Research Explorer

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Researcher

Ruth Wittoek

Publications & Research Data

Awards & Distinctions

73 Results

2026

Cigarette smoke-primed citrullinated HLA-DR4 T cell reactivity is modulated by γ8-T cells

Matthias JarlborgTine DecruyTeddy ManuelloJulie CoudenysRenée Van der CruyssenThomas MalfaitLeander MeurisTania MaesKen BrackeDiane van der Woude et al.

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

2025

Impressions of erosive hand osteoarthritis : the physical handprint and molecular fingerprint

Tine VanhaverbekeRuth WittoekDirk ElewautKoen Venken

Presence of erosions is not a risk factor for the development of knee OA in a hand OA population: results from the Framingham OA study

Tine VanhaverbekeG. MillerNene C. UkonuRuth WittoekI.K. HaugenD. Felson

A2 Journal Article in OSTEOARTHRITIS AND CARTILAGE OPEN

Validation of HAND OA US inflammatory and structural damage score (HOUSE) for thumb-base joints : systematic review on truth and discrimination

Marion C KortekaasTine VanhaverbekeHelen I KeenLene TerslevHilde B HammerMaria Antonietta D’AgostinoRuth WittoekIngrid MöllerAlexander MathiessenFlorian Berghea et al.

A1 Journal Article in RHEUMATOLOGY

2024

2023 EULAR classification criteria for hand osteoarthritis

Ida K HaugenDavid T FelsonAbhishek AbhishekFrancis BerenbaumSita Bierma-ZeinstraKrysia S DziedzicJohn James EdwardsMartin EnglundMerete Hermann-EriksenGabriel Herrero-Beaumont et al.

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

Exercise and footwear in medial knee osteoarthritis : a randomized controlled trial comparing flat flexible footwear to stable supportive shoes

Paolo DaineseJan StautemasSophie De MitsRuth WittoekAns Van GinckelWouter HuysseHeleen DemeyerHanne MahieuPatrick Calders

A2 Journal Article in RHEUMATOLOGY ADVANCES IN PRACTICE

Neuropathic-like pain in knee osteoarthritis : exploring differences in knee loading and inflammation : a cross-sectional study

Paolo DaineseSophie De MitsRuth WittoekAns Van GinckelWouter HuysseHanne MahieuJan StautemasPatrick Calders

A1 Journal Article in EUROPEAN JOURNAL OF PHYSICAL AND REHABILITATION MEDICINE

RANKL blockade for erosive hand osteoarthritis : a randomized placebo-controlled phase 2a trial

Ruth WittoekGust VerbruggenTine VanhaverbekeRoos ColmanDirk Elewaut

A1 Journal Article in NATURE MEDICINE

Shared lung and joint T cell repertoire in early rheumatoid arthritis driven by cigarette smoking

Koen VenkenMatthias JarlborgFrederik StevenaertThomas MalfaitCarolien VliegheYann AbrahamTeddy ManuelloTine DecruyStijn VanheeHans Wils et al.

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

2023

Associations between markers of inflammation and altered pain perception mechanisms in people with knee osteoarthritis : a systematic review

Paolo DaineseHanne MahieuSophie De MitsRuth WittoekJan StautemasPatrick Calders

A1 Journal Article in RMD OPEN

Exploring pain, inflammation, and loading in knee osteoarthritis : implications for self-management strategies

Paolo DainesePatrick CaldersRuth WittoekAns Van Ginckel

Structural ultrasound of joints and tendons in healthy children : development of normative data

Ruth WittoekCéline DecockNele DewaeleLara ArnoldPieter BaeyensIgnace De SchrijverLisa PardaensIoannis RaftakisThomas RensonCharline Rinkin et al.

A1 Journal Article in PEDIATRIC RHEUMATOLOGY

2022

Association between knee inflammation and knee pain in patients with knee osteoarthritis : a systematic review

Paolo DaineseKarsten Vanden WyngaertSophie De MitsRuth WittoekAns Van GinckelPatrick Calders

A1 Journal Article in OSTEOARTHRITIS AND CARTILAGE

Blood transcriptomics to facilitate diagnosis and stratification in pediatric rheumatic diseases : a proof of concept study

My Kieu HaEsther BartholomeusLuc Van OsJulie DandelooyJulie LeysenOlivier AertsVasiliki SiozopoulouEline De SmetJan GielenKhadija Guerti et al.

A1 Journal Article in PEDIATRIC RHEUMATOLOGY

Development of radiographic classification criteria for hand osteoarthritis : a methodological report (phase 2)

Ida K HaugenDavid FelsonAbhishek AbhishekFrancis BerenbaumJohn James EdwardsGabriel Herrero BeaumontMerete Hermann-EriksenCatherine L HillMariko IshimoriHelgi Jonsson et al.

A1 Journal Article in RMD OPEN

Ultrasonography of inflammatory and structural lesions in hand osteoarthritis : an outcome measures in rheumatology agreement and reliability study

Alexander MathiessenHilde B. HammerLene TerslevMarion C. KortekaasMaria A. D’AgostinoIda K. HaugenGeorge A. BruynGeorgios FilippouEmilio FilippucciMargreet Kloppenburg et al.

A1 Journal Article in ARTHRITIS CARE & RESEARCH

Very low prevalence of ultrasound-detected tenosynovial abnormalities in healthy subjects throughout the age range : OMERACT ultrasound minimal disease study

Jeanette TrickeyIlfita SahbudinMads Ammitzbøll-DanielsenIrene AzzolinCarina BorstAlessandra BortoluzziGeorge AW BruynPhilippe CarronCoziana CiurtinGeorgios Filippou et al.

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

2021

Core outcome measurement instrument selection for physical function in hand osteoarthritis using the OMERACT Filter 2.1 process

Féline P.B. KroonDésirée van der HeijdeLara J. MaxwellDorcas E. BeatonAbishek AbishekFrancis BerenbaumFrancisco J. BlancoPhilip G. ConaghanKrysia DziedzicCatherine L. Hill et al.

A1 Journal Article in SEMINARS IN ARTHRITIS AND RHEUMATISM

Methotrexate treatment in hand osteoarthritis refractory to usual treatments : a randomised, double-blind, placebo-controlled trial

Stéphanie FerreroRuth WittoekEdem AlladoCoralie CruzelEric FontasVeronique BreuilLiana ZieglerJoel KremerDamien LoeuilleChristian H. Roux

A1 Journal Article in SEMINARS IN ARTHRITIS AND RHEUMATISM

MRI-based synthetic CT in the detection of structural lesions in patients with suspected sacroiliitis : comparison with MRI

Lennart JansMin ChenDirk ElewautFilip Van den BoschPhilippe CarronPeggy JacquesRuth WittoekJacob L. JaremkoNele Herregods

A1 Journal Article in RADIOLOGY

Topographical analysis of structural lesions between dominant and non-dominant hands in erosive osteoarthritis

Edem AlladoRuth WittoekEliane AlbuissonStephanie FerreroBruno ChenuelIsabelle Chary-ValckenaereChristian RouxDamien Loeuille

A1 Journal Article in RHEUMATOLOGY INTERNATIONAL

2020

Assessment of structural lesions, synovitis and bone marrow lesions in erosive hand osteoarthritis on MRI (0.3T) compared to the radiographic anatomical Verbruggen-Veys score

Edem AlladoRuth WittoekStephanie FerreroEliane AlbuissonIsabelle Chary-ValckenaereChristian RouxDamien Loeuille

A1 Journal Article in PLOS ONE

Correction to: Prevalence of musculoskeletal complaints in urban communities in multi-ethnic Suriname : a cross-sectional study with the COPCORD methodology (stage 1, phase 1 and 2)

N. Ho-A-ThamY. VanlandewijckL. De DonderRuth WittoekB. Ting-A-KeeR. BasantramW. Dankaerts

Development of classification criteria for hand osteoarthritis : comparative analyses of persons with and without hand osteoarthritis

Ida K. HaugenDavid T. FelsonAbhishek AbhishekFrancis BerenbaumSita Bierma-ZeinstraTove BorgenGabriel Herrero BeaumontMariko IshimoriHelgi JonssonFeline P. B. Kroon et al.

A1 Journal Article in RMD OPEN

Etanercept therapy leads to reductions in matrix metalloproteinase-3 in patients with erosive hand osteoarthritis

Féline PB KroonAnne C Bay-JensenRuth WittoekAugust VerbruggenJoseph S SmolenMargreet KloppenburgRoberta Ramonda

A1 Journal Article in SCANDINAVIAN JOURNAL OF RHEUMATOLOGY

Influence of non-steroidal anti-inflammatory drugs on the inflammatory sonographic features in erosive hand osteoarthritis : an intervention study

Qun Xia XuRuth Wittoek

A2 Journal Article in RHEUMATOLOGY ADVANCES IN PRACTICE

Natural disease progression in finger osteoarthritis : results from a 10 year follow-up cohort

Tine VanhaverbekeLisa PardaensRuth Wittoek

A1 Journal Article in SCANDINAVIAN JOURNAL OF RHEUMATOLOGY

Prevalence of musculoskeletal complaints in urban communities in multi-ethnic Suriname : a cross-sectional study with the COPCORD methodology (stage 1, phase 1 and 2)

N. Ho-A-ThamY. VanlandewijckL. de DonderRuth WittoekB. Ting-A-KeeR. BasantramW. Dankaerts

A1 Journal Article in CLINICAL RHEUMATOLOGY

Responses to 'Bio-optimized Curcuma longa extract is efficient on knee osteoarthritis pain : a double-blind multicenter randomized placebo controlled three-arm study' : authors’ reply

Yves HenrotinAnne-Françoise DonneauKurt de VlamRuth WittoekFrank Luyten

A1 Journal Article in ARTHRITIS RESEARCH & THERAPY

2019

Bio-optimized Curcuma longa extract is efficient on knee osteoarthritis pain : a double-blind multicenter randomized placebo controlled three-arm study

Y. HenrotinM. MalaiseRuth WittoekK. de VlamJ.-P. BrasseurF. P. LuytenQ. JiangangM. Van den BergheR. UhodaJ. Bentin et al.

A1 Journal Article in ARTHRITIS RESEARCH & THERAPY

Diet-induced weight loss alone or combined with exercise in overweight or obese people with knee osteoarthritis : a systematic review and metaanalysis

Michelle HallBirgit CasteleinRuth WittoekPatrick CaldersAns Van Ginckel

A1 Journal Article in SEMINARS IN ARTHRITIS AND RHEUMATISM

Efficacy of bio-optimised curcuma extract (FLEXOFYTOL®) for painful knee osteoarthritis : data from copra, a multicenter randomised controlled study

Yves HenrotinMichel MalaiseRuth WittoekKurt De VlamJean P BrasseurFrank LuytenQ JiangangMarthe Van den BergheR UhodaJacques Bentin et al.

Methotrexate in patients with hand erosive osteoarthritis refractory to usual treatments : a randomized, double-blind, placebo-controlled trial

Stéphanie FerreroRuth WittoekEdem AlladoCoralie CruzelVéronique BreuilLiana Euller ZieglerDamien Damien LoeuilleChristian RouxJoel Kremer

Methotrexate in patients with hand osteoarthritis refractory to analgesics : a randomised, double-blind, placebo controlled trial

Stéphanie FerreroRuth WittoekAdem AlladoEric FontasCoralie CruzelLiana Euller ZieglerDamien LoeuilleChristian Roux

Natural disease progression in hand osteoarthritis : results from a Belgian ten-years prospective cohort study

Lisa PardaensTine VanhaverbekeJordy Vander CruyssenRuth Wittoek

Natural disease progression in hand osteoarthritis : results from a Belgian ten-years prospective cohort study

Lisa PardaensTine VanhaverbekeJordy VandercruyssenRuth Wittoek

Phase IIa, placebo-controlled, randomised study of lutikizumab, an anti-interleukin-1α and anti-interleukin-1β dual variable domain immunoglobulin, in patients with erosive hand osteoarthritis

Margreet KloppenburgCharles PeterfyIda K HaugenFéline KroonSu ChenLi WangWei LiuGwen LevyRoy M FleischmannFrancis Berenbaum et al.

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

Predictors of radiographic progression in hand osteoarthritis : a ten-years prospective cohort study

Tine VanhaverbekeLisa PardaensRuth Wittoek

Repetitive knee bending and synovitis in individuals at risk of and with knee osteoarthritis : data from the Foundation for the National Institutes of Health Osteoarthritis Biomarkers Consortium

Ans Van GinckelRuth WittoekSophie De MitsPatrick Calders

A1 Journal Article in ARTHRITIS CARE & RESEARCH

Report from the Hand Osteoarthritis Working Group at OMERACT 2018 : update on core instrument set development

Ruth WittoekFéline PB KroonBurak KundakciAbhishek AbhishekIda K HaugenFrancis BerenbaumPhilip G ConaghanMariko L IshimoriWilma SmeetsDésirée van der Heijde et al.

A1 Journal Article in JOURNAL OF RHEUMATOLOGY

RORγt inhibition selectively targets IL-17 producing iNKT and γδ-T cells enriched in Spondyloarthritis patients

Koen VenkenPeggy JacquesCéline MortierMark E. LabadiaTine DecruyJulie CoudenysKathleen HoytAnita L. WayneRobert HughesMichael Turner et al.

A1 Journal Article in NATURE COMMUNICATIONS

The influence of non-steroidal anti-inflammatory drugs on inflammatory sonographic features in erosive hand osteoarthritis

Xiaxia XuRuth Wittoek

Very low prevalence of ultrasound determined tendon abnormalities in healthy subjects throughout the age range : an outcome measures in rheumatology (OMERACT) ultrasound minimal disease study

Jeanette TrickeyIlfita SahbudinAlessandra BortoluzziAnnamaria IagnoccoCarlos PinedaCesar Sifuentes-CantuCoziana CiurtinCristina Reategui-SokolovaDaniela FodorEsperanza Naredo et al.

2018

2018 update of the EULAR recommendations for the management of hand osteoarthritis

Margreet KloppenburgFéline PB KroonFrancisco J BlancoMichael DohertyKrysia S DziedzicElsie GreibrokkIda K HaugenGabriel Herrero-BeaumontHelgi JonssonIngvild Kjeken et al.

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

Efficacy of bio-optimised curcuma extract (Flexofytol®) for painful knee osteoarthritis : data from COPRA, a multicenter randomised controlled study

Y HenrotinM MalaiseRuth WittoekK DevlamJ-P BrasseurF LuytenQ JiangangMarthe Van Den BergheR UhodaJ Bentin et al.

Etanercept in patients with inflammatory hand osteoarthritis (EHOA) : a multicentre, randomised, double-blind, placebo-controlled trial

Margreet KloppenburgRoberta RamondaKlaus BobaczWing-Yee KwokDirk ElewautTom WJ HuizingaFeline PB KroonLeonardo PunziJosef S SmolenBert Vander Cruyssen et al.

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

Immunoscintigraphic detection of tumour necrosis factor by radiolabelled certolizumab pegol in patients with erosive hand osteoarthritis : a proof-of-concept study

Ruth WittoekPhilippe CarronBieke LambertPaulien MeerssemanAugust VerbruggenFilip Van den BoschDirk Elewaut

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

Nieuwe EULAR-aanbevelingen over de behandeling van osteoartritis van de hand

Tine VanhaverbekeLisa PardaensRuth Wittoek

A2 Journal Article in ORTHO RHUMATO (NEDERLANDSE ED.)

Prevalence and risk factors of low back pain in the indigenous population of Galibi in Suriname : a cross-sectional community-based study

NB Ho-A-ThamB Ting-A-KeeN StruyfRuth WittoekY VanlandewijckW Dankaerts

2017

To be or not to be rheumatologist : survey among Belgian medical students and internal medicine trainees : what do certified rheumatologists think about the current rheumatology training program?

Ruth WittoekHerman Mielants

A1 Journal Article in CLINICAL RHEUMATOLOGY

2016

Hand-related physical function in rheumatic hand conditions : a protocol for developing a patient-reported outcome measurement instrument

Louise KlokkerCaroline B TerweeEva Ejlersen WæhrensMarius HenriksenSandra NolteGregor LieglMargreet KloppenburgRene WesthovenRuth WittoekIngvild Kjeken et al.

A1 Journal Article in BMJ OPEN

Translation of clinical problems in osteoarthritis into pathophysiological research goals

Peter M van der KraanFrancis BerenbaumFrancisco J Blancode Bari CosimoFloris LafeberEllen HaugeAdele HigginbottomAndreea Ioan-FacsinayJohn LoughlinIngrid Meulenbelt et al.

A2 Journal Article in RMD OPEN

2015

Clinical and radiological factors associated with erosive radiographic progression in hand osteoarthritis

Paulien MeerssemanCeline Van de VyverAugust VerbruggenDirk ElewautRuth Wittoek

A1 Journal Article in OSTEOARTHRITIS AND CARTILAGE

Sustained response to tocilizumab in a patient with relapsing polychondritis with aortic involvement : a case based review

REBECCA STAELVanessa SmithRuth WittoekDavid CreytensHerman Mielants

A1 Journal Article in CLINICAL RHEUMATOLOGY

2014

A challenging case of septic sacroiliitis with psoas involvement

Elke O. KrepsVanessa SmithHerman MielantsRuth Wittoek

A1 Journal Article in ACTA CLINICA BELGICA

2013

3 T DCE-MRI assessment of synovitis of the interphalangeal joints in patients with erosive osteoarthritis for treatment response monitoring

Lennart JansTineke De ConinckRuth WittoekVALERIE LAMBRECHTWouter HuysseAugust VerbruggenKoenraad Verstraete

A1 Journal Article in SKELETAL RADIOLOGY

2012

Predictors of functional impairment and pain in erosive osteoarthritis of the interphalangeal joints: comparison with controlled inflammatory arthritis

Ruth WittoekBert Vander CruyssenAugust Verbruggen

A1 Journal Article in ARTHRITIS AND RHEUMATISM

Tumour necrosis factor blockade for the treatment of erosive osteoarthritis of the interphalangeal finger joints : a double blind, randomised trial on structure modification

August VerbruggenRuth WittoekBert Vander CruyssenDirk Elewaut

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

2011

Reliability and construct validity of ultrasonography of soft tissue and destructive changes in erosive osteoarthritis of the interphalangeal finger joints: a comparison with MRI

Ruth WittoekLennart JansVALERIE LAMBRECHTPhilippe CarronKoenraad VerstraeteAugust Verbruggen

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

2010

Beyond the scope of erosive osteoarthritis of the interphalangeal finger joints: new insights from epidemiological, clinical and imaging based studies

Ruth WittoekAugust VerbruggenDirk Elewaut

Morbid anatomy of 'erosive osteoarthritis' of the interphalangeal finger joints : an optimised scoring system to monitor disease progression in affected joints

August VerbruggenRuth WittoekBert Vander CruyssenDirk Elewaut

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

Structural and inflammatory sonographic findings in erosive and non-erosive osteoarthritis of the interphalangeal finger joints

Ruth WittoekPhilippe CarronAugust Verbruggen

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

2009

Classification models for disease: the effect of associations between markers on calculating the risk for disease by likelihood ratio products

Ruth WittoekFilip De KeyserA BoonenKurt de VlamNathan VastesaegerHerman MielantsBert Vander Cruyssen

A1 Journal Article in CLINICAL AND EXPERIMENTAL RHEUMATOLOGY

Clinical assessment in the spondyloarthropathies

Ruth WittoekHerman Mielants

A1 Journal Article in Advances in Experimental Medicine and Biology

Correlation between FIHOA and AUSCAN and radiographic damage in patients with osteoarthritis of the hands

Ruth WittoekAugust Verbruggen

Cross-cultural adaptation of the Dutch version of the functional index for hand osteoarthritis (FIHOA)and a study on its construct validity

Ruth WittoekBert Vander CruyssenE MaheuAugust Verbruggen

A1 Journal Article in OSTEOARTHRITIS AND CARTILAGE

2008

Agreement between evidence and Belgian rheumatologists' experience on HLA B27 determination in patients with specific imaging features in ankylosing spondylitis

Ruth WittoekKurt De VlamR FRANCOISL GOTLIEBJ LENAERTSFilip Van den BoschHerman Mielants

Agreement between evidence and Belgian rheumatologists' experience on the use of DMARDs for arthritis and/or enthesitis in ankylosing spondylitis

Ruth WittoekKurt De VlamR FRANCOISL GOTLIEBJ LENAERTSFilip Van den BoschHerman Mielants

Correlation between FIHOA and AUSCAN and radiographic damage in patients with osteoarthritis of the hands

Ruth WittoekAugust Verbruggen

Prediction models for disease: The effect of associations between markers on calculating the risk for disease by likelihood ratio products in SpA

Bert Vander CruyssenRuth WittoekA BOONENKurt De VlamN VASTESAEGERW NOELHerman MielantsFilip De Keyser

Spontaneous amelioration in early RA: Role of antibody profiles in predicting decrease of disease activity

Bert Vander CruyssenAMM MILTENBURGFilip Van den BoschJ HOUBIERSRuth WittoekAMH BOOTSFilip De Keyser

2007

Decrease of disease activity under ineffective therapy in DMARD-naive patients with early rheumatoid arthritis: Role of antibody profiles and carriage of the HLA shared epitope in predicting decrease of disease activity

BERT VANDER CRUYSSENAMM MILTENBURGFilip Van den BoschJGA HOUBIERSRuth WittoekAMH BOOTSFilip De Keyser

A1 Journal Article in JOURNAL OF RHEUMATOLOGY

Osteochondral repair in synovial joints

August VerbruggenRuth WittoekSara GroeneboerBert Vander CruyssenStefan GoemaereDirk Elewaut

A1 Journal Article in CURRENT OPINION IN RHEUMATOLOGY