Research Explorer

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Researcher

Pieter-Jan Van Bockstal

Awards & Distinctions

33 Results

2021

A NIR-based study of desorption kinetics during continuous spin freeze-drying

Laurens LeysGust NuyttenJoris LammensPieter-Jan Van BockstalJos CorverChris VervaetThomas De Beer

A1 Journal Article in PHARMACEUTICS

Development and application of a mechanistic cooling and freezing model of the spin freezing step within the framework of continuous freeze-drying

Gust NuyttenSusan Ríos RevattaPieter-Jan Van BockstalAshish KumarJoris LammensLaurens LeysBrecht VanbillemontJos CorverChris VervaetThomas De Beer

A1 Journal Article in PHARMACEUTICS

Spin freezing and its impact on pore size, tortuosity and solid state

Joris LammensNiloofar Moazami GoudarziLaurens LeysGust NuyttenPieter-Jan Van BockstalChris VervaetMatthieu BooneThomas De Beer

A1 Journal Article in PHARMACEUTICS

2020

A primary drying model-based comparison of conventional batch freeze-drying to continuous spin-freeze-drying for unit doses

Laurens LeysBrecht VanbillemontPieter-Jan Van BockstalJoris LammensGust NuyttenJos CorverChris VervaetThomas De Beer

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

2019

Analysis of a pharmaceutical batch freeze dryer : resource consumption, hotspots, and factors for potential improvement

Ana Gabriela Rentería GámizPieter-Jan Van BockstalSteven De MeesterThomas De BeerJos CorverJo Dewulf

A1 Journal Article in DRYING TECHNOLOGY

Dual chamber cartridges in a continuous pharmaceutical freeze-drying concept : determination of the optimal dynamic infrared heater temperature during primary drying

Laurens De MeyerJoris LammensBrecht VanbillemontPieter-Jan Van BockstalJos CorverChris VervaetWolfgang FriessThomas De Beer

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

The generation and use of recombinant extracellular vesicles as biological reference material

Edward GeeurickxJoeri TulkensBert DhondtJan Van DeunLien LippensGlenn VergauwenElisa HeyrmanDelphine De SutterKris GevaertFrancis Impens et al.

A1 Journal Article in NATURE COMMUNICATIONS

2018

Developing a framework to model the primary drying step of a continuous freeze-drying process based on infrared radiation

Pieter-Jan Van BockstalJos CorverSéverine MortierLaurens De MeyerIngmar NopensKrist V GernaeyThomas De Beer

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Global Sensitivity Analysis as Good Modelling Practices tool for the identification of the most influential process parameters of the primary drying step during freeze-drying

Pieter-Jan Van BockstalSéverine MortierJos CorverIngmar NopensKrist V GernaeyThomas De Beer

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Potential of near-infrared chemical imaging as process analytical technology tool for continuous freeze-drying

Davinia BrouckaertLaurens De MeyerBrecht VanbillemontPieter-Jan Van BockstalJoris LammensSéverine MortierJos CorverChris VervaetIngmar NopensThomas De Beer

A1 Journal Article in ANALYTICAL CHEMISTRY

Recombinant extracellular vesicles : biological reference material to standardize extracellular vesicle research

Edward GeeurickxElisa HeyrmanJan Van DeunLien LippensJoeri TulkensBert DhondtGlenn VergauwenKris GevaertFrancis ImpensIlkka Miinalainen et al.

Recombinant extracellular vesicles : biological reference material to standardize extracellular vesicle research

Edward GeeurickxElisa HeyrmanJan Van DeunLien LippensJoeri TulkensBert DhondtGlenn VergauwenKris GevaertFrancis ImpensIlkka Miinalainen et al.

The development of a continuous and controlled freeze-drying concept for biopharmaceutical unit doses

Pieter-Jan Van BockstalThomas De Beer

The relevance of shear, sedimentation and diffusion during spin freezing, as potential first step of a continuous freeze-drying process for unit doses

Joris LammensSéverine MortierLaurens De MeyerBrecht VanbillemontPieter-Jan Van BockstalSimon Van HerckJos CorverIngmar NopensValérie VanhoorneBruno De Geest et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Thermal imaging as a noncontact inline process analytical tool for product temperature monitoring during continuous freeze-drying of unit doses

Pieter-Jan Van BockstalJos CorverLaurens De MeyerChris VervaetThomas De Beer

A1 Journal Article in ANALYTICAL CHEMISTRY

2017

In-line monitoring of compaction properties on a rotary tablet press during tablet manufacturing of hot-melt extruded amorphous solid dispersions

Wouter GrymonpréGlenn VerstraetePieter-Jan Van BockstalJeroen Van RenterghemPieter RomboutsThomas De BeerJean Paul RemonChris Vervaet

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Mechanistic modelling of infrared mediated energy transfer during the primary drying step of a continuous freeze-drying process

Pieter-Jan Van BockstalSéverine MortierLaurens De MeyerJos CorverChris VervaetIngmar NopensThomas De Beer

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Modelling the primary drying step for the determination of the optimal dynamic heating pad temperature in a continuous pharmaceutical freeze-drying process for unit doses

Laurens De MeyerJoris LammensSéverine MortierBrecht VanbillemontPieter-Jan Van BockstalJos CorverIngmar NopensChris VervaetThomas De Beer

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Noncontact infrared-mediated heat transfer during continuous freeze-drying of unit doses

Pieter-Jan Van BockstalLaurens De MeyerJos CorverChris VervaetThomas De Beer

A1 Journal Article in JOURNAL OF PHARMACEUTICAL SCIENCES

Practical implementation of dynamic primary drying settings in a continuous freeze-drying process

Brecht VanbillemontNiels NicolaïPieter-Jan Van BockstalLaurens De MeyerSéverine MortierJos CorverChris VervaetThomas De Beer

Quantitative risk assessment via uncertainty analysis in combination with error propagation for the determination of the dynamic Design Space of the primary drying step during freeze-drying

Pieter-Jan Van BockstalSéverine MortierJos CorverIngmar NopensKrist V GernaeyThomas De Beer

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

2016

A comparative study between melt granulation/compression and hot melt extrusion/injection molding for the manufacturing of oral sustained release thermoplastic polyurethane matrices

Glenn VerstraetePieter MertensWouter GrymonpréPieter-Jan Van BockstalThomas De BeerMatthieu BooneLuc Van HoorebekeJean Paul RemonChris Vervaet

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

A dynamic design space for primary drying during batch freeze-drying

Séverine MortierPieter-Jan Van BockstalIngmar NopensThomas De BeerKrist V Gernaey

A1 Journal Article in CHIMICA OGGI-CHEMISTRY TODAY

Comparison of metoprolol tartrate multiple-unit lipid matrix systems produced by different technologies

Aleksandar AleksovskiPieter-Jan Van BockstalRobert RoškarTamás SoványGéza RegdonThomas De BeerChris VervaetRok Dreu

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Continuous manufacturing of delta mannitol by cospray drying with PVP

Valérie VanhoornePieter-Jan Van BockstalBernd Van SnickE PeetersTinne MonteyneP GomesThomas De BeerJean Paul RemonChris Vervaet

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Hydrophilic thermoplastic polyurethanes for the manufacturing of highly dosed oral sustained release matrices via hot melt extrusion and injection molding

Glenn VerstraeteJeroen Van RenterghemPieter-Jan Van BockstalSabah KasmiBruno De GeestThomas De BeerJean Paul RemonChris Vervaet

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Impact of vacuum-induced surface freezing on inter- and intra-vial heterogeneity

Irene OddonePieter-Jan Van BockstalThomas De BeerRoberto Pisano

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Uncertainty analysis as essential step in the establishment of the dynamic Design Space of primary drying during freeze-drying

Séverine MortierPieter-Jan Van BockstalJos CorverIngmar NopensKrist V GernaeyThomas De Beer

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

2015

Evaluation of spin freezing versus conventional freezing as part of a continuous pharmaceutical freeze-drying concept for unit doses

Laurens De MeyerPieter-Jan Van BockstalJos CorverChris VervaetJean Paul RemonThomas De Beer

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

In-line near infrared spectroscopy during freeze-drying as a tool to measure efficiency of hydrogen bond formation between protein and sugar, predictive of protein storage stability

Maarten A. MensinkPieter-Jan Van BockstalSigrid PietersLaurens De MeyerHenderik W FrijlinkKees van der Voort MaarschalkWouter LJ HinrichsThomas De Beer

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Model-based optimization of the primary drying step during freeze-drying

Séverine MortierKrist V GernaeyIngmar NopensPieter-Jan Van BockstalThomas De Beer

Model-based optimization of the primary drying step during freeze-drying

Séverine MortierPieter-Jan Van BockstalIngmar NopensKrist V GernaeyThomas De Beer

2013

Analytical QbD development of a pharmacopeial monograph for the anticancer drug asparaginase

Han YaoMatthias D'HondtPieter-Jan Van BockstalYves BenoitTieneke BautersBart De Spiegeleer