Research Explorer

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Researcher

Sabine Van daele

Publications & Research Data

Awards & Distinctions

83 Results

2025

Evaluating the real-world applicability of healthcare transition : a qualitative study across disciplines

Freya BrusselleSara DebulpaepKenneth ChambaereKim BeernaertSabine Van daeleWim Van BiesenStephanie Van BiervlietKarsten Vanden Wyngaert

A2 Journal Article in BELGIAN JOURNAL OF PAEDIATRICS

Realist evaluation of Belgian pilot projects for paediatric transmural care: protocol for a mixed methods study

Sara DequekerKatrien VanderweeSabine Van daeleVeerle Duprez

U Journal Article in BMJ Open

2024

The roles and experiences of adolescents with cystic fibrosis and their parents during transition : a qualitative interview study

Karsten Vanden WyngaertSara DebulpaepWim Van BiesenSabine Van daeleSue BraunKenneth ChambaereKim Beernaert

A1 Journal Article in JOURNAL OF CYSTIC FIBROSIS

2023

Comparison of SARS-CoV-2 seroconversion in children with chronic diseases with healthy children and adults during the first waves of the COVID-19 pandemic

Levi HosteAgnieszka Prytula-EbelsJo DehoorneRuth De BruyneStephanie Van BiervlietKathleen De WaeleEvelyn MaesVictoria BordonArnaud VanlanderKarlien Claes et al.

A1 Journal Article in FRONTIERS IN PEDIATRICS

Glycemic indices at night measured by CGM are predictive for a lower pulmonary function in adults but not in children with cystic fibrosis

Dimitri DeclercqSimon HelleputteSophie MarchandSara Van AkenEva Van BraeckelSabine Van daeleGuy T'SjoenStephanie Van BiervlietBruno Lapauw

A1 Journal Article in JOURNAL OF CYSTIC FIBROSIS

The role and the composition of a liaison team to facilitate the transition of adolescents and young adults : an umbrella review

Karsten Vanden WyngaertMarie-Lise NédéeOdile PiessevauxTine De MartelaerWim Van BiesenVeronique CocquytSabine Van daeleJohan De Munter

A1 Journal Article in EUROPEAN JOURNAL OF PEDIATRICS

2022

Urinary sodium/creatinine ratio is a predictor for fractional sodium excretion and related to age in patients with cystic fibrosis

Dimitri DeclercqLieselot PeremansMichiel GlorieusYannick Vande WeygaerdeHeidi SchaballieEva Van BraeckelEvelien SnauwaertSabine Van daeleStephanie Van Biervliet

A1 Journal Article in JOURNAL OF CYSTIC FIBROSIS

2021

Long-term use of tube feeding in children with cystic fibrosis : results from two Belgian CF centers

Dimitri DeclercqK. HuysentruytB. HauserE. De WachterSabine Van daeleFrans De BaetsStephanie Van Biervliet

A1 Journal Article in EUROPEAN JOURNAL OF CLINICAL NUTRITION

SeroCovid19 : prospective seroprevalence monitoring reveals substantially reduced SARS-CoV-2 infection rate among tertiary pediatric patients

Levi HosteAgnieszka Prytula-EbelsJo DehoorneRuth De BruyneStephanie Van BiervlietKATHLEEN DE WAELEPetra SchelstraeteEvelyn MaesMaria Bordon Cueto De BraemArnaud Vanlander et al.

Sodiumstatus in patients with cystic fibrosis : how to monitor based on urine sample?

Stephanie Van BiervlietDimitri DeclercqSaskia Vande VeldeRuth De BruyneYannick Vande WeygaerdeHeidi SchaballieEva Van BraeckelSabine Van daele

2020

Sodium status and replacement in children and adults living with cystic fibrosis : a narrative review

Dimitri DeclercqEva Van BraeckelSophie MarchandSabine Van daeleStephanie Van Biervliet

A1 Journal Article in JOURNAL OF THE ACADEMY OF NUTRITION AND DIETETICS

2019

The nutritional status in CF : being certain about the uncertainties

Dimitri DeclercqSvenya Van MeerhaegheSophie MarchandEva Van BraeckelSabine Van daeleFrans De BaetsStephanie Van Biervliet

A2 Journal Article in CLINICAL NUTRITION ESPEN

2018

A CARD9 founder mutation disrupts NF-κB signaling by inhibiting BCL10 and MALT1 recruitment and signalosome formation

Marieke De BruyneLevi HosteDelfien BogaertLien Van den BosscheSimon TavernierEef ParthoensMélanie MigaudDeborah KonopnickiJean Cyr YombiBart Lambrecht et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Body composition measured by BIA of tube-fed cystic fibrosis patients compared to age-sex matched controls

Stephanie Van BiervlietEva Van BraeckelFrans De BaetsSabine Van daeleSvenya Van MeerhaegheDimitri Declercq

Development and validation of an LC tandem MS assay for the quantification of β-lactam antibiotics in the sputum of cystic fibrosis patients

Katrien ForierVirginie Van HeckMieke CarlierEva Van BraeckelSabine Van daeleFrans De BaetsPetra SchelstraeteFilomeen HaerynckVeronique StoveLeen Van Simaey et al.

A1 Journal Article in JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Establishing the diagnosis of chronic colonization with Pseudomonas aeruginosa of cystic fibrosis patients : comparison of the European consensus criteria with genotyping of P. aeruginosa isolates

Leander JonckheerePetra SchelstraeteLeen Van SimaeyEva Van BraeckelJulie WillekensSabine Van daeleFrans De BaetsMario Vaneechoutte

A1 Journal Article in JOURNAL OF CYSTIC FIBROSIS

Long-term experience with tube feeding in children with cystic fibrosis in two Belgian CF Centers : preliminary results

Dimitri DeclercqStephanie Van BiervlietK. HuysentruytE. De WachterSabine Van daeleFrans De Baets

Risk factors and impact of allergic bronchopulmonary aspergillosis in Pseudomonas aeruginosa-negative CF patients

Frans De BaetsLinde De KeyzerSabine Van daelePetra SchelstraeteStephanie Van BiervlietEva Van BraeckelMuriel ThomasSimeon S Wanyama

A1 Journal Article in PEDIATRIC ALLERGY AND IMMUNOLOGY

The effect of enteral tube feeding in cystic fibrosis : a registry based study

Denis LibeertDimitri DeclercqSimeon WanyamaMuriel ThomasSabine Van daeleFrans De BaetsStephanie Van Biervliet

A1 Journal Article in JOURNAL OF CYSTIC FIBROSIS

When one rare disease hides another : Kartagener syndrome masking FMF

Levi HosteFrans De BaetsSabine Van daelePetra SchelstraeteMieke BoonMarieke De BruyneMelissa DullaersFrauke CoppietersFilomeen Haerynck

A1 Journal Article in CLINICAL PEDIATRICS

2017

Characteristics at baseline of tube-fed cystic fibrosis (CF) patients with matched controls : a registry study

D LibeertS WanyamaDimitri DeclercqM ThomasSabine Van daeleFrans De BaetsStephanie Van Biervliet

Effects of propidium monoazide (PMA) treatment on mycobiome and bacteriome analysis of cystic fibrosis airways during exacerbation

Linh Do Ngoc NguyenPieter DeschaghtSophie MerlinAlexandre LoywickChristophe AudebertSabine Van daeleEric ViscogliosiMario VaneechoutteLaurence Delhaes

A1 Journal Article in PLOS ONE

Evaluation of HbA1c and OGTT-results after a first abnormal OGTT

Dimitri DeclercqSabine Van daeleFrans De BaetsSara Van AkenStephanie Van Biervliet

Exercise performance and quality of life in children with cystic fibrosis and mildly impaired lung function : relation with antibiotic treatments and hospitalization

Kristof VandekerckhoveMichiel KeyzerJasper CornetteIlse CoomansFilip PylFrans De BaetsPetra SchelstraeteFilomeen HaerynckDaniël De WolfSabine Van daele et al.

A1 Journal Article in EUROPEAN JOURNAL OF PEDIATRICS

Impact of tube feeding (TF) on pulmonary function in children and adults with cystic fibrosis

D LibeertS WanyamaDimitri DeclercqM ThomasSabine Van daeleFrans De BaetsStephanie Van Biervliet

Single centre long-term experience with tube feeding in children with cystic fibrosis

Stephanie Van BiervlietDimitri DeclercqSabine Van daeleFrans De Baets

The impact of tube feeding in children and adults with cystic fibrosis

D LibeertS WanyamaDimitri DeclercqM ThomasSabine Van daeleFrans De BaetsStephanie Van Biervliet

2016

Chronic and invasive fungal infections in a family with CARD9 deficiency

Ana Alves de MedeirosEVELYNE LODEWICKDelfien BogaertFilomeen HaerynckSabine Van daeleBart LambrechtSarah BosmaLaure VanderdoncktOlivier LortholaryMélanie Migaud et al.

A1 Journal Article in JOURNAL OF CLINICAL IMMUNOLOGY

Chronic and invasive fungal infections in a family with CARD9 deficiency (vol 36, pg 204, 2016)

Ana Karina Alves de MedeirosEVELYNE LODEWICKDelfien BogaertFilomeen HaerynckSabine Van daeleBart LambrechtSarah BosmaLaure VanderdoncktOlivier LortholaryMélanie Migaud et al.

Epidemic Achromobacter xylosoxidans strain among Belgian cystic fibrosis patients and review of literature

Piet CoolsErwin HoKatleen VranckxPetra SchelstraeteBettina WurthHilde FranckxGreet IevenLeen Van SimaeySabine Van daeleStijn Verhulst et al.

A1 Journal Article in BMC MICROBIOLOGY

Gastro-intestinal manifestations in cystic fibrosis patients

Stephanie Van BiervlietCharlotte de ClercqDimitri DeclercqEva Van BraeckelSabine Van daeleFrans De BaetsDanny De Looze

A1 Journal Article in ACTA GASTRO-ENTEROLOGICA BELGICA

When two rare diseases coincide : Kartagener Syndrome and Familial Mediterranean Fever

Levi HosteFrans De BaetsSabine Van daelePetra SchelstraeteMieke BoonElfride De BaereFrauke CoppietersFilomeen Haerynck

2015

A single clone of Achromobacter xylosoxidans colonizes Belgian cystic fibrosis patients from different centres

Piet CoolsE HoPetra SchelstraeteB WürthH FranckxLeen Van SimaeySabine Van daeleS VerhulstFrans De BaetsMario Vaneechoutte

ABPAs in Pseudomonas aeruginosa colonized CF patients

Frans De BaetsLinde De KeyzerPetra SchelstraeteSabine Van daeleS Wanyama

Achromobacter xylosoxidans/ruhlandii colonized CF patients have more hospitalisations and IV antibiotic days

Frans De BaetsPetra SchelstraeteFilomeen HaerynckL Van SimaeyMario VaneechoutteSabine Van daele

Colistin and neurotoxicity : recommendations for optimal use in cystic fibrosis patients

Barbara ClausSylvie SnauwaertFilomeen HaerynckSabine Van daeleFrans De BaetsPetra Schelstraete

A1 Journal Article in INTERNATIONAL JOURNAL OF CLINICAL PHARMACY

Communication in healthcare : a narrative review of the literature and practical recommendations

Peter VermeirDominique VandijckSophie DegrooteRenaat PelemanRik VerhaegheEric MortierGiorgio HallaertSabine Van daeleWalter BuylaertDirk Vogelaers

A1 Journal Article in INTERNATIONAL JOURNAL OF CLINICAL PRACTICE

Impact van communicatie tussen zorgverstrekkers op de kwaliteit van patiëntenzorg

Peter VermeirKirsty De FluiterSabine Van daeleGiorgio HallaertWalter BuylaertDirk VogelaersDominique Vandijck

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE

Pseudomonas aeruginosa genotyping: predicting transition to chronic colonization in cystic fibrosis patients

Leander JonckheereMario VaneechoutteFrans De BaetsSabine Van daeleFilomeen HaerynckLeen Van SimaeyPetra Schelstraete

Quantitative bone ultrasound at the distal radius in adults with cystic fibrosis

Inge RoggenOlivia LouisStephanie Van BiervlietSabine Van daeleEddy RobberechtElke DewachterAnne MalfrootKATHLEEN DE WAELEInge GiesJesse Vanbesien et al.

A1 Journal Article in ULTRASOUND IN MEDICINE AND BIOLOGY

Validity of the oxygen uptake efficiency slope (OUES) as a parameter of maximal and submaximal exercise testing in children with mild CF

J CornetteM KeyzerF PylI CoomansSabine Van daeleKristof Vandekerckhove

2014

ABPA syndrome (ABPAs) in CF : FEV1 decline, infectious exacerbations and BMI before and after the year of diagnosis (index year), a case control study

Frans De BaetsS WanyamaLinde De KeyzerFilomeen HaerynckPetra SchelstraeteM ThomasSabine Van daele

Achromobacter xylosoxidans induced bronchiolitis obliterans in cystic fibrosis

Frans De BaetsPetra SchelstraeteFilomeen HaerynckStephanie Van BiervlietRuth De BruyneH FranckxSabine Van daele

A1 Journal Article in PEDIATRIC PULMONOLOGY

Aspergillus nodi in cystic fibrosis (CF) patients: a rare entity: report of two pediatric cases

Petra SchelstraeteSabine Van daeleFilomeen HaerynckFrans De Baets

Characterization of CSF2RA mutation related juvenile pulmonary alveolar proteinosis

Jenna HildebrandtEbru YalcinHans-Georg BresserGuzin CinelMonika GappaAlireza HaghighiNural KiperSoheila KhalilzadehKarl ReiterJohn Sayer et al.

A1 Journal Article in ORPHANET JOURNAL OF RARE DISEASES

De impact van communicatie tussen zorgverstrekkers op de kwaliteit van patiëntenzorg

Peter VermeirKirsty De FluiterSabine Van daeleGiorgio HallaertWalter BuylaertDirk VogelaersDominique Vandijck

Bookchapter in Jaarboek voor de intensievezorgenverpleegkundige 2014

Genotyping of Achromobacter xylosoxidans in a cystic fibrosis (CF) centre

Sabine Van daelePetra SchelstraeteFrans De BaetsMARLEEN VANDERKERKENAnne RamanAN CARTONL MahieuF PylL Van SimaeyMario Vaneechoutte

Primary ciliary dyskinesia : critical evaluation of clinical symptoms and diagnosis in patients with normal and abnormal ultrastructure

Mieke BooneAnne SmitsHarry CuppensMartine JaspersMarijke ProesmansLieven J DupontFrançois L VermeulenSabine Van daeleAnne MalfrootVeronique Godding et al.

A1 Journal Article in ORPHANET JOURNAL OF RARE DISEASES

Psychiatrische aandoeningen bij mucoviscidose: een overzicht

Sabine Van daeleISABELLE MUSSCHEERIC SCHOENTJES

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE

2013

Eradication therapy for Pseudomonas aeruginosa colonization episodes in cystic fibrosis patients not chronically colonized by P. aeruginosa

Petra SchelstraeteFilomeen HaerynckFrans De BaetsSARAH DESEYNESabine Van daele

A1 Journal Article in JOURNAL OF CYSTIC FIBROSIS

Genetic variations in toll-like receptor pathway and lung function decline in Cystic Fibrosis patients

Filomeen HaerynckJM Mahachie JohnKristel Van SteenPetra SchelstraeteSabine Van daeleBart LoeysMira Van ThielenI De CanckLieve NuytinckFrans De Baets

A1 Journal Article in HUMAN IMMUNOLOGY

Is the improvement of CF patients, hospitalized for pulmonary exacerbation, correlated to a decrease in bacterial load?

Pieter DeschaghtPetra SchelstraeteLeen Van SimaeyMarleen VanderkerckenANN RAMANLinda MahieuSabine Van daeleFrans De BaetsMario Vaneechoutte

A1 Journal Article in PLOS ONE

2012

Genetic variations in toll-like receptor pathway and lung function decline in cystic fibrosis patients

Filomeen HaerynckKristel Van SteenJM JohnPetra SchelstraeteSabine Van daeleBart LoeysM Van ThielenI De CanckFrans De Baets

Malacia, inflammation and bronchoalveolar lavage culture in children with persistent respiratory symptoms

Frans De BaetsI De SchutterC AartsFilomeen HaerynckSabine Van daeleE De WachterA MalfrootPetra Schelstraete

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

Polymorphisms in the lectin pathway genes as a possible cause of early chronic Pseudomonas aeruginosa colonization in cystic fibrosis patients

Filomeen HaerynckKristel Van SteenT CattaertBart LoeysSabine Van daelePetra SchelstraeteKathleen ClaesM Van ThielenI De CanckJM Mahachie John et al.

A1 Journal Article in HUMAN IMMUNOLOGY

2011

Neonatal pulmonary interstitial glycogenosis in a patient with Hunter syndrome

Koenraad SmetsSabine Van daele

A1 Journal Article in EUROPEAN JOURNAL OF PEDIATRICS

PCR and the detection of Pseudomonas aeruginosa in respiratory samples of CF patients: a literature review

Pieter DeschaghtSabine Van daeleFrans De BaetsMario Vaneechoutte

A1 Journal Article in JOURNAL OF CYSTIC FIBROSIS

2010

Comparison of culture and qPCR for the detection of Pseudomonas aeruginosa in not chronically infected cystic fibrosis patients

Pieter DeschaghtPetra SchelstraeteGuido Lopes dos Santos SantiagoLeen Van SimaeyFilomeen HaerynckSabine Van daeleElke De WachterAnne MalfrootPatrick LebecqueChristiane Knoop et al.

A1 Journal Article in BMC MICROBIOLOGY

Genotype based evaluation of Pseudomonas aeruginosa eradication treatment success in cystic fibrosis patients

Petra SchelstraetePieter DeschaghtLeen Van SimaeySabine Van daeleFilomeen HaerynckMario VaneechoutteFrans De Baets

A1 Journal Article in JOURNAL OF CYSTIC FIBROSIS

Milk protein and Oil-Red-O staining of alveolar macrophages in chronic respiratory disease of infancy

Frans De BaetsClaudia AartsSabine Van daeleFilomeen HaerynckElke De WachterIris De SchutterAnne MalfrootPetra Schelstraete

A1 Journal Article in PEDIATRIC PULMONOLOGY

2009

Comparison of the sensitivity of culture, PCR and quantitative real-time PCR for the detection of Pseudomonas aeruginosa in sputum of cystic fibrosis patients

Pieter DeschaghtThierry De BaereLeen Van SimaeySabine Van daeleFrans De BaetsDaniel De VosJean-Paul PirnayMario Vaneechoutte

A1 Journal Article in BMC MICROBIOLOGY

Een pediatrische patiënt met het syndroom van Lemierre

Astrid VerbistCatharina DhoogeANNIK DE JAEGERPetra SchelstraeteSabine Van daele

A2 Journal Article in Tijdschrift voor geneeskunde

Genotype based evaluation of eradication treatment success for new Pseudomonas aeruginosa infections in cystic fibrosis patients

Petra SchelstraetePieter DeschaghtLeen Van SimaeySabine Van daeleFilomeen HaerynckMario VaneechoutteFrans De Baets

2008

Pseudomonas aeruginosa in the home environment of newly infected cystic fibrosis patients

Petra SchelstraeteSabine Van daeleK DE BOECKM PROESMANSP LEBECQUEJ LECLERCQ-FOUCARTA MALFROOTMario VaneechoutteFrans De Baets

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

Severe corticosteroid-dependent asthma in association with eczema and type 1 diabetes mellitus as an early manifestation of the IPEX syndrome: a case report

Filomeen HaerynckFrans De BaetsPetra SchelstraeteSabine Van daeleCatharina DhoogeK De WaeleMaria Bordon Cueto De Braem

2007

Achromobacter xylosoxidans in cystic fibrosis: Prevalence and clinical relevance

Frans De BaetsP SCHELSTRAETESabine Van daeleFilomeen HaerynckMario Vaneechoutte

A1 Journal Article in JOURNAL OF CYSTIC FIBROSIS

Single nucleotide polymorphisms in genes of the innate immunity in cystic fibrosis patients: Correlation with lung function and pseudomonas aeruginosa colonisation

Filomeen HaerynckSabine Van daelePetra SchelstraeteE DE MEESTERR ROSSAUFrans De Baets

2006

Epidemiology of Pseudomomas aeruginosa and Achromobacter xylosoxidans in Belgian cystic fibrosis patients, relying on molecular typing techniques

Sabine Van daeleFrans De BaetsMario Vaneechoutte

Evidence for autosomal dominant inheritance in prenatally diagnosed CHAOS

Piet VanhaesebrouckKris De CoenPaul DefoortHubert VermeerschGeert MortierLinde GoossensKoenraad SmetsAleksandra ZecicSabine Van daeleFrans De Baets

A1 Journal Article in EUROPEAN JOURNAL OF PEDIATRICS

Perinatale aanpak bij congenitale luchtwegmalformaties

Piet VanhaesebrouckPaul DefoortKoenraad SmetsHubert VermeerschVALERIE MEERSSCHAUTLinde GoossensSabine Van daeleFrans De BaetsMarleen Temmerman

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE

Survey of Pseudomonas aeruginosa genotypes in colonised cystic fibrosis patients

Sabine Van daeleMario VaneechoutteK DE BOECKC KNOOPA MALFROOTP LEBECQUEJ LECLERCQ-FOUCARTL VAN SCHILK DESAGERFrans De Baets

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

2005

Epidemiology of Pseudomonas aeruginosa in a cystic fibrosis rehabilitation centre

Sabine Van daeleH FRANCKXRita VerhelstPetra SchelstraeteFilomeen HaerynckI VAN SIMAEYGeert ClaeysMario VaneechoutteFrans De Baets

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

Evidence for autosomal dominant inheritance in prenatally diagnosed CHAOS

Piet VanhaesebrouckKris De CoenPaul DefoortHubert VermeerschGeert MortierClaudine De PraeterLinde GoossensKoenraad SmetsAleksandra ZecicSabine Van daele et al.

Exercise-induced respiratory symptoms are poor predictors of bronchoconstriction

Frans De BaetsE BODARTM DRAMAIX-WILMETSabine Van daeleG DE BILDERLINGS MASSETP VERMEIREO MICHEL

A1 Journal Article in PEDIATRIC PULMONOLOGY

Shared genotypes of Achromobacter xylosoxidans strains isolated from patients at a cystic fibrosis rehabilitation center

Sabine Van daeleRita VerhelstGeert ClaeysGerda VerschraegenHilde FranckxLeen Van SimaeyCatharine Clara De GanckFrans De BaetsMario Vaneechoutte

A1 Journal Article in JOURNAL OF CLINICAL MICROBIOLOGY

2004

Asphyxiating tracheal bronchogenic cyst

Frans De BaetsSabine Van daelePetra SchelstraeteFilomeen HaerynckFrank VermassenC BROERS

A1 Journal Article in PEDIATRIC PULMONOLOGY

Clinical relevance of Achromobacter xylosoxidans and Stenotrophomonas maltophilia in cystic fibrosis

Frans De BaetsSabine Van daele

Epidemiology of Pseudomonas aeruginosa in Belgian CF patients

Sabine Van daeleFrans De BaetsMario Vaneechoutte

2003

Een geconjugeerd pneumococcen vaccin voor kinderen.

Frans De BaetsPetra SchelstraeteSabine Van daele

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE

1998

Diagnose en beleid van pseudo-kroep en epiglottitis

Sabine Van daeleFrans De Baets

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE

Inhaled steroids compared with disodium cromoglycate in preschool children with episodic viral wheeze.

Frans De BaetsSabine Van daeleH FRANCKXF VINAIMONT

A1 Journal Article in PEDIATRIC PULMONOLOGY

1996

Astma op kleuterleeftijd: astma?

Frans De BaetsSabine Van daele

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE

1989

Cytogenetic analysis of a mesenchymal hamartoma of the liver

Franki SpelemanVeronique De TelderKristiaan R De PotterPaola Dal CinSabine Van daeleYves BenoitJules G LeroyHerman Van Den Berghe

A1 Journal Article in CANCER GENETICS AND CYTOGENETICS