Research Explorer

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Researcher

Sandrine Aspeslagh

24 Results

2021

New paradigm in NKT cell antigens : MCS-0208 (2-(hydroxymethyl)phenylthio-phytoceramide) - an aryl-phytoceramide compound with a single hydroxyl group stimulates NKT cells

Roser Borras-TuduriAnna AlcaideSANDRINE ASPESLAGHLorena UseroCarmen SerraCarme Roura-MirDirk ElewautAmadeu Llebaria

A1 Journal Article in CHEMMEDCHEM

2018

Importance of choice of materials and methods in PD-L1 and TIL assessment in oropharyngeal squamous cell carcinoma

Astrid De MeulenaereTijl VermassenDavid CreytensSANDRINE ASPESLAGHPhilippe DeronFréderic DuprezSylvie RotteyJo Van DorpeLiesbeth Ferdinande

A1 Journal Article in HISTOPATHOLOGY

2017

TILs in head and neck cancer : ready for clinical implementation and why (not)?

Astrid De MeulenaereTijl VermassenSANDRINE ASPESLAGHKatrien VandecasteeleSylvie RotteyLiesbeth Ferdinande

A2 Journal Article in HEAD & NECK PATHOLOGY

Tumor PD-L1 status and CD8+ tumor-infiltrating T cells : markers of improved prognosis in oropharyngeal cancer

Astrid De MeulenaereTijl VermassenSANDRINE ASPESLAGHPhilippe DeronFréderic DuprezDebby LaukensJo Van DorpeLiesbeth FerdinandeSylvie Rottey

A1 Journal Article in ONCOTARGET

Turning the tide : clinical utility of PD-L1 expression in squamous cell carcinoma of the head and neck

Astrid De MeulenaereTijl VermassenSANDRINE ASPESLAGHWouter HuvenneJo Van DorpeLiesbeth FerdinandeSylvie Rottey

A1 Journal Article in ORAL ONCOLOGY

2015

Synthesis of C-5" and C-6"-modified α-GalCer analogues as iNKT-cell agonists

Joren GuillaumeNora PauwelsSANDRINE ASPESLAGHDirk ZajoncDirk ElewautSerge Van Calenbergh

A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY

2014

An in silico approach for modelling T-helper polarizing iNKT cell agonists

Anton De SpiegeleerEvelien WynendaeleMatthias VandekerckhoveSofie StalmansMaxime BoucartNele Van Den NoortgateKoen VenkenSerge Van CalenberghSANDRINE ASPESLAGHDirk Elewaut

A1 Journal Article in PLOS ONE

2013

A computational high-throughput screening approach of iNKT-agonists: a novel tool to find optimized iNKT cell ligands

Anton De SpiegeleerEvelien WynendaeleSofie StalmansNele Van Den NoortgateMatthias VandekerckhoveSerge Van CalenberghSANDRINE ASPESLAGHKoen VenkenDirk Elewaut

Bacterial CD1d-restricted glycolipids induce IL-10 production by human regulatory T cells upon cross-talk with invariant NKT cells

Koen VenkenTine DecruySANDRINE ASPESLAGHSerge Van CalenberghBart LambrechtDirk Elewaut

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Enhanced TCR footprint by a novel glycolipid increases NKT-dependent tumor protection

SANDRINE ASPESLAGHMarek NemčovičNora PauwelsKoen VenkenJing WangSerge Van CalenberghDirk M ZajoncDirk Elewaut

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Preclinical evaluation of invariant natural killer T cells in the 5T33 multiple myeloma model

Haneen NurKarel FostierSANDRINE ASPESLAGHWim RenmansElisabeth BertrandXavier LeleuMérédis FavreauKarine BreckpotRik SchotsMarc De WaeleEls Van ValckenborghElke De BruyneThierry FaconDirk ElewautKarin VanderkerkenEline Menu

A1 Journal Article in PLOS ONE

2012

Adjuvantia of de queeste naar het ultieme vaccin

Anton De SpiegeleerMatthias VandekerckhoveSANDRINE ASPESLAGHDirk Elewaut

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE

Synthesis of 6”-triazole-substituted α-GalCer analogues as potent iNKT cell stimulating ligands

Nora PauwelsSANDRINE ASPESLAGHDirk ElewautSerge Van Calenbergh

A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY

Versatile synthesis of C-5" and C-6"-modified α-GalCer analogues as new iNKT cell ligands

Nora PauwelsSANDRINE ASPESLAGHDirk ElewautSerge Van Calenbergh

2011

6''-Modified alpha-GalCer analogs capable of establishing an extra interaction with Cd1d leading to a polarized Th1 response and superior tumor protection

Serge Van CalenberghNora PauwelsSANDRINE ASPESLAGHYaLi LiMatthias TrappeniersDirk ZajoncDirk Elewaut

Divergent synthetic approach to 6''-modified α-GalCer analogues

Nora PauwelsSANDRINE ASPESLAGHGerd VanhoenackerKoen SandraEsther D. YuDirk M. ZajoncDirk ElewautBruno LinclauSerge Van Calenbergh

A1 Journal Article in ORGANIC & BIOMOLECULAR CHEMISTRY

Galactose modified iNKT cell agonists stabilised by a novel structural modification of CD1D lead to marked TH1 polarisation in vivo

SANDRINE ASPESLAGHYaLi LiEsther Dawen YuNora PauwelsMatthias TrappeniersEnrico GirardiTine DecruyKatrien Van BenedenKoen VenkenMichael DrennanLuc LeybaertJing WangSerge Van CalenberghDirk M ZajoncDirk Elewaut

Galactose-modified iNKT cell agonists stabilized by an induced fit of CD1d prevent tumour metastasis

SANDRINE ASPESLAGHYali LiEsther Dawen YuNora PauwelsMatthias TrappeniersEnrico GirardTine DecruyKatrien Van BenedenKoen VenkenMichael DrennanLuc LeybaertJing WangRichard W FranckSerge Van CalenberghDirk M ZajoncDirk Elewaut

A1 Journal Article in EMBO JOURNAL

2010

Invariant natural killer T cells in rheumatic disease : a joint dilemma

Michael DrennanSANDRINE ASPESLAGHDirk Elewaut

A1 Journal Article in NATURE REVIEWS RHEUMATOLOGY

Optimizing the iNKT cell dependent antitumor effect using an altered glycolipid

SANDRINE ASPESLAGHYali LiTine DecruyKatrien Van BenedenKoen VenkenMatthias TrappeniersSerge Van CalenberghDirk ZajoncDirk Elewaut

Optimizing the iNKT cell dependent antitumor effect using an altered glycolipid

SANDRINE ASPESLAGHYali LiTine DecruyKatrien Van BenedenMichael DrennanKoen VenkenMatthias TrappeniersSerge Van CalenberghDirk ZajoncDirk Elewaut

Suppression of human natural killer T cell function by CD4(+)CD25(+)FOXP3(+) regulatory T cells

Koen VenkenTine DecruyKim DeswarteSANDRINE ASPESLAGHSerge Van CalenberghBart LambrechtDirk Elewaut

Synthesis and evaluation of amino-modified α-GalCer analogues

Matthias TrappeniersRené ChoforSANDRINE ASPESLAGHYali LiBruno LinclauDirk M ZajoncDirk ElewautSerge Van Calenbergh

A1 Journal Article in ORGANIC LETTERS

2003

Pharmacological sensitivity of ATP release triggered by photoliberation of inositol-1,4,5-trisphosphate and zero extracellular calcium in brain endothelial cells

Katleen BraetSandrine AspeslaghW VANDAMMEK WILLECKEPEM MARTINWH EVANSLuc Leybaert

A1 Journal Article in JOURNAL OF CELLULAR PHYSIOLOGY