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Researcher
Sarah Cosyns
Profile
Projects
Publications
Activities
Awards & Distinctions
48
Results
2025
From Passive Diffusion to Active Penetration: Translating Electromotive Drug Administration Through Experimental Nanoparticle Transport Models for Peritoneal Metastasis
Nidda Saeed
Katrien Remaut
Sarah Cosyns
Hooman Salavati
Wim Ceelen
Annelies Coene
U
Conference
2025
2024
Development and validation of an UPLC-MS/MS method for the determination of irinotecan (CPT-11), SN-38 and SN-38 glucuronide in human plasma and peritoneal tumor tissue from patients with peritoneal carcinomatosis
Elke Gasthuys
Judith van Ovost
Sofie Vande Casteele
Sarah Cosyns
Wim Ceelen
Jan Van Bocxlaer
An Vermeulen
A1
Journal Article
in
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
2024
Effects of hyperthermia on cisplatin tissue penetration and gene expression in peritoneal metastases : results from a randomized trial in ovarian cancer
Jesse Demuytere
Charlotte Carlier
Tom Van Helden
Joke Belza
Frank Vanhaecke
Feifan Xie
An Vermeulen
Joseph Weerts
Jürgen Thomale
Hannelore Denys
et al.
A1
Journal Article
in
BRITISH JOURNAL OF SURGERY
2024
2023
External multicentre validation of pseudomyxoma peritonei PSOGI-Ki67 classification
A Arjona-Sanchez
A Martinez-López
MT Moreno-Montilla
J Mulsow
P Lozano-Lominchar
B Martínez-Torres
B Rau
E Canbay
A Sommariva
M Milione
et al.
A1
Journal Article
in
EJSO
2023
2022
Cisplatin uptake in peritoneal metastases of ovarian cancer following CRS+ HIPEC
Jesse Demuytere
Charlotte Carlier
Tom Van Helden
Joke Belza
Frank Vanhaecke
Joseph Weerts
Sarah Cosyns
Wim Ceelen
C3
Conference
2022
Computational investigation of the effective forces on droplets during electrostatic precipitation pressurized intraperitoneal aerosol chemotherapy (ePIPAC)
Mohammad Rahimi Gorji
Charlotte Debbaut
Ghader Ghorbaniasl
Sarah Cosyns
Wouter Willaert
Wim Ceelen
C3
Conference
2022
Efficacy of additional electrostatic precipitation to intraperitoneal aerosolized chemotherapy in a realistically reconstructed human peritoneal cavity : a computational study
Mohammad Rahimi Gorji
Charlotte Debbaut
Ghader Ghorbaniasl
Sarah Cosyns
Wouter Willaert
Wim Ceelen
C3
Conference
2022
Electrostatic precipitation pressurized intraperitoneal aerosol chemotherapy in a realistically reconstructed human peritoneal cavity : computational modelling approach
Mohammad Rahimi Gorji
Charlotte Debbaut
Ghader Ghorbaniasl
Sarah Cosyns
Wouter Willaert
Wim Ceelen
C3
Conference
2022
In silico modeling of regional droplet deposition during aerosolized intraperitoneal chemotherapy using a patient-inspired geometry
Mohammad Rahimi Gorji
Charlotte Debbaut
Ghader Ghorbaniasl
Sarah Cosyns
Wouter Willaert
Wim Ceelen
C3
Conference
2022
Optimization of intraperitoneal aerosolized drug delivery using computational fluid dynamics (CFD) modeling
Mohammad Rahimi Gorji
Charlotte Debbaut
Ghader Ghorbaniasl
Sarah Cosyns
Wouter Willaert
Wim Ceelen
A1
Journal Article
in
SCIENTIFIC REPORTS
2022
Phase I study of intraperitoneal aerosolized nanoparticle albumin based paclitaxel (NAB-PTX) for unresectable peritoneal metastases
Wim Ceelen
Louis Sandra
Leen Van de Sande
M Graversen
MB Mortensen
An Vermeulen
Elke Gasthuys
Dries Reynders
Sarah Cosyns
Anne Hoorens
et al.
A1
Journal Article
in
EBIOMEDICINE
2022
Simulation of electrostatic precipitation pressurized intraperitoneal aerosol chemotherapy (ePIPAC) in a realistic human abdominal model
Mohammad Rahimi Gorji
Charlotte Debbaut
Ghader Ghorbaniasl
Sarah Cosyns
Wouter Willaert
Wim Ceelen
C3
Conference
2022
The impact of hyperthermia on survival and pharmacokinetics in cisplatin HIPEC in stage III epithelial ovarian cancer
Jesse Demuytere
Charlotte Carlier
Wouter Willaert
Philippe Tummers
Hannelore Denys
Tom Van Helden
Joke Belza
Frank Vanhaecke
Feifan Xie
An Vermeulen
et al.
C3
Conference
2022
The impact of hyperthermia on survival and pharmacokinetics in cisplatin HIPEC in stage III epithelial ovarian cancer
Jesse Demuytere
Charlotte Carlier
Wouter Willaert
Philippe Tummers
Hannelore Denys
Tom Van Helden
Joke Belza
Frank Vanhaecke
Feifan Xie
An Vermeulen
et al.
C3
Conference
2022
The tumor immune microenvironment in peritoneal carcinomatosis
Jesse Demuytere
Sam Ernst
Judith van Ovost
Sarah Cosyns
Wim Ceelen
Bookchapter
in
Cellular immunity in the peritoneum
2022
2021
Aerosolization of thermosensitive hydrogels using pressurized intraperitoneal aerosol chemotherapy (PIPAC)
Mohammad Rahimi Gorji
Helena Braet
Charlotte Debbaut
Ghader Ghorbaniasl
Sarah Cosyns
Wouter Willaert
Katrien Remaut
Wim Ceelen
C3
Conference
2021
Analysis of the effect of liquid viscosity on the aerosol distribution during Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) using computational modeling
Mohammad Rahimi Gorji
Sarah Cosyns
Charlotte Debbaut
Ghader Ghorbaniasl
Wouter Willaert
Wim Ceelen
C3
Conference
2021
Debulking and HIPEC for ovarian cancer : effects of perfusion temperature on morbidity and cisplatin pharmacokinetics
Jesse Demuytere
Charlotte Carlier
Wouter Willaert
Philippe Tummers
Hannelore Denys
Olivier Van Kerschaver
Joseph Weerts
Sarah Cosyns
Wim Ceelen
C3
Conference
2021
Effect of fluid flow rate and droplet size on spatial aerosol distribution during pressurized intraperitoneal aerosol chemotherapy (PIPAC)
Mohammad Rahimi Gorji
Ghader Ghorbaniasl
Sarah Cosyns
Wouter Willaert
Wim Ceelen
Charlotte Debbaut
C3
Conference
2021
Electrostatic precipitation pressurized intraperitoneal aerosol chemotherapy (ePIPAC) : finding the optimal electrical potential
Mohammad Rahimi Gorji
Charlotte Debbaut
Ghader Ghorbaniasl
Wouter Willaert
Sarah Cosyns
Wim Ceelen
C3
Conference
2021
Exploring high pressure nebulization of pluronic F127 hydrogels for intraperitoneal drug delivery
Helena Braet
Mohammad Rahimi Gorji
Charlotte Debbaut
G Ghorbaniasl
Thibault Van Walleghem
Senne Cornelis
Sarah Cosyns
Chris Vervaet
Wouter Willaert
Wim Ceelen
et al.
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
2021
In vitro study of aerosol droplet impact on the peritoneal surface after nebulization using the CapnoPen device
Mohammad Rahimi Gorji
Stéphane Dorbolo
Sarah Cosyns
Charlotte Debbaut
Ghader Ghorbaniasl
Wouter Willaert
Wim Ceelen
C3
Conference
2021
Intraperitoneal aerosolized nanoparticle albumin based paclitaxel (NAB-PTX) for irresectable peritoneal metastases : a first in human phase I study
Wim Ceelen
Louis Sandra
Leen Van de Sande
Martin Graversen
An Vermeulen
Dries Reynders
Sarah Cosyns
Anne Hoorens
Wouter Willaert
C3
Conference
2021
2020
Albumin-based cancer therapeutics for intraperitoneal drug delivery : a review
Leen Van de Sande
Sarah Cosyns
Wouter Willaert
Wim Ceelen
A1
Journal Article
in
DRUG DELIVERY
2020
Effects of electrostatic precipitation on IP drug distribution and tissue penetration of nanoparticles
Mohammad Rahimi Gorji
Leen Van de Sande
Charlotte Debbaut
Ghader Ghorbaniasl
Wouter Willaert
Sarah Cosyns
Wim Ceelen
C3
Conference
2020
Electrostatic intraperitoneal aerosol delivery of nanoparticles : proof of concept and preclinical validation
Leen Van de Sande
Mohammad Rahimi Gorji
Silvia Giordano
Enrico Davoli
Cristina Matteo
Sonke Detlefsen
Katharina D'Herde
Helena Braet
Molood Shariati
Katrien Remaut
et al.
A1
Journal Article
in
ADVANCED HEALTHCARE MATERIALS
2020
Electrostatic precipitation is a valuable adjunct to pressurized intraperitoneal aerosol chemotherapy : an in vitro study
Leen Van de Sande
Melanie Coetsier
Azarie Victor
Sarah Cosyns
Wouter Willaert
Molood Shariati
Helena Braet
Katrien Remaut
Wim Ceelen
C3
Conference
2020
Intraperitoneal aerosolized drug delivery : technology, recent developments, and future outlook
Mohammad Rahimi Gorji
Leen Van de Sande
Charlotte Debbaut
Ghader Ghorbaniasl
Helena Braet
Sarah Cosyns
Katrien Remaut
Wouter Willaert
Wim Ceelen
A1
Journal Article
in
ADVANCED DRUG DELIVERY REVIEWS
2020
2019
Establishment of a rat ovarian peritoneal metastasis model to study pressurized intraperitoneal aerosol chemotherapy (PIPAC)
Leen Van de Sande
Wouter Willaert
Sarah Cosyns
Kaat De Clercq
Molood Shariati
Katrien Remaut
Wim Ceelen
A1
Journal Article
in
BMC CANCER
2019
2018
Biology-based surgery : the extent of lymphadenectomy in cancer of the colon
Wouter Willaert
Sarah Cosyns
Wim Ceelen
A1
Journal Article
in
EUROPEAN SURGICAL RESEARCH
2018
Intraperitoneal aerosolization of albumin-stabilized paclitaxel nanoparticles (Abraxane™) for peritoneal carcinomatosis : a phase I first-in-human study
Leen Van de Sande
Martin Graversen
Martin Hubner
Marc Pocard
Marc Reymond
Marco Vaira
Sarah Cosyns
Wouter Willaert
Wim Ceelen
A2
Journal Article
in
PLEURA AND PERITONEUM
2018
The impact of surgical resection of the primary tumor on the development of synchronous colorectal liver metastasis : a systematic review
Harry Pinson
Sarah Cosyns
Wim Ceelen
A1
Journal Article
in
ACTA CHIRURGICA BELGICA
2018
2017
Establishment of a rat model for pressurized intraperitoneal aerosol chemotherapy
Leen Van de Sande
Wouter Willaert
Sarah Cosyns
Wim Ceelen
C3
Conference
2017
Pressurized IntraPeritoneal Aerosol Chemotherapy for unresectable peritoneal carcinomatosis : experience of 63 procedures
Wouter Willaert
Leen Van de Sande
Sarah Cosyns
Elke Van Daele
Dirk Van de Putte
Lucas E Matthyssens
Katrien Van Renterghem
Yves Van Nieuwenhove
Piet Pattyn
Wim Ceelen
C3
Conference
2017
Pressurized intraperitoneal aerosol chemotherapy, a new surgical technique for the treatment of unresectable peritoneal carcinomatosis
Wouter Willaert
Sarah Cosyns
Leen Van de Sande
Piet Pattyn
Wim Ceelen
C3
Conference
2017
2016
Pressurized intraperitoneal aerosol chemotherapy (PIPAC), a new surgical technique for the treatment of unresectable peritoneal carcinomatosis
Sarah Cosyns
Leen Van de Sande
Wim Ceelen
Wouter Willaert
C3
Conference
2016
2015
Protective effect of exogenous nitrite in postoperative ileus
Sarah Cosyns
S Shiva
Romain Lefebvre
A1
Journal Article
in
BRITISH JOURNAL OF PHARMACOLOGY
2015
2014
Effect of exogenous nitrite in postoperative ileus
Sarah Cosyns
Romain Lefebvre
C3
Conference
2014
Gastrointestinal effects of soluble guanylate cyclase activation by NO-independent compounds and by NO delivery via nitrite
Sarah Cosyns
Romain Lefebvre
Dissertation
2014
Influence of cinaciguat on gastrointestinal motility in apo-sGC mice
Sarah Cosyns
Leander Huyghe
Robrecht Thoonen
Johannes-Peter Stasch
Peter Brouckaert
Romain Lefebvre
A1
Journal Article
in
NEUROGASTROENTEROLOGY AND MOTILITY
2014
2013
BAY 58-2667 does not improve delayed gastric emptying in APO-SGC mice
Sarah Cosyns
Johannes Peter Stasch
Peter Brouckaert
Romain Lefebvre
C3
Conference
2013
Cinaciguat in the gastrointestinal tract of apo-sGC mice
Sarah Cosyns
Johannes Peter Stasch
Peter Brouckaert
Romain Lefebvre
C3
Conference
2013
Effect of exogenous nitrite in postoperative ileus
Sarah Cosyns
Romain Lefebvre
C3
Conference
2013
Heme deficiency of soluble guanylate cyclase induces gastroparesis
Sarah Cosyns
Ingeborg Dhaese
Robrecht Thoonen
ES Buys
Anne Vral
Peter Brouckaert
Romain Lefebvre
A1
Journal Article
in
NEUROGASTROENTEROLOGY AND MOTILITY
2013
2012
Mechanism of action of BAY 41-2272 in gastrointestinal relaxation
Sarah Cosyns
Romain Lefebvre
C3
Conference
2012
Mechanism of relaxation and interaction with nitric oxide of the soluble guanylate stimulator BAY 41-2272 in mouse gastric fundus and colon
Sarah Cosyns
Romain Lefebvre
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACOLOGY
2012
2011
Relaxant effect of BAY 41-2272 and BAY 58-2667 in the gastric fundus of apo-sGC mice
Sarah Cosyns
JP Stasch
Peter Brouckaert
Romain Lefebvre
C3
Conference
2011
Relaxant effect of BAY 41-2272 and BAY 58-2667 in the gastrointestinal tract of apo-sGC mice
Sarah Cosyns
Johannes-Peter Stasch
Peter Brouckaert
Romain Lefebvre
C3
Conference
2011