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Researcher
Séan Mc Cafferty
Profile
Projects
Publications
Activities
Awards & Distinctions
14
Results
2022
A dual-antigen self-amplifying RNA SARS-CoV-2 vaccine induces potent humoral and cellular immune responses and protects against SARS-CoV-2 variants through T cell-mediated immunity
Séan Mc Cafferty
A. K. M. Ashiqul Haque
Aster Vandierendonck
Brian Weidensee
Magalie Plovyt
Magdalena Stuchlikova
Nathalie François
Sophie Valembois
Leo Heyndrickx
Johan Michiels
et al.
A1
Journal Article
in
MOLECULAR THERAPY
2022
The self-amplifying RNA platform for vaccination and in vivo controllable production of therapeutic proteins
Séan Mc Cafferty
Niek Sanders
Dissertation
2022
2021
Corticosteroids and cellulose purification improve, respectively, the in vivo translation and vaccination efficacy of sa-mRNAs
Zifu Zhong
Séan Mc Cafferty
Lisa Opsomer
Haixiu Wang
Hanne Huysmans
Joyca De Temmerman
Stefan Lienenklaus
João Portela Catani
Francis Combes
Niek Sanders
A1
Journal Article
in
MOLECULAR THERAPY
2021
In Vivo Validation of a Reversible Small Molecule-Based Switch for Synthetic Self-Amplifying mRNA Regulation
Séan Mc Cafferty
Joyca De Temmerman
Tasuku Kitada
Jacob R. Becraft
Ron Weiss
Darrell J. Irvine
Mathias Devreese
Siegrid De Baere
Francis Combes
Niek Sanders
A1
Journal Article
in
MOLECULAR THERAPY
2021
2019
Bovine embryo-secreted microRNA-30c is a potential non-invasive biomarker for hampered preimplantation developmental competence
Xiaoyuan Lin
Evy Beckers
Séan Mc Cafferty
Yannick Gansemans
Katarzyna Joanna Szymańska-Vandendriessche
Krishna Pavani
João Portela Catani
Filip Van Nieuwerburgh
Dieter Deforce
Petra De Sutter
et al.
A1
Journal Article
in
FRONTIERS IN GENETICS
2019
Expression kinetics and innate immune response after electroporation and LNP-mediated delivery of a self-amplifying mRNA in the skin
Hanne Huysmans
Zifu Zhong
Joyca De Temmerman
Barbara L Mui
Ying K Tam
Séan Mc Cafferty
Arlieke Gitsels
Daisy Vanrompay
Niek Sanders
A1
Journal Article
in
MOLECULAR THERAPY-NUCLEIC ACIDS
2019
Immunogenicity and protection efficacy of a naked self-replicating mRNA-based Zika virus vaccine
Zifu Zhong
João Paulo Portela Catani
Séan Mc Cafferty
Liesbeth Couck
Wim Van Den Broeck
Nina Gorlé
Roosmarijn Vandenbroucke
Bert Devriendt
Sebastian Ulbert
Lieselotte Cnops
et al.
A1
Journal Article
in
VACCINES
2019
Improving the repeatability and efficacy of intradermal electroporated self-replicating mRNA
Hanne Huysmans
Joyca De Temmerman
Zifu Zhong
Séan Mc Cafferty
Francis Combes
Freddy Haesebrouck
Niek Sanders
A1
Journal Article
in
MOLECULAR THERAPY-NUCLEIC ACIDS
2019
Mononuclear but not polymorphonuclear phagocyte depletion increases circulation times and improves mammary tumor-homing efficiency of donor bone marrow-derived monocytes
Francis Combes
Alexandros Marios Sofias
Séan Mc Cafferty
Hanne Huysmans
Joyca De Temmerman
Sjoerd Hak
Evelyne Meyer
Niek Sanders
A1
Journal Article
in
CANCERS
2019
2018
Off-target and tumor-specific accumulation of monocytes, macrophages and myeloid-derived suppressor cells after systemic injection
Francis Combes
Séan Mc Cafferty
Evelyne Meyer
Niek Sanders
A1
Journal Article
in
NEOPLASIA
2018
mRNA therapeutics deliver a hopeful message
Zifu Zhong
Séan Mc Cafferty
Francis Combes
Hanne Huysmans
Joyca De Temmerman
Arlieke Gitsels
Daisy Vanrompay
João Portela Catani
Niek Sanders
A1
Journal Article
in
NANO TODAY
2018
2017
Evaluation of a xenogeneic vascular endothelial growth factor-2 vaccine in two preclinical metastatic tumor models in mice
Sofie Denies
Bregje Leyman
Hanne Huysmans
Francis Combes
Séan Mc Cafferty
Laetitia Cicchelero
Marjan Steppe
Joyca De Temmerman
Niek Sanders
A1
Journal Article
in
CANCER IMMUNOLOGY IMMUNOTHERAPY
2017
In vitro exploration of a myeloid-derived suppressor cell line as vehicle for cancer gene therapy
Sofie Denies
Francis Combes
Cynthia Ghekiere
Séan Mc Cafferty
Laetitia Cicchelero
Niek Sanders
A1
Journal Article
in
CANCER GENE THERAPY
2017
2015
N-1-methylpseudouridine-incorporated mRNA outperforms pseudouridine-incorporated mRNA by providing enhanced protein expression and reduced immunogenicity in mammalian cell lines and mice
Oliwia Andries
Séan Mc Cafferty
Stefaan De Smedt
Ron Weiss
Niek Sanders
Tasuku Kitada
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2015