Research Explorer

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Researcher

Roberta Guagliardo

8 Results

2022

A lipid nanoparticle platform for mRNA delivery through repurposing of cationic amphiphilic drugs

Bram BogaertFelix SauvageRoberta GuagliardoCristina Muntean[missing] Van Phuc NguyenEline PottieMike WelsAn-Katrien MinnaertRiet De RyckeQiangbing Yang et al.

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

2021

Surfactant protein B promotes cytosolic SiRNA delivery by adopting a virus-like mechanism of action

Roberta GuagliardoLore HermanJelle PendersAgata ZamborlinHerlinde De KeersmaeckerThijs Van de VyverSandrine VerstraetenPieterjan MerckxMarie-Paule Mingeot-LeclercqMercedes Echaide et al.

A1 Journal Article in ACS NANO

2020

Beyond the surface : unraveling the intracellular mechanism behind surfactant protein B (SP-B) mediated siRNA delivery

Roberta GuagliardoKoen RaemdonckStefaan De Smedt

Cationic amphiphilic drugs boost the lysosomal escape of small nucleic acid therapeutics in a nanocarrier-dependent manner

Thijs Van de VyverBram BogaertLynn De BackerFreya JorisRoberta GuagliardoJelter Van HoeckPieterjan MerckxSerge Van CalenberghSrinivas RamishettiDan Peer et al.

A1 Journal Article in ACS NANO

Lyophilization and nebulization of pulmonary surfactant-coated nanogels for siRNA inhalation therapy

Pieterjan MerckxJoris LammensGust NuyttenBram BogaertRoberta GuagliardoTania MaesChris VervaetThomas De BeerStefaan De SmedtKoen Raemdonck

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

2019

Nanocarrier lipid composition modulates the impact of pulmonary surfactant protein B (SP-B) on cellular delivery of siRNA

Roberta GuagliardoPieterjan MerckxAgata ZamborlinLynn De BackerMercedes EchaideJesus Pérez-GilStefaan De SmedtKoen Raemdonck

A1 Journal Article in PHARMACEUTICS

2018

Pulmonary surfactant and drug delivery : focusing on the role of surfactant proteins

Roberta GuagliardoJésus Pérez-GilStefaan De SmedtKoen Raemdonck

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Surfactant protein B (SP-B) enhances the cellular siRNA delivery of proteolipid coated nanogels for inhalation therapy

Pieterjan MerckxLynn De BackerLien Van HoeckeRoberta GuagliardoMercedes EchaidePieter BaatsenBárbara OlmedaXavier SaelensJésus Pérez-GilStefaan De Smedt et al.

A1 Journal Article in ACTA BIOMATERIALIA