Research Explorer

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Researcher

Ria Roelandt

Awards & Distinctions

26 Results

2024

Neoantigen-targeted dendritic cell vaccination in lung cancer patients induces long-lived T cells exhibiting the full differentiation spectrum

Joline IngelsLaurenz De CockDieter StevensRupert MayerFabien Henri TheryGuillem Sanchez SanchezDavid VermijlenKarin WeeningSaskia De SmetNele Lootens et al.

A1 Journal Article in CELL REPORTS MEDICINE

TL1A and IL-18 synergy promotes GM-CSF-dependent thymic granulopoiesis in mice

Mario Ruiz PérezChristian MaueröderWolf SteelsBruno VerstraetenSahine LameireWei XieLaura WyckaertJelle HuysentruytTatyana DivertRia Roelandt et al.

A1 Journal Article in CELLULAR & MOLECULAR IMMUNOLOGY

Type 1 immunity enables neonatal thymic ILC1 production

Peter TougaardMario Ruiz PérezWolf SteelsJelle HuysentruytBruno VerstraetenJessica VettersTatyana DivertAmanda GonçalvesRia RoelandtNozomi Takahashi et al.

A1 Journal Article in SCIENCE ADVANCES

2023

Ferroptosis and pyroptosis signatures in critical COVID-19 patients

Cédric PelemanSamya Van CoillieSymen LigthartSze Men ChoiJan De WaelePieter DepuydtDominique BenoitHANNAH SCHAUBROECKSven M. FrancqueKarolien Dams et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

LXR signaling controls homeostatic dendritic cell maturation

Victor BosteelsSandra MaréchalClint De NolfSofie RennenJonathan MaelfaitSimon TavernierJessica VettersEvelien Van De VeldeFarzaneh FayazpourKim Deswarte et al.

A1 Journal Article in SCIENCE IMMUNOLOGY

2022

Executioner caspases 3 and 7 are dispensable for intestinal epithelium turnover and homeostasis at steady state

Farzaneh GhazaviJelle HuysentruytJordy De ConinckStephanie KourulaSofie MartensBehrouz HassanniaTim WartewigTatyana DivertRia RoelandtBastian Popper et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting ferroptosis protects against experimental (multi)organ dysfunction and death

Samya Van CoillieEmily Van SanInes GoetschalckxBartosz WiernickiBanibrata MukhopadhyayWulf TonnusSze Men ChoiRia RoelandtCatalina DumitrascuLudwig Lamberts et al.

A1 Journal Article in NATURE COMMUNICATIONS

2021

MLKL in cancer : more than a necroptosis regulator

Sofie MartensJolien BridelanceRia RoelandtPeter VandenabeeleNozomi Takahashi

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Punching holes in cellular membranes : biology and evolution of gasdermins

Elke De SchutterRia RoelandtFranck RiquetGuy Van CampAndy WullaertPeter Vandenabeele

A1 Journal Article in TRENDS IN CELL BIOLOGY

Targeting ferroptosis protects against multiorgan dysfunction and death

Tom Vanden BergheSamya Van CoillieInes GoetschalckxBartosz WiernickiBanibrata MukhopadhyayWulf TonnusEmily Van SanSze Men ChoiRia RoelandtCatalina Dumitrascu et al.

2019

Delivery of mixed-lineage kinase domain-like protein by vapor nanobubble photoporation induces necroptotic-like cell death in tumor cells

Lien Van HoeckeLaurens RaesStephan StremerschToon BransJuan FraireRia RoelandtWim DeclercqPeter VandenabeeleKoen RaemdonckKevin Braeckmans et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Epithelial HMGB1 delays skin wound healing and drives tumor initiation by priming neutrophils for NET formation

Esther HosteChristian MaueröderLisette Van HoveLeen CatrysseHanna-Kaisa VikkulaMozes SzeBastiaan MaesDyah KarjosukarsoLiesbet MartensAmanda Gonçalves et al.

A1 Journal Article in CELL REPORTS

Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation

Yves DondelingerTom DelangheDario PriemMeghan A Wynosky-DolfiDaniel SorobeteaDiego Rojas RiveraPiero GiansantiRia RoelandtJulia GropengiesserKlaus Ruckdeschel et al.

A1 Journal Article in NATURE COMMUNICATIONS

Synthesis and evaluation of novel benzotropolones as Atg4B inhibiting autophagy blockers

Muhammet TancMatthias CleenewerckAmmar KurdiRia RoelandtWim DeclercqGuido De MeyerKoen AugustynsWim MartinetPieter Van der Veken

A1 Journal Article in BIOORGANIC CHEMISTRY

2018

MLKL reveals its friendly face : a role in nerve regeneration

Peter VandenabeeleWim DeclercqRia RoelandtTom Vanden Berghe

Editorial material

Nuclear RIPK3 and MLKL contribute to cytosolic necrosome formation and necroptosis

Kathrin WeberRia RoelandtInge BruggemanYann EstornesPeter Vandenabeele

A1 Journal Article in COMMUNICATIONS BIOLOGY

2017

When PERK inhibitors turn out to be new potent RIPK1 inhibitors : critical issues on the specificity and use of GSK2606414 and GSK2656157

Diego Rojas RiveraTinneke DelvaeyeRia RoelandtWim NerinckxKoen AugustynsPeter VandenabeeleMathieu Bertrand

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

2016

Inhibitor screening and enzymatic activity determination for autophagy target Atg4B using a gel electrophoresis-based assay

Matthias CleenewerckMandy OJ GrootaertRafaela GladyszYves AdriaenssensRia RoelandtJurgen JoossensAnne-Marie LambeirGuido RY De MeyerWim DeclercqKoen Augustyns et al.

A1 Journal Article in EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

2014

Depletion of RIPK3 or MLKL blocks TNF-driven necroptosis and switches towards a delayed RIPK1 kinase-dependent apoptosis

Quinten RemijsenVera GoossensSasker GrootjansC Van den HauteNele VanlangenakkerYves DondelingerRia RoelandtInge BruggemanAmanda GonçalvesMathieu Bertrand et al.

A1 Journal Article in CELL DEATH & DISEASE

Deregulation of the replisome factor MCMBP prompts oncogenesis in colorectal carcinomas through chromosomal instability

Mauricio Quimbaya GomezEric RaspéGeertrui DeneckerBram De CraeneRia RoelandtWim DeclercqXavier SagaertLieven De VeylderGeert Berx

A1 Journal Article in NEOPLASIA

MLKL compromises plasma membrane integrity by binding to phosphatidylinositol phosphates

Yves DondelingerWim DeclercqSylvie MontessuitRia RoelandtAmanda GonçalvesInge BruggemanPaco HulpiauKathrin WeberClark A SehonRobert W Marquis et al.

A1 Journal Article in CELL REPORTS

Simultaneous targeting of IL-1 and IL-18 is required for protection against inflammatory and septic shock

Tom Vanden BergheDieter DemonPieter BogaertBenjamin VandendriesscheAlain GoethalsBart DepuydtMarnik VuylstekeRia RoelandtElien Van WonterghemJill Vandenbroecke et al.

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

2012

Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models

Nozomi TakahashiLinde DuprezSasker GrootjansAnje CauwelsWim NerinckxJB DuHadawayVera GoossensRia RoelandtFilip Van HauwermeirenClaude Libert et al.

A1 Journal Article in CELL DEATH & DISEASE

2011

Caspase-14 is required for filaggrin degradation to natural moisturizing factors in the skin

Esther HostePatrick KempermanMichael DevosGeertrui DeneckerSanja KezicNico YauBarbara GilbertSaskia LippensPhilippe De GrooteRia Roelandt et al.

A1 Journal Article in JOURNAL OF INVESTIGATIVE DERMATOLOGY

cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4)

Mathieu BertrandSaskia LippensAn StaesBarbara GilbertRia RoelandtJelle De MedtsKris GevaertWim DeclercqPeter Vandenabeele

A1 Journal Article in PLOS ONE

2010

Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria

Ellen WirawanLieselotte Vande WalleKristof KersseSigrid CornelisS ClaerhoutIsabel VanoverbergheRia RoelandtRiet De RyckeJelle VerspurtenWim Declercq et al.

A1 Journal Article in CELL DEATH & DISEASE