Research Explorer

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Researcher

Pieter Van Vlierberghe

Publications & Research Data

Awards & Distinctions

235 Results

2025

A human-like glutaminase-free asparaginase is highly efficacious in ASNS-low leukemia and solid cancer mouse xenograft models

Maaike Van TrimpontAmanda M. SchalkKenneth HofkensEvelien PeetersSara T'SasKatrien VandemeulebroeckeYing SuAshley De LoeraAlyssa GarciaHui Chen et al.

A1 Journal Article in CANCER LETTERS

CCR1 inhibition sensitizes multiple myeloma cells to glucocorticoid therapy

Bert LuyckxMaaike Van TrimpontFien DeclerckEleni StaessensAnnick VerheeSara T'SasSven EyckermanFritz OffnerPieter Van VlierbergheSteven Goossens et al.

A1 Journal Article in PHARMACOLOGICAL RESEARCH

Depletion of the RNA binding protein QKI and circular RNA dysregulation in T-cell acute lymphoblastic leukemia

Alessia BuratinBruno PalhaisEnrico GaffoJuliette RoelsJulie MorscioJolien Van LaereSilvia OrsiGeertruij Te KronniePieter Van VlierberghePanagiotis Ntziachristos et al.

A1 Journal Article in HAEMATOLOGICA

Epigenetic rewiring of protein kinase signalling in T-cell acute lymphoblastic leukaemia

Claudina A. Pérez-NovoAmber DriesenMaaike Van TrimpontClaudia TheysEmilie LogiePieter Van VlierbergheWim Vanden Berghe

A2 Journal Article in KINASES AND PHOSPHATASES

Modeling of glucocorticoid resistance in multiple myeloma reveals mechanisms and markers of glucocorticoid resistance

Bert LuyckxMélanie DerollezEleni StaessensAnnick VerheeDaria FijalkowskaPieter Van VlierbergheSteven GoossensDorien ClarisseKarolien De Bosscher

A1 Journal Article in BIOMEDICINE & PHARMACOTHERAPY

Profiling histone post-translational modifications to identify signatures of epigenetic drug response in T-cell acute lymphoblastic leukemia

Laura CorveleynLien ProvezOsman SatilmisNina RefhagenMattias LandforsWouter SleeckxBéatrice LintermansAmélie De MaesschalckRishi S. KotechaBarbara De Moerloose et al.

2024

A dual role for PSIP1/LEDGF in T cell acute lymphoblastic leukemia

Lisa DemoenFilip MatthijssensLindy ReunesBruno PalhaisBéatrice LintermansSara T'SasIgor FijalkowskiJoachim TaminauMuluembet Z. AkeleSiska Van Belle et al.

A1 Journal Article in SCIENCE ADVANCES

CASZ1 upregulates PI3K-AKT-mTOR signaling and promotes T-cell acute lymphoblastic leukemia

Bruno A. CardosoMafalda DuqueAna GírioRita FragosoMariana L. OliveiraJames R. AllenLeila R. MartinsNádia C. CorreiaAndré Bortolini SilveiraAlexandra Veloso et al.

A1 Journal Article in HAEMATOLOGICA

Functional evaluation of transcription factors in T-ALL : MYB and SOX11

André Pedro Pinto De AlmeidaPieter Van VlierbergheSteven GoossensTim PietersTom Taghon

Ikaros loss enhances pre-leukemic thymocyte self-renewal and drives T-all in mice

Maaike Van TrimpontSara T'SasTim LammensPieter Van VlierbergheTim PietersSteven Goossens

Myb overexpression synergizes with the loss of Pten and is a dependency factor and therapeutic target in T-cell lymphoblastic leukemia

André Pedro Pinto De AlmeidaSara T'SasLuca PagliaroIgor FijalkowskiWouter SleeckxHannah Van SteenbergeRaffaella ZamponiBéatrice LintermansWouter Van LoockeBruno Palhais et al.

A1 Journal Article in HEMASPHERE

Targeting hyperactive platelet-derived growth factor receptor-β signaling in T-cell acute lymphoblastic leukemia and lymphoma

Stien De ConinckRenate De SmedtBéatrice LintermansLindy ReunesHansen J. KosasihAlexandra ReekmansLauren M. BrownNadine Van RoyBruno PalhaisJuliette Roels et al.

A1 Journal Article in HAEMATOLOGICA

Tet2 is a tumor suppressor in the pre-leukemic phase of T-cell acute lymphoblastic leukemia

Stien De ConinckJuliette RoelsBéatrice LintermansSara T'SasTom TaghonDavid CurtisTim PietersSteven GoossensPieter Van Vlierberghe

A1 Journal Article in BLOOD ADVANCES

Unravelling novel key players in T-cell acute lymphoblastic leukemia and lymphoma

Stien De ConinckPieter Van VlierbergheSteven GoossensTim Pieters

2023

A novel mammalian L-asparaginase with no L-glutaminase activity is highly efficacious against T-cell acute lymphoblastic leukemia in vivo

Maaike Van TrimpontAmanda SchalkEvelien PeetersTim LammensSteven GoossensArnon LaviePieter Van Vlierberghe

A role for IKZF1 in pre-leukemic T-all?

Maaike Van TrimpontTim LammensSteven GoossensPieter Van Vlierberghe

CircFBXW7 in patients with T-cell ALL : depletion sustains MYC and NOTCH activation and leukemia cell viability

Alessia BuratinCristina BorinCaterina Tretti ParenzanAnna Dal MolinSilvia OrsiAndrea BinattiKatharina SimonMaddalena PaganinValentina SerafinEnrico Gaffo et al.

A1 Journal Article in EXPERIMENTAL HEMATOLOGY & ONCOLOGY

Epidrugs in cancer : epigenetic profiling to improve treamtent for T-cell lymphoblastic leukemia and lymphoma

Lien ProvezPieter Van VlierbergheSteven GoossensMaarten Dhaenens

In vivo stabilization of a less toxic asparaginase variant leads to a durable antitumor response in acute leukemia

Maaike Van TrimpontAmanda M. SchalkYanti De VisserHien Anh NguyenLindy ReunesKatrien VandemeulebroeckeEvelien PeetersYing SuHyun LeePhilip L. Lorenzi et al.

A1 Journal Article in HAEMATOLOGICA

Intrathymic dendritic cell-biased precursors promote human T cell lineage specification through IRF8-driven transmembrane TNF

Kai Ling LiangJuliette RoelsMarieke LavaertTom PuttemanLena BoehmeLaurentijn TillemanImke VelgheValentina PegorettiInge Van de WalleStephanie Sontag et al.

A1 Journal Article in NATURE IMMUNOLOGY

Mutations in the histone methyltransferase Ezh2 drive context-dependent leukemia in Xenopus tropicalis

Dieter TulkensMarthe BoelensThomas NaertMarjolein CarronSuzan DemuynckSylviane DewaeleGert Van IsterdaelDavid CreytensTim PietersSteven Goossens et al.

A1 Journal Article in LEUKEMIA

Pre-clinical evaluation of the hypomethylating agent decitabine for the treatment of T-cell lymphoblastic lymphoma

Lien ProvezTom PuttemanMattias LandforsJuliette RoelsLindy ReunesSara T'SasWouter Van LoockeBéatrice LintermansStien De ConinckMorgan Thenoz et al.

A1 Journal Article in CANCERS

RNA helicase DHX15 exemplifies a unique dependency in acute leukemia

Hao GuoJin XuPeiqi XingQilong LiDonghai WangChao TangBruno PalhaisJuliette RoelsJiaxu LiuSa Pan et al.

A1 Journal Article in HAEMATOLOGICA

SOX11 is a mediator of core regulatory circuit robustness : upregulation of SWI/SNF components and recruitment of transcriptional enhancer NONO

Amber LouwagieBieke DecaestekerSarah-Lee BekaertFanny De VloedEllen SandersStéphane Van HaverTim PietersPieter Van VlierbergheS RobertsS Ek et al.

SOX11 regulates SWI/SNF complex components as member of the adrenergic neuroblastoma core regulatory circuitry

Bieke DecaestekerAmber LouwagieSiebe LoontiensFanny De VloedSarah-Lee BekaertJuliette RoelsSuzanne VanhauwaertSara De BrouwerEllen SandersA Berezovskaya et al.

A1 Journal Article in NATURE COMMUNICATIONS

2022

A multi-omic, functional precision oncology method to identify responsive glioblastoma tumor cells at single cell resolution

Yanti De VisserDena PanovskaBasiel ColeLotte HermansAsier Antoranz MartinezPouya NazariMaaike Van TrimpontMarleen DerweduweAnnelies ClaeysSteven De Vleeschouwer et al.

An interactive mass spectrometry atlas of histone posttranslational modifications in T-cell acute leukemia

Lien ProvezBart Van PuyveldeLaura CorveleynNina DemeulemeesterSigrid VerhelstBeatrice LintermansSimon DaledJuliette RoelsLieven ClementLennart Martens et al.

A1 Journal Article in SCIENTIFIC DATA

Direct and indirect anti-leukemic properties of Activity-on-Target interferons for the treatment of T-cell acute lymphoblastic leukemia

Steven GoossensAnje CauwelsTim PietersRenate De SmedtSara T'SasAndré Pedro Pinto De AlmeidaWillem DaneelsPieter Van VlierbergheJan Tavernier

A1 Journal Article in HAEMATOLOGICA

Engraftment of allotransplanted tumor cells in adult rag2 mutant Xenopus tropicalis

Dieter TulkensDionysia DimitrakopoulouMarthe BoelensTom Van NieuwenhuysenSuzan DemuynckWendy ToussaintDavid CreytensPieter Van VlierbergheKris Vleminckx

A1 Journal Article in CANCERS

ETV6-NCOA2 fusion induces T/myeloid mixed-phenotype leukemia through transformation of nonthymic hematopoietic progenitor cells

Hila FishmanShreyas MadiwaleIfat GeronVase BariWouter Van LoockeYael KirschenbaumItamar GanmoreEitan KuglerAvigail Rein-GilGilgi Friedlander et al.

A1 Journal Article in BLOOD

Functional mapping of PHF6 complexes in chromatin remodeling, replication dynamics and DNA repair

Silvia AlvarezAna da Silva AlmeidaRobert AlberoMayukh BiswasAngelica Barreto-GalvezThomas S. GunningAnam ShaikhTomas AparicioAgnieszka Anya WendorffErich Piovan et al.

A1 Journal Article in BLOOD

IRF2 is required for development and functional maturation of human NK cells

Eva PersynSigrid WahlenLaura KiekensWouter Van LoockeHannah SiweEls Van AmmelZenzi De VosFilip Van NieuwerburghPatrick MatthysTom Taghon et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

MDACT : a new principle of adjunctive cancer treatment using combinations of multiple repurposed drugs, with an example regimen

Richard E. KastAlex AlfieriI Assi, HazemTerry C. BurnsAshraf M. ElyamanyMaria Gonzalez-CaoGeorg Karpel-MasslerChristine MarosiMichael E. SalaczIacopo Sardi et al.

A1 Journal Article in CANCERS

Multiomics to investigate the mechanisms contributing to repression of PTPRC and SOCS2 in pediatric T-ALL : focus on miR-363-3p and promoter methylation

Monika Drobna-SledzinskaNatalia Mackowska-MaslakRoman JaksikMaria KosmalskaBronislawa SzarzynskaMonika LejmanLukasz SedekTomasz SzczepanskiTom TaghonPieter Van Vlierberghe et al.

A1 Journal Article in GENES CHROMOSOMES & CANCER

Myb drives B-cell neoplasms and myeloid malignancies in vivo

Tim PietersAndré Pedro Pinto De AlmeidaSara T'SasKelly LemeireTino HochepiedGeert BerxAlex KentsisSteven GoossensPieter Van Vlierberghe

A1 Journal Article in BLOOD ADVANCES

Novel insights on the use of L-asparaginase as an efficient and safe anti-cancer therapy

Maaike Van TrimpontEvelien PeetersYanti De VisserAmanda M. SchalkVeerle MondelaersBarbara De MoerlooseArnon LavieTim LammensSteven GoossensPieter Van Vlierberghe

A1 Journal Article in CANCERS

Novel molecular insights and improved therapies in T-cell acute lymphoblastic leukemia

Maaike Van TrimpontPieter Van VlierbergheSteven Goossens

Oncogenic deubiquitination controls tyrosine kinase signaling and therapy response in acute lymphoblastic leukemia

Qi JinBlanca Gutierrez DiazTim PietersYalu ZhouSonali NarangIgor FijalkowskiCristina BorinJolien Van LaereMonique PaytonByoung-Kyu Cho et al.

A1 Journal Article in SCIENCE ADVANCES

PDGFR-β as a new therapeutic target in T-cell acute lymphoblastic leukemia

Stien De ConinckRenate De SmedtBéatrice LintermansSteven GoossensPieter Van Vlierberghe

The role of TET2 in (pre-) leukemic T-ALL : TET2 to the rescue?

Stien De ConinckJuliette RoelsMorgan ThénozBéatrice LintermansSteven GoossensPieter Van Vlierberghe

The transcription factor RUNX2 drives the generation of human NK cells and promotes tissue residency

Sigrid WahlenFilip MatthijssensWouter Van LoockeSylvie TaveirneLaura KiekensEva PersynEls Van AmmelZenzi De VosStijn De MunterPatrick Matthys et al.

A1 Journal Article in ELIFE

TXNIP promotes human NK cell development but is dispensable for NK cell functionality

Eva PersynSigrid WahlenLaura KiekensSylvie TaveirneWouter Van LoockeEls Van AmmelFilip Van NieuwerburghTom TaghonBart VandekerckhovePieter Van Vlierberghe et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Uncovering novel cancer driver genes using CRISPR/Cas9 multiplexing in Xenopus tropicalis

Dieter TulkensKris VleminckxPieter Van Vlierberghe

2021

A tumor suppressor enhancer of PTEN in T-cell development and leukemia

L TottoneO LanchoJW LohA SinghS KimuraJuliette RoelsAnna KuchmiySteven StrubbeMA LawlorV da Silva-Diz et al.

A2 Journal Article in BLOOD CANCER DISCOVERY

Alternative glycosylation controls endoplasmic reticulum dynamics and tubular extension in mammalian cells

Despoina KerselidouBushra Saeed DohaiDavid R. NelsonSarah DaakourNicolas De CockZahra Al Oula HassounDae-Kyum KimJulien OlivetDiana C. El AssalAshish Jaiswal et al.

A1 Journal Article in SCIENCE ADVANCES

Cell-penetrating Alphabody protein scaffolds for intracellular drug targeting

Erwin PannecouckeMaaike Van TrimpontJohan DesmetTim PietersLindy ReunesLisa DemoenMarnik VuylstekeStefan LoverixKaren VandenbrouckePhilippe Alard et al.

A1 Journal Article in SCIENCE ADVANCES

CircRNAs dysregulated in juvenile myelomonocytic leukemia : CircMCTP1 stands out

Anna Dal MolinMattias HofmansEnrico GaffoAlessia BuratinHélène CavéChristian FlothoValerie de HaasCharlotte M. NiemeyerJan StaryPieter Van Vlierberghe et al.

A1 Journal Article in FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY

Covalent cysteine targeting of Bruton's tyrosine kinase (BTK) family by withaferin-A reduces survival of glucocorticoid-resistant multiple myeloma MM1 cells

Emilie LogieChandra S. ChirumamillaClaudina Perez-NovoPriyanka ShawKen DeclerckAjay PalaganiSavithri RangarajanBart CuypersNicolas De NeuterFazil Mobashar Hussain Urf Turabe et al.

A1 Journal Article in CANCERS

Cross-talk between GLI transcription factors and FOXC1 promotes T-cell acute lymphoblastic leukemia dissemination

Valeria ToselloDeborah BongiovanniJingjing LiuQingfei PanKoon-kiu YanValentina SaccomaniMaaike Van TrimpontMarco PizziMartina MazzoniAngelo Paolo Dei Tos et al.

A1 Journal Article in LEUKEMIA

Cyclin D2 overexpression drives B1a-derived MCL-like lymphoma in mice

Tim PietersSara T'SasStijn VanheeAndré Pedro Pinto De AlmeidaYasmine DriegeJuliette RoelsWouter Van LoockeWillem DaneelsMathijs BaensArnaud Marchand et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

HES1 and HES4 have non-redundant roles downstream of Notch during early human T-cell development

Matthias De DeckerMarieke LavaertJuliette RoelsLaurentijn TillemanBart VandekerckhoveGeorges LeclercqFilip Van NieuwerburghPieter Van VlierbergheTom Taghon

A1 Journal Article in HAEMATOLOGICA

Long non-coding RNAs as novel therapeutic targets in juvenile myelomonocytic leukemia

Mattias HofmansTim LammensBarbara DepreterYing WuMiriam ErlacherAurélie CayeHélène CavéChristian FlothoValerie de HaasCharlotte M. Niemeyer et al.

A1 Journal Article in SCIENTIFIC REPORTS

MYB rearrangements and over‐expression in T‐cell acute lymphoblastic leukemia

Valentina BardelliSilvia ArnianiValentina PieriniTiziana PieriniDanika Di GiacomoPaolo GorelloMartina MorettiFabrizia PellaneraLoredana EliaAntonella Vitale et al.

A1 Journal Article in GENES CHROMOSOMES & CANCER

Phosphocatalytic kinome activity profiling of apoptotic and ferroptotic agents in multiple myeloma cells

Emilie LogieClaudina Perez NovoAmber DriesenPieter Van VlierbergheWim Vanden Berghe

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

PRL3 enhances T-cell acute lymphoblastic leukemia growth through suppressing T-cell signaling pathways and apoptosis

E. G. GarciaA. VelosoM. L. OliveiraJ. R. AllenS. LoontiensD. BrunsonD. DoC. YanR. MorrisS. Iyer et al.

A1 Journal Article in LEUKEMIA

RUNX2 regulates leukemic cell metabolism and chemotaxis in high-risk T cell acute lymphoblastic leukemia

Filip MatthijssensNitesh D. SharmaMonique NysusChristian K. NicklHuining KangDominique R. PerezBéatrice LintermansWouter Van LoockeJuliette RoelsSofie Peirs et al.

A1 Journal Article in JOURNAL OF CLINICAL INVESTIGATION

SOX11 as guardian of epigenetic plasticity in neuroblastoma

Bieke DecaestekerAmber LouwagieSiebe LoontiensSara De BrouwerCarolina de Carvalho NunesGeertrui DeneckerFanny De VloedLisa DepestelJuliette RoelsKaren Verboom et al.

SOX11 functions as an oncogene in Lmo2-driven T-cell lymphoblastic leukemia (T-ALL)

André Pedro Pinto De AlmeidaTim PietersSara T'SasSteven GoossensPieter Van Vlierberghe

T-ALL can evolve to oncogene independence

Hesham AbdullaAnh VoBenjamin J. ShieldsTenae J. DaviesJacob T. JacksonRaed AlserihiElizabeth M. VineyTin WongFeng YanNicholas C. Wong et al.

A1 Journal Article in LEUKEMIA

T-BET and EOMES accelerate and enhance functional differentiation of human natural killer cells

Laura KiekensWouter Van LoockeSylvie TaveirneSigrid WahlenEva PersynEls Van AmmelZenzi De VosPatrick MatthysFilip Van NieuwerburghTom Taghon et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

The spleen as a sanctuary site for residual leukemic cells following ABT-199 monotherapy in ETP-ALL

Alessandra Di GrandeSofie PeirsPaul D. DonovanMaaike Van TrimpontJulie MorscioBéatrice LintermansLindy ReunesNiels VandammeSteven GoossensHien Anh Nguyen et al.

A1 Journal Article in BLOOD ADVANCES

Unlike its paralog LEDGF/p75, HRP-2 is dispensable for MLL-R leukemogenesis but important for leukemic cell survival

Siska Van BelleSara El AshkarKateřina ČermákováFilip MatthijssensSteven GoossensAlessandro CanellaCourtney H. HodgesFrauke ChristJan De RijckPieter Van Vlierberghe et al.

A1 Journal Article in CELLS

2020

A novel TLX1-driven T-ALL zebrafish model : comparative genomic analysis with other leukemia models

Siebe LoontiensSuzanne VanhauwaertLisa DepestelGivani DewynWouter Van LoockeFinola E. MooreElaine G. GarciaLance BatchelorChiara BorgaBarbara Squiban et al.

A1 Journal Article in LEUKEMIA

Aging of preleukemic thymocytes drives CpG island hypermethylation in T-cell acute lymphoblastic leukemia

Juliette RoelsMorgan ThénozBronislawa SzarzynskaMattias LandforsStien De ConinckLisa DemoenLien ProvezAnna KuchmiySteven StrubbeLindy Reunes et al.

Aging of preleukemic thymocytes drives CpG island hypermethylation in T-cell acute lymphoblastic leukemia

Juliette RoelsMorgan ThénozB SzarzyńskaM LandforsStien De ConinckLisa DemoenLien ProvezAnna KuchmiySteven StrubbeLindy Reunes et al.

A2 Journal Article in BLOOD CANCER DISCOVERY

Chemotherapy at the wheel of ALL relapse

Julie MorscioPieter Van Vlierberghe

Editorial material

Design of a comprehensive fluorescence in situ hybridization assay for genetic classification of T-cell acute lymphoblastic leukemia

Roberta La StarzaValentina PieriniTiziana PieriniValeria NofriniCaterina MatteucciSilvia ArnianiMartina MorettiAnair G. Lema FernandezFabrizia PellaneraDanika Di Giacomo et al.

A1 Journal Article in JOURNAL OF MOLECULAR DIAGNOSTICS

Distinct and temporary-restricted epigenetic mechanisms regulate human αβ and γδ T cell development

Juliette RoelsAnna KuchmiyMatthias De DeckerSteven StrubbeMarieke LavaertKai Ling LiangGeorges LeclercqBart VandekerckhoveFilip Van NieuwerburghPieter Van Vlierberghe et al.

A1 Journal Article in NATURE IMMUNOLOGY

Distinct Notch1 and BCL11B requirements mediate human γδ/αβ T cell development

Anne-Catherine DolensKaat DurinckMarieke LavaertJoni Van der MeulenImke VelgheJelle De MedtsKarin WeeningJuliette RoelsKatrien De MulderPieter-Jan Volders et al.

A1 Journal Article in EMBO REPORTS

Exploring the role of PHF6 in malignant and normal hematopoiesis through zebrafish modeling

Siebe LoontiensFranki SpelemanPieter Van VlierbergheKaat Durinck

Finding the 'key' in leukemia : PIM1 inhibition as a novel therapy in T-cell acute lymphoblastic leukemia

Renate De SmedtPieter Van VlierbergheSteven Goossens

hsa-miR-20b-5p and hsa-miR-363-3p affect expression of PTEN and BIM tumor suppressor genes and modulate survival of T-ALL cells in vitro

Monika DrobnaBronisława SzarzyńskaRoman JaksikŁukasz SędekAnna KuchmiyTom TaghonPieter Van VlierbergheTomasz SzczepańskiMichał WittMałgorzata Dawidowska

A1 Journal Article in CELLS

Integrated scRNA-seq identifies human postnatal thymus seeding progenitors and regulatory dynamics of differentiating immature thymocytes

Marieke LavaertKai Ling LiangNiels VandammeJong-Eun ParkJuliette RoelsMonica S. KowalczykBo LiOrr AshenbergMarcin TabakaDanielle Dionne et al.

A1 Journal Article in IMMUNITY

Large-scale circular RNA deregulation in T-ALL : unlocking unique ectopic expression of molecular subtypes

Alessia BuratinMaddalena PaganinEnrico GaffoAnna Dal MolinJuliette RoelsGiuseppe GermanoMaria Teresa SiddiValentina SerafinMatthias De DeckerStéphanie Gachet et al.

A1 Journal Article in BLOOD ADVANCES

Malignant progression of donor-engrafted clonal hematopoiesis in sibling recipients after stem cell transplantation

Louis NevejanFriedel NolletHelena DevosMatthijs VynckPieter Van VlierbergheMercedeh TajdarTom LodewyckDominik Selleslag

Editorial material

PHF6 expression levels impact human hematopoietic stem cell differentiation

Siebe LoontiensAnne-Catherine DolensSteven StrubbeInge Van de WalleFinola E. MooreLisa DepestelSuzanne VanhauwaertFilip MatthijssensDavid M. LangenauFranki Speleman et al.

A1 Journal Article in FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY

Posttranslational regulation of the exon skipping machinery controls aberrant splicing in leukemia

Yalu ZhouCuijuan HanEric WangAdam H. LorchValentina SerafinByoung-Kyu ChoBlanca T. Guttierrez DiazJulien CalvoCelestia FangAlireza Khodadadi-Jamayran et al.

A1 Journal Article in CANCER DISCOVERY

Publisher correction : Zeb2 drives invasive and microbiota-dependent colon carcinoma

Karolina SlowickaIoanna PettaGillian BlanckeEsther HosteEmilie DumasMozes SzeHanna-Kaisa VikkulaEnrico RadaelliJody J. HaighSven Jonckheere et al.

Targeting cytokine- and therapy-induced PIM1 activation in preclinical models of T-cell acute lymphoblastic leukemia and lymphoma

Renate De SmedtJulie MorscioLindy ReunesJuliette RoelsValentina BardelliBéatrice LintermansWouter Van LoockeAfonso AlmeidaLaurence C. CheungRishi S. Kotecha et al.

A1 Journal Article in BLOOD

Teaching an old dog new tricks : activity-on-target interferon to treat T-cell acute lymphoblastic leukemia

Steven GoossensAnje CauwelsTim PietersWillem DaneelsPieter Van VlierbergheJan Tavernier

The EMT modulator SNAI1 contributes to AML pathogenesis via its interaction with LSD1

Catherine L. CarmichaelJueqiong WangThao NguyenOluseyi KolawoleAissa BenyoucefCharlotte De MazièreAnna MilneSona SamuelKevin Robert GillinderSoroor Hediyeh-zadeh et al.

A1 Journal Article in BLOOD

The EMT transcription factor ZEB2 promotes proliferation of primary and metastatic melanoma while suppressing an invasive, mesenchymal-like phenotype

Niels VandammeGeertrui DeneckerKenneth BruneelGillian BlanckeOzden AkayJoachim TaminauJordy De ConinckEva De SmedtNicolas SkrypekWouter Van Loocke et al.

A1 Journal Article in CANCER RESEARCH

The epigenetic landscape of normal and malignant T cell development

Juliette RoelsPieter Van VlierbergheTom Taghon

The transcription factor ETS1 is an important regulator of human NK cell development and terminal differentiation

Sylvie TaveirneSigrid WahlenWouter Van LoockeLaura KiekensEva PersynEls Van AmmelKatrien De MulderJuliette RoelsLaurentijn TillemanMarc Aumercier et al.

A1 Journal Article in BLOOD

Three-dimensional chromatin landscapes in T cell acute lymphoblastic leukemia

Andreas KloetgenPalaniraja ThandapaniPanagiotis NtziachristosYohana GhebrechristosSofia NomikouCharalampos LazarisXufeng ChenHai HuSofia BakogianniJingjing Wang et al.

A1 Journal Article in NATURE GENETICS

Zeb2 drives invasive and microbiota-dependent colon carcinoma

Karolina SlowickaIoanna PettaGillian BlanckeEsther HosteEmilie DumasMozes SzeHanna-Kaisa VikkulaEnrico RadaelliJody J. HaighSven Jonckheere et al.

A1 Journal Article in NATURE CANCER

2019

Fanconi-BRCA pathway mutations in childhood T-cell acute lymphoblastic leukemia

Gayle P PouliotJames DegarLaura HinzeBose KochupurakkalChau D VoMelissa A BurnsLisa MoreauChirag GanesaJustine RoderickSofie Peirs et al.

A1 Journal Article in PLOS ONE

Genetic characterization and therapeutic targeting of MYC-rearranged T cell acute lymphoblastic leukaemia

Gloria MilaniFilip MatthijssensWouter Van LoockeKaat DurinckJuliette RoelsSofie PeirsMorgan ThénozTim PietersLindy ReunesBéatrice Lintermans et al.

A1 Journal Article in BRITISH JOURNAL OF HAEMATOLOGY

Long non-coding RNAs as novel therapeutic targets in juvenile myelomonocytic leukemia : proof of concept study

Mattias HofmansBarbara DepreterTim LammensHelene CaveChristian FlothoHenrik HasleValerie de HaasCharlotte M. NiemeyerJan StaryPieter Van Vlierberghe et al.

Modeling human hereditary cancer syndromes using CRISPR/Cas9 mediated genome editing in Xenopus tropicalis

D. DimitrakopoulouT. NaertD. TulkensR. NoelandersT. Van NieuwenhuysePieter Van VlierbergheKris Vleminckx

Modeling human hereditary cancer syndromes using CRISPR/Cas9 mediated genome editing in Xenopus tropicalis

D. DimitrakopoulouT. NaertD. TulkensR. NoelandersT. Van NieuwenhuysePieter Van VlierbergheKris Vleminckx

Novel strategy for rapid functional in vivo validation of oncogenic drivers in haematological malignancies

Tim PietersSara T'SasLisa DemoenAndré Pedro Pinto De AlmeidaLieven HaenebalckeFilip MatthijssensKelly LemeireJinke D'HontFrédérique VanrockeghemTino Hochepied et al.

A1 Journal Article in SCIENTIFIC REPORTS

Phf6 loss enhances HSC self-renewal driving tumor initiation and leukemia stem cell activity in T-ALL

Agnieszka A WendorffS Aidan QuinnMarissa RashkovanChioma J MadubataAlberto Ambesi-ImpiombatoMark R LitzowMartin S TallmanElisabeth PaiettaMaddalena PaganinGiuseppe Basso et al.

A1 Journal Article in CANCER DISCOVERY

PHF6loss drives IL7R oncogene addiction in TLX1 driven T-ALL

Siebe LoontiensKaat DurinckSuzanne VanhauwaertLisa DepestelMariana L OliveiraGivani DewynCharles De BockJoao T BarataDavid LangenauJan Cools et al.

PTEN abnormalities predict poor outcome in children with T-cell acute lymphoblastic leukemia treated according to ALL IC-BFM protocols

Bronisława Szarzyńska-ZawadzkaJoachim B. KunzŁukasz SędekMaria KosmalskaKatarzyna ZdonPrzemysław BiecekObul R BandapalliMonika Kraszewska-HamiltonRoman JaksikMonika Drobna et al.

A1 Journal Article in AMERICAN JOURNAL OF HEMATOLOGY

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A1 Journal Article in BRITISH JOURNAL OF HAEMATOLOGY

T-cell acute lymphoblastic leukemias express a unique truncated FAT1 isoform that cooperates with NOTCH1 in leukemia development

Charles E de BockMichelle DownKinsha BaidyaBram SweronAndrew W BoydMark FiersGordon F BurnsTimothy J MolloyRichard B LockJean Soulier et al.

A1 Journal Article in HAEMATOLOGICA

Targeting steroid resistance in T-cell acute lymphoblastic leukemia

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A1 Journal Article in BLOOD REVIEWS

USP7 cooperates with NOTCH1 to drive the oncogenic transcriptional program in T-cell leukemia

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A1 Journal Article in CLINICAL CANCER RESEARCH

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A1 Journal Article in FRONTIERS IN PHYSIOLOGY

ZEB2 and LMO2 drive immature T-cell lymphoblastic leukemia via distinct oncogenic mechanisms

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A1 Journal Article in HAEMATOLOGICA

ZEB2 in T-cells and T-ALL

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A2 Journal Article in ADVANCES IN BIOLOGICAL REGULATION

2018

A comprehensive inventory of TLX1 controlled long non-coding RNAs in T-cell acute lymphoblastic leukemia through polyA+ and total RNA sequencing

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A1 Journal Article in HAEMATOLOGICA

A novel L-asparaginase with low L-glutaminase coactivity is highly efficacious against both T- and B-cell acute lymphoblastic leukemias in vivo

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A1 Journal Article in CANCER RESEARCH

A novel t(8;14)(q24;q11) rearranged human cell line as a model for mechanistic and drug discovery studies of NOTCH1-independent human T-cell leukemia

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A1 Journal Article in CELLS

Deletion 6q drives T-cell leukemia progression by ribosome modulation

Stéphanie GachetTiama El-ChaarDavid AvranEulalia GenescaFrédéric CatezSamuel QuentinMarc DelordGabriel ThérizolsDelphine BriotGodelieve Meunier et al.

A1 Journal Article in CANCER DISCOVERY

Exploring the long non-coding RNA landscape in juvenile myelomonocytic leukemia

Mattias HofmansTim LammensS BresolinH CavéC FlothoH HasleHetty HelsmoortelM Van den Heuvel-EibrinkC NiemeyerJ Stary et al.

Expressed repetitive elements are broadly applicable reference targets for normalization of reverse transcription-qPCR data in mice

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A1 Journal Article in SCIENTIFIC REPORTS

LEDGF/p75 is dispensable for hematopoiesis but essential for MLL-rearranged leukemogenesis

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A1 Journal Article in BLOOD

Mutant JAK3 phosphoproteomic profiling predicts synergism between JAK3 inhibitors and MEK/BCL2 inhibitors for the treatment of T-cell acute lymphoblastic leukemia

S. DegryseC. E. de BockS. DemeyerI. GovaertsS. BornscheinD. VerbekeK. JacobsS. BinosD. A. Skerrett-ByrneH. C. Murray et al.

A1 Journal Article in LEUKEMIA

Mutant JAK3 phosphoproteomic profiling predicts synergism between JAK3 inhibitors and MEK/BCL2 inhibitors for the treatment of T-cell acute lymphoblastic leukemia (vol 32, pg 788, 2018)

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A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Pre-clinical evaluation of second generation PIM inhibitors for the treatment of T-cell acute lymphoblastic leukemia and lymphoma

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A1 Journal Article in HAEMATOLOGICA

Scrutinizing PHF6 regulatory networks in T-ALL and normal hematopoiesis using zebrafish

Siebe LoontiensKaat DurinckInge Van de WalleFinola MooreSuzanne VanhauwaertEls JanssensGivani DewynLisa DepestelChristophe Van NesteDavid Langenau et al.

SHQ1 regulation of RNA splicing is required for T-lymphoblastic leukemia cell survival

Hexiu SuJuncheng HuLiang HuangYang YangMorgan ThénozAnna KuchmiyYufeng HuPeng LiHui FengYu Zhou et al.

A1 Journal Article in NATURE COMMUNICATIONS

The long non-coding RNA landscape in juvenile myelomonocytic leukemia

Mattias HofmansTim LammensHetty HelsmoortelSilvia BresolinHélène CavéChristian FlothoHenrik HasleMarry M van den Heuvel-EibrinkCharlotte NiemeyerJan Stary et al.

A1 Journal Article in HAEMATOLOGICA

The TLX1 oncogene modules the enhancer RNA landscape in T-ALL

Karen VerboomWouter Van LoockeJo VandesompeleNiels VandammeGeert BerxYvan SaeysLiesbet MartensPieter Van VlierbergheFranki SpelemanKaat Durinck

TLX1 controlled long non-coding RNAs in T-cell acute lymphoblastic leukemia

Karen VerboomWouter Van LoockeJo VandesompeleNiels VandammeGeert BerxLiesbet MartensYvan SaeysPieter Van VlierbergheFranki SpelemanKaat Durinck

ZEB proteins in leukemia : friends, foes, or friendly foes?

Bieke SoenNiels VandammeGeert BerxJürg SchwallerPieter Van VlierbergheSteven Goossens

A2 Journal Article in HEMASPHERE

2017

Comprehensive miRNA expression profiling in human T-cell acute lymphoblastic leukemia by small RNA-sequencing

Annelynn WallaertWouter Van LoockeLucie HernandezTom TaghonFranki SpelemanPieter Van Vlierberghe

A1 Journal Article in SCIENTIFIC REPORTS

Deciphering the untranslated message in T-cell acute lymphoblastic leukemia

Annelynn WallaertFranki SpelemanPieter Van VlierberghePieter Rondou

Digital multiplex ligation-dependent probe amplification for detection of key copy number alterations in T- and B-cell lymphoblastic leukemia

Anne Benard-SlagterIlse ZondervanKarel de GrootFarzaneh GhazaviVirinder SarhadiPieter Van VlierbergheBarbara De MoerlooseClaire SchwabKim VettenrantaChristine J Harrison et al.

A1 Journal Article in JOURNAL OF MOLECULAR DIAGNOSTICS

EMT transcription factors in cancer development re-evaluated : beyond EMT and MET

Steven GoossensNiels VandammePieter Van VlierbergheGeert Berx

A1 Journal Article in BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Genetic insights in ETV6/RUNX1-positive B-cell precursor acute lymphoblastic leukaemia

Farzaneh GhazaviTim LammensPieter Van VlierbergheBarbara De Moerloose

A2 Journal Article in BELGIAN JOURNAL OF HEMATOLOGY

Long non-coding RNAs in leukemia : biology and clinical impact

Tim LammensKaat DurinckAnnelynn WallaertFranki SpelemanPieter Van Vlierberghe

A1 Journal Article in CURRENT OPINION IN HEMATOLOGY

Novel molecular genetic insights in paediatric B-cell precursor acute lymphoblastic leukaemia

Farzaneh GhazaviTim LammensPieter Van VlierbergheBarbara De Moerloose

A2 Journal Article in BELGIAN JOURNAL OF HEMATOLOGY

Novel molecular insights and targeted therapies in T-cell acute lymphoblastic leukemia

Sofie PeirsBruce PoppePieter Van Vlierberghe

Novel oncogenic noncoding mutations in T-ALL

Steven GoossensPieter Van Vlierberghe

Editorial material

Oncogenic ZEB2 activation drives sensitivity toward KDM1A inhibition in T-cell acute lymphoblastic leukemia

Steven GoossensSofie PeirsWouter Van LoockeJueqiong WangMina TakawyFilip MatthijssensStefan E SondereggerKatharina HaighThao NguyenNiels Vandamme et al.

A1 Journal Article in BLOOD

T-ALL and thymocytes : a message of noncoding RNAs

Annelynn WallaertKaat DurinckTom TaghonPieter Van VlierbergheFranki Speleman

A1 Journal Article in JOURNAL OF HEMATOLOGY & ONCOLOGY

Targeting BET proteins improves the therapeutic efficacy of BCL-2 inhibition in T-cell acute lymphoblastic leukemia

Sofie PeirsV FrismantasFilip MatthijssensW Van LoockeTim PietersNiels VandammeBéatrice LintermansMP DobayGeert BerxBruce Poppe et al.

A1 Journal Article in LEUKEMIA

The TLX1 oncogene modulates the enhancer RNA landscape in T-ALL

Karen VerboomKaat DurinckMatthias De DeckerWouter Van LoockeFilip MatthijssensJean-Jacques SoulierWouter De LaatTom TaghonPieter Van VlierbergheFranki Speleman

Unravelling the biology of juvenile myelomonocytic leukaemia using transcriptomics

Hetty HelsmoortelTim LammensPieter Van VlierbergheBarbara De Moerloose

A2 Journal Article in BELGIAN JOURNAL OF HEMATOLOGY

2016

A novel multiplex NGS-based digital MLPA assay for copy number detection of 700 target sequences in childhood acute lymphoblastic leukemia

Anne BenardIlse ZondervanJan SchoutenKarel de GrootFarzaneh GhazaviVirinder SarhadiPieter Van VlierbergheBarbara De MoerlooseChristine HarrisonClaire Schwab et al.

A quantitative proteomics approach identifies ETV6 and IKZF1 as new regulators of an ERG-driven transcriptional network

Ashwin UnnikrishnanYi Fang GuanYizhou HuangDominik BeckJulie AI ThomsSofie PeirsKathy KnezevicShiyong MaInge Van de WalleIneke de Jong et al.

A1 Journal Article in NUCLEIC ACIDS RESEARCH

BRD4 inhibition improves the efficacy of ABT-199 in T-cell acute lymphoblastic leukemia

Sofie PeirsFilip MatthijssensTim PietersNiels VandammeGeert BerxBruce PoppePieter Van Vlierberghe

BRD4 inhibition improves the efficacy of ABT-199 in T-cell acute lymphoblastic leukemia

Sofie PeirsFilip MatthijssensTim PietersNiels VandammeGeert BerxBruce PoppePieter Van Vlierberghe

CRISPR-Cas9 modeling of cell lines and zebrafish to study the TLX1-PHF6 cooperative interrelationship in T-cell acute lymphoblastic leukemia

Siebe LoontiensKaat DurinckNina De RockerAnnekatrien BoelEls JanssensSuzanne VanhauwaertPieter RondouCharles De BockInge Van de WalleFinola Moore et al.

Cyclin D2 overexpression recapitulates mantle cell lymphoma in mice

Tim PietersSteven GoossensSara T'SasGeert BerxJody J HaighPieter Van Vlierberghe

Digital MLPA(TM) for copy number detection in childhood acute lymphoblasic leukemia : a novel multiplex NGS-based assay

A BenardBarbara De MoerlooseI ZondervanFarzaneh GhazaviV SarhadiPieter Van VlierbergheTim LammensS KnuutilaS Savola

Dissecting the NOTCH1 driven transcriptional landscape in T-cell acute lymphoblastic leukemia at single cell level

Karen VerboomKaat DurinckCeline EveraertRobrecht CannoodtPieter Van VlierbergheJo VandesompeleFranki Speleman

Expanding the TLX1 regulome in T-cell acute lymphoblastic leukemia towards long noncoding RNAs

Kaat DurinckWouter Van LoockeInge Van de WalleJoni Van der MeulenPieter-Jan VoldersNadine Van RoyYves BenoitBruce PoppePieter MestdaghJo Vandesompele et al.

Fast generation of conditional ROSA26-based mouse models that recapitulate genomic events in human T-ALL

Tim PietersSteven GoossensSara T'SasLieven HaenebalckeTino HochepiedBéatrice LintermansSofie PeirsFilip MatthijssensJ HaighGeert Berx et al.

Functional dissection of transcriptional regulation during normal and malignant T-cell development : an integrative (epi)genomic approach

Kaat DurinckFranki SpelemanPieter Van VlierbergheTom Taghon

GATA3 induces human T-cell commitment by restraining Notch activity and repressing NK-cell fate

Inge Van de WalleAnne-Catherine DolensKaat DurinckKatrien De MulderWouter Van LoockeSagar DamleEls WaegemansJelle De MedtsImke VelgheMagda De Smedt et al.

A1 Journal Article in NATURE COMMUNICATIONS

Genetic characterization and therapeutic targeting of MYC translocated pediatric T-cell acute lymphoblastic leukemia

Gloria MilaniKaat DurinckFilip MatthijssensSofie PeirsTim PietersLindy ReunesBéatrice LintermansNiels VandammeTim LammensYunlei Li et al.

Identification of candidate oncogenes and chromosomal breakpoint sequencing by targeted locus amplification in T-cell acute lymphoblastic leukemia

Eric VroegindeweijTim LammensKirsten Cante-BarrettErik SplinterA UyttebroeckJessica GC Buijs-GladdinesWilco SmitsPeter VandenbergheRenate De SmedtBarbara De Moerloose et al.

LIN28B is over-expressed in specific subtypes of pediatric leukemia and regulates lncRNA H19

Hetty HelsmoortelBarbara De MoerlooseTim PietersFarzaneh GhazaviSilvia BresolinHelene CaveAndrica de VriesValerie de HaasChristian FlothoVeerle Labarque et al.

A1 Journal Article in HAEMATOLOGICA

LIN28B is overexpressed in pediatric leukemia and regulates LNCRNA H19

Hetty HelsmoortelBarbara De MoerlooseSilvia BresolinHélèe CavéChristian FlothoCharlotte NiemeyerJan StaryMarry van den Heuvel-EibrinkPieter Van VlierbergheTim Lammens

LIN28B overexpression defines a novel fetal-like subgroup of juvenile myelomonocytic leukemia

Hetty HelsmoortelSilvia BresolinTim LammensHélène CavéPeter NoellkeAurélie CayeFarzaneh GhazaviAndrica de VriesHenrik HasleVeerle Labarque et al.

A1 Journal Article in BLOOD

Long noncoding RNA signatures define oncogenic subtypes in T-cell acute lymphoblastic leukemia

Annelynn WallaertKaat DurinckWouter Van LoockeInge Van de WalleFilip MatthijssensPieter-Jan VoldersFrancisco Avila CobosDries RombautPieter RondouPieter Mestdagh et al.

A1 Journal Article in LEUKEMIA

Modeling the TLX1-PHF6 cooperative interrelationship in T-cell acute lymphoblastic leukemia in zebrafish

Siebe LoontiensKaat DurinckELS JANSSENSSuzanne VanhauwaertPieter RondouJan CoolsCharles De BockInge Van de WalleFinola MooreDavid Langenau et al.

Novel molecular genetic insights in pediatric B-cell precursor acute lymphoblastic leukemia

Farzaneh GhazaviBarbara De MoerloosePieter Van VlierbergheTim Lammens

Oncogenic ZEB2 activation drives sensitivity towards LSD1 inhibition in T-Cell acute lymphoblastic leukemia

Steven GoossensSofie PeirsGeert BerxPieter Van VlierbergheJody J Haigh

Overcoming steroid resistance in T cell acute lymphoblastic leukemia

Steven GoossensPieter Van Vlierberghe

Editorial material

PRC2 mutations induce resistance to conventional chemotherapy by inhibiting mitochondrial apoptosis in T-cell acute lymphoblastic leukemia

Ingrid AriesTriona Ni ChonghaileSalmaan KarimMina JacobKristen E StevensonDonna S NeubergMeenakshi DevidasMignon LohStephen HungerDavid T Teachey et al.

RPPA-Based protein profiling reveals enhanced PI3K/AKT/mTOR signaling in ETV6/RUNX1-positive acute lymphoblastic leukemia patients with low CD200 expression

Farzaneh GhazaviValentina SerafinPieter RondouTim LammensFranki SpelemanBenedetta AccordiBarbara De MoerloosePieter Van Vlierberghe

Targeting BET family proteins improves the efficacy of ABT-199 in T-cell acute lymphoblastic leukemia

Sofie PeirsFilip MatthijssensBéatrice LintermansTim PietersNiels VandammeGeert BerxBruce PoppePieter Van Vlierberghe

Targeting BET family proteins improves the therapeutic efficacy of BCL-2 inhibition in T-cell acute lymphoblastic leukemia

Sofie PeirsViktoras FrismantasFilip MatthijssensBéatrice LintermansTim PietersNiels VandammeWouter Van LoockeGeert BerxBruce PoppeJean-Pierre Bourquin et al.

The combination of ABT-199 and JQ1 as a novel therapeutic strategy in T-cell acute lymphoblastic leukemia

Sofie PeirsFilip MatthijssensTim PietersNiels VandammeBéatrice LintermansLindy ReunesGeert BerxBruce PoppePieter Van Vlierberghe

The T-ALL oncogene TLX1 controls enhancer lncRNA expression

Karen VerboomKaat DurinckWouter Van LoockeFilip MatthijssensInge Van de WalleAnnelynn WallaertPieter-Jan VoldersNadine Van RoyYves BenoitBruce Poppe et al.

Therapeutic targeting of the histone ubiquitination-methylation axis in T cell leukemia

Panagiotis NtziachristosKelly ArcipowskiCarlos Alberto MartinezYixing ZhuAndrew G VolkSuresh KumarPaul M ThomasPieter Van VlierbergheNobuko HijiyaStacy Marshall et al.

Unique long non-coding RNA expression signature in ETV6/RUNX1-Driven B-cell precursor acute lymphoblastic leukemia

Farzaneh GhazaviBarbara De MoerlooseWouter Van LoockeAnnelynn WallaertAlina FersterMarleen BakkusGeneviève PlatEric DelabesseAnne UyttebroeckFilip Van Nieuwerburgh et al.

Unique long non-coding RNA expression signature in ETV6/RUNX1-driven B-cell precursor acute lymphoblastic leukemia

Farzaneh GhazaviBarbara De MoerlooseWouter Van LoockeAnnelynn WallaertHetty HelsmoortelAlina FersterMarleen BakkusGeneviève PlatEric DelabesseAnne Uyttebroeck et al.

A1 Journal Article in ONCOTARGET

Unraveling the biology of juvenile myelomonocytic leukemia using transcriptomics

Hetty HelsmoortelBarbara De MoerlooseTim LammensPieter Van Vlierberghe

2015

CD200/BTLA deletions in pediatric precursor B-cell acute lymphoblastic leukemia treated according to the EORTC-CLG 58951 protocol

Farzaneh GhazaviEmmanuelle ClappierTim LammensStefan SuciuAurélie CayeSamira ZegrariMarleen BakkusNathalie GrardelYves BenoitOdile Minckes et al.

A1 Journal Article in HAEMATOLOGICA

Characterization of the genome-wide TLX1 binding profile in T-cell acute lymphoblastic leukemia

Kaat DurinckWouter Van LoockeJoni Van der MeulenInge Van de WalleMaté OngenaertPieter RondouAnnelynn WallaertCE de BockNadine Van RoyBruce Poppe et al.

A1 Journal Article in LEUKEMIA

Delineating the roles of lysine 27 methylation-associated epigenetic modulators in T cell leukemia

Panagiotis NtziachristosGrant WelsteadThomas TrimarchiSofia BakogianniLuyao XuPieter Van VlierbergheRab PrinjhaAdolfo FerrandoRudolf JaenischCharles Mullighan et al.

Epigenetics in T-cell acute lymphoblastic leukemia

Sofie PeirsJoni Van der MeulenInge Van de WalleTom TaghonFranki SpelemanBruce PoppePieter Van Vlierberghe

A1 Journal Article in IMMUNOLOGICAL REVIEWS

MicroRNA-193b-3p acts as a tumor suppressor by targeting the MYB oncogene in T-cell acute lymphoblastic leukemia

Evelien MetsJoni Van der MeulenGert Van PeerMichael BoicePieter MestdaghInge Van de WalleTim LammensSteven GoossensBarbara De MoerlooseYves Benoit et al.

A1 Journal Article in LEUKEMIA

Molecular basis and clinical significance of genetic aberrations in B-cell precursor acute lymphoblastic leukemia

Farzaneh GhazaviTim LammensNadine Van RoyBruce PoppeFranki SpelemanYves BenoitPieter Van VlierbergheBarbara De Moerloose

A1 Journal Article in EXPERIMENTAL HEMATOLOGY

Novel biological insights in T-cell acute lymphoblastic leukemia

Kaat DurinckSteven GoossensSofie PeirsAnnelynn WallaertWouter Van LoockeFilip MatthijssensTim PietersGloria MilaniTim LammensPieter Rondou et al.

A1 Journal Article in EXPERIMENTAL HEMATOLOGY

The H3K27me3 demethylase UTX is a gender-specific tumor suppressor in T-cell acute lymphoblastic leukemia

Joni Van der MeulenViraj SanghviKonstantinos MavrakisKaat DurinckFang FangFilip MatthijssensPieter RondouMonica RosenTim PietersPeter Vandenberghe et al.

A1 Journal Article in BLOOD

The long non-coding RNA H19 is regulated by LIN28B

Hetty HelsmoortelBarbara De MoerlooseTim PietersFarzaneh GhazaviS BresolinH CavéA CayeACH de VriesC FlothoV Labarque et al.

Transcriptional antagonism between the cooperative oncogenes TLX1 and NOTCH1 in T-cell acute lymphoblastic leukemia.

Kaat DurinckWouter Van LoockeJoni Van der MeulenInge Van de WallePieter RondouCharles E De BockBruce PoppeJan CoolsJean SoulierTom Taghon et al.

ZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling

Steven GoossensEnrico RadaelliOdile BlanchetKaat DurinckJoni Van der MeulenSofie PeirsTom TaghonCedric S TremblayMagdaline CostaMorvarid Farhang Ghahremani et al.

A1 Journal Article in NATURE COMMUNICATIONS

2014

ABT-199 mediated inhibition of BCL-2 as a novel therapeutic strategy in early immature T-cell acute lymphoblastic leukemia

Sofie PeirsFilip MatthijssensSteven GoossensKirsten Canté-BarrettTim LammensBarbara De MoerlooseYves BenoitJean SoulierBruce PoppeTom Taghon et al.

ABT-199 mediated inhibition of BCL-2 as a novel therapeutic strategy in T-cell acute lymphoblastic leukemia

Sofie PeirsFilip MatthijssensSteven GoossensInge Van de WalleKatia RuggeroCharles E de BockSandrine DegryseKirsten Canté-BarrettDelphine BriotEmmanuelle Clappier et al.

A1 Journal Article in BLOOD

ABT-199 mediated inhibition of BCL2 as a novel therapeutic strategy in T-cell acute lymphoblastic leukemia

Sofie PeirsFilip MatthijssensSteven GoossensCharles De BockKirsten Canté-BarrettTim LammensInge Van de WalleBarbara De MoerlooseYves BenoitBruce Poppe et al.

Characterization of a set of tumor suppressor microRNAs in T cell acute lymphoblastic leukemia

Viraj R SanghviKonstantinos J MavrakisJoni Van der MeulenMichael BoiceAndrew L WolfeMark CartyPrathibha MohanPieter RondouNicholas D SocciYves Benoit et al.

A1 Journal Article in SCIENCE SIGNALING

Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia

Panagiotis NtziachristosAristotelis TsirigosG Grant WelsteadThomas TrimarchiSofia BakogianniLuyao XuEvangelia LoizouLinda HolmfeldtAlexandros StrikoudisBryan King et al.

A1 Journal Article in NATURE

Controlling pre-leukemic thymocyte self-renewal

Steven GoossensPieter Van Vlierberghe

Editorial material

Integrative analysis of the NOTCH1 regulatory network identifies key downstream lncRNAs in acute T-cell lymphoblastic leukemia and normal T-cell development

Annelynn WallaertKaat DurinckPieter RondouInge Van de WalleWouter Van LoockePieter-Jan VoldersMaté OngenaertNadine Van RoyBruce PoppeYves Benoit et al.

Juvenile myelomonocytic leukaemia: the quest for more specific therapies

Hetty HelsmoortelTim LammensNadine Van RoyJan PhilippéPascale De PaepeYves BenoitFranki SpelemanPieter Van VlierbergheBarbara De Moerloose

A2 Journal Article in BELGIAN JOURNAL OF HEMATOLOGY

LIN28B defines an aggressive subtype of juvenile myelomonocytic leukemia

Hetty HelsmoortelTim LammensFarzaneh GhazaviAurelie CayeHélène CavéChristian FlothoCharlotte NiemeyerJan StarySilvia BresolinRiccardo Masetti et al.

LncRNA profiling in T-cell acute lymphoblastic leukemia predicts a functional connection between lncRNAs and the major T-ALL genetic subgroups

Annelynn WallaertKaat DurinckWouter Van LoockePieter-Jan VoldersYves BenoitBruce PoppePieter MestdaghJo VandesompeleJean SoulierJan Cools et al.

MicroRNA-128-3p is a novel oncomiR targeting PHF6 in T-cell acute lymphoblastic leukemia

Evelien MetsGert Van PeerJoni Van der MeulenMichael BoiceTom TaghonSteven GoossensPieter MestdaghYves BenoitBarbara De MoerlooseNadine Van Roy et al.

A1 Journal Article in HAEMATOLOGICA

Phf6 plays a role in hematopoiesis and thymopoiesis in zebrafish

Els JanssensSuzanne VanhauwaertAndy WillaertKaat DurinckAnne De PaepePieter Van VlierberghePieter RondouFranki Speleman

Prognostic relevance of BTLA/CD200 deletion in pediatric pre-B cell acute lymphoblastic leukemia

Farzaneh GhazaviTim LammensStefan SuciuMarleen BakkusHélène CavéFranki SpelemanYves BenoitBarbara De MoerloosePieter Van Vlierberghe

Prognostic relevance of CD200/BTLA deletions in pediatric precursor-B cell acute lymphoblastic leukemia treated according to the EORTD-CLG 58951 protocol

Farzaneh GhazaviTim LammensEmmanuelle ClappierStefan SuciuAurélie CayeSamira ZegrariMarleen BakkusNathalie GrardelYves BenoitYves Bertrand et al.

The epigenetic landscape of T-cell acute lymphoblastic leukemia

Joni Van der MeulenNadine Van RoyPieter Van VlierbergheFranki Speleman

A1 Journal Article in INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The first lncRNA landscape of major genetic T-ALL subsets and guilt-by-association analysis for ETP-ALL specific lncRNAs

Annelynn WallaertKaat DurinckWouter Van LoockePieter-Jan VoldersInge Van de WalleYves BenoitBruce PoppeJo VandesompeleTom TaghonJean Soulier et al.

The H3K27me3 demethylase UTX in normal development and disease

Joni Van der MeulenFranki SpelemanPieter Van Vlierberghe

A1 Journal Article in EPIGENETICS

The Notch driven long non-coding RNA repertoire in T-cell acute lymphoblastic leukemia

Kaat DurinckAnnelynn WallaertInge Van de WalleWouter Van LoockePieter-Jan VoldersSuzanne VanhauwaertEllen GeerdensYves BenoitNadine Van RoyBruce Poppe et al.

A1 Journal Article in HAEMATOLOGICA

The NOTCH1 driven long non-coding RNA repertoire in T-cell acute lymphoblastic leukemia

Annelynn WallaertKaat DurinckPieter RondouInge Van de WalleWouter VanloockePieter-Jan VoldersSuzanne VanhauwaertEllen GeerdensMaté OngenaertNadine Van Roy et al.

Unique lncRNA signatures mark the major T-ALL genetic subgroups

Annelynn WallaertKaat DurinckWouter Van LoockePieter-Jan VoldersYves BenoitBruce PoppePieter MestdaghJo VandesompeleJean SoulierJan Cools et al.

2013

Expanding the TLX1 regulate in T-cell acute lymphoblastic leukemia towards long non-coding RNAs

Kaat DurinckJoni Van der MeulenMaté OngenaertPieter-Jan VoldersAnnelynn WallaertNadine Van RoyYves BenoitBruce PoppePieter MestdaghJo Vandesompele et al.

Expanding the TLX1-regulome in T cell acute lymphoblastic leukemia towards long non-coding RNAs

Kaat DurinckJoni Van der MeulenMaté OngenaertPieter-Jan VoldersAnnelynn WallaertNadine Van RoyYves BenoitBruce PoppePieter MestdaghJo Vandesompele et al.

MiR-128 is a novel PHF6 targeting regulatory non-coding RNA acting as a T-ALL oncogene

Evelien MetsJoni Van der MeulenGert Van PeerMichael BoicePieter MestdaghTom TaghonDavid AvranBarbara De MoerlooseYves BenoitBruce Poppe et al.

miRNAs distinguish children with myelodysplastic syndrome from healthy donors

Hetty HelsmoortelTim LammensPieter MestdaghNadine Van RoyAnne UyttebroeckAlina FersterYves BenoitJo VandesompeleFranki SpelemanPieter Van Vlierberghe et al.

miRNAs distinguish children with myelodysplastic syndrome from healthy donors

Hetty HelsmoortelTim LammensPieter MestdaghNadine Van RoyAnne UyttebroeckAlina FersterYves BenoitJo VandesompeleFranki SpelemanPieter Van Vlierberghe et al.

Prognostic relevance of integrated genetic profiling in adult T-cell acute lymphoblastic leukemia

Pieter Van VlierbergheAlberto Ambesi-ImpiombatoKim De KeersmaeckerMichael HadlerElisabeth PaiettaMartin S TallmanJacob M RoweCarles ForneMonserrat RueAdolfo A Ferrando

A1 Journal Article in BLOOD

2012

Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia

Panagiotis NtziachristosAristotelis TsirigosPieter Van VlierbergheJelena NedjicThomas TrimarchiMaria Sol FlahertyDolors Ferres-MarcoVanina da RosZuojian TangJasmin Siegle et al.

A1 Journal Article in NATURE MEDICINE

Pediatric T- and NK-cell lymphomas : new biologic insights and treatment strategies

NK El-MallawanyJK FrazerPieter Van VlierbergheAA FerrandoS PerkinsM LimY ChuMS Cairo

A1 Journal Article in BLOOD CANCER JOURNAL

Prognostic relevance of integrated genetic profiling in acute myeloid leukemia

Jay P PatelMithat GönenMaria E FigueroaHugo FernandezZhuoxin SunJanis RacevskisPieter Van VlierbergheIgor DolgalevSabrena ThomasOlga Aminova et al.

A1 Journal Article in NEW ENGLAND JOURNAL OF MEDICINE

The molecular basis of T cell acute lymphoblastic leukemia

Pieter Van VlierbergheAdolfo Ferrando

A1 Journal Article in JOURNAL OF CLINICAL INVESTIGATION

2011

A cooperative microRNA-tumor suppressor gene network in acute T-cell lymphoblastic leukemia (T-ALL)

Konstantinos J MavrakisJoni Van der MeulenAndrew L WolfeXiaoping LiuEvelien MetsTom TaghonAly A KhanManu SettyPieter RondouPeter Vandenberghe et al.

A1 Journal Article in NATURE GENETICS

A cooperative microRNA-tumor suppressor gene network in acute T-cell lymphoblastic leukemia (T-ALL)

Evelien MetsJoni Van der MeulenKonstantinos J MavrakisAndrew L WolfeTom TaghonAly A KhanManu SettyXiaoping LiuPieter RondouPeter Vandenberghe et al.

Cooperative miRNA mediated FBXW7 suppression contributes to T-cell lymphoblastic leukemogenesis

Evelien MetsJoni Van der MeulenKonstantinos J MavrakisAndrew L WolfeTom TaghonAly A KhanManu SettyXiaoping LiuPeter VandenbergheEric Delabesse et al.

ETV6 mutations in early immature human T cell leukemias

Pieter Van VlierbergheAlberto Ambesi-ImpiombatoArianne Perez-GarciaJ Erika HayduIsaura RigoMichael HadlerValeria ToselloGiusy Della GattaElisabeth PaiettaJanis Racevskis et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

EVI1-mediated down regulation of MIR449A is essential for the survival of EVI1 positive leukaemic cells

An De WeerJoni Van der MeulenPieter RondouTom TaghonTorsten A KonradKatleen De PreterPieter MestdaghTom Van MaerkenNadine Van RoyMarta Jeison et al.

A1 Journal Article in BRITISH JOURNAL OF HAEMATOLOGY

Integrated transcript and genome analyses reveal NKX2-1 and MEF2C as potential oncogenes in T cell acute lymphoblastic leukemia

Irene HommingaRob PietersAnton W LangerakJohan J de RooiAndrew StubbsMonique VerstegenMaartje VuerhardJessica Buijs-GladdinesClarissa KooiPetra Klous et al.

A1 Journal Article in CANCER CELL

Late recurrence of childhood T-cell acute lymphoblastic leukemia frequently represents a second leukemia rather than a relapse: first evidence for genetic predisposition

Tomasz SzczepańskiVincent HJ van der VeldenEsmé WaandersRoland P KuiperPieter Van VlierbergheBernd GruhnCornelia EckertRenate Panzer-GrümayerGiuseppe BassoHélène Cavé et al.

A1 Journal Article in JOURNAL OF CLINICAL ONCOLOGY

PHF6 mutations in adult acute myeloid leukemia

Pieter Van VlierbergheJ PatelO Abdel-WahabC LobryCV HedvatM BalbinC NicolasAR PayerHF FernandezMS Tallman et al.

A1 Journal Article in LEUKEMIA

Regulatory networks governed by microRNAs in T-ALL oncogenesis and normal T-cell development

Joni Van der MeulenEvelien MetsPieter MestdaghPeter PipelersTom TaghonDavid Camacho TrujilloDavid AvranGert Van PeerNadine Van RoyOlivier Thas et al.

2010

Identification of two critically deleted regions within chromosome segment 7q35-q36 in EVI1 deregulated myeloid leukemia cell lines

An De WeerBruce PoppeSarah VergultPieter Van VlierbergheMarjan PetrickRobrecht De BockYves BenoitLucien NoensAnne De PaepeNadine Van Roy et al.

A1 Journal Article in PLOS ONE

NOTCH1 and FBXW7 mutations have a favorable impact on early response to treatment, but not on outcome, in children with T-cell acute lymphoblastic leukemia (T-ALL) treated on EORTC trials 58881 and 58951

E ClappierS ColletteN GrardelS GirardL SuarezG BrunieS KaltenbachK YakoubenF MazingueA Robert et al.

A1 Journal Article in LEUKEMIA

PHF6 mutations in T-cell acute lymphoblastic leukemia

Pieter Van VlierbergheTeresa PalomeroHossein KhiabanianJoni Van der MeulenMireia CastilloNadine Van RoyBarbara De MoerlooseJan PhilippéSara Gonzalez-GarciaMaria L Toribio et al.

A1 Journal Article in NATURE GENETICS

The TLX1 oncogene drives aneuploidy in T cell transformation

Kim De KeersmaeckerPedro J RealGiusy Della GattaTeresa PalomeroMaria Luisa SulisValeria ToselloPieter Van VlierbergheKelly BarnesMireia CastilloXavier Sole et al.

A1 Journal Article in NATURE MEDICINE

2009

A novel and universal method for microRNA RT-qPCR data normalization

Pieter MestdaghPieter Van VlierbergheAn De WeerDaniel MuthFrank WestermannFranki SpelemanJo Vandesompele

A1 Journal Article in GENOME BIOLOGY

Comparison of miRNA profiles of microdissected Hodgkin/Reed-Sternberg cells and Hodgkin cell lines versus CD77+ B-cells reveals a distinct subset of differentially expressed miRNAs

Pieter Van VlierbergheAn De WeerPieter MestdaghTom FeysKatleen De PreterAnne De PaepeKathleen LambeinJo VandesompeleNadine Van RoyBruno Verhasselt et al.

A1 Journal Article in BRITISH JOURNAL OF HAEMATOLOGY

Downregulation of miR-449a is essential for the survival of EVI1 positive leukemic cells through modulation of NOTCH1 and BCL2

An De WeerPieter MestdaghKatleen De PreterJoni Van der MeulenPieter Van VlierbergheTom Van MaerkenNadine Van RoyMarta JeisonIsaac YanivBarbara Cauwelier et al.

MICRORNA SIGNATURES IN GENETIC SUBTYPES OF T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA

Joni Van der MeulenPieter Van VlierberghePieter MestdaghJo VandesompeleBruce PoppeNadine Van RoyTom TaghonJean PlumB. CauwelierDLD Selleslag et al.

MODULATION OF MIR-449A EXPRESSION DECREASES CELL VIABILITY, INCREASES APOPTOSIS AND INDUCES DIFFERENTIATION IN EVI1 DEREGULATED LEUKEMIA CELLS

An De WeerBruce PoppePieter MestdaghKatleen De PreterPieter Van VlierbergheNadine Van RoyM JeisonB CauwelierBruno VerhasseltJan Philippé et al.

2008

Cooperative genetic defects in TLX3 rearranged pediatric T-ALL

Pieter Van VlierbergheI HommingaL ZuurbierJ Gladdines-BuijsER van WeringM HorstmannHB BeverlooR PietersJPP Meijerink

A1 Journal Article in LEUKEMIA

Leukemia-associated NF1 inactivation in patients with pediatric T-ALL and AML lacking evidence for neurofibromatosis

Brian V BalgobindPieter Van VlierbergheAns MW van den OuwelandH Berna BeverlooJoan NR Terlouw-KromosoetoElisabeth R van WeringDirk ReinhardtMartin HorstmannGertjan JL KaspersRob Pieters et al.

A1 Journal Article in BLOOD

MICRORNA PROFILING OF EVI1 DEREGULATED MYELOID LEUKEMIA

An De WeerBruce PoppePieter MestdaghPieter Van VlierbergheNadine Van RoyAnne De PaepeBruno VerhasseltJo VandesompeleFranki Speleman

MicroRNA signatures in genetic subtypes of T-cell acute lymphoblastic leukemia.

Pieter Van VlierbergheBruce PoppeNadine Van RoyTom TaghonJean PlumB CauwelierD SelleslagP HeimannP VandenbergheN Dastugue et al.

Molecular-genetic insights in paediatric T-cell acute lymphoblastic leukaemia

Pieter Van VlierbergheRob PietersH Berna BeverlooJules PP Meijerink

A1 Journal Article in BRITISH JOURNAL OF HAEMATOLOGY

Monoallelic or biallelic LMO2 expression in relation to the LMO2 rearrangement status in pediatric T-cell acute lymphoblastic leukemia

Pieter Van VlierbergheHB BeverlooJ Buijs-GladdinesER van WeringM HorstmannR PietersJPP Meijerink

A1 Journal Article in LEUKEMIA

The recurrent SET-NUP214 fusion as a new HOXA activation mechanism in pediatric T-cell acute lymphoblastic leukemia

Pieter Van VlierbergheMartine van GrotelJoëlle TchindaCharles LeeH Berna BeverlooPeter J van der SpekAndrew StubbsJan CoolsKyosuke NagataMaarten Fornerod et al.

A1 Journal Article in BLOOD

2007

Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia

Idoya LahortigaKim De KeersmaeckerPieter Van VlierbergheCarlos GrauxBarbara CauwelierFrederic LambertNicole MentensH Berna BeverlooRob PietersFranki Speleman et al.

A1 Journal Article in NATURE GENETICS

2006

A new recurrent 9q34 duplication in pediatric T-cell acute lymphoblastic leukemia

Pieter Van VlierbergheJPP MeijerinkC LeeAA FerrandoAT LookER van WeringHB BeverlooJC AsterR Pieters

A1 Journal Article in LEUKEMIA

The cryptic chromosomal deletion del(11)(p12p13) as a new activation mechanism of LMO2 in pediatric T-cell acute lymphoblastic leukemia

Pieter Van VlierbergheMartine van GrotelH Berna BeverlooCharles LeeTryggvi HelgasonJessica Buijs-GladdinesMonique PassierElisabeth R van WeringAnjo JP VeermanWillem A Kamps et al.

A1 Journal Article in BLOOD

2005

Activating FLT3 mutations in CD4(+)/CD8(-) pediatric T-cell acute lymphoblastic leukemias

Pieter Van VlierbergheJules PP MeijerinkRonald W StamWendy van der SmissenElisabeth R van WeringH Berna BeverlooRob Pieters

A1 Journal Article in BLOOD