Research Explorer

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Researcher

Rob De Vreese

Awards & Distinctions

19 Results

2019

Selective pharmacological inhibitors of HDAC6 reveal biochemical activity but functional tolerance in cancer models

Yves DepetterSilke GeursRob De VreeseSophie GoethalsElien VandoornAlien LaevensJonas SteenbruggeEvelyne MeyerPascal de TullioMarc Bracke et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF CANCER

2018

Assessment of the trifluoromethyl ketone functionality as an alternative zinc-binding group for selective HDAC6 inhibition

Yves DepetterSilke GeursFlore Vanden BusscheRob De VreeseJorick FranceusTom DesmetOlivier De WeverMatthias D'hooghe

A1 Journal Article in MEDCHEMCOMM

2017

Exploration of thiaheterocyclic hHDAC6 inhibitors as potential antiplasmodial agents

Rob De VreeseCarmen de KockPeter J SmithKelly ChibaleMatthias D'hooghe

A1 Journal Article in FUTURE MEDICINAL CHEMISTRY

Synthesis and applications of benzohydroxamic acid-based histone deacetylase inhibitors

Rob De VreeseMatthias D'hooghe

A1 Journal Article in EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of bis-8-hydroxyquinolines via an imination or a Suzuki-Miyaura coupling approach

Rob De VreeseKoen MuylaertCédric MatonLise DereuFrederique TaillieuThomas HarthRik Van DeunHenk VrielinckChristian StevensMatthias D'hooghe

A1 Journal Article in TETRAHEDRON LETTERS

Synthesis of potent and selective HDAC6 inhibitors bearing a cyclohexane- or cycloheptane-annulated 1,5-benzothiazepine scaffold

Rob De VreeseLisa GalleYves DepetterJorick FranceusTom DesmetKristof Van HeckeVeronick BenoyLudo Van Den BoschMatthias D'hooghe

A1 Journal Article in CHEMISTRY-A EUROPEAN JOURNAL

Synthesis of thiaheterocyclic benzohydroxamic acids and evaluation of their HDAC6 inhibitory activity

Rob De VreeseMatthias D'hooghe

2016

Converting bulk sugars into prebiotics : semirational design of a transglucosylase with controlled selectivity

Tom VerhaegheKarel De WinterMagali BerlandRob De VreeseMatthias D'hoogheBernard OffmannTom Desmet

A1 Journal Article in CHEMICAL COMMUNICATIONS

Synthesis and SAR assessment of novel Tubathian analogs in the pursuit of potent and selective HDAC6 inhibitors

Rob De VreeseYves DepetterTom VerhaegheTom DesmetVeronick BenoyWanda HaeckLudo Van Den BoschMatthias D'hooghe

A1 Journal Article in ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis and biological assessment of novel N-(hydroxy/methoxy)alkyl β-enaminone curcuminoids

Mr. Atiruj TheppawongRob De VreeseLore VanneckeCharlotte GrootaertJohn Van CampMatthias D'hooghe

A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of novel curcuminoids accommodating a central β-enaminone motif and their impact on cell growth and oxidative stress

Rob De VreeseCharlotte GrootaertSander D'hooreMr. Atiruj TheppawongSam Van DammeMaarten Van BogaertJohn Van CampMatthias D'hooghe

A1 Journal Article in EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

2015

Synthesis of benzothiophene-based hydroxamic acids as potent and selective HDAC6 inhibitors

Rob De VreeseNicholas Van SteenTom VerhaegheTom DesmetNadia BougarneKarolien De BosscherVeronick BenoyWanda HaeckLudo Van Den BoschMatthias D'hooghe

A1 Journal Article in CHEMICAL COMMUNICATIONS

Synthesis of novel thymine-β-lactam hybrids and evaluation of their anti-tumor activity

Nicola PiensRob De VreeseNympha De NeveKristof Van HeckeJan BalzariniNorbert De KimpeMatthias D'hooghe

2014

Engineering the specificity of trehalose phosphorylase as a general strategy for the production of glycosyl phosphates

Chao ChenJef Van der BorghtRob De VreeseMatthias D'hoogheWim SoetaertTom Desmet

A1 Journal Article in CHEMICAL COMMUNICATIONS

Synthesis of novel thymine-β-lactam hybrids and evaluation of their anti-tumor activity

Nicola PiensRob De VreeseNympha De NeveKristof Van HeckeJan BalzariniNorbert De KimpeMatthias D'hooghe

Synthesis of novel thymine-β-lactam hybrids and evaluation of their anti-tumor activity

Nicola PiensRob De VreeseNympha De NeveKristof Van HeckeJan BalzariniNorbert De KimpeMatthias D'hooghe

A1 Journal Article in SYNTHESIS-STUTTGART

2013

Potent and selective HDAC6 inhibitory activity of N-(4-hydroxycarbamoylbenzyl)-1,2,4,9-tetrahydro-3-thia-9-azafluorenes as novel sulfur analogues of Tubastatin A

Rob De VreeseTom VerhaegheTom DesmetMatthias D'hooghe

A1 Journal Article in CHEMICAL COMMUNICATIONS

2012

Design, synthesis and antiviral evaluation of purine-β-lactam and purine-aminopropanol hybrids

Matthias D'hoogheKaren MolletRob De VreeseTim JonckersGéry DamsNorbert De Kimpe

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

N-Heterocyclic carbene/Brønsted acid cooperative catalysis as a powerful tool in organic synthesis

Rob De VreeseMatthias D'hooghe

A1 Journal Article in BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY