Research Explorer

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Researcher

Sam Lievens

Awards & Distinctions

81 Results

2018

KISS : a mammalian two-hybrid method for in situ analysis of protein-protein interactions

Delphine MasschaeleSarah GerloIrma LemmensSam LievensJan Tavernier

Bookchapter in Two-hybrid systems : methods and protocols

Modifying Rap1-signalling by targeting Pde6δ is neuroprotective in models of Alzheimer’s disease

Michael DumbacherTom Van DoorenKatrien PrincenKoen De WitteMélissa FarinelliSam LievensJan TavernierWim DehaenStefaan WeraJoris Winderickx et al.

A1 Journal Article in MOLECULAR NEURODEGENERATION

2017

Glucocorticoid receptor-mediated transactivation is hampered by Striatin-3, a novel interaction partner of the receptor

Ioanna PettaNadia BougarneJolien VandewalleLien DejagerSofie VandevyverMarlies BallegeerSofie DesmetJonathan ThommisLode De CauwerSam Lievens et al.

A1 Journal Article in SCIENTIFIC REPORTS

MAPPI-DAT : data management and analysis for protein-protein interaction data from the high-throughput MAPPIT cell microarray platform

Surya GuptaVeronic De PuysseleyrJosé Van Der HeydenDavy MaddeleinIrma LemmensSam LievensSven DegroeveJan TavernierLennart Martens

A1 Journal Article in BIOINFORMATICS

RNF41 interacts with the VPS52 subunit of the GARP and EARP complexes

Delphine MasschaeleLeentje De CeuninckJoris WaumanDieter DefeverFrank StennerSam LievensFrank PeelmanJan Tavernier

A1 Journal Article in PLOS ONE

2016

Chemical dimerizers in three-hybrid systems for small molecule-target protein profiling

Dries De ClercqJan TavernierSam LievensSerge Van Calenbergh

A1 Journal Article in ACS CHEMICAL BIOLOGY

Chromatin recruitment of activated AMPK drives fasting response genes co-controlled by GR and PPARα

Dariusz RatmanViacheslav MylkaNadia BougarneMichal PawlakSandrine CaronNathalie HennuyerRéjane PaumelleLode De CauwerJonathan ThommisMark H Rider et al.

A1 Journal Article in NUCLEIC ACIDS RESEARCH

Modulation of protein-protein interactions for the development of novel therapeutics

Ioanna PettaSam LievensClaude LibertJan TavernierKarolien De Bosscher

A1 Journal Article in MOLECULAR THERAPY

OTUB1 triggers lung cancer development by inhibiting RAS monoubiquitination

Maria Francesca BaiettiMichal SimicekLayka Abbasi AsbaghEnrico RadaelliSam LievensJonathan CrowtherMikhail SteklovVasily N AushevDavid Martínez GarcíaJan Tavernier et al.

A1 Journal Article in EMBO MOLECULAR MEDICINE

Proteome-scale binary interactomics in human cells

Sam LievensJosé Van Der HeydenDelphine MasschaeleLeentje De CeuninckIoanna PettaSurya GuptaVeronic De PuysseleyrVirginie VauthierIrma LemmensDries De Clercq et al.

A1 Journal Article in MOLECULAR & CELLULAR PROTEOMICS

Synthesis of chemical dimerizers for the optimization of MASPIT

Dries De ClercqSerge Van CalenberghJan TavernierSam Lievens

The interactome of the glucocorticoid receptor and its influence on the actions of glucocorticoids in combatting inflammatory and infectious diseases

Ioanna PettaLien DejagerMarlies BallegeerSam LievensJan TavernierKarolien De BosscherClaude Libert

A2 Journal Article in MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Trapping mammalian protein complexes in viral particles

Sven EyckermanKevin TitecaEmmy Van QuickelbergheEva ClootsAnnick VerheeNoortje SamynLeentje De CeuninckEvy TimmermanDelphine De SutterSam Lievens et al.

A1 Journal Article in NATURE COMMUNICATIONS

Ubiquitin D regulates IRE1 α/c-Jun N-terminal kinase (JNK) protein-dependent apoptosis in pancreatic beta cells

Flora BrozziSarah GerloFabio Arturo GriecoMatilda JuusolaAlexander BalhuizenSam LievensConny GysemansMarco BuglianiChantal MathieuPiero Marchetti et al.

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

2015

Alternative reagents for methotrexate as immobilizing anchor moieties in the optimization of MASPIT: synthesis and biological evaluation

Dries De ClercqMartijn RisseeuwIzet KaralicAnne-Sophie De SmetDieter DefeverJan TavernierSam LievensSerge Van Calenbergh

A1 Journal Article in CHEMBIOCHEM

An interactomics approach to unravel IRE1α function

Sarah GerloSam LievensElien RuyssinckDieter DefeverHannes DemaréJan Tavernier

MAPK-induced Gab1 translocation to the plasma membrane depends on a regulated intramolecular switch

Alexandra WolfRené EulenfeldHannes BongartzWiebke HessenkemperPhilip C SimisterSam LievensJan TavernierStephan M FellerFred Schaper

A1 Journal Article in CELLULAR SIGNALLING

Small molecule fusion compounds for the optimization of MASPIT, a high throughput three-hybrid target deconvolution assay

Dries De ClercqSam LievensMartijn RisseeuwJan TavernierSerge Van Calenbergh

Synthesis and biological evaluation of small-molecule fusion compounds for the optimization of MASPIT, a three-hybrid target deconvolution assay

Dries De ClercqSam LievensMartijn RisseeuwJan TavernierSerge Van Calenbergh

2014

A combined 'omics' approach identifies N-Myc interactor as a novel cytokine-induced regulator of IRE1α protein and c-Jun N-terminal kinase in pancreatic beta cells

Flora BrozziSarah GerloFabio Arturo GriecoTarlliza Romanna NardelliSam LievensConny GysemansLorella MarselliPiero MarchettiChantal MathieuJan Tavernier et al.

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

A combined 'omics' approach identifies NMI as a novel cytokine-induced regulator of IRE1 alpha and JNK in pancreatic beta cells

F BrozziSarah GerloFA GriecoSam LievensC GysemansL MarselliP MarchettiC MathieuJan TavernierDL Eizirik

An interactomics approach to unravel IRE1α function

Sarah GerloSam LievensElien RuyssinckDieter DefeverHannes DemaréJan Tavernier

Design, synthesis and biological evaluation of tamoxifen-fusion compounds for the optimization of MASPIT, a three-hybrid target deconvolution assay

Dries De ClercqMartijn RisseeuwSam LievensJan TavernierSerge Van Calenbergh

Kinase Substrate Sensor (KISS), a mammalian in situ protein interaction sensor

Sam LievensSarah GerloIrma LemmensDries De ClercqMartijn RisseeuwNele VanderroostAnne-Sophie De SmetElien RuyssinckEric ChevetSerge Van Calenbergh et al.

A1 Journal Article in MOLECULAR & CELLULAR PROTEOMICS

Synthesis and biological evaluation of tamoxifen fusion compounds for the optimization of MASPIT, a three-hybrid target deconvolution assay

Dries De ClercqMartijn RisseeuwSam LievensJan TavernierSerge Van Calenbergh

2013

A 'clickable' MTX-reagent as a practical tool for profiling small molecule-intracellular target interactions via MASPIT

Martijn RisseeuwDries De ClercqSam LievensUlrik HillaertDavy SinnaeveFreya Van den BroeckJosé MartinsJan TavernierSerge Van Calenbergh

A1 Journal Article in CHEMMEDCHEM

Compound A, a selective glucocorticoid receptor modulator, enhances heat shock protein Hsp70 gene promoter activation

Ilse BeckZuzanna DrebertRuben Hoya-AriasAli A BaharMichael DevosDorien ClarisseSofie DesmetNadia BougarneBart RuttensValerie Gossye et al.

A1 Journal Article in PLOS ONE

MAPPIT and Co: the importance of system artifacts

Jan TavernierLeentje De CeuninckSarah GerloIrma LemmensSam LievensJosé Van Der HeydenJoris Wauman

Syntheses of MTX-fusion compounds for target profiling of small molecules with MASPIT

Dries De ClercqMartijn RisseeuwSam LievensJan TavernierSerge Van Calenbergh

The deubiquitylase USP33 discriminates between RALB functions in autophagy and innate immune response

Michal SimicekSam LievensMathias LagaDmytro GuzenkoVasily N AushevPeter KalevMaria Francesca BaiettiSergei V StrelkovKris GevaertJan Tavernier et al.

A1 Journal Article in NATURE CELL BIOLOGY

Using KISS mammalian two-hybrid technology to study IRE1α function

Sarah GerloSam LievensElien RuyssinckHannes DemaréDieter DefeverJan Tavernier

2012

ArrayMAPPIT: a screening platform for human protein interactome analysis

Sam LievensNele VanderroostDieter DefeverJosé Van Der HeydenJan Tavernier

Bookchapter in Two hybrid technologies : methods and protocols

MAPPIT as a high-throughput screening assay for modulators of protein-protein interactions in HIV and HCV

Bertrand Van SchoubroeckKoen Van AckerGéry DamsDirk JochmansReginald ClaytonJan Martin BerkeSam LievensJosé Van Der HeydenJan Tavernier

Bookchapter in Two hybrid technologies : methods and protocols

MASPIT: a high throughput assay for the identification of cytosolic targets of small molecules : proof of principle

Martijn RisseeuwSam LievensDries De ClercqUlrik HillaertJan TavernierSerge Van Calenbergh

Opposed regulation of type I IFN-induced STAT3 and ISGF3 transcriptional activities by histone deacetylases (HDACS) 1 and 2

Laura IcardiSam LievensRaffaele MoriJulie PiessevauxLode De CauwerKarolien De BosscherJan Tavernier

A1 Journal Article in FASEB JOURNAL

Protein-protein interactions: network analysis and applications in drug discovery

Jennyfer BultinckSam LievensJan Tavernier

A1 Journal Article in CURRENT PHARMACEUTICAL DESIGN

Syntheses of methotrexate-hybrid compounds for target profiling of small molecules with MASPIT

Dries De ClercqMartijn RisseeuwSam LievensJan TavernierSerge Van Calenbergh

Syntheses of methotrexate-hybrid compounds for target profiling of small molecules with MASPIT

Dries De ClercqMartijn RisseeuwSam LievensJan TavernierSerge Van Calenbergh

Syntheses of methotrexate-hybrid compounds for target profiling of small molecules with MASPIT

Dries De ClercqMartijn RisseeuwSam LievensJan TavernierSerge Van Calenbergh

The use of mammalian two-hybrid technologies for high-throughput drug screening

Sam LievensMaureen CaligiuriNiko KleyJan Tavernier

A1 Journal Article in METHODS

2011

A protein engineering approach differentiates the functional importance of carbohydrate moieties of interleukin-5 receptor α

Tetsuya IshinoNicoleta J EconomouKaryn McFaddenMeirav Zaks-ZilbermanMonika JostSabine BaxterMark R ContarinoAdrian E HarringtonPatrick J LollGianfranco Pasut et al.

A1 Journal Article in BIOCHEMISTRY

MAPPIT: a protein interaction toolbox built on insights in cytokine receptor signaling

Sam LievensFrank PeelmanKarolien De BosscherIrma LemmensJan Tavernier

A1 Journal Article in CYTOKINE & GROWTH FACTOR REVIEWS

Opposite regulation of type I IFN-induced STAT3 and ISGF3 transcriptional activities by histone deacetylases (HDACS) 1 and 2

Laura IcardiKarolien De BosscherRaffaele MoriLode De CauwerSam LievensJan Tavernier

RNF41 (Nrdp1) controls type 1 cytokine receptor degradation and ectodomain shedding

Joris WaumanLeentje De CeuninckNele VanderroostSam LievensJan Tavernier

A1 Journal Article in JOURNAL OF CELL SCIENCE

STAT3 transcriptional activity is controlled by regulated acetylation

Jan TavernierLaura IcardiViola GesellchenRaffaele MoriSam LievensSven EyckermanJennyfer BultinckM BoutrosKarolien De Bosscher

2010

Abrogation of the Brd4-positive transcription elongation factor b complex by Papillomavirus E2 protein contributes to viral oncogene repression

JunPeng YanQing LiSam LievensJan TavernierJianXin You

A1 Journal Article in JOURNAL OF VIROLOGY

Caspase-1 targets the TLR adaptor Mal at a crucial TIR-domain interaction site

Peter UlrichtsCelia BovijnSam LievensRudi BeyaertJan TavernierFrank Peelman

A1 Journal Article in JOURNAL OF CELL SCIENCE

Large-scale protein interactome mapping: strategies and opportunities

Sam LievensSven EyckermanIrma LemmensJan Tavernier

A1 Journal Article in EXPERT REVIEW OF PROTEOMICS

Strategies towards high-quality binary protein interactome maps

Irma LemmensSam LievensJan Tavernier

A1 Journal Article in JOURNAL OF PROTEOMICS

2009

Array MAPPIT: High-Throughput Interactome Analysis in Mammalian Cells

Sam LievensNele VanderroostJosé Van Der HeydenViola GesellchenMarc VidalJan Tavernier

A1 Journal Article in JOURNAL OF PROTEOME RESEARCH

Mammalian two-hybrids come of age

Sam LievensIrma LemmensJan Tavernier

A1 Journal Article in TRENDS IN BIOCHEMICAL SCIENCES

2008

Evaluation of Digitally Encoded Layer-by-layer Coated Microparticles as Cell Carriers

Farzaneh FayazpourBart LucasRoosmarijn VandenbrouckeStefaan DerveauxJan TavernierSam LievensJo DemeesterStefaan De Smedt

A1 Journal Article in ADVANCED FUNCTIONAL MATERIALS

MAPPIT (MAmmalian Protein-Protein Interaction Trap) as a tool to study HIV reverse transcriptase dimerization in intact human cells

Els PattynDelphine LavensJosé Van Der HeydenAnnick VerheeSam LievensIrma LemmensS HALLENBERGERD JOCHMANSJan Tavernier

A1 Journal Article in JOURNAL OF VIROLOGICAL METHODS

MAPPIT: a versatile tool to study cytokine receptor signalling

Irma LemmensSam LievensJan Tavernier

A1 Journal Article in BIOCHEMICAL SOCIETY TRANSACTIONS

2007

A symbiotic plant peroxidase involved in bacterial invasion of the tropical legume Sesbania rostrata

Jeroen Den HerderSam LievensStephane RombautsMarcella HolstersSofie Goormachtig

A1 Journal Article in PLANT PHYSIOLOGY

Identification and evaluation of protein-protein interactions involved in NF-kB signaling using MAPPIT technology

Lars VereeckeSam LievensJan TavernierGeert van LooMozes SzeRudi Beyaert

The MAPPIT toolbox: novel strategies to analyze molecular interactions in intact cells

Jan TavernierIrma LemmensSam Lievens

2006

MASPIT: Three-hybrid trap for quantitative proteome fingerprinting of small molecule-protein interactions in mammalian cells

M CALIGIURIL MOLZQ LIUF KAPLANJP XUJZ MAJETIR RAMOS-KELSEYK MURTHISam LievensJan Tavernier et al.

A1 Journal Article in CHEMISTRY & BIOLOGY

Reverse MAPPIT detects disruptors of protein-protein interactions in human cells

Irma LemmensSam LievensSven EyckermanJan Tavernier

A1 Journal Article in NATURE PROTOCOLS

Single protein complex visualization: Seeing is believing

Sam LievensJan Tavernier

Editorial material

Two-hybrid and its recent adaptations

Sam LievensIrma LemmensTony MontoyeSven EyckermanJan Tavernier

A2 Journal Article in DRUG DISCOVERY TODAY. TECHNOLOGIES

2005

Gibberellins are involved in nodulation of Sesbania rostrata

Sam LievensSofie GoormachtigJeroen Den HerderWard CapoenRené MathisPeter HeddenMarcella Holsters

A1 Journal Article in PLANT PHYSIOLOGY

Reverse MAPPIT: screening for protein-protein interaction modifiers in mammalian cells

Sven EyckermanIrma LemmensDominiek CatteeuwAnnick VerheeJoël VandekerckhoveSam LievensJan Tavernier

A1 Journal Article in NATURE METHODS

2004

Design of a fluorescence-activated cell sorting-based Mammalian protein-protein interaction trap

Sam LievensJ HEYDENEls VertentenJean PlumJoël VandekerckhoveJan Tavernier

Bookchapter in Methods in molecular biology

Nodule-enhanced protease inhibitor gene: emerging patterns of gene expression in nodule development on Sesbania rostrata

Sam LievensSofie GoormachtigMarcella Holsters

A1 Journal Article in JOURNAL OF EXPERIMENTAL BOTANY

2002

Design and use of a mammalian protein-protein interaction trap (MAPPIT)

Sven EyckermanIrma LemmensSam LievensJ VAN DER HEYDENA VERHEEJoël VandekerckhoveJan Tavernier

A2 Journal Article in Science's signal transduction knowledge environment

Patterns of pectin methylesterase transcripts in developing stem nodules of Sesbania rostrata

Sam LievensSofie GoormachtigSylvia HermanMarcella Holsters

A1 Journal Article in MOLECULAR PLANT-MICROBE INTERACTIONS

Role of reactive oxygen species and ethylene in programmed cell death during nodule initiation on Sesbania rostrata

Wim D'HaezeC ChaparroAnnick De KeyserSteven DeleuRiet De RyckeSofie GoormachtigSam LievensRené MathisKatrien SchroeyersWillem Van De Velde et al.

2001

A critical evaluation of differential display as a tool to identify genes involved in legume nodulation : looking back and looking forward

Sam LievensSofie GoormachtigMarcella Holsters

A1 Journal Article in NUCLEIC ACIDS RESEARCH

Early gene expression during Sesbania rostrata nodule development

Sam LievensMarcella HolstersMarc Van Montagu

Srchi24, a chitinase homolog lacking an essential glutamic acid residue for hydrolytic activity, is induced during nodule development on Sesbania rostrata

Sofie GoormachtigWillem Van De VeldeSam LievensChrista VerplanckeSylvia HermanAnnick De KeyserMarcella Holsters

A1 Journal Article in PLANT PHYSIOLOGY

2000

Early symbiotic functions of Sesbania rostrata

Marcella HolstersSam LievensWillem Van De VeldeMercè Caturla-GoñiWim D'HaezeMengsheng GaoSofie Goormachtig

Study of gene expression during activation of dormant adventititous rootlet meristem

Mercè Caturla GoniSam LievensSylvia HermanMarc Van MontaguMarcella Holsters

1999

Chalcone reductase-homologous transcripts accumulate during development of stem-borne nodules on the tropical legume Sesbania rostrata

Sofie GoormachtigSam LievensSylvia HermanMarc Van MontaguMarcella Holsters

A1 Journal Article in PLANTA

1998

Chitinase gene expression during stem nodulation on Sesbania rostrata

Sofie GoormachtigWillem Van De VeldeSam LievensMarc Van MontaguMarcella Holsters

Chitinase gene expression during stem nodulation on Sesbania rostrata

Sofie GoormachtigWillem Van De VeldeSam LievensMarc Van MontaguMarcella Holsters

Early gene expression during stem nodule formation on Sesbania rostrata

Sam LievensSofie GoormachtigWillem Van De VeldeS HermanMarc Van MontaguMarcella Holsters

Early gene expression during stem nodule formation on Sesbania rostrata

Sam LievensSofie GoormachtigWillem Van De VeldeS HermanMarc Van MontaguMarcella Holsters

Patterns of ENOD40 gene expression in stem-borne nodules of Sesbania rostrata

Viviana CorichSofie GoormachtigSam LievensMarc Van MontaguMarcella Holsters

A1 Journal Article in PLANT MOLECULAR BIOLOGY

Srchi13, a novel early nodulin from Sesbania rostrata, is related to acidic class III chitinases

Sofie GoormachtigSam LievensWillem Van De VeldeMarc Van MontaguMarcella Holsters

A1 Journal Article in PLANT CELL

1997

Plant gene expression during stem nodule development on Sesbania rostrata

Sofie GoormachtigMarcio Alves FerreiraSam LievensViviana CorichPeter MergaertWim D'HaezeManuel Fernández-LópezMengsheng GaoMarc Van MontaguMarcella Holsters