Research Explorer

Your browser does not support JavaScript or JavaScript is not enabled. Without JavaScript some functions of this webapplication may be disabled or cause error messages. To enable JavaScript, please consult the manual of your browser or contact your system administrator.

Researcher

Séan Mc Cafferty

Publications & Research Data

Awards & Distinctions

15 Results

2026

Mucosal administration of lipid nanoparticles containing self-amplifying mRNA induces local uptake and expression in a pig model as a potential vaccination platform against STIs

Ibe Van de CasteeleMagalie PlovytMagdalena StuchlíkováMichiel LanssensBen VerschuerenQuenten DenonPaul Van der MeerenSéan Mc CaffertyArlieke GitselsPieter Cornillie et al.

A1 Journal Article in DRUG DELIVERY AND TRANSLATIONAL RESEARCH

2022

A dual-antigen self-amplifying RNA SARS-CoV-2 vaccine induces potent humoral and cellular immune responses and protects against SARS-CoV-2 variants through T cell-mediated immunity

Séan Mc CaffertyA. K. M. Ashiqul HaqueAster VandierendonckBrian WeidenseeMagalie PlovytMagdalena StuchlikovaNathalie FrançoisSophie ValemboisLeo HeyndrickxJohan Michiels et al.

A1 Journal Article in MOLECULAR THERAPY

The self-amplifying RNA platform for vaccination and in vivo controllable production of therapeutic proteins

Séan Mc CaffertyNiek Sanders

2021

Corticosteroids and cellulose purification improve, respectively, the in vivo translation and vaccination efficacy of sa-mRNAs

Zifu ZhongSéan Mc CaffertyLisa OpsomerHaixiu WangHanne HuysmansJoyca De TemmermanStefan LienenklausJoão Portela CataniFrancis CombesNiek Sanders

A1 Journal Article in MOLECULAR THERAPY

In Vivo Validation of a Reversible Small Molecule-Based Switch for Synthetic Self-Amplifying mRNA Regulation

Séan Mc CaffertyJoyca De TemmermanTasuku KitadaJacob R. BecraftRon WeissDarrell J. IrvineMathias DevreeseSiegrid De BaereFrancis CombesNiek Sanders

A1 Journal Article in MOLECULAR THERAPY

2019

Bovine embryo-secreted microRNA-30c is a potential non-invasive biomarker for hampered preimplantation developmental competence

Xiaoyuan LinEvy BeckersSéan Mc CaffertyYannick GansemansKatarzyna Szymańska-VandendriesscheKrishna Chaitanya PavaniJoão Portela CataniFilip Van NieuwerburghDieter DeforcePetra De Sutter et al.

A1 Journal Article in FRONTIERS IN GENETICS

Expression kinetics and innate immune response after electroporation and LNP-mediated delivery of a self-amplifying mRNA in the skin

Hanne HuysmansZifu ZhongJoyca De TemmermanBarbara L MuiYing K TamSéan Mc CaffertyArlieke GitselsDaisy VanrompayNiek Sanders

A1 Journal Article in MOLECULAR THERAPY-NUCLEIC ACIDS

Immunogenicity and protection efficacy of a naked self-replicating mRNA-based Zika virus vaccine

Zifu ZhongJoão Paulo Portela CataniSéan Mc CaffertyLiesbeth CouckWim Van Den BroeckNina GorléRoosmarijn VandenbrouckeBert DevriendtSebastian UlbertLieselotte Cnops et al.

A1 Journal Article in VACCINES

Improving the repeatability and efficacy of intradermal electroporated self-replicating mRNA

Hanne HuysmansJoyca De TemmermanZifu ZhongSéan Mc CaffertyFrancis CombesFreddy HaesebrouckNiek Sanders

A1 Journal Article in MOLECULAR THERAPY-NUCLEIC ACIDS

Mononuclear but not polymorphonuclear phagocyte depletion increases circulation times and improves mammary tumor-homing efficiency of donor bone marrow-derived monocytes

Francis CombesAlexandros Marios SofiasSéan Mc CaffertyHanne HuysmansJoyca De TemmermanSjoerd HakEvelyne MeyerNiek Sanders

A1 Journal Article in CANCERS

2018

mRNA therapeutics deliver a hopeful message

Zifu ZhongSéan Mc CaffertyFrancis CombesHanne HuysmansJoyca De TemmermanArlieke GitselsDaisy VanrompayJoão Portela CataniNiek Sanders

A1 Journal Article in NANO TODAY

Off-target and tumor-specific accumulation of monocytes, macrophages and myeloid-derived suppressor cells after systemic injection

Francis CombesSéan Mc CaffertyEvelyne MeyerNiek Sanders

A1 Journal Article in NEOPLASIA

2017

Evaluation of a xenogeneic vascular endothelial growth factor-2 vaccine in two preclinical metastatic tumor models in mice

Sofie DeniesBregje LeymanHanne HuysmansFrancis CombesSéan Mc CaffertyLaetitia CiccheleroMarjan SteppeJoyca De TemmermanNiek Sanders

A1 Journal Article in CANCER IMMUNOLOGY IMMUNOTHERAPY

In vitro exploration of a myeloid-derived suppressor cell line as vehicle for cancer gene therapy

Sofie DeniesFrancis CombesCynthia GhekiereSéan Mc CaffertyLaetitia CiccheleroNiek Sanders

A1 Journal Article in CANCER GENE THERAPY

2015

N-1-methylpseudouridine-incorporated mRNA outperforms pseudouridine-incorporated mRNA by providing enhanced protein expression and reduced immunogenicity in mammalian cell lines and mice

Oliwia AndriesSéan Mc CaffertyStefaan De SmedtRon WeissNiek SandersTasuku Kitada

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE