Research Explorer

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Researcher

Pieter Rottiers

Awards & Distinctions

34 Results

2008

Paracellular entry of interleukin-10 producing Lactococcus lactis in inflamed intestinal mucosa in mice

Anouk WaeytensLiesbeth FerdinandeSabine NeirynckPieter RottiersMartine De VosLothar SteidlerClaude Cuvelier

A1 Journal Article in INFLAMMATORY BOWEL DISEASES

2007

Agalactosyl immunoglobulins are a useful marker for clinical progression and successful therapy of collagen-induced arthritis

Katrien Van BenedenKen CoppietersWouter LaroyPieter RottiersAugust VerbruggenNico CallewaertDirk Elewaut

CARD15 variants determine a disturbed early response of monocytes to adherent-invasive Escherichia coli strain LF82 in Crohn's disease

Harald PeetersSara BogaertDebby LaukensPieter RottiersFilip De KeyserA Darfeuille-MichaudAL GlasserDirk ElewautMartine De Vos

A1 Journal Article in INTERNATIONAL JOURNAL OF IMMUNOGENETICS

Downregulation of metallothioneins (MTS) in intestinal epithelial cells (IECs) is associated with impaired chemoattractant activity

Anouk WaeytensDebby LaukensSylvie JanssensHarald PeetersPieter RottiersClaude CuvelierMartine De Vos

Induction of antigen-specific oral tolerance by genetically modified Lactococcus lactis delivering DQ8-specific immunodominant gliadin epitopes to gluten-sensitized class II transgenic mice

I HUIBREGTSEE MARIETTAS RASHTOKC DAVIDPieter RottiersS VAN DEVENTERJ MURRAY

Induction of antigen-specific tolerance by oral administration of Lactococcus lactis delivered antigen

IL HUIBREGTSEVeerle SnoeckH BRAATEC DE JONGSJ VAN DEVENTERPieter Rottiers

Induction of ovalbumin-specific tolerance by oral administration of Lactococcus lactis secreting ovalbumin

IL HUIBREGTSEVeerle SnoeckAn De CreusH BRAATEC DE JONGSJH VAN DEVENTERPieter Rottiers

A1 Journal Article in GASTROENTEROLOGY

Intestinal secretion of murine trefoil factor 3 via orally administered L-Lactis shows strong therapeutic effect in 5-fluorouracil induced mucositis

Karolien Van HuynegemKlaas VandenbrouckeB COULIEPieter Rottiers

Murine trefoil factor 3 does not directly modulate LPS-mediated dendritic cell function

Michaela LoosAn De CreusL THIMErik RemautPieter Rottiers

A1 Journal Article in SCANDINAVIAN JOURNAL OF IMMUNOLOGY

2006

A phase I trial with Transgenic bacteria expressing interleukin-10 in Crohn's disease

H BRAATPieter RottiersDW HOMMESNathalie HuyghebaertErik RemautJean Paul RemonSJH VAN DEVENTERS NEIRYNCKMP PEPPELENBOSCHLothar Steidler

A1 Journal Article in CLINICAL GASTROENTEROLOGY AND HEPATOLOGY

Altered gut transcriptome in spondyloarthropathy

Debby LaukensHarald PeetersBert Vander CruyssenTom BoonefaesDirk ElewautFilip De KeyserHerman MielantsClaude CuvelierEric VeysKenny Knecht et al.

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

Blocking tumor cell eicosanoid synthesis by GPx4 impedes tumor growth and malignancy

Ingeborg HeirmanDaisy GinnebergeB BRIGELIUS-FLOHEN HENDRICKXP AGOSTINISPeter BrouckaertPieter RottiersJohan Grooten

A1 Journal Article in FREE RADICAL BIOLOGY AND MEDICINE

Clinical potential of Lactococcus lactis mediated delivery of human Interleukin-10 and Trefoil Factors

Erik RemautH BRAATKlaas VandenbrouckePieter RottiersLothar Steidler

A2 Journal Article in Bioscience and microflora

Formatted anti-tumor necrosis factor alpha VHH proteins derived from camelids show superior potency and targeting to inflamed joints in a murine model of collagen-induced arthritis

Ken CoppietersTorsten DreierKaren SilenceHans de HaardMarc LauwereysPeter CasteelsEls BeirnaertHeidi JonckheereChristophe Van De WieleLudovicus Staelens et al.

A1 Journal Article in ARTHRITIS AND RHEUMATISM

Intracellular accumulation of trehalose protects Lactococcus lactis from freeze-drying damage and bile toxicity and increases gastric acid resistance

Sofie TermontKlaas VandenbrouckeDirk IserentantSabine NeirynckLothar SteidlerErik RemautPieter Rottiers

A1 Journal Article in APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Mucosal delivery of ovalbumin by the genetically modified L. lactis suppresses systemic and local inflammatory T-cell responses in DO11.10 mice

IL HUIBREGTSEH BRAATVeerle SnoeckK VAN LAERAAT VELDEPieter RottiersSJ VAN DEVENTER

Mucosal delivery of ovalbumin by the genetically modified Lactocossus lactis suppresses T cell responses in DO11.10 mice

IL HUIBREGTSEH BRAATK VAN LAERAA TE VELDEPieter RottiersSJH VAN DEVENTER

Therapeutic drug delivery by genetically modified Lactococcus lactis

Lothar SteidlerPieter Rottiers

A1 Journal Article in INFLAMMATORY BOWEL DISEASE: GENETICS, BARRIER FUNCTION, IMMUNOLOGIC MECHANISMS, AND MICROBIAL PATHWAYS

Therapeutic effect of mouse trefoil factor 3 in 5-fluorouracil induced mucositis

K VAN HUYNEGEMKlaas VandenbrouckePieter Rottiers

2005

CARD15 gene polymorphisms in patients with spondyloarthropathies identify a specific phenotype previously related to Crohn's disease

Debby LaukensHarald PeetersDENIS MARICHALBert Vander CruyssenHerman MielantsDirk ElewautPieter DemetterClaude CuvelierM VAN DEN BERGHEPieter Rottiers et al.

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

Development of an enteric-coated, layered multi-particulate formulation for ileal delivery of viable recombinant Lactococcus lactis

Nathalie HuyghebaertAN VERMEIREPieter RottiersErik RemautJean Paul Remon

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

2004

Active delivery of trefoil factors by genetically modified Lactococcus lactis prevents and heals acute colitis in mice

Klaas VandenbrouckeWolfgang HansJacques Van HuysseSabine NeirynckPieter DemetterErik RemautPieter RottiersLothar Steidler

A1 Journal Article in GASTROENTEROLOGY

Cytoglobin expression is upregulated in all tissues upon hypoxia: an in vitro and in vivo study by quantitative real-time PCR

E FordelE GeuensSylvia DewildePieter RottiersP CarmelietJohan GrootenLuc Moens

A1 Journal Article in BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Gene-expression profiling reveals distinct expression patterns for classic versus variant Merkel cell phenotypes and new classifier genes to distinguish Merkel cell from small-cell lung carcinoma

M VAN GELEGM BOYLEAL COOKJo VandesompeleTom BoonefaesPieter RottiersNadine Van RoyAnne De PaepePG PARSONSJH LEONARD et al.

A1 Journal Article in ONCOGENE

2003

A comprehensive analysis of gene expression during H2O2 induced cell death in tobacco

Steven VandenabeeleKatrien Van Der KelenTom BoonefaesJames F DatIlya GadjevStijn MorsaPieter RottiersMarc ZabeauDirk InzéFrank Van Breusegem

A comprehensive analysis of hydrogen peroxide-induced gene expression in tobacco

Steven VandenabeeleKatrien Van Der KelenJames F DatIlya GadjevTom BoonefaesStijn MorsaPieter RottiersLuit SlootenMarc Van MontaguMarc Zabeau et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antigen presentation by local macrophages promotes nonallergic airway responses in sensitized mice

Gwenda PynaertPieter RottiersAnuschka HaegemanSarita SehraTom Van BelleJohanna KorfJohan Grooten

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Gene expression profiling reveals two distinct subtypes of Merkel cell carcinoma

M VAN GELEG BOYLEAL COOKTom BoonefaesPieter RottiersNadine Van RoyAnne De PaepeP PARSONSJH LEONARDFranki Speleman

2002

Induction of IL-15 by TCR/CD3 aggregation depends on IFN-gamma and protects against apoptosis of immature thymocytes in vivo.

P MATTHYSHans DoomsPieter RottiersT MITERAL OVERBERGHGeorges LeclercqA BILLIAUJohan Grooten

A1 Journal Article in CLINICAL AND EXPERIMENTAL IMMUNOLOGY

2000

Interleukin-15 redirects the outcome of a tolerizing T-cell stimulus from apoptosis to anergy.

Hans DoomsTom Van BelleMarjory DesmedtPieter RottiersJohan Grooten

A1 Journal Article in BLOOD

1999

Tumoral environment triggers transcript anomalies in established tumors : induction of altered gene expression and of aberrant, truncated and B2 repeat-containing gene transcripts

Pieter RottiersMarjory DesmedtHans DoomsRoland ContrerasJohan Grooten

A2 Journal Article in NEOPLASIA

1998

Differentiation of EL4 lymphoma cells by tumoral environment is associated with inappropriate expression of the large chondroitin sulfate proteoglycan PG-M and the tumor-associated antigen HTgp-175.

Pieter RottiersT VERFAILLIERoland ContrerasH REVETSMarjory DesmedtH DOOMSWalter FiersJohan Grooten

A1 Journal Article in INTERNATIONAL JOURNAL OF CANCER

Moleculaire analyse van een tumor-geassocieerd antigeen en zijn toepassing voor de studie van genetische fenomenen betrokken in progressie tot kanker

Pieter RottiersR. ContrerasJ. Grooten

Quiescence-inducing and antiapoptotic activities of IL-15 enhance secondary CD4(+) T cell responsiveness to antigen.

B DOOMSMarjory DesmedtS VANCAENEGHEMPieter RottiersVera GoossensWalter FiersJohan Grooten

A1 Journal Article in JOURNAL OF IMMUNOLOGY