Research Explorer

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Researcher

Pieter De Cock

Publications & Research Data

Awards & Distinctions

148 Results

2025

A pooled pharmacokinetic analysis for piperacillin/tazobactam across different patient populations : from premature infants to the elderly

Daming KongJason A. RobertsJeffrey LipmanFabio Silvio TacconeMichael Cohen-WolkowiezFekade B. SimeDanny TsaiPieter De CockSutep JaruratanasirikulSofie A. M. Dhaese et al.

A1 Journal Article in CLINICAL PHARMACOKINETICS

A pooled population pharmacokinetic study of oral and intravenous administration of clavulanic acid in neonates and infants : targeting effective beta-lactamase inhibition

Stef SchouwenburgFleur M. KeijGerdien A. Tramper-StrandersRene F. KornelisseIrwin K. M. ReissPieter De CockEvelyn DhontKevin M. WattAnouk E. MullerRobert B. Flint et al.

A1 Journal Article in CLINICAL PHARMACOLOGY & THERAPEUTICS

Accurate estimation of glomerular filtration rate in critically ill children using iohexol population pharmacokinetics

Evelyn DhontAlexandre DestereCharles BouveyronMilou-Daniel DriciEvelien SnauwaertJean-baptiste WoillardPieter De CockPeter De Paepe

Characterizing meropenem pharmacokinetics in paediatric critical care patients : a population-based analysis

Thi Van Anh NguyenEvelyn DhontEmma BeelNick VerougstraeteVeronique StoveSophie VanhaesebrouckDaphne VensPeter De PaepePieter De Cock

Developing evidence-based dosing recommendations for intravenous ciprofloxacin in critically ill children: a population pharmacokinetic study using total and unbound concentrations

Pieter-Jan De SutterEvelyn DhontDaphné VensPeter De PaepeJef WillemsPetra SchelstraeteJan Van BocxlaerAn VermeulenPieter De Cock

Dynamically calibrated microdialysis for investigating drug penetration in juvenile pigs : advancing pediatric antibiotic research

Isis Van herteryckEline HermansPeter De PaepePieter De CockMathias Devreese

From insight to impact : bridging kidney function and drug dosing in critically ill children

Evelyn DhontPieter De CockPeter De PaepeJohan Vande Walle

Individualised amoxicillin-clavulanate dosing recommendations for critically ill children with augmented clearance after cardiac surgery

Evelyn DhontJoseph F StandingEmma BeelThi Viet Anh NguyenIngrid HerckHarlinde PeperstraeteWim VandenbergheThierry BovéKristof VandekerckhoveNick Verougstraete et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Model-based dose optimization for teicoplanin in patients receiving chronic hemodialysis

Sebastian TandarArnaud De ClercqLinda AulinWim Van BiesenPeter De PaepeSunny ElootCoen van HasseltPieter De Cock

Optimization of microdialysis experiments to study antibiotic disposition in children : lessons learnt

Isis Van herteryckMathias DevreeseEline HermansPeter De PaepeIngeborg DhoogeFrank PlasschaertErik Van LaeckeKatrien Van RenterghemAnnemie BautersPieter De Cock

Pharmacokinetics and target attainment of fluoroquinolones in older adults : a systematic review

Arnaud De ClercqJeroen VervalckeCristina De PetterStef De RyckTania DesmetPeter De PaepeMirko PetrovicPieter De Cock

A1 Journal Article in CLINICAL PHARMACOKINETICS

Pharmacokinetics and target attainment of fluoroquinolones in older adults : a systematic review

Cristina De PetterStef De RyckArnaud De ClercqJeroen VervalckePieter De CockMirko PetrovicTania DesmetPeter De Paepe

Pharmacokinetics and target attainment of teicoplanin : a systematic review

Arnaud De ClercqJaap MoutonPeter De PaepeMirko PetrovicTania DesmetRoger BrüggemannJeroen SchoutenNynke JagerPieter De Cock

Pharmacokinetics and target attainment of teicoplanin : a systematic review

Arnaud De ClercqJaap MoutonPeter De PaepeMirko PetrovicTania DesmetRoger BrüggemanJeroen SchoutenNynke JagerPieter De Cock

Pharmacokinetics and target attainment of teicoplanin : a systematic review

Jaap MoutonArnaud De ClercqPeter De PaepeMirko PetrovicTania DesmetRoger BrüggemannJeroen SchoutenNynke JagerPieter De Cock

A1 Journal Article in CLINICAL PHARMACOKINETICS

Pharmacokinetics of paracetamol and cefazolin in children undergoing minor surgery

Anica De Smet-Van DammeChiel MolletIsis Van herteryckAnnemie BautersAlix HanetMathias DevreeseLaura BoffelChristophe StoveIngeborg DhoogeFrank Plasschaert et al.

Plasma protein binding : can we use piglets to study unbound drug disposition in children?

Isis Van herteryckEline HermansPeter De PaepePieter De CockMathias Devreese

Studying paracetamol disposition in children using a minimally invasive microsampling technique : a preliminary PK analysis

Isis Van herteryckMathias DevreeseAnnemie BautersEline HermansLaura BoffelChristophe StoveP De PaepeIngeborg DhoogeFrank PlasschaertErik Van Laecke et al.

Therapeutic drug monitoring versus Bayesian AUC-based dosing for vancomycin in routine practice : a cost-benefit analysis

Barbara ClausDelphine De SmedtPieter De Cock

A1 Journal Article in JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Understanding meropenem disposition in critically ill children : a population PK analysis

Thi Van Anh NguyenEvelyn DhontEmma BeelNick VerougstraeteVeronique StoveSophie VanhaesebrouckDaphne VensPeter De PaepePieter De CockAn Vermeulen

2024

A multicentric, randomized, controlled clinical trial to study the impact of bedside model-informed precision dosing of vancomycin in critically ill children : BENEFICIAL trial

Pieter De CockRoos ColmanAnca AmzaPeter De PaepeHans De PlaLieselot VanlanduytDimitri Van der Linden[missing] Beneficial Trial Consortium

A1 Journal Article in TRIALS

Comparative assessment of renal function estimating equations as surrogates for amoxicillin clearance in geriatric inpatients

Arnaud De ClercqTania DesmetVeronique StoveNick VerougstraeteMirko PetrovicPeter De PaepePieter De Cock

Comparative assessment of renal function estimating equations as surrogates for amoxicillin clearance in geriatric inpatients

Arnaud De ClercqTania DesmetVeronique StoveNick VerougstraeteMirko PetrovicPeter De PaepePieter De Cock

Comparison of renal function estimating equations as surrogates for amoxicillin clearance in hospitalized older patients

Arnaud De ClercqTania DesmetVeronique StoveNick VerougstraeteMirko PetrovicPeter De PaepePieter De Cock

Dose optimization of β-lactam antibiotics in children : from population pharmacokinetics to individualized therapy

Perrin Ngougni PokemDorian VannesteStef SchouwenburgAlan AbdullaMatthias GijsenEvelyn DhontDimitri van der LindenIsabel SprietPieter De CockBirgit Koch et al.

A1 Journal Article in EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY

Evaluation and expansion of a pharmacy-led therapeutic drug monitoring advisory service as part of an antimicrobial stewardship programme

Pieter De CockSabine DeryckereBarbara ClausFranky BuyleKatleen Van ButselePetra SchelstraeteDiana Huis in 't VeldAnnemie Somers

Evaluation of dosing and therapeutic drug monitoring practices of teicoplanin in hospitalized patients planned for outpatient parenteral antimicrobial therapy

Lotte DeschepperStephen DepoorterSabine DeryckereAnnemie SomersDiana Huis in 't VeldFranky BuylePieter De Cock

Have we neglected to study target-site drug exposure in children? A systematic review of the literature

Eline HermansJozefien MeersschautIsis Van herteryckMathias DevreeseJohan Vande WallePeter De PaepePieter De Cock

A1 Journal Article in CLINICAL PHARMACOKINETICS

Impact of model-informed precision dosing in adults receiving vancomycin via continuous infusion : interim analysis of a randomised, controlled clinical trial

Glenn Van WynsbergeAnnemie SomersDiana Huis in 't VeldPieter De Cock

Impact of model-informed precision dosing in adults receiving vancomycin via continuous infusion : a randomized, controlled clinical trial

Glenn Van WynsbergeVeerle GrootaertFranky BuyleJens Van PraetRoos ColmanIne MoorsAnnemie SomersDiana Huis in 't VeldPieter De CockKim Bigler et al.

A1 Journal Article in TRIALS

Oral flucloxacillin compared to other oral antibiotic regimens for treatment of orthopedic infections in a tertiary Belgian hospital : a retrospective non-inferiority analysis

Sanne De SmetPieter De CockNick VerougstraeteFranky BuyleDiana Huis in 't Veld

Penetration of antibiotics into subcutaneous and intramuscular interstitial fluid : a meta-analysis of microdialysis studies in adults

Pieter-Jan De SutterEline HermansPieter De CockJan Van BocxlaerElke GasthuysAn Vermeulen

A1 Journal Article in CLINICAL PHARMACOKINETICS

Performing clinical drug trials in acute and critically ill neonates and children

Pieter De CockAnne SmitsMehdi OualhaGideon StittTuuli MetsvahtNori SmeetsKarel AllegaertMark A. TurnerAngela AmigoniAthena F. Zuppa et al.

Bookchapter in Essentials of translational pediatric drug development : from past needs to future oportunities

Pharmacokinetic/pharmacodynamic target attainment of beta-lactam antibiotics in geriatric inpatients using standard-of-care dosing regimens

Arnaud De ClercqJeroen VervalckeTania DesmetJerina BoelensAnnemie SomersVeronique StoveNick VerougstraeteGert-Jan WijnantFrançoise Van BambekeMirko Petrovic et al.

Pharmacokinetic/pharmacodynamic target attainment of commonly used ß-lactam antibiotics in hospitalized older patients using current dosing regimens

Arnaud De ClercqJeroen VervalckeTania DesmetJerina BoelensAnnemie SomersVeronique StoveNick VerougstraeteGert-Jan WijnantFrançoise Van BambekeMirko Petrovic et al.

Predictors of augmented renal clearance based on iohexol plasma clearance in critically ill children

Evelyn DhontTatjana Van Der HeggenEvelien SnauwaertJef WillemsSiska CroubelsJoris DelangheJan De WaeleRoos ColmanJohan Vande WallePeter De Paepe et al.

A1 Journal Article in PEDIATRIC NEPHROLOGY

Retrospective analysis of a flucloxacillin oral absorption test in patients requiring flucloxacillin therapy : results and determination of factors associated with adequate absorption

Sanne De SmetPieter De CockNick VerougstraeteFranky BuyleJerina BoelensDiana Huis in 't Veld

A1 Journal Article in ACTA CLINICA BELGICA

Studying antibiotic tissue distribution using microdialysis : from piglets to critically ill children

Eline HermansPieter De CockMathias DevreesePeter De Paepe

The use of information technology to improve interdisciplinary communication during infectious diseases ward rounds on the paediatric intensive care unit

Jef WillemsAdeline HeyndrickxPetra SchelstraeteBram GadeynePieter De CockStien VandendriesschePieter Depuydt

A1 Journal Article in SCIENTIFIC REPORTS

Towards the end of iohexol pharmacokinetics in intensive care children?

Alexandre DestereEvelyn DhontCharles BouveyronMilou-Daniel DriciJean-baptiste WoillardPieter De Cock

‘Let’s START TO TDM’ : advancing a pharmacy-led therapeutic drug monitoring advisory service within an antimicrobial stewardship program

Pieter De CockElise SevensSabine DeryckereBarbara ClausFranky BuyleKatleen Van ButselePetra SchelstraeteDiana Huis in 't VeldAnnemie Somers

2023

A systematic review on pharmacokinetics and target attainment of ß-lactam antibiotics in older people

Jeroen VervalckeArnaud De ClercqPeter De PaepeMirko PetrovicTania DesmetPieter De Cock

Acute aminoglycoside overdose : management and risks

Eline HermansEvelien SnauwaertPieter De CockKarolien De LeenerAgnieszka Prytula-EbelsJo DehoorneLien DosscheJohan Vande WalleDominique VandijckAnn Raes

Aiming for optimal antibiotic treatment : clinical clues on exposure in hospitalized children

Tatjana Van Der HeggenPieter De CockPeter De PaepeSophie Vanhaesebrouck

Antibiotic tissue penetration in the septic piglet versus the child : lessons learnt from microdialysis

Eline HermansPieter De CockPeter De PaepeJohan Vande WalleMathias Devreese

Concentration target attainment after therapeutic drug monitoring of linezolid in critically ill patients

Jolien LanguiPieter De CockNick VerougstraeteJerina BoelensAnnemie SomersJan De WaeleBarbara Claus

Microdialysis as a safe and feasible method to study target-site piperacillin-tazobactam disposition in septic piglets and children

Eline HermansMathias DevreeseMarkus ZeitlingerEvelyn DhontNick VerougstraeteRoos ColmanJohan Vande WallePeter De PaepePieter De Cock

A1 Journal Article in INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Multinational consensus antimicrobial stewardship recommendations for children managed in hospital settings

B McMullanPA BryantE DuffyJ BielickiPieter De CockM ScienceT ZemblesK TimberlakeE MonseesRF Hamdy et al.

A1 Journal Article in LANCET INFECTIOUS DISEASES

Pharmacokinetics and target attainment of ß-lactam antibiotics in older adults : a systematic review

Arnaud De ClercqJeroen VervalckePeter De PaepeMirko PetrovicTania DesmetPieter De Cock

Pharmacokinetics and target attainment of ß-lactam antibiotics in older people : a systematic review of current literature

Jeroen VervalckeArnaud De ClercqPeter De PaepeMirko PetrovicTania DesmetPieter De Cock

A1 Journal Article in CLINICAL PHARMACOKINETICS

PK/PD target attainment of amoxicillin-clavulanate and piperacillin-tazobactam in hospitalized older patients using current dosing regimens

Arnaud De ClercqJeroen VervalckeTania DesmetJerina BoelensAnnemie SomersVeronique StoveNick VerougstraeteMirko PetrovicPeter De PaepePieter De Cock

PK/PD target attainment of current amoxicillin-clavulanic acid and piperacillin-tazobactam dosing regimens in older patients

Arnaud De ClercqJeroen VervalckeTania DesmetJerina BoelensAnnemie SomersVeronique StoveNick VerougstraeteMirko PetrovicPeter De PaepePieter De Cock

Predictive performance of physiologically based pharmacokinetic modelling of beta-lactam antibiotic concentrations in adipose, bone and muscle tissues

Pieter-Jan De SutterPieter De CockTN JohnsonH MustherElke GasthuysAn Vermeulen

A1 Journal Article in DRUG METABOLISM AND DISPOSITION

Risk and management of an acute aminoglycoside overdose : case report and literature review

Eline HermansEvelien SnauwaertPieter De CockAgnieszka Prytula-EbelsJoke DehoorneLien DosscheJohan Vande WalleAnn Raes

Tissue penetration of piperacillin-tazobactam in critically ill children : a microdialysis study

Eline HermansEvelyn DhontMathias DevreeseJohan Vande WallePeter De PaepePieter De Cock

2022

A guideline for therapeutic drug monitoring of linezolid in critically ill patients

Jolien LanguiPieter De CockNick VerougstraeteJerina BoelensDiana Huis in 't VeldAnnemie SomersJan De WaeleBarbara Claus

A piglet model of pediatric sepsis to investigate tissue penetration of antibiotics in children : a microdialysis study on piperacillin-tazobactam

Eline HermansPeter De PaepeJohan Vande WallePieter De CockMathias Devreese

Accuracy of PBPK-predicted tissue concentrations : a case study of beta-lactam antibiotics in fat, bone and muscle

Pieter-Jan De SutterPieter De CockTrevor N JohnsonHelen MustherElke GasthuysAn Vermeulen

General clinical and methodological considerations on the extrapolation of pharmacokinetics and optimization of study protocols for small molecules and monoclonal antibodies in children

Naim BouazzaAristides DokoumetzidisCatherijne A. J. KnibbeSaskia N. de WildtClaire AmberyPieter De CockElke GasthuysFrantz FoissacSaik UrienAnna-Karin Hamberg et al.

A1 Journal Article in BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Model-informed precision dosing of vancomycin via continuous infusion : a clinical fit-for-purpose evaluation of published PK models

Astrid HeusDavid W. UsterVeerle GrootaertNele VermeulenAnnemie SomersDiana Huis in 't VeldSebastian G. WichaPieter De Cock

A1 Journal Article in INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Physiologically based pharmacokinetic models for the prediction of beta-lactam antibiotic concentrations in perfusion-limited tissues

Pieter-Jan De SutterPieter De CockElke GasthuysAn Vermeulen

Reliability of glomerular filtration rate estimating formulas compared to iohexol plasma clearance in critically ill children

Evelyn DhontCharlotte WindelsEvelien SnauwaertTatjana Van Der HeggenAnnik de JaegerLaura DhondtJoris DelangheSiska CroubelsJohan Vande WallePeter De Paepe et al.

A1 Journal Article in EUROPEAN JOURNAL OF PEDIATRICS

Reply to commenting letter for 'Reliability of glomerular filtration rate estimating formulas compared to iohexol plasma clearance in critically ill children' by Smeets et al

Evelyn DhontTatjana Van Der HeggenPieter De Cock

A1 Journal Article in EUROPEAN JOURNAL OF PEDIATRICS

Risk factors of augmented renal clearance in critically ill children using iohexol clearance for renal function assessment

Evelyn DhontTatjana Van Der HeggenEvelien SnauwaertJef WillemsSiska CroubelsJoris DelangheJohan Vande WallePeter De PaepePieter De Cock

Suboptimal beta-lactam therapy in critically ill children : risk factors and outcome

Tatjana Van Der HeggenEvelyn DhontJef WillemsINGRID HERCKJoris DelangheVeronique StoveAlain VerstraeteSophie VanhaesebrouckPeter De PaepePieter De Cock

A1 Journal Article in PEDIATRIC CRITICAL CARE MEDICINE

The influence of sepsis on the tissue penetration of piperacillin-tazobactam in children : a microdialysis study in the juvenile pig

Eline HermansFreya MeganckPeter De PaepeJohan Vande WallePieter De CockMathias Devreese

The translation from in vitro experiments to in vivo microdialysis trials : a case study of piperacillin-tazobactam

Eline HermansMarkus ZeitlingerEvelyn DhontPeter De PaepeJohan Vande WalleMathias DevreesePieter De Cock

Variation in vancomycin dosing and therapeutic drug monitoring practices in neonatal intensive care units

Anouk van der VeenAnnemie SomersSophie VanhaesebrouckRob ter HeineRoger BrüggemannKarel AllegaertPieter De Cock

A1 Journal Article in INTERNATIONAL JOURNAL OF CLINICAL PHARMACY

2021

A model-averaging approach performs superior to distinct population pharmacokinetic models in Bayesian forecasting of vancomycin administered as continuous infusion

David William UsterA HeusAnnemie SomersVeerle GrootaertN VermeulenDiana Huis in 't VeldPieter De CockS. G. Wicha

Accuracy of creatinine-based and cystatin c-based eGFR formulas compared to plasma iohexol clearance in children after cardio-pulmonary bypass

Evelyn DhontCharlotte WindelsANNIK DE JAEGERSiska CroubelsJohan Vande WallePeter De PaepePieter De Cock

Accuracy of creatinine-based and cystatin C-based eGFR formulas compared to plasma iohexol clearance in children after cardio-pulmonary bypass

Evelyn DhontC. WindelsANNIK DE JAEGERSiska CroubelsJohan Van de WallePeter De PaepePieter De Cock

Accuracy of renal function estimating equations compared to iohexol clearance in critically ill children

Evelyn DhontCharlotte WindelsTatjana Van Der HeggenJohan Vande WalleSiska CroubelsSiegrid De BaerePeter De PaepePieter De Cock

Accuracy of renal function estimating equations compared to iohexol clearance in critically ill children

Evelyn DhontCharlotte WindelsTatjana Van Der HeggenJohan Vande WalleSiska CroubelsSiegrid De BaerePeter De PaepePieter De Cock

Antibiotics in critically ill children : a focus on tissue penetration

Eline HermansMathias DevreesePeter De PaepeJohan Vande WallePieter De Cock

Belgian experience with a flucloxacillin absorption test to guide antibiotic treatment

Nick VerougstraeteFranky BuylePieter De CockJerina BoelensSanne De SmetDiana Huis in 't VeldAlain Verstraete

Beta-lactam antibiotics in critically ill children : who is at risk for suboptimal treatment?

Tatjana Van Der HeggenEvelyn DhontJoris DelanghePeter De PaepeSophie VanhaesebrouckPieter De Cock

Critically ill children treated with beta-lactam antibiotics : how to identify patients at risk for suboptimal exposure and clinical failure?

Tatjana Van Der HeggenEvelyn DhontINGRID HERCKJoris DelanghePeter De PaepeSophie VanhaesebrouckPieter De Cock

Determination of recovery and optimal calibration technique for piperacillin tazobactam and meropenem : an in vitro microdialysis study

Eline HermansPieter De CockMathias DevreesePeter De PaepeJohan Vande WalleMarkus Zeitlinger

Determination of recovery and optimal calibration technique for piperacillin-tazobactam : an in vitro microdialysis study

Eline HermansMathias DevreesePeter De PaepeJohan Vande WallePieter De Cock

Estimation of ontogeny functions for renal transporters using a combined population pharmacokinetic and physiology-based pharmacokinetic approach : application to OAT1,3

Sînziana CristeaElke H. J. KrekelsKarel AllegaertPeter De PaepeAnnik de JaegerPieter De CockCatherijne A. J. Knibbe

A1 Journal Article in AAPS JOURNAL

Microdialysis to study tissue penetration of drugs in the juvenile pig : an opportunity for pediatric drug research

Eline HermansPieter De CockPeter De PaepeJohan Vande WalleMathias Devreese

Optimizing amoxicillin/clavulanic acid dosing regimens in patients on maintenance high-flux hemodialysis

Kelly De SchuyterPieter J. ColinFloris VanommeslaegheSigurd DelanghePieter De CockNic VeysPeter De PaepeWim Van BiesenSunny Eloot

A1 Journal Article in AMERICAN JOURNAL OF KIDNEY DISEASES

Optimizing the use of antibiotic agents in the pediatric intensive care unit : a narrative review

Jef WillemsEline HermansPetra SchelstraetePieter DepuydtPieter De Cock

A1 Journal Article in PEDIATRIC DRUGS

Population pharmacokinetics of unbound and total teicoplanin in critically ill pediatric patients

L. B. S. AulinPeter De PaepeEvelyn DhontAnnik de JaegerJohan Vande WalleWim VandenbergheB. C. McWhinneyJ. P. J. UngererJ. G. C. van HasseltPieter De Cock

A1 Journal Article in CLINICAL PHARMACOKINETICS

Reproducibility of fluid status measured by bioelectrical impedance analysis in healthy volunteers : a key requirement to monitor fluid status in the intensive care unit

Matthias GijsenEline SimonsPieter De CockManu L. N. G. MalbrainJoost WautersIsabel Spriet

A2 Journal Article in ANAESTHESIOLOGY INTENSIVE THERAPY

The development of a juvenile porcine augmented renal clearance model through continuous infusion of lipopolysaccharides : an exploratory study

Laura DhondtSiska CroubelsRobin TemmermanPieter De CockEvelyne MeyerWim Van Den BroeckPeter De PaepeMathias Devreese

A1 Journal Article in FRONTIERS IN VETERINARY SCIENCE

Unraveling the contribution of fluid therapy to the development of augmented renal clearance in a piglet model

Laura DhondtSiska CroubelsPeter De PaepeKlara GoethalsPieter De CockMathias Devreese

A1 Journal Article in FRONTIERS IN PHARMACOLOGY

Vancomycin dosing and therapeutic drug monitoring practices : guidelines versus real-life

Tatjana Van Der HeggenFranky BuyleBarbara ClausAnnemie SomersPetra SchelstraetePeter De PaepeSophie VanhaesebrouckPieter De Cock

A1 Journal Article in INTERNATIONAL JOURNAL OF CLINICAL PHARMACY

Volumetric absorptive microsampling as alternative sampling technique for renal function assessment in the paediatric population using iohexol

Laura DhondtSiska CroubelsPieter De CockEvelyn DhontSiegrid De BaerePeter De PaepeMathias Devreese

A1 Journal Article in JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

2020

Augmented renal clearance in pediatric intensive care : are we undertreating our sickest patients?

Evelyn DhontTatjana Van Der HeggenANNIK DE JAEGERJohan Vande WallePeter De PaepePieter De Cock

A1 Journal Article in PEDIATRIC NEPHROLOGY

Conventional pig as animal model for human renal drug excretion processes : unravelling the porcine renal function by use of a cocktail of exogenous markers

Laura DhondtSiska CroubelsPeter De PaepeSteven C. WallisSaurabh PandeyJason A. RobertsJeffrey LipmanPieter De CockMathias Devreese

A1 Journal Article in FRONTIERS IN PHARMACOLOGY

Dried blood microsamples : suitable as an alternative matrix for the quantification of paracetamol-protein adducts?

Lisa DelahayeEvelyn DhontPieter De CockPeter De PaepeChristophe Stove

A1 Journal Article in TOXICOLOGY LETTERS

Grasping the phenomenon of augmented renal clearance in the critically ill using the conventional pig as juvenile animal model

Laura DhondtMathias DevreeseSiska CroubelsPeter De PaepePieter De Cock

Lessons to learn from vancomycin dosing and TDM practices in children and neonates

Tatjana Van Der HeggenFranky BuyleAnouk van der VeenJoery VerbruggenJasmien Van de WalPetra SchelstraetePeter De PaepeSophie VanhaesebrouckPieter De Cock

Off-label use of medicines in neonates, infants, children, and adolescents : a joint policy statement by the European Academy of Paediatrics and the European Society for Developmental, Perinatal and Pediatric Pharmacology

Lenneke SchrierAdamos HadjipanayisTom StirisRob Ross-RussellArunas ValiulisMark TurnerWei ZhaoPieter De CockSaskia de WildtKarel Allegaert et al.

A1 Journal Article in EUROPEAN JOURNAL OF PEDIATRICS

2019

Accuracy of renal function estimating equations compared to iohexol clearance in critically ill children

Evelyn DhontCharlotte WindelsTatjana Van Der HeggenANNIK DE JAEGERJef WillemsSiska CroubelsSiegrid De BaereJohan Vande WallePeter De PaepePieter De Cock

Amoxicillin/clavulanic acid dosing in frail geriatric patients : do we need a tailored dosing regimen?

Tania DesmetTim KrolsBram Van BraeckelVeronique StoveAlain VerstraeteAnnemie SomersDirk VogelaersMirko PetrovicPeter De PaepePieter De Cock

Amoxicilline/clavulaanzuur bij geriatrische patiënten : is er nood aan een geriatrische dosering?

Bram Van BraeckelTim KrolsTania DesmetPieter De CockMirko PetrovicPeter De Paepe

Appropriateness of vancomycin dosing and therapeutic drug monitoring practices in a Belgian tertiary hospital

Pieter De CockJasmien Van de WalBarbara ClausPetra SchelstraeteDirk VogelaersFranky Buyle

Augmented renal clearance : a common condition in critically ill children

Tatjana Van Der HeggenEvelyn DhontHarlinde PeperstraeteJoris DelangheJohan Vande WallePeter De PaepePieter De Cock

A1 Journal Article in PEDIATRIC NEPHROLOGY

Clinical validation of published vancomycin population PK models in critically ill neonates

Anouk van der VeenRon KeizerWillem de BoodeAnnemie SomersRoger BrüggemannRob ter HeinePieter De Cock

Comparison of renal function estimation methods in critically ill children : a pilot study

Evelyn DhontTatjana Van Der HeggenANNIK DE JAEGERJef WillemsSiska CroubelsSiegrid De BaereJohan Vande WallePeter De PaepePieter De Cock

Development and validation of an ultra-high performance liquid chromatography-tandem mass spectrometry method for the simultaneous determination of iohexol, p-aminohippuric acid and creatinine in porcine and broiler chicken plasma

Laura DhondtSiska CroubelsPieter De CockPeter De PaepeSiegrid De BaereMathias Devreese

A1 Journal Article in JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Disease condition affects amikacin pharmacokinetics and dosing in children

Anne SmitsXiaoxi LiuYuhuan WangMarleen RenardStephanie WeadRichard KaganDaniel HealyPieter De CockCatherine SherwinKarel Allegaert

Dose rationale and pharmacokinetics of dexmedetomidine in mechanically ventilated new-borns : impact of design optimisation

Sven C van DijkmanPieter De CockKoenraad SmetsWim DecaluweAnne SmitsKarel AllegaertJohan Vande WallePeter De PaepeOscar Della Pasqua

A1 Journal Article in EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Drug research in the critically ill child : beyond the beaten track

Pieter De CockKarel AllegaertEvelyn Dhont

A2 Journal Article in BELGIAN JOURNAL OF PAEDIATRICS

Impact of disease on amikacin pharmacokinetics and dosing in children

Xiu LiuAnne SmitsYuhuan WangMarleen RenardStephanie WeadRichard KaganDaniel HealyPieter De CockKarel AllegaertCatherine Sherwin

A1 Journal Article in THERAPEUTIC DRUG MONITORING

Pharmacokinetic model development for total and free vancomycin in critically ill children

Ferran GonzalezPieter De CockEvelyn DhontSophie VanhaesebrouckDominique BiarentFrank KloproggePeter De PaepeJoe Standing

Piglets as animal model to assess the contribution of fluid therapy to the development of augmented renal clearance in children

Laura DhondtSiska CroubelsPeter De PaepePieter De CockMathias Devreese

Retrospective evaluation of teicoplanin dosing, therapeutic drug monitoring practices and target attainment in a Belgian tertiary hospital

Franky BuyleJasmien Van de WalBarbara ClausDirk VogelaersPieter De Cock

Target attainment of amikacin therapy in critically ill children

Joery VerbruggenKamilya JakipbayevaEvelyn DhontLaura DhondtTatjana Van Der HeggenINGRID HERCKJohan Vande WallePeter De PaepePieter De Cock

The juvenile pig as animal model for unraveling renal drug elimination processes in children

Laura DhondtSiska CroubelsPeter De PaepePieter De CockMathias Devreese

Untangling maturation functions for kidney transporters using a combined population pharmacokinetics and physiology-based pharmacokinetics approach

Sinzea CristeaElke KrekelsPieter De CockPeter De PaepeKarel AllegaertCatherijne Knibbe

Volumetric absorptive microsampling as an alternative sampling strategy for the determination of paracetamol in blood and cerebrospinal fluid

Lisa DelahayeEvelyn DhontPieter De CockPeter De PaepeChristophe Stove

A1 Journal Article in ANALYTICAL AND BIOANALYTICAL CHEMISTRY

2018

Antibiotic dosing in pediatric critically ill patients

Pieter De CockKarel AllegaertMatthew W LinakisCatherine MT Sherwin

Bookchapter in Antibiotic pharmacokinetic/pharmacodynamic considerations in the critically ill

Antibiotic PK/PD research in critically ill neonates and children : how do we proceed?

Anne SmitsPieter De Cock

Editorial material

Assessment of renal function in the critically ill child : focus on augmented renal clearance

Evelyn DhontJef WillemsAnn VerrijcktANNIK DE JAEGERJohan Vande WallePeter De PaepePieter De Cock

A2 Journal Article in BELGIAN JOURNAL OF PAEDIATRICS

Disease condition affects amikacin pharmacokinetics and dosing in children

Anne SmitsXiaoxi LiuYuhuan WangMarleen RenardStephanie WeadRichard KaganDaniel HealyPieter De CockCatherine SherwinKarel Allegaert

Dosing renally cleared drugs in critically ill children : mind the trap of glomerular hyperfiltration!

Pieter De CockTatjana Van Der HeggenEvelyn DhontNicky BoeykensKarlien RoelandtBenjamin LeenknegtHarlinde PeperstraeteJoris DelangheJohan Vande WallePeter De Paepe

Glomerular hyperfiltration : a new concept in critically ill children

Tatjana Van Der HeggenEvelyn DhontHarlinde PeperstraeteJoris DelangheJohan Vande WallePeter De PaepePieter De Cock

Simultaneous determination of creatinine, iohexol and p-aminohippuric acid in animal plasma by ultra-high-performance liquid chromatography-tandem mass spectrometry

Laura DhondtSiska CroubelsPieter De CockPeter De PaepeMathias Devreese

Subtherapeutic antimicrobial plasma concentrations with standard amoxicillin-clavulanate dosing regimens in paediatric cardiac surgery patients

Evelyn DhontJef WillemsWim VandenbergheMieke CarlierAlain VerstraeteJohan Vande WallePeter De PaepePieter De Cock

Teicoplanin therapy in critically ill children : an observational study on protein binding and target attainment

MARGOT WOLLAERTSarah DesmetBrett McWhinneyJacobus UngererANNIK DE JAEGERJohan Vande WallePeter De PaepePieter De Cock

The development of a juvenile porcine augmented renal clearance model for paediatric drug research during sepsis : the effect of different continuously administered LPS doses on the renal function

Laura DhondtSiska CroubelsPieter De CockPeter De PaepeMathias Devreese

2017

An observational study on plasma protein binding and target attainment of teicoplanin in critically ill children

Pieter De Cock. WollaertSanne DesmetAnnick De JaegerJohan Vande WallePeter De Paepe

Antibiotic dosing in ICU children : so you think you can prescribe?

Pieter De CockEvelyn DhontPeter De Paepe

Editorial material

Dose optimization of piperacillin/tazobactam in critically ill children

Pieter De CockSven C van DijkmanANNIK DE JAEGERJef WillemsMieke CarlierAlain VerstraeteJoris DelangheHugo RobaysJohan Vande WalleOscar E Della Pasqua et al.

A1 Journal Article in JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Hyperfiltration in the paediatric intensive care unit (HYPIC) : a pilot study

Tatjana Van Der Heggen. Leenkneght. Roelandt. De JaegerINGRID HERCKJoris DelangheJohan Vande WallePeter De PaepePieter De Cock

Hyperfiltration in the pediatric intensive care unit : a pilot study

Tatjana Van Der HeggenBenjamin LeenknegtKarlien RoelandtANNIK DE JAEGER. Van HerckJoris DelangheJohan Vande WallePeter De PaepePieter De Cock

Impact of critical illness and cardiopulmonary bypass on antibiotic disposition in children

Pieter De CockPeter De PaepeJohan Vande WalleOscar Della Pasqua

Impact of vancomycin protein binding on target attainment in critically ill children : back to the drawing board?

Pieter De CockSarah DesmetANNIK DE JAEGERDominique BiarentEvelyn DhontIngrid HerckDaphné VensSofie ColmanVeronique StoveSABRINA COMMEYNE et al.

A1 Journal Article in JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Participating in pediatric drug research : identifying the burden

Fien DewolfThierry Christiaens. De BruynePieter De CockJohan Vande Walle

Population pharmacokinetics of cefazolin before, during and after cardiopulmonary bypass to optimize dosing regimens for children undergoing cardiac surgery

Pieter De CockHussain MullaSarah DesmetFilip De SomerBrett C McWhinneyJacobus PJ UngererAnneliese MoermanSABRINA COMMEYNEJohan Vande WalleKatrien Francois et al.

A1 Journal Article in JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Teicoplanin therapy in critically ill children : a plea for more dedicated research on optimal pharmacokinetic-pharmacodynamic indices

MARGOT WOLLAERTSarah DesmetB McWhinneyANNIK DE JAEGERJohan Vande WallePeter De PaepePieter De Cock

2016

Bypassing the impact of cardiopulmonary bypass on cefazolin disposition in children using a model-based dosing regimen

Pieter De CockAnneliese Moerman

Piperacollin-tazobactam pharmacokinetis- pharmacodynamics implies a need for higher dosing in critically ill children

Pieter De CockSven Van DijckmanAnnick De JaegerJef WillemsMieke CarlierAlain VerstraeteJoris DelangheHugo RobaysJohan Vande WalleOscar Della Pasqua et al.

2015

Augmented renal clearance implies a need for increased amoxicillin-clavulanic acid dosing in critically ill children

Pieter De CockJoseph F StandingCharlotte IS BarkerANNIK DE JAEGEREvelyn DhontMieke CarlierAlain VerstraeteJoris DelangheHugo RobaysPeter De Paepe

A1 Journal Article in ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Population cefazolin pharmacokinetics before, during and after cardiopulmonary bypass in children undergoing cardiac surgery

Pieter De CockHussain MullaKaren JacobsKim VanderburghtSarah DesmetBrett McWhinneyJacobus UngererFilip De SomerAnneliese MoermanHugo Robays et al.

Population cefazolin pharmacokinetics before, during and after cardiopulmonary bypass in children undergoing cardiac surgery

Pieter De CockHussain MullaKaren JacobsKim VanderburghtSarah DesmetBrett McWhinneyJacobus UngererFilip De SomerAnneliese MoermanHugo Robays et al.

2014

The clinical relevance of pediatric formulations

Karel AllegaertPieter De CockJohannes N van den Anker

Bookchapter in Pediatric formulations : a roadmap

2013

A pilot qualitative analysis of vancomycin dosing and monitoring in children at a Belgian teaching hospital

Pieter De CockEVELIEN HAEGEMANNele GoerlandtVeronique StoveAlain VerstraetePiet VanhaesebrouckPetra SchelstraeteHugo Robays

2012

Geneesmiddelenformulering, klinische farmacologie en de zuigeling: over de relevantie van pediatrische formuleringen

Pieter De CockAnne SmitsRoosmarijn De CockKatrien CosaertHugo RobaysKarel Allegaert

A4 Journal Article in PERCENTIEL (NEDERLANDSE ED.)

2011

Pharmacokinetics of two formulations of omeprazole administered through a gastrostomy tube in patients with severe neurodevelopmental problems

Koen BousseryJulie De SmetPieter De CockSaskia Vande VeldeEls MehuysPeter De PaepeJean Paul RemonJan Van BocxlaerMyriam Van Winckel

A1 Journal Article in BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

2010

A bio-analytical hydrophilic interaction LC-MS/MS method for the simultaneous quantification of omeprazole and lansoprazole in human plasma in support of a pharmacokinetic omeprazole study in children

Julie De SmetKoen BousseryPieter De CockPeter De PaepeJean Paul RemonMyriam Van WinckelJan Van Bocxlaer

A1 Journal Article in JOURNAL OF SEPARATION SCIENCE

CPOE and prevention of prescribing errors

Pieter De CockBarbara ClausHugo Robays

A4 Journal Article in HOSPITAL PHARMACY EUROPE

2009

Safety of short-acting nifedipine in children: a literature review

Pieter De CockLucas Van BortelAnn RaesJohan Vande WalleANNIK DE JAEGERHugo Robays

Tacrolimus-clarithromycin interaction in a paediatric liver transplant with severe diarrhea: a case report

Pieter De CockMyriam Van WinckelAnn VerrijcktANNIK DE JAEGERMARIJKE VAN HOOREWEGHEHugo Robays

2006

Clinical pharmacy and pediatrics : why focus on antibiotics?

Tieneke BautersBT NguyenFranky BuylePetra SchelstraetePieter De CockANNIK DE JAEGERAnn VerrijcktHugo Robays

Editorial material