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Researcher
Rein Verbeke
Profile
Projects
Publications & Research Data
Activities
Awards & Distinctions
Patents
43
Results
2025
A historical overview on mRNA vaccine development
Rein Verbeke
Miffy H.Y. Cheng
Pieter C. Cullis
Bookchapter
in
Trends in mRNA vaccine research
2025
Challenges and opportunities in mRNA vaccine development against bacteria
Ilke Aernout
Rein Verbeke
Fabien Henri Thery
Patrick Willems
Uri Elia
Stefaan De Smedt
Rino Rappuoli
Dan Peer
Francis Impens
Ine Lentacker
A1
Journal Article
in
NATURE MICROBIOLOGY
2025
Current state of mRNA vaccine development against Mycobacterium tuberculosis
Ilke Aernout
Rein Verbeke
Stefaan De Smedt
Francis Impens
Ine Lentacker
Bookchapter
in
Trends in mRNA vaccine research
2025
Immunopeptidomics identified antigens for mRNA-lipid nanoparticle vaccines with alpha-galactosylceramide in multiple myeloma therapy
Arne van der Vreken
Fabien Henri Thery
Chenggong Tu
Kevin Mwangi
Sofie Meulewaeter
Lien De Beck
Edith Janssens
Kim De Veirman
Karin Vanderkerken
Elke De Bruyne
et al.
A1
Journal Article
in
JOURNAL FOR IMMUNOTHERAPY OF CANCER
2025
Lipid nanoparticles as a tool to dissect dendritic cell maturation pathways
Sofie Rennen
Victor Bosteels
Clint De Nolf
Greta Webb
Karo Van Lil
Sandra Maréchal
Jessica Vetters
Evelien Van De Velde
Farzaneh Fayazpour
Ria Roelandt
et al.
Preprint
2025
Lipid nanoparticles as a tool to dissect dendritic cell maturation pathways
Sofie Rennen
Victor Bosteels
Clint De Nolf
Sandra Maréchal
Jessica Vetters
Karo Van Lil
Greta Webb
Janne Swinnen
Evelien Van De Velde
Farzaneh Fayazpour
et al.
A1
Journal Article
in
CELL REPORTS
2025
Lipid-stabilized ICG nanoaggregates for the photodisruption of vitreous opacities
Pouria Ramezani
Jan Félix
Mariana Hugo Borges Barreto Silva
Ine Lentacker
Rein Verbeke
Kevin Braeckmans
Stefaan De Smedt
Félix Sauvage
Preprint
2025
mRNA galsomes vaccine protects budgerigars against virulent Chlamydia psittaci challenge
Anne De Meyst
Joeri Van Mieghem
Koen Chiers
Koen Raemdonck
Rein Verbeke
Ine Lentacker
Daisy Vanrompay
A1
Journal Article
in
VACCINES
2025
Preclinical toxicological assessment of an α-galactosylceramide-adjuvanted mRNA cancer vaccine in Wistar Han rats and domestic pigs
Sofie Meulewaeter
Margo De Velder
Diethard Reckelbus
Kevin Mwangi
Thomas Ehouarne
Ilke Aernout
Yanou Engelen
Fëllanza Halimi
Isis Van herteryck
Lobke De Bels
et al.
A1
Journal Article
in
MOLECULAR THERAPY METHODS & CLINICAL DEVELOPMENT
2025
2024
Alpha-galactosylceramide improves the potency of mRNA LNP vaccines against cancer and intracellular bacteria
Sofie Meulewaeter
Ilke Aernout
Joke Deprez
Yanou Engelen
Margo De Velder
Lorenzo Franceschini
Karine Breckpot
Serge Van Calenbergh
Caroline Asselman
Katie Boucher
et al.
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2024
Considerations on the design of lipid-based mRNA vaccines against cancer
Sofie Meulewaeter
Yao Zhang
Abishek Wadhwa
Kevin Fox
Ine Lentacker
Kenneth W. Harder
Pieter R. Cullis
Stefaan De Smedt
Miffy H.Y. Cheng
Rein Verbeke
A1
Journal Article
in
JOURNAL OF MOLECULAR BIOLOGY
2024
Immunopeptidomics mapping of Listeria monocytogenes T cell epitopes in mice
Adillah Gul
Lecia L. Pewe
Patrick Willems
Rupert Mayer
Fabien Henri Thery
Caroline Asselman
Ilke Aernout
Rein Verbeke
Denzel Eggermont
Laura Van Moortel
et al.
A1
Journal Article
in
MOLECULAR & CELLULAR PROTEOMICS
2024
TCR transgenic clone selection guided by immune receptor analysis and single-cell RNA expression of polyclonal responders
Nincy Debeuf
Sahine Lameire
Manon Vanheerswynghels
Julie Deckers
Caroline De Wolf
Wendy Toussaint
Rein Verbeke
Kevin Verstaen
Hamida Hammad
Stijn Vanhee
et al.
A2
Journal Article
in
ELIFE
2024
The role of mRNA-galsomes and LNPs in enhancing HIV-specific T cell responses across various lymphoid organs
Sigrid D’haese
Sabine den Roover
Rein Verbeke
Ilke Aernout
Sofie Meulewater
Joëlle Cosyns
Jessy Meert
Sarah Vanbellingen
Thessa Laeremans
Ine Lentacker
et al.
A1
Journal Article
in
MOLECULAR THERAPY NUCLEIC ACIDS
2024
2023
Continuous freeze-drying of messenger RNA lipid nanoparticles enables storage at higher temperatures
Sofie Meulewaeter
Gust Nuytten
Miffy H.Y. Cheng
Stefaan De Smedt
Pieter R. Cullis
Thomas De Beer
Ine Lentacker
Rein Verbeke
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2023
Nanobody-mediated SPECT/CT imaging reveals the spatiotemporal expression of programmed death-ligand 1 in response to a CD8+ T cell and iNKT cell activating mRNA vaccine
Thomas Ertveldt
Sofie Meulewaeter
Yannick De Vlaeminck
Oscar Olarte
Katrijn Broos
Serge Van Calenbergh
Stephanie Bourgeois
Joke Deprez
Yves Heremans
Cleo Goyvaerts
et al.
A1
Journal Article
in
THERANOSTICS
2023
Transport by circulating myeloid cells drives liposomal accumulation in inflamed synovium
Joke Deprez
Rein Verbeke
Sofie Meulewaeter
Ilke Aernout
Heleen Dewitte
Tine Decruy
Julie Coudenys
Julie Van Duyse
Gert Van Isterdael
Dan Peer
et al.
A1
Journal Article
in
NATURE NANOTECHNOLOGY
2023
2022
Exciting times for lipid nanoparticles : how Canadian discoveries are enabling gene therapies
Miffy H. Y. Cheng
Cedric A. Brimacombe
Rein Verbeke
Pieter R. Cullis
A1
Journal Article
in
MOLECULAR PHARMACEUTICS
2022
Fluorine MR imaging probes dynamic migratory profiles of perfluorocarbon-loaded dendritic cells after streptozotocin-induced inflammation
Shweta Saini
An-Sofie Vanherwegen
Sayuan Liang
Rein Verbeke
Hannelie Korf
Ine Lentacker
Stefaan De Smedt
Conny Gysemans
Uwe Himmelreich
A1
Journal Article
in
MOLECULAR IMAGING AND BIOLOGY
2022
Immunopeptidomics-based design of mRNA vaccine formulations against Listeria monocytogenes
Rupert Mayer
Rein Verbeke
Caroline Asselman
Ilke Aernout
Adillah Gul
Denzel Eggermont
Katie Boucher
Fabien Henri Thery
Teresa Maia
Hans Demol
et al.
A1
Journal Article
in
NATURE COMMUNICATIONS
2022
Innate immune mechanisms of mRNA vaccines
Rein Verbeke
Michael J. Hogan
Karin Loré
Norbert Pardi
A1
Journal Article
in
IMMUNITY
2022
2021
Covipendium : information available to support the development of medical countermeasures and interventions against COVID-19
Martine Denis
Valerie Vandeweerd
Rein Verbeke
Anne Laudisoit
Tristan Reid
Emma Hobbs
Laure Wynants
Diane Van der Vliet
A4
Journal Article
in
TRANSDISCIPLINARY INSIGHTS
2021
mRNA in cancer immunotherapy : beyond a source of antigen
Lien Van Hoecke
Rein Verbeke
Heleen Dewitte
Ine Lentacker
Karim Vermaelen
Karine Breckpot
Sandra Van Lint
A1
Journal Article
in
MOLECULAR CANCER
2021
mRNA-lipid nanoparticle COVID-19 vaccines : structure and stability
Linde Schoenmaker
Dominik Witzigmann
Jayesh A. Kulkarni
Rein Verbeke
Gideon Kersten
Wim Jiskoot
Daan J. A. Crommelin
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2021
Strategies for controlling the innate immune activity of conventional and self-amplifying mRNA therapeutics : getting the message across
An-Katrien Minnaert
Helena Vanluchene
Rein Verbeke
Ine Lentacker
Stefaan De Smedt
Koen Raemdonck
Niek Sanders
Katrien Remaut
A1
Journal Article
in
ADVANCED DRUG DELIVERY REVIEWS
2021
The dawn of mRNA vaccines : the COVID-19 case
Rein Verbeke
Ine Lentacker
Stefaan De Smedt
Heleen Dewitte
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2021
2020
Intracellular delivery of mRNA in adherent and suspension cells by vapor nanobubble photoporation
Laurens Raes
Stephan Stremersch
Juan Fraire
Toon Brans
Glenn Goetgeluk
Stijn De Munter
Lien Van Hoecke
Rein Verbeke
Jelter Van Hoeck
Ranhua Xiong
et al.
A1
Journal Article
in
NANO-MICRO LETTERS
2020
mRNA encoding a bispecific single domain antibody construct protects against influenza A virus infection in mice
Lien Van Hoecke
Rein Verbeke
Dorien De Vlieger
Heleen Dewitte
Kenny Roose
Sharon Van Nevel
Olga Krysko
Claus Bachert
Bert Schepens
Ine Lentacker
et al.
A1
Journal Article
in
MOLECULAR THERAPY-NUCLEIC ACIDS
2020
2019
Broadening the message : a nanovaccine co-loaded with messenger RNA and α-GalCer induces antitumor immunity through conventional and natural killer T cells
Rein Verbeke
Ine Lentacker
Karine Breckpot
Jonas Janssens
Serge Van Calenbergh
Stefaan De Smedt
Heleen Dewitte
A1
Journal Article
in
ACS NANO
2019
Challenges for labeling and longitudinal tracking of adoptively transferred autoreactive T lymphocytes in an experimental type-1 diabetes model
Shweta Saini
Hannelie Korf
Sayuan Liang
Rein Verbeke
Bella Manshian
Koen Raemdonck
Ine Lentacker
Conny Gysemans
Stefaan De Smedt
Uwe Himmelreich
A1
Journal Article
in
MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE
2019
Design of messenger RNA lipid nanoparticles for cancer immunotherapy
Rein Verbeke
Stefaan De Smedt
Heleen Dewitte
Dissertation
2019
Longitudinal in vivo assessment of host-microbe interactions in a murine model of pulmonary aspergillosis
Shweta Saini
Jennifer Poelmans
Hannelie Korf
James L. Dooley
Sayuan Liang
Bella B. Manshian
Rein Verbeke
Stefaan J. Soenen
Greetje Vande Velde
Ine Lentacker
et al.
A1
Journal Article
in
ISCIENCE
2019
Three decades of messenger RNA vaccine development
Rein Verbeke
Ine Lentacker
Stefaan De Smedt
Heleen Dewitte
A1
Journal Article
in
NANO TODAY
2019
2018
Optimized messenger RNA immunolipoplexes for cancer immunotherapy : balancing immunogenicity and adjuvancy
Rein Verbeke
Ine Lentacker
Karine Breckpot
Serge Van Calenbergh
Stefaan De Smedt
Heleen Dewitte
C3
Conference
2018
Tri-modal in vivo imaging of pancreatic islets transplanted subcutaneously in mice
Sayuan Liang
Karim Louchami
Bryan Holvoet
Rein Verbeke
Christophe M Deroose
Bella Manshian
Stefaan J Soenen
Ine Lentacker
Uwe Himmelreich
A1
Journal Article
in
MOLECULAR IMAGING AND BIOLOGY
2018
2017
Co-delivery of nucleoside-modified mRNA and immunomodulators for cancer immunotherapy: restoring the immunogenicity of immunosilent mRNA
Rein Verbeke
Ine Lentacker
Laura Wayteck
Karine Breckpot
Benedicte Descamps
Christian Vanhove
Stefaan De Smedt
Heleen Dewitte
C3
Conference
2017
Co-delivery of nucleoside-modified mRNA and TLR agonists for cancer immunotherapy : restoring the immunogenicity of immunosilent mRNA
Rein Verbeke
Ine Lentacker
Laura Wayteck
Karine Breckpot
Mieke Van Bockstal
Benedicte Descamps
Christian Vanhove
Stefaan De Smedt
Heleen Dewitte
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2017
mRNA-based nanoparticles for therapeutic cancer vaccination
Rein Verbeke
Laura Wayteck
Karine Breckpot
Christian Vanhove
Benedicte Descamps
Stefaan De Smedt
Heleen Dewitte
Ine Lentacker
C3
Conference
2017
2016
Particle-mediated intravenous delivery of antigen mRNA results in strong antigen-specific T-cell responses despite the induction of type I interferon
Katrijn Broos
Kevin Vanderjeught
Janik Puttemans
Cleo Goyvaerts
Carlo Heirman
Heleen Dewitte
Rein Verbeke
Ine Lentacker
Kris Thielemans
Karine Breckpot
A2
Journal Article
in
MOLECULAR THERAPY-NUCLEIC ACIDS
2016
2015
Evaluation of mRNA lipoplexes for single-step antigen loading and maturation of dendritic cells in cancer immunotherapy
Rein Verbeke
Heleen Dewitte
Ine Lentacker
Stefaan De Smedt
C3
Conference
2015
Immunogenic mRNA nanoparticles for dendritic cell-based cancer vaccination
Rein Verbeke
Heleen Dewitte
Ine Lentacker
Stefaan De Smedt
C3
Conference
2015
2014
Choose your models wisely: how different murine bone marrow-derived dendritic cell protocols influence the success of nanoparticulate vaccines in vitro
Heleen Dewitte
Rein Verbeke
Karine Breckpot
Roosmarijn Vandenbroucke
Claude Libert
Stefaan De Smedt
Ine Lentacker
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2014
Nanoparticle design to induce tumor immunity and challenge the suppressive tumor microenvironment
Heleen Dewitte
Rein Verbeke
Karine Breckpot
Stefaan De Smedt
Ine Lentacker
A1
Journal Article
in
NANO TODAY
2014