Research Explorer

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Researcher

Sander Lefere

Awards & Distinctions

64 Results

2024

Adipose tissue insulin resistance correlates with disease severity in pediatric metabolic dysfunction-associated steatotic liver disease : a prospective cohort study

Anneleen HeldensEllen DupontLindsey DevisscherMaarten BuytaertXavier VerhelstSarah RaevensHans Van VlierbergheAnja GeertsRuth De BruyneSander Lefere

A1 Journal Article in JOURNAL OF PEDIATRICS

An international multidisciplinary consensus on pediatric metabolic dysfunction-associated fatty liver disease

Le ZhangMortada El-ShabrawiLouise A. BaurChristopher D. ByrneGiovanni TargherMohit KeharGilda PortaWay Seah LeeSander LefereSerap Turan et al.

A2 Journal Article in MED

External validation of the IAIHG autoimmune hepatitis response criteria in a multicentric real-world cohort

Lorenz GrossarSarah RaevensChristophe Van SteenkisteIsabelle ColleCharlotte De VlooHans OrlentJeoffrey SchoutenMarie GallantAnnelien Van DriesscheSander Lefere et al.

A1 Journal Article in JHEP REPORTS

Noninvasive scores are poorly predictive of histological fibrosis in paediatric fatty liver disease

Laura KalveramUlrich BaumannRuth De BruyneLaura DraijerWojciech JanczykDeirdre KellyBart G. KootFlorence LacailleSander LefereHadar Moran Lev et al.

A1 Journal Article in JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Osteopontin characterizes bile duct-associated macrophages and correlates with liver fibrosis severity in primary sclerosing cholangitis

Kevin De MuynckLander HeyerickFederico Francesco De PontiBart VanderborghtTim MeeseSanne Van CampenhoutLeen BaudonckEva GijbelsPedro M. RodriguesJesus M. Banales et al.

A1 Journal Article in HEPATOLOGY

Systematic review : glycomics as diagnostic markers for hepatocellular carcinoma

Emma ButayeNicky SomersLorenz GrossarNele PauwelsSander LefereLindsey DevisscherSarah RaevensAnja GeertsLeander MeurisNico Callewaert et al.

A1 Journal Article in ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Ultra-processed food intake does not correlate with pediatric MASLD in the National Health and Nutrition Examination Survey

Maarten BuytaertDimitri DeclercqFleur DepoorterZerlina CosijnLindsey DevisscherAnja GeertsXavier VerhelstHans Van VlierbergheSarah RaevensRuth De Bruyne et al.

Unlocking therapeutic potential : exploring cross-talk among emerging nuclear receptors to combat metabolic dysfunction in steatotic liver disease

Milton Boaheng AntwiAriann JenningsSander LefereDorien ClarisseAnja GeertsLindsey DevisscherKarolien De Bosscher

A2 Journal Article in NPJ METABOLIC HEALTH AND DISEASE

2023

Bariatric surgery for NAFLD : indications and post-operative management

Anja GeertsSander Lefere

A1 Journal Article in CLINICAL AND MOLECULAR HEPATOLOGY

Diagnosis of fatty liver in children should occur in parallel to investigation for other causes of liver disease

ESPGHAN [missing]EASL [missing]Sander LefereRuth De BruyneJake Mann

Editorial material

Glycomics-based serum markers as reliable tool for assessment of viral response after treatment with direct-acting antiviral drugs in hepatitis C virus infection

Nicky SomersElisabeth VandekerckhoveAnja GeertsHelena DegrooteSander LefereLindsey DevisscherLeander MeurisNico CallewaertHans Van VlierbergheXavier Verhelst

A1 Journal Article in ACTA CLINICA BELGICA

Intensive lifestyle management improves steatosis and fibrosis in pediatric nonalcoholic fatty liver disease : reply

Sander LefereAnja GeertsRuth De Bruyne

A1 Journal Article in CLINICAL GASTROENTEROLOGY AND HEPATOLOGY

Kupffer cells contested as early drivers in the pathogenesis of primary sclerosing cholangitis

Kevin De MuynckBart VanderborghtFederico Francesco De PontiEva GijbelsSophie Van WeldenMartin GuilliamsCharlotte ScottAlain BeschinMathieu VinkenSander Lefere et al.

A1 Journal Article in AMERICAN JOURNAL OF PATHOLOGY

Meta-analysis : the impact of light-to-moderate alcohol consumption on progressive non-alcoholic fatty liver disease

Louise MaghermanRobbe Van ParysNele PauwelsXavier VerhelstLindsey DevisscherHans Van VlierbergheAnja GeertsSander Lefere

A1 Journal Article in ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Patients hospitalized with alcohol-related liver disease and prior bariatric surgery are more prone to develop acute-on-chronic liver failure

Louis OnghenaYves Van NieuwenhoveLaurissa DemeulenaereLindsey DevisscherXavier VerhelstHelena DegrooteSarah RaevensHans Van VlierbergheSander LefereAnja Geerts

A1 Journal Article in LIVER INTERNATIONAL

Transient Kupffer cell depletion and subsequent replacement by infiltrating monocyte-derived cells does not alter the induction or progression of hepatocellular carcinoma

Bart VanderborghtKevin De MuynckEva GijbelsSander LefereCharlotte ScottMartin GuilliamsAlain BeschinMathieu VinkenXavier VerhelstAnja Geerts et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF CANCER

‘A radical operation’ : a thematic analysis of newspaper framing of bariatric surgery in adolescents

Sander LefereKato VerghoteRuth De BruyneVeerle ProvoostPriya Pramod Satalkar

A1 Journal Article in BMC PUBLIC HEALTH

‘A radical operation’ : a thematic analysis of newspaper framing of bariatric surgery in adolescents (vol 23, 447, 2023)

Sander LefereKato VerghoteRuth De BruyneVeerle ProvoostPriya Pramod Satalkar

2022

A mouse model of hepatic encephalopathy : bile duct ligation induces brain ammonia overload, glial cell activation and neuroinflammation.

Wouter ClaeysLien Van HoeckeAnja GeertsHans Van VlierbergheSander LefereGriet Van ImschootElien Van WonterghemBart GhesquièreRoosmarijn VandenbrouckeChristophe Van Steenkiste

A1 Journal Article in SCIENTIFIC REPORTS

Adipose tissue insulin resistance is a determinant of disease severity in pediatric nonalcoholic fatty liver disease

Anneleen HeldensEllen DupontLindsey DevisscherAnja GeertsRuth De BruyneXavier VerhelstHans Van VlierbergheSander Lefere

Combined therapy with a CCR2/CCR5 antagonist and FGF21 analogue synergizes in ameliorating steatohepatitis and fibrosis

Tobias PuengelSander LefereJana HundertmarkMarlene KohlheppChristian PennersFrederique Van de VeldeBruno LapauwAnne HoorensLindsey DevisscherAnja Geerts et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Glycomics-based serum marker as reliable tool for assessment of viral response after treatment with direct-acting antiviral drugs in hepatitis C virus infection

Nicky SomersElisabeth VandekerckhoveAnja GeertsHelena DegrooteSander LefereLindsey DevisscherLeander MeurisNico CallewaertHans Van VlierbergheXavier Verhelst

Intensive lifestyle management improves steatosis and fibrosis in pediatric non-alcoholic fatty liver disease

Sander LefereEllen DupontAnn De GuchtenaereStephanie Van BiervlietSaskia Vande VeldeXavier VerhelstLindsey DevisscherHans Van VlierbergheAnja GeertsRuth De Bruyne

A1 Journal Article in CLINICAL GASTROENTEROLOGY AND HEPATOLOGY

MD2 AMP(K)s up the link between lipid accumulation and inflammation in NAFLD COMMENT

Anneleen HeldensSander Lefere

Editorial material

Maternal and perinatal risk factors for pediatric nonalcoholic fatty liver disease : a systematic review

Ilya QuerterNele PauwelsRuth De BruyneEllen DupontXavier VerhelstLindsey DevisscherHans Van VlierbergheAnja GeertsSander Lefere

A1 Journal Article in CLINICAL GASTROENTEROLOGY AND HEPATOLOGY

Metallothioneins alter macrophage phenotype and represent novel therapeutic targets for acetaminophen-induced liver injury

Lindsey DevisscherSanne Van CampenhoutSander LefereSarah RaevensLaurentijn TillemanFilip Van NieuwerburghHannelore P. Van EeckhoutteAnne HoorensMichael A. LynesAnja Geerts et al.

A1 Journal Article in JOURNAL OF LEUKOCYTE BIOLOGY

Neurometabolic and gliovascular changes in murine hepatic encephalopathy

Wouter ClaeysLien Van HoeckeAnja GeertsHans Van VlierbergheXavier VerhelstSander LefereHelena DegrooteGriet Van ImschootElien Van WonterghemRoosmarijn Vandenbroucke et al.

Perinatal risk factors for pediatric nonalcoholic fatty liver disease : impact of inborn errors of metabolism : reply

Ilya QuerterRuth De BruyneAnja GeertsSander Lefere

A1 Journal Article in CLINICAL GASTROENTEROLOGY AND HEPATOLOGY

2021

Bariatric surgery and the liver : mechanisms, benefits, and risks

Sander LefereLouis OnghenaAude VanlanderYves Van NieuwenhoveLindsey DevisscherAnja Geerts

A1 Journal Article in OBESITY REVIEWS

Characterization of the inflammatory microenvironment and hepatic macrophage subsets in experimental hepatocellular carcinoma models

Helena DegrooteSander LefereAstrid VandierendonckBart VanderborghtTim MeeseFilip Van NieuwerburghXavier VerhelstAnja GeertsHans Van VlierbergheLindsey Devisscher

A2 Journal Article in ONCOTARGET

Intensive lifestyle management improves steatosis and fibrosis in pediatric metabolic-associated fatty liver disease

Sander LefereEllen DupontAnn De GuchtenaereStephanie Van BiervlietSaskia Vande VeldeXavier VerhelstLindsey DevisscherHans Van VlierbergheAnja GeertsRuth De Bruyne

The neurogliovascular unit in hepatic encephalopathy

Wouter ClaeysLien Van HoeckeSander LefereAnja GeertsXavier VerhelstHans Van VlierbergheHelena DegrooteLindsey DevisscherRoosmarijn VandenbrouckeChristophe Van Steenkiste

A1 Journal Article in JHEP REPORTS

2020

A murine model of hepatic encephalopathy : validation and neurobehavioral testing

Wouter ClaeysAnja GeertsSander LefereHans Van VlierbergheGriet Van ImschootElien Van WonterghemRoosmarijn VandenbrouckeChristophe Van Steenkiste

Angiogenesis in the progression of non-alcoholic fatty liver disease

Sander LefereLindsey DevisscherAnja Geerts

A1 Journal Article in ACTA GASTRO-ENTEROLOGICA BELGICA

Bariatric surgery patients are at risk for alcoholic liver disease with need for liver transplantation

Sander LefereLenka StroobantXavier VerhelstAude VanlanderFrederik BerrevoetRoberto TroisiYves Van NieuwenhoveXavier RogiersHans Van VlierbergheAnja Geerts

A1 Journal Article in OBESITY SURGERY

Combination of sivelestat and N-acetylcysteine alleviates the inflammatory response and exceeds standard treatment for acetaminophen-induced liver injury

Sarah RaevensSanne Van CampenhoutPieter-Jan DebackerSander LefereXavier VerhelstAnja GeertsHans Van VlierbergheIsabelle ColleLindsey Devisscher

A1 Journal Article in JOURNAL OF LEUKOCYTE BIOLOGY

Differential effects of selective- and pan-PPAR agonists on experimental steatohepatitis and hepatic macrophages

Sander LefereTobias PuengelJana HundertmarkChristian PennersAnna Katharina FrankAdrien GuillotKevin De MuynckFelix HeymannVanessa AdarbesEvelyne Defrene et al.

A1 Journal Article in JOURNAL OF HEPATOLOGY

Effect of isoform-specific HIF-1α and HIF-2α antisense oligonucleotides on tumorigenesis, inflammation and fibrosis in a hepatocellular carcinoma mouse model

Bart VanderborghtKevin De MuynckSander LefereAnja GeertsHelena DegrooteXavier VerhelstHans Van VlierbergheLindsey Devisscher

A2 Journal Article in ONCOTARGET

Lighter serum copper isotopic composition in patients with early non-alcoholic fatty liver disease

Sanne Van CampenhoutAgustina Ari Murti Budi HastutiSander LefereHans Van VlierbergheFrank VanhaeckeMarta Costas RodriguezLindsey Devisscher

A2 Journal Article in BMC RESEARCH NOTES

Myeloid IRE1a deletion alters hepatic macrophage phenotype and attenuates experimental non-alcoholic steatohepatitis-related hepatocellular carcinoma

Sanne Van CampenhoutLaurentijn TillemanSander LefereAstrid VandierendonckAnja GeertsXavier VerhelstFilip Van NieuwerburghHans Van VlierbergheLindsey Devisscher

Myeloid-specific IRE1alpha deletion reduces tumour development in a diabetic, non-alcoholic steatohepatitis-induced hepatocellular carcinoma mouse model

Sanne Van CampenhoutLaurentijn TillemanSander LefereAster VandierendonckSarah RaevensXavier VerhelstAnja GeertsFilip Van NieuwerburghHans Van VlierbergheLindsey Devisscher

A1 Journal Article in METABOLISM-CLINICAL AND EXPERIMENTAL

Targeting CCR2/5 in the treatment of nonalcoholic steatohepatitis (NASH) and fibrosis : opportunities and challenges

Sander LefereLindsey DevisscherFrank Tacke

Editorial material

The angiopoietin/tie2 pathway in hepatocellular carcinoma

Bart VanderborghtSander LefereHans Van VlierbergheLindsey Devisscher

A1 Journal Article in CELLS

2019

Angiogenesis and macrophages as diagnostic and therapeutic targets in non-alcoholic fatty liver disease

Sander LefereAnja GeertsLindsey DevisscherChristophe Van Steenkiste

Angiopoietin-2 promotes pathological angiogenesis and is a therapeutic target in murine nonalcoholic fatty liver disease

Sander LefereFrederique Van de VeldeAnne HoorensSarah RaevensSanne Van CampenhoutAster VandierendonckSara NeytBert VandeghinsteChristian VanhoveCharlotte Debbaut et al.

A1 Journal Article in HEPATOLOGY

Macrophages in obesity and non-alcoholic fatty liver disease : crosstalk with metabolism

Sander LefereFrank Tacke

A1 Journal Article in JHEP REPORTS

Myeloid-specific IRE1 alpha deletion reduces tumour development in a non-alcoholic steatohepatitis-induced hepatocellular carcinoma mouse model

Sanne Van CampenhoutSander LefereAster VandierendonckXavier VerhelstAnja GeertsHans Van VlierbergheLindsey Devisscher

Unveiling the depletion of Kupffer cells in experimental hepatocarcinogenesis through liver macrophage subtype-specific markers

Sander LefereHelena DegrooteHans Van VlierbergheLindsey Devisscher

A1 Journal Article in JOURNAL OF HEPATOLOGY

2018

Angiopoietin-2 as therapeutic target for pathological angiogenesis and inflammation in non-alcoholic steatohepatitis

Sander LefereFrederique Van de VeldeSarah RaevensSanne Van CampenhoutAster VandierendonckS NeytChristian VanhoveAnne HoorensChristophe CasteleynXavier Verhelst et al.

Angiopoietin-2 as therapeutic target for pathological angiogenesis and inflammation in non-alcoholic steatohepatitis

Sander LefereF Van de VeldeSarah RaevensSanne Van CampenhoutAster VandierendonckSara NeytChristian VanhoveAnne HoorensCHRISTINE CASTELEYNXavier Verhelst et al.

Angiopoietin-2 promotes pathological angiogenesis and is a novel therapeutic target in non-alcoholic fatty liver disease

Sander LefereFrederique Van de VeldeAnne HoorensSarah RaevensSanne Van CampenhoutAster VandierendonckSara NeytBert VandeghinsteChristian VanhoveCharlotte Debbaut et al.

Placental growth factor inhibition targets pulmonary angiogenesis and represents a therapy for hepatopulmonary syndrome in mice

Sarah RaevensAnja GeertsAnnelies ParidaensSander LefereXavier VerhelstAnne HoorensJo Van DorpeTania MaesKen BrackeChristophe Casteleyn et al.

A1 Journal Article in HEPATOLOGY

The combination of N-acetylcysteine and anti-MT antibodies as novel therapy for acetaminophen-induced liver injury

Lindsey DevisscherDebby LaukensHannelore Van EeckhoutteSarah RaevensSander LefereAnne HoorensXavier VerhelstM LynesAnja GeertsHans Van Vlierberghe

2017

Anti-placental growth factor therapy attenuates experimental hepatopulmonary syndrome

Sarah RaevensAnnelies ParidaensSander LefereChristophe CasteleynB JonckxXavier VerhelstHans Van VlierbergheChristophe Van SteenkisteAnja GeertsLindsey Devisscher et al.

Kupffer cell pool is maintained by local proliferation and the differentiation of bone marrow monocytes into short-lived monocyte-derived Kupffer cells during non-alcoholic steatohepatitis and recovery

Lindsey DevisscherCharlotte ScottSander LefereSarah RaevensEliene BogaertsAnnelies ParidaensXavier VerhelstAnja GeertsMartin GuilliamsHans Van Vlierberghe

Non-alcoholic steatohepatitis induces transient changes within the liver macrophage pool

Lindsey DevisscherCharlotte ScottSander LefereSarah RaevensEliene BogaertsAnnelies ParidaensXavier VerhelstAnja GeertsMartin GuilliamsHans Van Vlierberghe

A1 Journal Article in CELLULAR IMMUNOLOGY

Refractory subacute steatohepatitis after biliopancreatic diversion

Sander LefereAnne HoorensSarah RaevensRoberto TroisiXavier VerhelstHans Van VlierbergheAnja Geerts

Editorial material

Serum vascular cell adhesion molecule-1 predicts significant liver fibrosis in non-alcoholic fatty liver disease

Sander LefereFrederique Van de VeldeLindsey DevisscherMarlies BekaertSarah RaevensXavier VerhelstYves Van NieuwenhoveMarleen PraetAnne HoorensChristophe Van Steenkiste et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF OBESITY

Serum vascular cell adhesion molecule-1 predicts significant liver fibrosis in obese patients with non-alcoholic fatty liver disease

Sander LefereFrederique Van de VeldeLindsey DevisscherMarlies BekaertSarah RaevensXavier VerhelstYves Van NieuwenhoveMarleen PraetAnne HoorensChristophe Van Steenkiste et al.

Serum vascular cell adhesion molecule-1 predicts significant liver fibrosis in obese patients with non-alcoholic fatty liver disease

Sander LefereFrederique Van de VeldeLindsey DevisscherMarlies BekaertSarah RaevensXavier VerhelstYves Van NieuwenhoveMarleen PraetAnne HoorensChristophe Van Steenkiste et al.

What to expect from reliability and validity claims? A pragmatic conception of psychiatric nosology

Sander LefereRuben De RouckLeen De Vreese

A1 Journal Article in JOURNAL OF EVALUATION IN CLINICAL PRACTICE

2016

Hypoxia-regulated mechanisms in the pathogenesis of obesity and non-alcoholic fatty liver disease

Sander LefereChristophe Van SteenkisteXavier VerhelstHans Van VlierbergheLindsey DevisscherAnja Geerts

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

Kinetics of pulmonary angiogenesis in mouse common bile duct ligation-induced liver fibrosis

Sarah RaevensLindsey DevisscherAnnelies ParidaensEliene BogaertsSander LefereYves-Paul VandewynckelCHRISTINE CASTELEYNKen BrackeTania MaesXavier Verhelst et al.

Placental growth factor inhibition alleviates hepatopulmonary syndrome in mice

Sarah RaevensAnnelies ParidaensSander LefereBart JonckxXavier VerhelstHans Van VlierbergheChristophe Van SteenkisteAnja GeertsLindsey DevisscherIsabelle Colle