Research Explorer

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Researcher

Pieterjan Merckx

Awards & Distinctions

7 Results

2021

Hydrogel-induced cell membrane disruptions enable direct cytosolic delivery of membrane-impermeable cargo

Jelter Van HoeckThijs Van de VyverAranit HarizajGlenn GoetgelukPieterjan MerckxJing LiuMike WelsFélix SauvageHerlinde De KeersmaeckerChristian Vanhove et al.

A1 Journal Article in ADVANCED MATERIALS

Surfactant protein B promotes cytosolic SiRNA delivery by adopting a virus-like mechanism of action

Roberta GuagliardoLore HermanJelle PendersAgata ZamborlinHerlinde De KeersmaeckerThijs Van de VyverSandrine VerstraetenPieterjan MerckxMarie-Paule Mingeot-LeclercqMercedes Echaide et al.

A1 Journal Article in ACS NANO

2020

Cationic amphiphilic drugs boost the lysosomal escape of small nucleic acid therapeutics in a nanocarrier-dependent manner

Thijs Van de VyverBram BogaertLynn De BackerFreya JorisRoberta GuagliardoJelter Van HoeckPieterjan MerckxSerge Van CalenberghSrinivas RamishettiDan Peer et al.

A1 Journal Article in ACS NANO

Lung surfactant-hydrogel nanocomposites for pulmonary siRNA delivery : breaching barriers for nanomedicine-based inhalation therapy

Pieterjan MerckxKoen RaemdonckStefaan De Smedt

Lyophilization and nebulization of pulmonary surfactant-coated nanogels for siRNA inhalation therapy

Pieterjan MerckxJoris LammensGust NuyttenBram BogaertRoberta GuagliardoTania MaesChris VervaetThomas De BeerStefaan De SmedtKoen Raemdonck

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

2019

Nanocarrier lipid composition modulates the impact of pulmonary surfactant protein B (SP-B) on cellular delivery of siRNA

Roberta GuagliardoPieterjan MerckxAgata ZamborlinLynn De BackerMercedes EchaideJesus Pérez-GilStefaan De SmedtKoen Raemdonck

A1 Journal Article in PHARMACEUTICS

2018

Surfactant protein B (SP-B) enhances the cellular siRNA delivery of proteolipid coated nanogels for inhalation therapy

Pieterjan MerckxLynn De BackerLien Van HoeckeRoberta GuagliardoMercedes EchaidePieter BaatsenBárbara OlmedaXavier SaelensJésus Pérez-GilStefaan De Smedt et al.

A1 Journal Article in ACTA BIOMATERIALIA