Research Explorer

Your browser does not support JavaScript or JavaScript is not enabled. Without JavaScript some functions of this webapplication may be disabled or cause error messages. To enable JavaScript, please consult the manual of your browser or contact your system administrator.

Researcher

Sara T'Sas

Awards & Distinctions

14 Results

2025

A human-like glutaminase-free asparaginase is highly efficacious in ASNS-low leukemia and solid cancer mouse xenograft models

Maaike Van TrimpontAmanda M. SchalkKenneth HofkensEvelien PeetersSara T'SasKatrien VandemeulebroeckeYing SuAshley De LoeraAlyssa GarciaHui Chen et al.

A1 Journal Article in CANCER LETTERS

2024

3187 – IKAROS LOSS ENHANCES PRE-LEUKEMIC THYMOCYTE SELF-RENEWAL AND DRIVES T-ALL IN MICE

Maaike Van TrimpontSara T'SasTim LammensPieter Van VlierbergheTim PietersSteven Goossens

A dual role for PSIP1/LEDGF in T cell acute lymphoblastic leukemia

Lisa DemoenFilip MatthijssensLindy ReunesBruno PalhaisBéatrice LintermansSara T'SasIgor FijalkowskiJoachim TaminauMuluembet Z. AkeleSiska Van Belle et al.

A1 Journal Article in SCIENCE ADVANCES

Myb overexpression synergizes with the loss of Pten and is a dependency factor and therapeutic target in T-cell lymphoblastic leukemia

André Pedro Pinto De AlmeidaSara T'SasLuca PagliaroIgor FijalkowskiWouter SleeckxHannah Van SteenbergeRaffaella ZamponiBéatrice LintermansWouter Van LoockeBruno Palhais et al.

A1 Journal Article in HEMASPHERE

Tet2 is a tumor suppressor in the pre-leukemic phase of T-cell acute lymphoblastic leukemia

Stien De ConinckJuliette RoelsBéatrice LintermansSara T'SasTom TaghonDavid CurtisTim PietersSteven GoossensPieter Van Vlierberghe

A1 Journal Article in BLOOD ADVANCES

2023

Pre-clinical evaluation of the hypomethylating agent decitabine for the treatment of T-cell lymphoblastic lymphoma

Lien ProvezTom PuttemanMattias LandforsJuliette RoelsLindy ReunesSara T'SasWouter Van LoockeBéatrice LintermansStien De ConinckMorgan Thenoz et al.

A1 Journal Article in CANCERS

2022

Direct and indirect anti-leukemic properties of Activity-on-Target interferons for the treatment of T-cell acute lymphoblastic leukemia

Steven GoossensAnje CauwelsTim PietersRenate De SmedtSara T'SasAndré Pedro Pinto De AlmeidaWillem DaneelsPieter Van VlierbergheJan Tavernier

A1 Journal Article in HAEMATOLOGICA

Myb drives B-cell neoplasms and myeloid malignancies in vivo

Tim PietersAndré Pedro Pinto De AlmeidaSara T'SasKelly LemeireTino HochepiedGeert BerxAlex KentsisSteven GoossensPieter Van Vlierberghe

A1 Journal Article in BLOOD ADVANCES

2021

Cyclin D2 overexpression drives B1a-derived MCL-like lymphoma in mice

Tim PietersSara T'SasStijn VanheeAndré Pedro Pinto De AlmeidaYasmine DriegeJuliette RoelsWouter Van LoockeWillem DaneelsMathijs BaensArnaud Marchand et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

SOX11 functions as an oncogene in Lmo2-driven T-cell lymphoblastic leukemia (T-ALL)

André Pedro Pinto De AlmeidaTim PietersSara T'SasSteven GoossensPieter Van Vlierberghe

2019

Novel strategy for rapid functional in vivo validation of oncogenic drivers in haematological malignancies

Tim PietersSara T'SasLisa DemoenAndré Pedro Pinto De AlmeidaLieven HaenebalckeFilip MatthijssensKelly LemeireJinke D'HontFrédérique VanrockeghemTino Hochepied et al.

A1 Journal Article in SCIENTIFIC REPORTS

ZEB2 and LMO2 drive immature T-cell lymphoblastic leukemia via distinct oncogenic mechanisms

Steven GoossensJueqiong WangCedric TremblayJelle De MedtsSara T'SasThao NguyenJesslyn SawKatharina HaighDavid J CurtisPieter Van Vlierberghe et al.

A1 Journal Article in HAEMATOLOGICA

2016

Cyclin D2 overexpression recapitulates mantle cell lymphoma in mice

Tim PietersSteven GoossensSara T'SasGeert BerxJody J HaighPieter Van Vlierberghe

Fast generation of conditional ROSA26-based mouse models that recapitulate genomic events in human T-ALL

Tim PietersSteven GoossensSara T'SasLieven HaenebalckeTino HochepiedBéatrice LintermansSofie PeirsFilip MatthijssensJ HaighGeert Berx et al.