Research Explorer

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Researcher

Sarah Gerlo

Awards & Distinctions

86 Results

2025

Beyond diagnosis : early antiretroviral treatment and HIV immunopathogenesis in a Belgian acute HIV infection cohort

Jozefien De ClercqLinos VandekerckhoveSarah Gerlo

Blood and tissue HIV-1 reservoirs display plasticity and lack of compartmentalization in virally suppressed people

Marion PardonsLaurens LambrechtsYtse NoppeLiesbet TermoteSofie De BraekeleerJerel VegaEllen Van GulckSarah GerloLinos Vandekerckhove

A1 Journal Article in NATURE COMMUNICATIONS

Integrative assessment of total and intact HIV-1 reservoir by a 5-region multiplexed rainbow DNA digital PCR assay

Mareva DelporteLaurens LambrechtsEvy BlommeWillem van SnippenbergSofie RutsaertMaxime VerschooreEvelien De SmetYtse NoppeNele De LangheMarie-Angélique De Scheerder et al.

A1 Journal Article in CLINICAL CHEMISTRY

2024

HIV-PULSE as a new platform to unveil HIV-1 reservoir composition : intactness, drug resistance, tropism and immune therapy predictions

Sofie De BraekeleerLiesbet TermoteSofie RutsaertLaurens LambrechtsWilhelm A. VosAlbert L. GroenendijkLouise E. van EekerenMarc BlaauwJanneke StalenhoefAnnelies Verbon et al.

In-depth analysis of the HIV reservoir confirms effectiveness and safety of dolutegravir/lamivudine in a phase 4 randomized controlled switch trial (RUMBA)

Marie-Angélique De ScheerderSophie DegrooteMareva DelporteMaja KiselinovaWim TrypsteenLara VinckeEvelien De SmetBram Van Den EeckhoutLoic SchrooyenMaxime Verschoore et al.

A1 Journal Article in JOURNAL OF INFECTIOUS DISEASES

Integrating artificial intelligence-based epitope prediction in a SARS-CoV-2 antibody discovery pipeline : caution is warranted

Delphine Diana AcarWojciech WitkowskiMagdalena WejdaRuifang WeiTim DesmetBert SchepensSieglinde De CaeKoen SedeynHannah EeckhautDaria Fijalkowska et al.

A1 Journal Article in EBIOMEDICINE

Longitudinal patterns of inflammatory mediators after acute HIV infection correlate to intact and total reservoir

Jozefien De ClercqMarie-Angélique De ScheerderVirginie MortierChris VerhofstedeStefaan J. VandecasteeleSabine D. AllardCoca NecsoiStephane De WitSarah GerloLinos Vandekerckhove

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Repeated COVID-19 mRNA-based vaccination contributes to SARS-CoV-2 neutralizing antibody responses in the mucosa

Jozefien DeclercqSarah GerloSharon Van NevelNatalie De RuyckGabriële HoltappelsLiesbeth DelesieEls TobbackInés LammensNikita GerebtsovKoen Sedeyn et al.

A1 Journal Article in SCIENCE TRANSLATIONAL MEDICINE

Staging of immuno-virological dynamics during acute HIV infection in a Belgian prospective cohort study

Jozefien De ClercqMarie-Angélique De ScheerderSophie VanherrewegeEls CaluweNathalie MoreelsDanny DeloozeAnnemieke DhondtMarc CoppensStefaan J. VandecasteeleSabine D. Allard et al.

A1 Journal Article in JOURNAL OF VIRUS ERADICATION

2023

Rethinking IL-1 antagonism in respiratory viral infections : a role for IL-1 signaling in the development of antiviral T cell immunity

Bram Van Den EeckhoutMarlies BallegeerJozefien De ClercqElianne BurgXavier SaelensLinos VandekerckhoveSarah Gerlo

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Unraveling ongoing inflammation after early ART by in-depth analysis of lymph nodes

Jozefien De ClercqKathleen Busman-SahayLaurens LambrechtsSofie RutsaertSol Taylor-BrillStephen BondocMarie-Angélique De ScheerderJacob EstesSarah GerloLinos Vandekerckhove

2022

COVID‐19 vaccination with BNT162b2 and ChAdOx1 vaccines has the potential to induce nasal neutralizing antibodies

Jozefien DeclercqEls TobbackStijn VanheeNatalie De RuyckSarah GerloPhilippe GevaertLinos Vandekerckhove

A1 Journal Article in ALLERGY

Distinct immune profiles of HIV‐infected subjects are linked to specific lipid mediator signature

Magdalena SipsSarah GerloLaura De ClercqEsteban A. GomezRomain A. ColasJesmond DalliLinos Vandekerckhove

A1 Journal Article in IMMUNITY INFLAMMATION AND DISEASE

Humoral and cellular responses to COVID-19 vaccination indicate the need for post-vaccination testing in frail population

Wojciech WitkowskiSarah GerloEvelien De SmetMagdalena WejdaDelphine AcarSteven CallensStefan HeytensElizaveta PadalkoHannelore VercruyssePiet Cools et al.

A1 Journal Article in VACCINES

Unraveling persistent inflammation after very early ART through in-depth analysis of lymph nodes

Jozefien De ClercqKathleen Busman-SahayLaurens LambrechtsSofie RutsaertStephen BondocSol Taylor-BrillMarie-Angélique De ScheerderJacob EstesSarah GerloLinos Vandekerckhove

2021

Cytokine and chemokine dynamics in acute HIV infection and the impact of early ART initiation

Jozefien De ClercqGrégoire ThomasSarah GerloLinos Vandekerckhove

Development of IL-1β AcTakines : towards new adjuvants in vaccination strategies

Bram Van Den EeckhoutSarah GerloJan Tavernier

Interleukin-1 as innate mediator of T cell immunity

Bram Van Den EeckhoutJan TavernierSarah Gerlo

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

New generation of HYBRID CAR-T cells efficiently kill HIV-infected cells and neutralize cell-free virus

Zoi StylianidouMagdalena WejdaTinus SchynkelSarah GerloWojciech WitkowskiLeila Bousbaine Vandekerckhove

Organ-specific genome diversity of replication-competent SARS-CoV-2

Jolien Van CleemputWillem van SnippenbergLaurens LambrechtsAmélie DendoovenValentino D'OnofrioLiesbeth CouckWim TrypsteenJan VanrusseltSebastiaan TheunsNick Vereecke et al.

A1 Journal Article in NATURE COMMUNICATIONS

Selective IL-1 activity on CD8+ T cells empowers antitumor immunity and synergizes with neovasculature-targeted TNF for full tumor eradication

Bram Van Den EeckhoutLeander HuygheSandra Van LintElianne BurgStéphane PlaisanceFrank PeelmanAnje CauwelsGilles UzéNiko KleySarah Gerlo et al.

A1 Journal Article in JOURNAL FOR IMMUNOTHERAPY OF CANCER

2020

End of dose interval symptoms in patients treated with natalizumab : a role for serum cytokines?

Cathérine DekeyserAnnelien De PueAnne SiebenLuc AlgoedLiesbeth Van HijfteSarah GerloGuy Laureys

A1 Journal Article in MULTIPLE SCLEROSIS AND RELATED DISORDERS

On the whereabouts of SARS-CoV-2 in the human body : a systematic review

Wim TrypsteenJolien Van CleemputWillem van SnippenbergSarah GerloLinos Vandekerckhove

A1 Journal Article in PLOS PATHOGENS

Selected IL-1 activity on CD8+ T cells allows for safe enhancement of cellular immune responses

Bram Van Den EeckhoutLien Van HoeckeElianne BurgSandra Van LintFrank PeelmanNiko KleyGilles UzéXavier SaelensJan TavernierSarah Gerlo

Specific targeting of IL-1β activity to CD8+ T cells allows for safe use as a vaccine adjuvant

Bram Van Den EeckhoutLien Van HoeckeElianne BurgSandra Van LintFrank PeelmanNiko KleyGilles UzéXavier SaelensJan TavernierSarah Gerlo

A1 Journal Article in NPJ VACCINES

2019

Towards the use of interleukin-1β as vaccine adjuvant

Bram Van Den EeckhoutLien Van HoeckeElianne BurgSandra Van LintFrank PeelmanXavier SaelensJan TavernierSarah Gerlo

2018

Delivering type I interferon to dendritic cells empowers tumor eradication and immune combination treatments

Anje CauwelsSandra Van LintFranciane PaulGenevieve GarcinStefaan De KokerAlexander Van ParysThomas WüestSarah GerloJosé Van Der HeydenYan Bordat et al.

A1 Journal Article in CANCER RESEARCH

IL-1β AcTaleukins : towards potent yet safe adjuvants for tumor vaccination

Bram Van Den EeckhoutElianne BurgAnje CauwelsFrank PeelmanSandra Van LintJan TavernierSarah Gerlo

KISS : a mammalian two-hybrid method for in situ analysis of protein-protein interactions

Delphine MasschaeleSarah GerloIrma LemmensSam LievensJan Tavernier

Bookchapter in Two-hybrid systems : methods and protocols

2017

A safe and highly efficient tumor-targeted type I interferon immunotherapy depends on the tumor microenvironment

Anje CauwelsSandra Van LintGeneviève GarcinJennyfer BultinckFranciane PaulSarah GerloJosé Van Der HeydenYann BordatDominiek CatteeuwLode De Cauwer et al.

A1 Journal Article in ONCOIMMUNOLOGY

IL-1β AcTaleukins : towards potent yet safe adjuvants for tumor vaccination

Bram Van Den EeckhoutElianne BurgAnje CauwelsFrank PeelmanSandra Van LintJan TavernierSarah Gerlo

The ER stress sensor PERK coordinates ER-plasma membrane contact site formation through interaction with filamin-A and F-actin remodeling

Alexander R van VlietFrancesca GiordanoSarah GerloInmaculada SeguraSofie Van EygenGeert MolenberghsSusana RochaAudrey HoucineRita DeruaTom Verfaillie et al.

A1 Journal Article in MOLECULAR CELL

2016

An omics strategy to unravel the role of the β2-adrenergic receptor in inflammation

Sarah GerloGuy LaureysKrzysztof KolmusSven EyckermanKris GevaertIrma LemmensJan Tavernier

JAK2 deficiency as a novel cause of impaired Th17 immunity

Filomeen HaerynckDelfien BogaertElfride De BaereKristof Van SchilFrauke CoppietersMarieke De BruyneMargot HagendorensTessa KerreFrans De BaetsMaria Bordon Cueto De Braem et al.

Ubiquitin D regulates IRE1 α/c-Jun N-terminal kinase (JNK) protein-dependent apoptosis in pancreatic beta cells

Flora BrozziSarah GerloFabio Arturo GriecoMatilda JuusolaAlexander BalhuizenSam LievensConny GysemansMarco BuglianiChantal MathieuPiero Marchetti et al.

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

2015

A novel STAT1 mutation in a patient with pneumocystis jiroveci and chronic mucocutaneous candidiasis

Delfien BogaertMelissa DullaersJens StaalSarah GerloElien VandermarliereVeronique De BackerMaria Bordon Cueto De BraemKATHLEEN DE WAELEIsabelle MeytsLeen Moens et al.

Adrenergic regulation of Interleukin-6 and chemokine expression : stressing NF-κB

Sarah GerloGuy LaureysAnneleen SpoorenKrzysztof KolmusJacques De KeyserJoeri AertsJan Tavernier

An interactomics approach to unravel IRE1α function

Sarah GerloSam LievensElien RuyssinckDieter DefeverHannes DemaréJan Tavernier

Plasma carnosine, but not muscle carnosine, attenuates high-fat diet-induced metabolic stress

Sanne StegenBart StegenGiancarlo AldiniAlessandra AltomareLuca CannizzaroMarica OrioliSarah GerloLouise DeldicqueMonique RamaekersPeter Hespel et al.

A1 Journal Article in APPLIED PHYSIOLOGY NUTRITION AND METABOLISM

β₂-Adrenergic receptors in immunity and inflammation: stressing NF-κB

Krzysztof KolmusJan TavernierSarah Gerlo

A1 Journal Article in BRAIN BEHAVIOR AND IMMUNITY

2014

A combined 'omics' approach identifies N-Myc interactor as a novel cytokine-induced regulator of IRE1α protein and c-Jun N-terminal kinase in pancreatic beta cells

Flora BrozziSarah GerloFabio Arturo GriecoTarlliza Romanna NardelliSam LievensConny GysemansLorella MarselliPiero MarchettiChantal MathieuJan Tavernier et al.

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

A combined 'omics' approach identifies NMI as a novel cytokine-induced regulator of IRE1 alpha and JNK in pancreatic beta cells

F BrozziSarah GerloFA GriecoSam LievensC GysemansL MarselliP MarchettiC MathieuJan TavernierDL Eizirik

A novel Stat1 mutation leading to hyperphosphorylation in a patient with Pneumocystis jjiroveci and chronic mucocutaneous candidiasis

Melissa DullaersJens StaalSarah GerloElien VandermarliereV DebackerMaria Bordon Cueto De BraemK De WaeleI MeytsL MoensX Bossuyt et al.

An interactomics approach to unravel IRE1α function

Sarah GerloSam LievensElien RuyssinckDieter DefeverHannes DemaréJan Tavernier

Ectopic microRNA-150-5p transcription sensitizes glucocorticoid therapy response in MM1S multiple myeloma cells but fails to overcome hormone therapy resistance in MM1R cells

Ajay PalaganiKen Op de BeeckStefan NaulaertsJolien DiddensChandra Sekhar ChirumamillaGuy Van CampKris LaukensKaren HeyninckSarah GerloPieter Mestdagh et al.

A1 Journal Article in PLOS ONE

Getting RIDD of RNA: IRE1 in cell fate regulation

Marion MaurelE ChevetJan TavernierSarah Gerlo

A1 Journal Article in TRENDS IN BIOCHEMICAL SCIENCES

How the venom from the ectoparasitoid wasp Nasonia vitripennis exhibits anti-inflammatory properties on mammalian cell lines

Ellen DanneelsSarah GerloKaren HeyninckKathleen Van CraenenbroeckKarolien De BosscherGuy HaegemanDirk de Graaf

A1 Journal Article in PLOS ONE

Kinase Substrate Sensor (KISS), a mammalian in situ protein interaction sensor

Sam LievensSarah GerloIrma LemmensDries De ClercqMartijn RisseeuwNele VanderroostAnne-Sophie De SmetElien RuyssinckEric ChevetSerge Van Calenbergh et al.

A1 Journal Article in MOLECULAR & CELLULAR PROTEOMICS

Study of crosstalk between G-protein coupled receptor-mediated signals and the Nuclear Factor-κB signal transduction cascade

Krzysztof KolmusSarah GerloJan Tavernier

The small GTPase Arf6 is essential for the Tram/Trif pathway in RLR4 signaling

Tim Van AckerSven EyckermanLieselotte Vande WalleSarah GerloMarc GoethalsMohamed LamkanfiCelia BovijnJan TavernierFrank Peelman

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

β-Agonists selectively modulate proinflammatory gene expression in skeletal muscle cells via non-canonical nuclear crosstalk mechanisms

Krzysztof KolmusMarleen Van TroysKarlien Van WesemaelChristophe AmpeGuy HaegemanJan TavernierSarah Gerlo

A1 Journal Article in PLOS ONE

β2-adrenergic agonists modulate TNF-α induced astrocytic inflammatory gene expression and brain inflammatory cell populations

Guy LaureysSarah GerloAnneleen SpoorenFrauke DemolJacques De KeyserJoeri L Aerts

A1 Journal Article in JOURNAL OF NEUROINFLAMMATION

2013

MAPPIT and Co: the importance of system artifacts

Jan TavernierLeentje De CeuninckSarah GerloIrma LemmensSam LievensJosé Van Der HeydenJoris Wauman

Using KISS mammalian two-hybrid technology to study IRE1α function

Sarah GerloSam LievensElien RuyssinckHannes DemaréDieter DefeverJan Tavernier

2012

A dissociated glucocorticoid receptor modulator reduces airway hyperresponsiveness and inflammation in a mouse model of asthma

Laurent L ReberFrançois DaubeufMaud PlantingaLode De CauwerSarah GerloWim WaelputSerge Van CalenberghJan TavernierGuy HaegemanBart Lambrecht et al.

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Compound A, a dissociated glucocorticoid receptor modulator, inhibits T-bet (Th1) and induces GATA-3 (Th2) activity in immune cells

Ana C LibermanMaria Antunica-NoguerolViviane Ferraz-de-PaulaJoao Palermo-NetoCarla N CastroJimena DrukerFlorian HolsboerMarcelo J PeroneSarah GerloKarolien De Bosscher et al.

A1 Journal Article in PLOS ONE

Gel-free proteomic analysis of enhanceosome composition at the IL-6 promoter upon β2-adrenergic/TNF-α receptor co-activation

Krzysztof KolmusAnneleen SpoorenKarlien Van WesemaelGuy HaegemanSarah Gerlo

2011

Cyclic AMP: a selective modulator of NF-κB action

Sarah GerloRon KooijmanIlse BeckKrzysztof KolmusAnneleen SpoorenGuy Haegeman

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

Dual effects of β2-adrenergic receptor on NF-κB-dependent genes: synergy versus inhibition

G LaureysAnneleen SpoorenR ClinckersJ De KeyserGuy HaegemanSarah Gerlo

IL-1 beta potently stabilizes IL-6 mRNA in human astrocytes

Anneleen SpoorenPieter MestdaghPieter RondouKrzysztof KolmusGuy HaegemanSarah Gerlo

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

Interleukin-6, a mental cytokine

Anneleen SpoorenKrzysztof KolmusGuy LaureysRalph ClinckersJacques De KeyserGuy HaegemanSarah Gerlo

A1 Journal Article in BRAIN RESEARCH REVIEWS

2010

Astrocytic beta(2)-adrenergic receptors : from physiology to pathology

Guy LaureysRalph ClinckersSarah GerloAnneleen SpoorenNadine WilczakRon KooijmanIlse SmoldersYvette MichotteJacques De Keyser

A1 Journal Article in PROGRESS IN NEUROBIOLOGY

Cooperation of NF kappa B and CREB to induce synergistic IL-6 expression in astrocytes

Anneleen SpoorenRon KooijmanBéatrice LintermansKathleen Van CraenenbroeckLinda VermeulenGuy HaegemanSarah Gerlo

A1 Journal Article in CELLULAR SIGNALLING

Differential chemosensitization of P-glycoprotein overexpressing K562/Adr cells by withaferin A and Siamois polyphenols

Wipob SuttanaSamlee MankhetkornWilart PoompimonAjay PalaganiSergey ZhokhovSarah GerloGuy HaegemanWim Vanden Berghe

A1 Journal Article in MOLECULAR CANCER

Hunting for serine 276-phosphorylated p65

Anneleen SpoorenKrzysztof KolmusLinda VermeulenKarlien Van WesemaelGuy HaegemanSarah Gerlo

A1 Journal Article in JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

IL-1 beta stabilizes IL-6 mRNA in human astrocytoma cells

Anneleen SpoorenGuy HaegemanSarah Gerlo

Modulation of cytokine production by cyclic adenosine monophosphate analogs in human leukocytes

Sarah GerloPeggy VerdoodRon Kooijman

A1 Journal Article in JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Proinflammatory stimuli and β2-adrenoreceptor agonists synergistically induce IL-6 expression in myotubes

Krzysztof KolmusAnneleen SpoorenKarlien Van WesemaelGuy HaegemanSarah Gerlo

2009

Cooperation of NF-κB and CREB to induce synergistic IL-6 transcription upon combined triggering of β2-adrenergic and TNF-receptors in astrocytes

Anneleen SpoorenRon KooijmanKathleen Van CraenenbroeckLinda VermeulenGuy HaegemanSarah Gerlo

Exploring TNF-α and cAMP-induced signaling pathways regulating IL-6 expression in skeletal muscle cells

Krzysztof KolmusGuy HaegemanSarah Gerlo

Glucocorticoids and mitogen- and stress-activated protein kinase 1 inhibitors: Possible partners in the combat against inflammation

Ilse BeckWim Vanden BergheSarah GerloNadia BougarneLinda VermeulenKarolien De BosscherGuy Haegeman

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

TLR4-mediated IL-6 gene expression in macrophages : who does the job?

Sarah GerloAnneleen SpoorenAgatha KoreckaGuy HaegemanWim Vanden Berghe

The astrocytic β2-adrenergic receptor : a novel target for treatment of neuro-inflammation?

Sarah GerloAnneleen SpoorenRon KooijmanBéatrice LintermansKathleen Van CraenenbroeckGuy Haegeman

2008

Transcriptional regulation of autocrine IL-6 expression in multiple myeloma cells

Sarah GerloGuy HaegemanWim Vanden Berghe

A1 Journal Article in CELLULAR SIGNALLING

2007

A critical role for p53 in the control of NF-kappa B-dependent gene expression in TLR4-stimulated dendritic cells exposed to genistein

Nathalie DijsselbloemS GORIELYV ALBARANISarah GerloSarah FrancozJean-Christophe MarineM GOLDMANGuy HaegemanWim Vanden Berghe

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Contribution of IKK and PKA pathways to TLR4-triggered chromatin relaxation and transcription of the IL-6 gene

Sarah GerloWim Vanden BergheGuy Haegeman

2006

Keeping up NF-kappa B appearances: Epigenetic control of immunity or inflammation-triggered epigenetics

Wim Vanden BergheMatladi NdlovuR. HOYA-ARIASNathalie DijsselbloemSarah GerloGuy Haegeman

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

Multiple cAMP-induced signaling cascades regulate prolactin expression in T cells

Sarah GerloP VerdoodEL Hooghe-PetersR Kooijman

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

Prolactin in man: a tale of two promoters

Sarah GerloJulian R. E. DavisDixie L. MagerRon Kooijman

A1 Journal Article in BIOESSAYS

Tumor necrosis factor-α activates the extrapituitary PRL promoter in myeloid leukemic cells

Sarah GerloP VerdoodR Kooijman

A1 Journal Article in JOURNAL OF NEUROIMMUNOLOGY

2005

Modulation of prolactin expression in human T lymphocytes by cytokines

Sarah GerloP VerdoodEL Hooghe-PetersR Kooijman

A1 Journal Article in JOURNAL OF NEUROIMMUNOLOGY

Multiple, PKA-dependent and PKA-independent, signals are involved in cAMP-induced PRL expression in the eosinophilic cell line Eol-1

Sarah GerloP VerdoodEL Hooghe-PetersR Kooijman

A1 Journal Article in CELLULAR SIGNALLING

2004

Mechanism of prostaglandin (PG)E2-induced prolactin expression in human T cells : cooperation of two PGE2 receptor subtypes, E-prostanoid (EP) 3 and EP4, via calcium- and cyclic adenosine 5'-monophosphate-mediated signaling pathways

Sarah GerloP VerdoodB GellersenEL Hooghe-PetersR Kooijman

A1 Journal Article in JOURNAL OF IMMUNOLOGY

2003

Regulation of prolactin expression in leukemic cell lines and peripheral blood mononuclear cells

Sarah GerloWim Vanden BergheP VerdoodEL Hooghe-PetersR Kooijman

A1 Journal Article in JOURNAL OF NEUROIMMUNOLOGY

2000

Growth hormone and prolactin expression in the immune system

R KooijmanSarah GerloA CoppensEL Hooghe-Peters

A1 Journal Article in Annals of the New York Academy of Sciences

Myeloid leukemic cells express and secrete bioactive pituitary-sized 23 kDa prolactin

R KooijmanSarah GerloA CoppensEL Hooghe-Peters

A1 Journal Article in JOURNAL OF NEUROIMMUNOLOGY