Research Explorer

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Researcher

Sarah-Lee Bekaert

Publications & Research Data

Awards & Distinctions

12 Results

2025

Second-generation AURKA-targeting PROTACs : structural optimization toward in vivo degradation in neuroblastoma

Simon KrolsMuhammad RishfiFien MartensAnouk Van HauwermeirenEllen SandersPieter-Jan De SutterAn VermeulenKaat De WeverSarah-Lee BekaertM. Emmy M. Dolman et al.

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

Synergistic inhibition of CHK1 and MUS81 to combat replication stress resistance in high-risk neuroblastoma

Elien HilgertChristophe Van NesteSarah-Lee BekaertFien MartensSuzanne VanhauwaertEllen SandersPeter VerstraelenMartijn RisseeuwEllen M. WesterhoutMark A. Grannetia et al.

A1 Journal Article in SCIENTIFIC REPORTS

2024

Human iPSC modeling recapitulates in vivo sympathoadrenal development and reveals an aberrant developmental subpopulation in familial neuroblastoma

Stéphane Van HaverYujie FanSarah-Lee BekaertCeline EveraertWouter Van LoockeVittorio ZanzaniJoke DeschildreInes Fernandez MaestreAdrianna AmaroVanessa Vermeirssen et al.

A1 Journal Article in ISCIENCE

NBAtlas : a harmonized single-cell transcriptomic reference atlas of human neuroblastoma tumors

Noah BonineVittorio ZanzaniAnnelies Van HemelrykBavo VannesteChristian ZwickerTinne ThonéSofie RoelandtSarah-Lee BekaertJan KosterIsabelle Janoueix-Lerosey et al.

A1 Journal Article in CELL REPORTS

Preclinical exploration of the DNA damage response pathway using the interactive neuroblastoma cell line explorer CLEAN

Jonatan Linus GabrePeter MerseburgerArne ClaeysJoachim SiawSarah-Lee BekaertFranki SpelemanBengt HallbergRuth H PalmerJimmy Van den Eynden

A2 Journal Article in NAR CANCER

2023

Post‐operative minimal residual disease models to study metastatic relapse in soft‐tissue sarcoma patient‐derived xenografts

Suzanne FischerDavid CreytensSofie De GeyterElly De VliegherePiet PattynSarah-Lee BekaertKaat DurinckNadine Van RoyAn HendrixLore Lapeire et al.

A1 Journal Article in CLINICAL AND TRANSLATIONAL MEDICINE

Preclinical exploration of the DNA Damage Response pathway using the interactive neuroblastoma cell line explorer CLEAN

Jonatan Linus GabrePeter MerseburgerArne ClaeysJoachim SiawSarah-Lee BekaertFranki SpelemanBengt HallbergRuth H. PalmerJimmy Van den Eynden

SOX11 is a mediator of core regulatory circuit robustness : upregulation of SWI/SNF components and recruitment of transcriptional enhancer NONO

Amber LouwagieBieke DecaestekerSarah-Lee BekaertFanny De VloedEllen SandersStéphane Van HaverTim PietersPieter Van VlierbergheS RobertsS Ek et al.

SOX11 regulates SWI/SNF complex components as member of the adrenergic neuroblastoma core regulatory circuitry

Bieke DecaestekerAmber LouwagieSiebe LoontiensFanny De VloedSarah-Lee BekaertJuliette RoelsSuzanne VanhauwaertSara De BrouwerEllen SandersA Berezovskaya et al.

A1 Journal Article in NATURE COMMUNICATIONS

Targeted AURKA degradation : towards new therapeutic agents for neuroblastoma

Muhammad RishfiSimon KrolsFien MartensSarah-Lee BekaertEllen SandersAline EggermontFanny De VloedJoshua Robert GouldingMartijn RisseeuwJan Molenaar et al.

A1 Journal Article in EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

2022

RRM2 enhances MYCN-driven neuroblastoma formation and acts as a synergistic target with CHK1 inhibition

Carolina de Carvalho NunesLisa DepestelLiselot MusKaylee M. KellerLouis DelhayeAmber LouwagieMuhammad RishfiAlex WhaleNeesha KaraSimon R. Andrews et al.

A1 Journal Article in SCIENCE ADVANCES

The adrenergic-specific long non-coding RNA NESPR controls survival of neuroblastoma cells

Louis DelhayeEric de Bony de LavergneDries RombautLim Fang QiBieke DecaestekerLisa DepestelAmber LouwagieEva D'haenePieter-Jan VoldersNurten Yigit et al.