Research Explorer

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Researcher

Sarah Cosyns

Publications & Research Data

Awards & Distinctions

52 Results

2025

A novel multi-electrode electrostatic precipitation system for optimized intraperitoneal aerosolized drug delivery in a large animal model

Mohammad Rahimi GorjiYiwen LongMargo VandenheedeDaryl ChiaSarah CosynsWouter WillaertCharlotte DebbautWim Ceelen

Feasibility and efficacy of electromotive intraperitoneal drug delivery : a hybrid study

Nidda SaeedHooman SalavatiJolene Wong Si MinSarah CosynsKatrien RemautCharlotte DebbautMieke AdriaensAnnelies CoeneWim Ceelen

A1 Journal Article in BIOMEDICINE & PHARMACOTHERAPY

From passive diffusion to active penetration : translating electromotive drug administration through experimental nanoparticle transport models for peritoneal metastasis

Nidda SaeedKatrien RemautSarah CosynsHooman SalavatiWim CeelenAnnelies Coene

Operating characteristics of nebulizers used for intraperitoneal aerosolized drug delivery

Mohammad Rahimi GorjiLotte DesmetStéphane DorboloCharlotte DebbautSarah CosynsWouter WillaertWim Ceelen

A1 Journal Article in JOURNAL OF AEROSOL SCIENCE

Optimizing intraperitoneal aerosolized drug delivery with multi-electrode electrostatic precipitation in a large animal model

Mohammad Rahimi GorjiYiwen LongMargo VandenheedeDaryl ChiaJana ZeebroekSarah CosynsWouter WillaertCharlotte DebbautWim Ceelen

2024

Development and validation of an UPLC-MS/MS method for the determination of irinotecan (CPT-11), SN-38 and SN-38 glucuronide in human plasma and peritoneal tumor tissue from patients with peritoneal carcinomatosis

Elke GasthuysJudith van OvostSofie Vande CasteeleSarah CosynsWim CeelenJan Van BocxlaerAn Vermeulen

A1 Journal Article in JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Effects of hyperthermia on cisplatin tissue penetration and gene expression in peritoneal metastases : results from a randomized trial in ovarian cancer

Jesse DemuytereCharlotte CarlierTom Van HeldenJoke BelzaFrank VanhaeckeFeifan XieAn VermeulenJoseph WeertsJürgen ThomaleHannelore Denys et al.

A1 Journal Article in BRITISH JOURNAL OF SURGERY

2023

External multicentre validation of pseudomyxoma peritonei PSOGI-Ki67 classification

A Arjona-SanchezA Martinez-LópezMT Moreno-MontillaJ MulsowP Lozano-LomincharB Martínez-TorresB RauE CanbayA SommarivaM Milione et al.

A1 Journal Article in EJSO

2022

Cisplatin uptake in peritoneal metastases of ovarian cancer following CRS+ HIPEC

Jesse DemuytereCharlotte CarlierTom Van HeldenJoke BelzaFrank VanhaeckeJoseph WeertsSarah CosynsWim Ceelen

Computational investigation of the effective forces on droplets during electrostatic precipitation pressurized intraperitoneal aerosol chemotherapy (ePIPAC)

Mohammad Rahimi GorjiCharlotte DebbautGhader GhorbaniaslSarah CosynsWouter WillaertWim Ceelen

Efficacy of additional electrostatic precipitation to intraperitoneal aerosolized chemotherapy in a realistically reconstructed human peritoneal cavity : a computational study

Mohammad Rahimi GorjiCharlotte DebbautGhader GhorbaniaslSarah CosynsWouter WillaertWim Ceelen

Electrostatic precipitation pressurized intraperitoneal aerosol chemotherapy in a realistically reconstructed human peritoneal cavity : computational modelling approach

Mohammad Rahimi GorjiCharlotte DebbautGhader GhorbaniaslSarah CosynsWouter WillaertWim Ceelen

In silico modeling of regional droplet deposition during aerosolized intraperitoneal chemotherapy using a patient-inspired geometry

Mohammad Rahimi GorjiCharlotte DebbautGhader GhorbaniaslSarah CosynsWouter WillaertWim Ceelen

Optimization of intraperitoneal aerosolized drug delivery using computational fluid dynamics (CFD) modeling

Mohammad Rahimi GorjiCharlotte DebbautGhader GhorbaniaslSarah CosynsWouter WillaertWim Ceelen

A1 Journal Article in SCIENTIFIC REPORTS

Phase I study of intraperitoneal aerosolized nanoparticle albumin based paclitaxel (NAB-PTX) for unresectable peritoneal metastases

Wim CeelenLouis SandraLeen Van de SandeM GraversenMB MortensenAn VermeulenElke GasthuysDries ReyndersSarah CosynsAnne Hoorens et al.

A1 Journal Article in EBIOMEDICINE

Simulation of electrostatic precipitation pressurized intraperitoneal aerosol chemotherapy (ePIPAC) in a realistic human abdominal model

Mohammad Rahimi GorjiCharlotte DebbautGhader GhorbaniaslSarah CosynsWouter WillaertWim Ceelen

The impact of hyperthermia on survival and pharmacokinetics in cisplatin HIPEC in stage III epithelial ovarian cancer

Jesse DemuytereCharlotte CarlierWouter WillaertPhilippe TummersHannelore DenysTom Van HeldenJoke BelzaFrank VanhaeckeFeifan XieAn Vermeulen et al.

The impact of hyperthermia on survival and pharmacokinetics in cisplatin HIPEC in stage III epithelial ovarian cancer

Jesse DemuytereCharlotte CarlierWouter WillaertPhilippe TummersHannelore DenysTom Van HeldenJoke BelzaFrank VanhaeckeFeifan XieAn Vermeulen et al.

The tumor immune microenvironment in peritoneal carcinomatosis

Jesse DemuytereSam ErnstJudith van OvostSarah CosynsWim Ceelen

Bookchapter in Cellular immunity in the peritoneum

2021

Aerosolization of thermosensitive hydrogels using pressurized intraperitoneal aerosol chemotherapy (PIPAC)

Mohammad Rahimi GorjiHelena BraetCharlotte DebbautGhader GhorbaniaslSarah CosynsWouter WillaertKatrien RemautWim Ceelen

Analysis of the effect of liquid viscosity on the aerosol distribution during Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) using computational modeling

Mohammad Rahimi GorjiSarah CosynsCharlotte DebbautGhader GhorbaniaslWouter WillaertWim Ceelen

Debulking and HIPEC for ovarian cancer : effects of perfusion temperature on morbidity and cisplatin pharmacokinetics

Jesse DemuytereCharlotte CarlierWouter WillaertPhilippe TummersHannelore DenysOlivier Van KerschaverJoseph WeertsSarah CosynsWim Ceelen

Effect of fluid flow rate and droplet size on spatial aerosol distribution during pressurized intraperitoneal aerosol chemotherapy (PIPAC)

Mohammad Rahimi GorjiGhader GhorbaniaslSarah CosynsWouter WillaertWim CeelenCharlotte Debbaut

Electrostatic precipitation pressurized intraperitoneal aerosol chemotherapy (ePIPAC) : finding the optimal electrical potential

Mohammad Rahimi GorjiCharlotte DebbautGhader GhorbaniaslWouter WillaertSarah CosynsWim Ceelen

Exploring high pressure nebulization of pluronic F127 hydrogels for intraperitoneal drug delivery

Helena BraetMohammad Rahimi GorjiCharlotte DebbautG GhorbaniaslThibault Van WalleghemSenne CornelisSarah CosynsChris VervaetWouter WillaertWim Ceelen et al.

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

In vitro study of aerosol droplet impact on the peritoneal surface after nebulization using the CapnoPen device

Mohammad Rahimi GorjiStéphane DorboloSarah CosynsCharlotte DebbautGhader GhorbaniaslWouter WillaertWim Ceelen

Intraperitoneal aerosolized nanoparticle albumin based paclitaxel (NAB-PTX) for irresectable peritoneal metastases : a first in human phase I study

Wim CeelenLouis SandraLeen Van de SandeMartin GraversenAn VermeulenDries ReyndersSarah CosynsAnne HoorensWouter Willaert

2020

Albumin-based cancer therapeutics for intraperitoneal drug delivery : a review

Leen Van de SandeSarah CosynsWouter WillaertWim Ceelen

A1 Journal Article in DRUG DELIVERY

Effects of electrostatic precipitation on IP drug distribution and tissue penetration of nanoparticles

Mohammad Rahimi GorjiLeen Van de SandeCharlotte DebbautGhader GhorbaniaslWouter WillaertSarah CosynsWim Ceelen

Electrostatic intraperitoneal aerosol delivery of nanoparticles : proof of concept and preclinical validation

Leen Van de SandeMohammad Rahimi GorjiSilvia GiordanoEnrico DavoliCristina MatteoSonke DetlefsenKatharina D'HerdeHelena BraetMolood ShariatiKatrien Remaut et al.

A1 Journal Article in ADVANCED HEALTHCARE MATERIALS

Electrostatic precipitation is a valuable adjunct to pressurized intraperitoneal aerosol chemotherapy : an in vitro study

Leen Van de SandeMelanie CoetsierAzarie VictorSarah CosynsWouter WillaertMolood ShariatiHelena BraetKatrien RemautWim Ceelen

Intraperitoneal aerosolized drug delivery : technology, recent developments, and future outlook

Mohammad Rahimi GorjiLeen Van de SandeCharlotte DebbautGhader GhorbaniaslHelena BraetSarah CosynsKatrien RemautWouter WillaertWim Ceelen

A1 Journal Article in ADVANCED DRUG DELIVERY REVIEWS

2019

Establishment of a rat ovarian peritoneal metastasis model to study pressurized intraperitoneal aerosol chemotherapy (PIPAC)

Leen Van de SandeWouter WillaertSarah CosynsKaat De ClercqMolood ShariatiKatrien RemautWim Ceelen

A1 Journal Article in BMC CANCER

2018

Biology-based surgery : the extent of lymphadenectomy in cancer of the colon

Wouter WillaertSarah CosynsWim Ceelen

A1 Journal Article in EUROPEAN SURGICAL RESEARCH

Intraperitoneal aerosolization of albumin-stabilized paclitaxel nanoparticles (Abraxane™) for peritoneal carcinomatosis : a phase I first-in-human study

Leen Van de SandeMartin GraversenMartin HubnerMarc PocardMarc ReymondMarco VairaSarah CosynsWouter WillaertWim Ceelen

A2 Journal Article in PLEURA AND PERITONEUM

The impact of surgical resection of the primary tumor on the development of synchronous colorectal liver metastasis : a systematic review

Harry PinsonSarah CosynsWim Ceelen

A1 Journal Article in ACTA CHIRURGICA BELGICA

2017

Establishment of a rat model for pressurized intraperitoneal aerosol chemotherapy

Leen Van de SandeWouter WillaertSarah CosynsWim Ceelen

Pressurized IntraPeritoneal Aerosol Chemotherapy for unresectable peritoneal carcinomatosis : experience of 63 procedures

Wouter WillaertLeen Van de SandeSarah CosynsElke Van DaeleDirk Van de PutteLucas E MatthyssensKatrien Van RenterghemYves Van NieuwenhovePiet PattynWim Ceelen

Pressurized intraperitoneal aerosol chemotherapy, a new surgical technique for the treatment of unresectable peritoneal carcinomatosis

Wouter WillaertSarah CosynsLeen Van de SandePiet PattynWim Ceelen

2016

Pressurized intraperitoneal aerosol chemotherapy (PIPAC), a new surgical technique for the treatment of unresectable peritoneal carcinomatosis

Sarah CosynsLeen Van de SandeWim CeelenWouter Willaert

2015

Protective effect of exogenous nitrite in postoperative ileus

Sarah CosynsS ShivaRomain Lefebvre

A1 Journal Article in BRITISH JOURNAL OF PHARMACOLOGY

2014

Effect of exogenous nitrite in postoperative ileus

Sarah CosynsRomain Lefebvre

Gastrointestinal effects of soluble guanylate cyclase activation by NO-independent compounds and by NO delivery via nitrite

Sarah CosynsRomain Lefebvre

Influence of cinaciguat on gastrointestinal motility in apo-sGC mice

Sarah CosynsLeander HuygheRobrecht ThoonenJohannes-Peter StaschPeter BrouckaertRomain Lefebvre

A1 Journal Article in NEUROGASTROENTEROLOGY AND MOTILITY

2013

BAY 58-2667 does not improve delayed gastric emptying in APO-SGC mice

Sarah CosynsJohannes Peter StaschPeter BrouckaertRomain Lefebvre

Cinaciguat in the gastrointestinal tract of apo-sGC mice

Sarah CosynsJohannes Peter StaschPeter BrouckaertRomain Lefebvre

Effect of exogenous nitrite in postoperative ileus

Sarah CosynsRomain Lefebvre

Heme deficiency of soluble guanylate cyclase induces gastroparesis

Sarah CosynsIngeborg DhaeseRobrecht ThoonenES BuysAnne VralPeter BrouckaertRomain Lefebvre

A1 Journal Article in NEUROGASTROENTEROLOGY AND MOTILITY

2012

Mechanism of action of BAY 41-2272 in gastrointestinal relaxation

Sarah CosynsRomain Lefebvre

Mechanism of relaxation and interaction with nitric oxide of the soluble guanylate stimulator BAY 41-2272 in mouse gastric fundus and colon

Sarah CosynsRomain Lefebvre

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACOLOGY

2011

Relaxant effect of BAY 41-2272 and BAY 58-2667 in the gastric fundus of apo-sGC mice

Sarah CosynsJP StaschPeter BrouckaertRomain Lefebvre

Relaxant effect of BAY 41-2272 and BAY 58-2667 in the gastrointestinal tract of apo-sGC mice

Sarah CosynsJohannes-Peter StaschPeter BrouckaertRomain Lefebvre