Research Explorer

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Researcher

Rein Verbeke

Publications & Research Data

Awards & Distinctions

46 Results

2026

High-throughput quantification of spike protein expression by LC–MS for mRNA-LNP evaluation and immune response profiling

Ruben AlmeyKevin MwangiAmélie De MaesschalckThomas EhouarneSieglinde De CaePathmanaban RamasamyMarijn Van HulleIne LentackerBert SchepensDieter Deforce et al.

A1 Journal Article in ANALYTICAL CHEMISTRY

Lipid-stabilized ICG nanoaggregates for the photodisruption of vitreous opacities

Pouria RamezaniJan FélixYera UssembayevMariana Hugo Borges Barreto SilvaIne LentackerRein VerbekeKevin BraeckmansStefaan De SmedtFélix Sauvage

A1 Journal Article in MATERIALS TODAY BIO

Protocol to annotate dendritic cell maturation types in vivo making use of lipid nanoparticle-based

Karo Van LilJanne SwinnenGreta WebbSofie RennenVictor BosteelsSandra MaréchalClint De NolfJessica VettersJiri BrezinaEvelien Van De Velde et al.

A2 Journal Article in STAR PROTOCOLS

2025

A historical overview on mRNA vaccine development

Rein VerbekeMiffy H.Y. ChengPieter C. Cullis

Bookchapter in Trends in mRNA vaccine research

Challenges and opportunities in mRNA vaccine development against bacteria

Ilke AernoutRein VerbekeFabien Henri TheryPatrick WillemsUri EliaStefaan De SmedtRino RappuoliDan PeerFrancis ImpensIne Lentacker

A1 Journal Article in NATURE MICROBIOLOGY

Current state of mRNA vaccine development against Mycobacterium tuberculosis

Ilke AernoutRein VerbekeStefaan De SmedtFrancis ImpensIne Lentacker

Bookchapter in Trends in mRNA vaccine research

Immunopeptidomics identified antigens for mRNA-lipid nanoparticle vaccines with alpha-galactosylceramide in multiple myeloma therapy

Arne van der VrekenFabien Henri TheryChenggong TuKevin MwangiSofie MeulewaeterLien De BeckEdith JanssensKim De VeirmanKarin VanderkerkenElke De Bruyne et al.

A1 Journal Article in JOURNAL FOR IMMUNOTHERAPY OF CANCER

Lipid nanoparticles as a tool to dissect dendritic cell maturation pathways

Sofie RennenVictor BosteelsClint De NolfGreta WebbKaro Van LilSandra MaréchalJessica VettersEvelien Van De VeldeFarzaneh FayazpourRia Roelandt et al.

Lipid nanoparticles as a tool to dissect dendritic cell maturation pathways

Sofie RennenVictor BosteelsClint De NolfSandra MaréchalJessica VettersKaro Van LilGreta WebbJanne SwinnenEvelien Van De VeldeFarzaneh Fayazpour et al.

A1 Journal Article in CELL REPORTS

Lipid-stabilized ICG nanoaggregates for the photodisruption of vitreous opacities

Pouria RamezaniJan FélixMariana Hugo Borges Barreto SilvaIne LentackerRein VerbekeKevin BraeckmansStefaan De SmedtFélix Sauvage

mRNA galsomes vaccine protects budgerigars against virulent Chlamydia psittaci challenge

Anne De MeystJoeri Van MieghemKoen ChiersKoen RaemdonckRein VerbekeIne LentackerDaisy Vanrompay

A1 Journal Article in VACCINES

Preclinical toxicological assessment of an α-galactosylceramide-adjuvanted mRNA cancer vaccine in Wistar Han rats and domestic pigs

Sofie MeulewaeterMargo De VelderDiethard ReckelbusKevin MwangiThomas EhouarneIlke AernoutYanou EngelenFëllanza HalimiIsis Van herteryckLobke De Bels et al.

A1 Journal Article in MOLECULAR THERAPY METHODS & CLINICAL DEVELOPMENT

2024

Alpha-galactosylceramide improves the potency of mRNA LNP vaccines against cancer and intracellular bacteria

Sofie MeulewaeterIlke AernoutJoke DeprezYanou EngelenMargo De VelderLorenzo FranceschiniKarine BreckpotSerge Van CalenberghCaroline AsselmanKatie Boucher et al.

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Considerations on the design of lipid-based mRNA vaccines against cancer

Sofie MeulewaeterYao ZhangAbishek WadhwaKevin FoxIne LentackerKenneth W. HarderPieter R. CullisStefaan De SmedtMiffy H.Y. ChengRein Verbeke

A1 Journal Article in JOURNAL OF MOLECULAR BIOLOGY

Immunopeptidomics mapping of Listeria monocytogenes T cell epitopes in mice

Adillah GulLecia L. PewePatrick WillemsRupert MayerFabien Henri TheryCaroline AsselmanIlke AernoutRein VerbekeDenzel EggermontLaura Van Moortel et al.

A1 Journal Article in MOLECULAR & CELLULAR PROTEOMICS

TCR transgenic clone selection guided by immune receptor analysis and single-cell RNA expression of polyclonal responders

Nincy DebeufSahine LameireManon VanheerswynghelsJulie DeckersCaroline De WolfWendy ToussaintRein VerbekeKevin VerstaenHamida HammadStijn Vanhee et al.

A2 Journal Article in ELIFE

The role of mRNA-galsomes and LNPs in enhancing HIV-specific T cell responses across various lymphoid organs

Sigrid D’haeseSabine den RooverRein VerbekeIlke AernoutSofie MeulewaterJoëlle CosynsJessy MeertSarah VanbellingenThessa LaeremansIne Lentacker et al.

A1 Journal Article in MOLECULAR THERAPY NUCLEIC ACIDS

2023

Continuous freeze-drying of messenger RNA lipid nanoparticles enables storage at higher temperatures

Sofie MeulewaeterGust NuyttenMiffy H.Y. ChengStefaan De SmedtPieter R. CullisThomas De BeerIne LentackerRein Verbeke

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Nanobody-mediated SPECT/CT imaging reveals the spatiotemporal expression of programmed death-ligand 1 in response to a CD8+ T cell and iNKT cell activating mRNA vaccine

Thomas ErtveldtSofie MeulewaeterYannick De VlaeminckOscar OlarteKatrijn BroosSerge Van CalenberghStephanie BourgeoisJoke DeprezYves HeremansCleo Goyvaerts et al.

A1 Journal Article in THERANOSTICS

Transport by circulating myeloid cells drives liposomal accumulation in inflamed synovium

Joke DeprezRein VerbekeSofie MeulewaeterIlke AernoutHeleen DewitteTine DecruyJulie CoudenysJulie Van DuyseGert Van IsterdaelDan Peer et al.

A1 Journal Article in NATURE NANOTECHNOLOGY

2022

Exciting times for lipid nanoparticles : how Canadian discoveries are enabling gene therapies

Miffy H. Y. ChengCedric A. BrimacombeRein VerbekePieter R. Cullis

A1 Journal Article in MOLECULAR PHARMACEUTICS

Fluorine MR imaging probes dynamic migratory profiles of perfluorocarbon-loaded dendritic cells after streptozotocin-induced inflammation

Shweta SainiAn-Sofie VanherwegenSayuan LiangRein VerbekeHannelie KorfIne LentackerStefaan De SmedtConny GysemansUwe Himmelreich

A1 Journal Article in MOLECULAR IMAGING AND BIOLOGY

Immunopeptidomics-based design of mRNA vaccine formulations against Listeria monocytogenes

Rupert MayerRein VerbekeCaroline AsselmanIlke AernoutAdillah GulDenzel EggermontKatie BoucherFabien Henri TheryTeresa MaiaHans Demol et al.

A1 Journal Article in NATURE COMMUNICATIONS

Innate immune mechanisms of mRNA vaccines

Rein VerbekeMichael J. HoganKarin LoréNorbert Pardi

A1 Journal Article in IMMUNITY

2021

Covipendium : information available to support the development of medical countermeasures and interventions against COVID-19

Martine DenisValerie VandeweerdRein VerbekeAnne LaudisoitTristan ReidEmma HobbsLaure WynantsDiane Van der Vliet

A4 Journal Article in TRANSDISCIPLINARY INSIGHTS

mRNA in cancer immunotherapy : beyond a source of antigen

Lien Van HoeckeRein VerbekeHeleen DewitteIne LentackerKarim VermaelenKarine BreckpotSandra Van Lint

A1 Journal Article in MOLECULAR CANCER

mRNA-lipid nanoparticle COVID-19 vaccines : structure and stability

Linde SchoenmakerDominik WitzigmannJayesh A. KulkarniRein VerbekeGideon KerstenWim JiskootDaan J. A. Crommelin

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Strategies for controlling the innate immune activity of conventional and self-amplifying mRNA therapeutics : getting the message across

An-Katrien MinnaertHelena VanlucheneRein VerbekeIne LentackerStefaan De SmedtKoen RaemdonckNiek SandersKatrien Remaut

A1 Journal Article in ADVANCED DRUG DELIVERY REVIEWS

The dawn of mRNA vaccines : the COVID-19 case

Rein VerbekeIne LentackerStefaan De SmedtHeleen Dewitte

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

2020

Intracellular delivery of mRNA in adherent and suspension cells by vapor nanobubble photoporation

Laurens RaesStephan StremerschJuan FraireToon BransGlenn GoetgelukStijn De MunterLien Van HoeckeRein VerbekeJelter Van HoeckRanhua Xiong et al.

A1 Journal Article in NANO-MICRO LETTERS

mRNA encoding a bispecific single domain antibody construct protects against influenza A virus infection in mice

Lien Van HoeckeRein VerbekeDorien De VliegerHeleen DewitteKenny RooseSharon Van NevelOlga KryskoClaus BachertBert SchepensIne Lentacker et al.

A1 Journal Article in MOLECULAR THERAPY-NUCLEIC ACIDS

2019

Broadening the message : a nanovaccine co-loaded with messenger RNA and α-GalCer induces antitumor immunity through conventional and natural killer T cells

Rein VerbekeIne LentackerKarine BreckpotJonas JanssensSerge Van CalenberghStefaan De SmedtHeleen Dewitte

A1 Journal Article in ACS NANO

Challenges for labeling and longitudinal tracking of adoptively transferred autoreactive T lymphocytes in an experimental type-1 diabetes model

Shweta SainiHannelie KorfSayuan LiangRein VerbekeBella ManshianKoen RaemdonckIne LentackerConny GysemansStefaan De SmedtUwe Himmelreich

A1 Journal Article in MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE

Design of messenger RNA lipid nanoparticles for cancer immunotherapy

Rein VerbekeStefaan De SmedtHeleen Dewitte

Longitudinal in vivo assessment of host-microbe interactions in a murine model of pulmonary aspergillosis

Shweta SainiJennifer PoelmansHannelie KorfJames L. DooleySayuan LiangBella B. ManshianRein VerbekeStefaan J. SoenenGreetje Vande VeldeIne Lentacker et al.

A1 Journal Article in ISCIENCE

Three decades of messenger RNA vaccine development

Rein VerbekeIne LentackerStefaan De SmedtHeleen Dewitte

A1 Journal Article in NANO TODAY

2018

Optimized messenger RNA immunolipoplexes for cancer immunotherapy : balancing immunogenicity and adjuvancy

Rein VerbekeIne LentackerKarine BreckpotSerge Van CalenberghStefaan De SmedtHeleen Dewitte

Tri-modal in vivo imaging of pancreatic islets transplanted subcutaneously in mice

Sayuan LiangKarim LouchamiBryan HolvoetRein VerbekeChristophe M DerooseBella ManshianStefaan J SoenenIne LentackerUwe Himmelreich

A1 Journal Article in MOLECULAR IMAGING AND BIOLOGY

2017

Co-delivery of nucleoside-modified mRNA and immunomodulators for cancer immunotherapy: restoring the immunogenicity of immunosilent mRNA

Rein VerbekeIne LentackerLaura WayteckKarine BreckpotBenedicte DescampsChristian VanhoveStefaan De SmedtHeleen Dewitte

Co-delivery of nucleoside-modified mRNA and TLR agonists for cancer immunotherapy : restoring the immunogenicity of immunosilent mRNA

Rein VerbekeIne LentackerLaura WayteckKarine BreckpotMieke Van BockstalBenedicte DescampsChristian VanhoveStefaan De SmedtHeleen Dewitte

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

mRNA-based nanoparticles for therapeutic cancer vaccination

Rein VerbekeLaura WayteckKarine BreckpotChristian VanhoveBenedicte DescampsStefaan De SmedtHeleen DewitteIne Lentacker

2016

Particle-mediated intravenous delivery of antigen mRNA results in strong antigen-specific T-cell responses despite the induction of type I interferon

Katrijn BroosKevin VanderjeughtJanik PuttemansCleo GoyvaertsCarlo HeirmanHeleen DewitteRein VerbekeIne LentackerKris ThielemansKarine Breckpot

A2 Journal Article in MOLECULAR THERAPY-NUCLEIC ACIDS

2015

Evaluation of mRNA lipoplexes for single-step antigen loading and maturation of dendritic cells in cancer immunotherapy

Rein VerbekeHeleen DewitteIne LentackerStefaan De Smedt

Immunogenic mRNA nanoparticles for dendritic cell-based cancer vaccination

Rein VerbekeHeleen DewitteIne LentackerStefaan De Smedt

2014

Choose your models wisely: how different murine bone marrow-derived dendritic cell protocols influence the success of nanoparticulate vaccines in vitro

Heleen DewitteRein VerbekeKarine BreckpotRoosmarijn VandenbrouckeClaude LibertStefaan De SmedtIne Lentacker

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Nanoparticle design to induce tumor immunity and challenge the suppressive tumor microenvironment

Heleen DewitteRein VerbekeKarine BreckpotStefaan De SmedtIne Lentacker

A1 Journal Article in NANO TODAY