERMANPiet Herdewijn

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

Amine-modified nucleosides as adenosine A(3) neoceptor ligands

Philippe Van RompaeyK JACOBSONZ GAOA CHEND BARAKS KIMKyooyoung LeeA LINKB LIANGPiet Herdewijn et al.

Determination of paramethoxyamphetamine and other amphetamine-related designer drugs by liquid chromatography/sonic spray ionization mass spectrometry

Kjell MortierRiet DamsWilly LambertEls De LetterSerge Van CalenberghAndreas De Leenheer

A1 Journal Article in RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Synthesis and evaluation of thymidine-5 '-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase.

Veerle VanheusdenH MUNIER-LEHMANNS POCHETPiet HerdewijnSerge Van Calenbergh

A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of homoceramides, novel ceramide analogues, and their lack of effect on the growth of hippocampal neurons

Steven De JongheInge LamoteK VENKATARAMANSA BOLDINUlrik HillaertJ ROZENSKIC HENDRIXR BUSSONDenis De KeukeleireSerge Van Calenbergh et al.

A1 Journal Article in JOURNAL OF ORGANIC CHEMISTRY

Thymidine (monophosphate) analogues as Mycobacterium tuberculosis thymidylate kinase inhibitors

Philippe Van RompaeyV VEERLES POCHETH MUNIER-LEHMANNM FROEYENPiet HerdewijnSerge Van Calenbergh

2001

Neoceptor concept based on molecular complementarity in GPCRs: A mutant adenosine A(3) receptor with selectively enhanced affinity for amine-modified nucleosides.

KA JACOBSONZG GAOAS CHEND BARAKSA KIMK LEEA LINKPhilippe Van RompaeySerge Van CalenberghBT LIANG

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

Sensitive gas chromatographic-mass spectrometric screening of acetylated benzodiazepines

Daniëlle BorreyEvelyne MeyerWilly LambertSerge Van CalenberghCarlos Van PeteghemAndreas De Leenheer

A1 Journal Article in JOURNAL OF CHROMATOGRAPHY A

2000

2 '-amino-2 '-deoxy-N-6-(1-naphthylmethyl)adenosine as novel scaffold for a polymer-assisted amidation protocol.

A GOLISADESerge Van CalenberghA LINK

A1 Journal Article in TETRAHEDRON

A heterogeneous collection of novel antiviral pyrimidines.

Serge Van CalenberghPiet Herdewijn

A1 Journal Article in EXPERT OPINION ON THERAPEUTIC PATENTS

Determination of the designer drugs 3,4-methylenedioxymethamphetamine, 3,4-methylenedioxyethylamphetamine, and 3,4-methylenedioxyamphetamine with HPLC and fluorescence detection in whole blood, serum, vitreous humor, and urine

Karine ClauwaertJan Van BocxlaerEls De LetterSerge Van CalenberghWilly LambertAndreas De Leenheer

A1 Journal Article in CLINICAL CHEMISTRY

Polymer-assisted solution-phase synthesis of 2 '-amido-2 '-deoxyadenosine derivatives targeted at the NAD(+)-binding sites of parasite enzymes.

A GOLISADEJC BRESSISerge Van CalenberghMH GELBA LINK

A1 Journal Article in JOURNAL OF COMBINATORIAL CHEMISTRY

Synthesis and biological evaluation of ceramide analogues with substituted aromatic rings or an allylic fluoride in the sphingoid moiety.

Ilse Van OvermeireSA BOLDINK VENKATARAMANR ZISLINGSteven De JongheSerge Van CalenberghDenis De KeukeleireAH FUTERMANPiet Herdewijn

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of fluorinated sphinganine and dihydroceramide analogues.

Steven De JongheIlse Van OvermeireSerge Van CalenberghC HENDRIXR BUSSONDenis De KeukeleirePiet Herdewijn

A1 Journal Article in EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

1999

5 '-deoxy congeners of 9-(3-amido-3-deoxy-beta-D-xylofuranosyl)-N-6-cyclopentyladenine: New adenosine A(1) receptor antagonists

Serge Van CalenberghA LINKS FUJIKAWAVeerle VanheusdenDenis De KeukeleireA IJZERMANPiet Herdewijn

5 '-Deoxy congeners of 9-(3-amido-3-deoxy-beta-D-xylofuranosyl)-N-6-cyclopentyladenine: New adenosine A(1) receptor antagonists and inverse agonists

Serge Van CalenberghA LINKS FUJIKAWAVeerle VanheusdenDenis De KeukeleireAP IJZERMAN

Effect of aromatic short-chain analogues of ceramide on axonal growth in hippocampal neurons.

Ilse Van OvermeireSA BOLDINFilip DumontSerge Van CalenberghG SLEGERSDenis De KeukeleireAH FUTERMANPiet Herdewijn

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

Exploration of the effect of sterically demanding 3 '-amido substitution of 3 '-deoxyadenosines towards inhibition of cyclin-dependent kinase 1.

Serge Van CalenberghA LINKC KUNICKPiet Herdewijn

A1 Journal Article in PHARMAZIE

Killing illusions by QUIET-NOESY

André De BruynSerge Van CalenberghJan SchramlRoger BussonPiet Herdewijn

Lead optimization of N⁶-cyclopentyl-3'-amido-3'-deoxyxylofuranosyladenines as adenosine A₁ receptor antagonists

Serge Van CalenberghA LinkDenis De KeukeleirePiet Herdewijn

A1 Journal Article in NUCLEOSIDES & NUCLEOTIDES

Structure-activity relationship of short-chain sphingoid bases as inhibitors of sphingosine kinase.

Steven De JongheIlse Van OvermeireS POULTONC HENDRIXR BUSSONSerge Van CalenberghDenis De KeukeleireS SPIEGELPiet Herdewijn

A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and apoptogenic activity of fluorinated ceramide and dihydroceramide analogues

Steven De JongheIlse Van OvermeireJ. GunstAndré De BruynC. HendrixSerge Van CalenberghR. BussonDenis De KeukeleireJan PhilippéPiet Herdewijn

A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of a nucleoside bioconjugate system as a potential anti-HIV agent.

Serge Van CalenberghVasu Nair

A1 Journal Article in NUCLEOSIDES & NUCLEOTIDES

Synthesis of novel isomeric dideoxydidehydronucleosides

Vasu NairSanjib BeraTravis MickleSerge Van Calenbergh

A1 Journal Article in NUCLEOSIDES & NUCLEOTIDES

1998

3'-Amidated 3'-deoxyxylofuranose analogues of N⁶-cyclopentyladenosines: a new class of non-xanthine antagonists at the adenosine A₁ receptor

Serge Van CalenberghAdriaan P IJzermanPiet Herdewijn

A1 Journal Article in NUCLEOSIDES & NUCLEOTIDES

Practical method for the parallel synthesis of 2 '-amido-2 '-deoxyadenosines.

A LINKSerge Van CalenberghPiet Herdewijn

A1 Journal Article in TETRAHEDRON LETTERS

1997

Access to a new type of homo-C-nucleosides with a 'split' 8-deazapurine via a 1,3-dipolar cycloaddition reaction

Serge Van CalenberghAndré De BruynJan SchramlNorbert BlatonOswald PeetersDenis De KeukeleireRobert BussonPiet Herdewijn

A1 Journal Article in NUCLEOSIDES & NUCLEOTIDES

N6-Cyclopentyl-3'-substituted-xylofuranosyladenosines : a new class of non-xanthine adenosine A1 receptor antagonists

Serge Van CalenberghJacobien K von FrijtagDrabbe KünzelNorbert M BlatonOswald M PeetersJef RozenskiArhtur Van AerschotAndré De BruynDenis De KeukeleireAdriaan P IJzeman et al.

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

Rational development of new sleeping sickness drugs

Serge Van CalenberghPiet Herdewijn

A1 Journal Article in CURRENT MEDICINAL CHEMISTRY

1995

Catalitic activity and stability of hammerhead ribozymes containing 2'-acetamido-2'-deoxyribonucleosides

C HENDRICKXM MAHIEUJ ANNESerge Van CalenberghA VAN AERSCHOTJ CONTENTPiet Herdewijn

A2 Journal Article in Biochem. Biophys., Res. Comm. 210

Catalytic activity and stability of hammerhead ribozymes containing 2'-acetamido-2'-deoxyribonucleosides

Chris HendrixMuriel MahieuJozef AnneSerge Van CalenberghArthur Van AerschotJean ContentPiet Herdewijn

A1 Journal Article in BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Synthesis and structure-activity relationships of analogs of 2'-deoxy-2'-(3-methoxybenzamido)adenosine, a selective inhibitor of trypanosomal glycosomal glyceraldehyde-3-phosphate dehydrogenase

Serge Van CalenberghChristophe LMJ VerlindeJohanna SoenensAndré De BruynMia CallensNorbert M BlatonOswald M PeetersPiet HerdewijnJef RozenskiWim GJ Hol

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

1994

Selective-inhibition of trypanosomal glyceraldehyde-3-phosphate dehydrogenase by protein structure-based design : toward new drugs for the treatment of sleeping sickness

CLMJ VerlindeM CallensSerge Van CalenberghArthur Van AerschotPiet HerdewijnV HannaertPAM MichelsFR OpperdoesWGJ Hol

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and conformational analysis of 2'-deoxy-2'-(3-methoxybenzamido)adenosine, a rational-designed inhibitor of trypanosomal glyceraldehyde phosphate dehydrogenase (GAPDH)

Serge Van CalenberghElfrida Van Den EeckhoutPiet HerdewijnAndré De BruynChristophe VerlindeWim HolMia CallensArthur Van AerschotJef Rozenski

A1 Journal Article in HELVETICA CHIMICA ACTA

1993

2'-Substituted adenosine analogues as trypanosomal glyceraldehyde phosphate dehydrogenase (GAPDH) inhibitors

Serge Van CalenberghChristophe VerlindeAndré De BruynMia CallensElfrida Van Den EeckhoutArthur Van AerschotPaul MichelsFred OpperdoesWim HolPiet Herdewijn

A2 Journal Article in COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS

Protein structure-based inhibitor desighn by cofactor modification towards new drugs for sleeping sickness: sinthesis of MAD-analogs. Journal de Pharmacie de Belgique, XLVIII, n° 2,1993.

Serge Van CalenberghA VAN AERSCHOTC VERLINDEPiet Herdewijn

A2 Journal Article

Protein structure-based inhibitor design: towards new drugs for sleeping sickness. Perspectives in Medicinal Chemistry. Proceedings of the 12th International Symposium of Medicinal Chemistry, Eds.: B. Testa, E. Kyburz, W. Fuhrer, R. Gieger, pp. 135 -148 (1993).

C VERLINDET PIJNINGK KALKSerge Van CalenberghA VAN AERSCHOTPiet HerdewijnM CALLENSP MICHELSF OPPERDOESR WIERINGA et al.