Research Explorer

Your browser does not support JavaScript or JavaScript is not enabled. Without JavaScript some functions of this webapplication may be disabled or cause error messages. To enable JavaScript, please consult the manual of your browser or contact your system administrator.

Researcher

Pieter De Cock

73 Results

2021

Accuracy of creatinine-based and cystatin C-based eGFR formulas compared to plasma iohexol clearance in children after cardio-pulmonary bypass

Evelyn DhontC. WindelsAnnik de JaegerSiska CroubelsJohan Van de WallePeter De PaepePieter De Cock

Accuracy of creatinine-based and cystatin c-based eGFR formulas compared to plasma iohexol clearance in children after cardio-pulmonary bypass

Evelyn DhontCharlotte WindelsAnnik de JaegerSiska CroubelsJohan Vande WallePeter De PaepePieter De Cock

Accuracy of renal function estimating equations compared to iohexol clearance in critically ill children

Evelyn DhontCharlotte WindelsTatjana Van Der HeggenJohan Vande WalleSiska CroubelsSiegrid De BaerePeter De PaepePieter De Cock

Accuracy of renal function estimating equations compared to iohexol clearance in critically ill children

Evelyn DhontCharlotte WindelsTatjana Van Der HeggenJohan Vande WalleSiska CroubelsSiegrid De BaerePeter De PaepePieter De Cock

Antibiotics in critically ill children : a focus on tissue penetration

Eline HermansMathias DevreesePeter De PaepeJohan Vande WallePieter De Cock

Beta-lactam antibiotics in critically ill children : who is at risk for suboptimal treatment?

Tatjana Van Der HeggenEvelyn DhontJoris DelanghePeter De PaepeSophie VanhaesebrouckPieter De Cock

Critically ill children treated with beta-lactam antibiotics : how to identify patients at risk for suboptimal exposure and clinical failure?

Tatjana Van Der HeggenEvelyn DhontIngrid HerckJoris DelanghePeter De PaepeSophie VanhaesebrouckPieter De Cock

Determination of recovery and optimal calibration technique for piperacillin tazobactam and meropenem : an in vitro microdialysis study

Eline HermansPieter De CockMathias DevreesePeter De PaepeJohan Vande WalleMarkus Zeitlinger

Determination of recovery and optimal calibration technique for piperacillin-tazobactam : an in vitro microdialysis study

Eline HermansMathias DevreesePeter De PaepeJohan Vande WallePieter De Cock

Estimation of ontogeny functions for renal transporters using a combined population pharmacokinetic and physiology-based pharmacokinetic approach : application to OAT1,3

Sînziana CristeaElke H. J. KrekelsKarel AllegaertPeter De PaepeAnnik de JaegerPieter De CockCatherijne A. J. Knibbe

A1 Journal Article in AAPS JOURNAL

Microdialysis to study tissue penetration of drugs in the juvenile pig : an opportunity for pediatric drug research

Eline HermansPieter De CockPeter De PaepeJohan Vande WalleMathias Devreese

Optimizing amoxicillin/clavulanic acid dosing regimens in patients on maintenance high-flux hemodialysis

Kelly De SchuyterPieter J. ColinFloris VanommeslaegheSigurd DelanghePieter De CockNic VeysPeter De PaepeWim Van BiesenSunny Eloot

A1 Journal Article in AMERICAN JOURNAL OF KIDNEY DISEASES

Population pharmacokinetics of unbound and total teicoplanin in critically ill pediatric patients

L. B. S. AulinPeter De PaepeEvelyn DhontAnnik de JaegerJohan Vande WalleWim VandenbergheB. C. McWhinneyJ. P. J. UngererJ. G. C. van HasseltPieter De Cock

A1 Journal Article in CLINICAL PHARMACOKINETICS

The development of a juvenile porcine augmented renal clearance model through continuous infusion of lipopolysaccharides : an exploratory study

Laura DhondtSiska CroubelsRobin TemmermanPieter De CockEvelyne MeyerWim Van Den BroeckPeter De PaepeMathias Devreese

A1 Journal Article in FRONTIERS IN VETERINARY SCIENCE

Unraveling the contribution of fluid therapy to the development of augmented renal clearance in a piglet model

Laura DhondtSiska CroubelsPeter De PaepeKlara GoethalsPieter De CockMathias Devreese

A1 Journal Article in FRONTIERS IN PHARMACOLOGY

Vancomycin dosing and therapeutic drug monitoring practices : guidelines versus real-life

Tatjana Van Der HeggenFranky BuyleBarbara ClausAnnemie SomersPetra SchelstraetePeter De PaepeSophie VanhaesebrouckPieter De Cock

A1 Journal Article in INTERNATIONAL JOURNAL OF CLINICAL PHARMACY

Volumetric absorptive microsampling as alternative sampling technique for renal function assessment in the paediatric population using iohexol

Laura DhondtSiska CroubelsPieter De CockEvelyn DhontSiegrid De BaerePeter De PaepeMathias Devreese

A1 Journal Article in JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

2020

Augmented renal clearance in pediatric intensive care : are we undertreating our sickest patients?

Evelyn DhontTatjana Van Der HeggenAnnik de JaegerJohan Vande WallePeter De PaepePieter De Cock

A1 Journal Article in PEDIATRIC NEPHROLOGY

Conventional pig as animal model for human renal drug excretion processes : unravelling the porcine renal function by use of a cocktail of exogenous markers

Laura DhondtSiska CroubelsPeter De PaepeSteven C. WallisSaurabh PandeyJason A. RobertsJeffrey LipmanPieter De CockMathias Devreese

A1 Journal Article in FRONTIERS IN PHARMACOLOGY

Dried blood microsamples : suitable as an alternative matrix for the quantification of paracetamol-protein adducts?

Lisa DelahayeEvelyn DhontPieter De CockPeter De PaepeChristophe Stove

A1 Journal Article in TOXICOLOGY LETTERS

Grasping the phenomenon of augmented renal clearance in the critically ill using the conventional pig as juvenile animal model

Laura DhondtMathias DevreeseSiska CroubelsPeter De PaepePieter De Cock

Lessons to learn from vancomycin dosing and TDM practices in children and neonates

Tatjana Van Der HeggenFranky BuyleAnouk van der VeenJoery VerbruggenJasmien Van de WalPetra SchelstraetePeter De PaepeSophie VanhaesebrouckPieter De Cock

Optimizing the Use of Antibiotic Agents in the Pediatric Intensive Care Unit: A Narrative Review.

Jef WillemsE HermansPetra SchelstraetePieter DepuydtPieter De Cock

U Journal Article in Paediatr Drugs

2019

Accuracy of renal function estimating equations compared to iohexol clearance in critically ill children

Evelyn DhontCharlotte WindelsTatjana Van Der HeggenAnnik de JaegerJef WillemsSiska CroubelsSiegrid De BaereJohan Vande WallePeter De PaepePieter De Cock

Amoxicillin/clavulanic acid dosing in frail geriatric patients : do we need a tailored dosing regimen?

Tania DesmetTim KrolsBram Van BraeckelVeronique StoveAlain VerstraeteAnnemie SomersDirk VogelaersMirko PetrovicPeter De PaepePieter De Cock

Amoxicilline/clavulaanzuur bij geriatrische patiënten : is er nood aan een geriatrisch doseringsregime?

Bram Van BraeckelTim KrolsTania DesmetPieter De CockMirko PetrovicPeter De Paepe

Appropriateness of vancomycin dosing and therapeutic drug monitoring practices in a Belgian tertiary hospital

Pieter De CockJasmien Van de WalBarbara ClausPetra SchelstraeteDirk VogelaersFranky Buyle

Augmented renal clearance : a common condition in critically ill children

Tatjana Van Der HeggenEvelyn DhontHarlinde PeperstraeteJoris DelangheJohan Vande WallePeter De PaepePieter De Cock

A1 Journal Article in PEDIATRIC NEPHROLOGY

Clinical validation of published vancomycin population PK models in critically ill neonates

Anouk van der VeenRon KeizerWillem de BoodeAnnemie SomersRoger BrüggemannRob ter HeinePieter De Cock

Comparison of renal function estimation methods in critically ill children : a pilot study

Evelyn DhontTatjana Van Der HeggenAnnik de JaegerJef WillemsSiska CroubelsSiegrid De BaereJohan Vande WallePeter De PaepePieter De Cock

Development and validation of an ultra-high performance liquid chromatography-tandem mass spectrometry method for the simultaneous determination of iohexol, p-aminohippuric acid and creatinine in porcine and broiler chicken plasma

Laura DhondtSiska CroubelsPieter De CockPeter De PaepeSiegrid De BaereMathias Devreese

A1 Journal Article in JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Disease condition affects amikacin pharmacokinetics and dosing in children

Anne SmitsXiaoxi LiuYuhuan WangMarleen RenardStephanie WeadRichard KaganDaniel HealyPieter De CockCatherine SherwinKarel Allegaert

Dose rationale and pharmacokinetics of dexmedetomidine in mechanically ventilated new-borns : impact of design optimisation

Sven C van DijkmanPieter De CockKoenraad SmetsWim DecaluweAnne SmitsKarel AllegaertJohan Vande WallePeter De PaepeOscar Della Pasqua

A1 Journal Article in EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Drug research in the critically ill child : beyond the beaten track

Pieter De CockKarel AllegaertEvelyn Dhont

A2 Journal Article in BELGIAN JOURNAL OF PAEDIATRICS

Impact of disease on amikacin pharmacokinetics and dosing in children

Xiu LiuAnne SmitsYuhuan WangMarleen RenardStephanie WeadRichard KaganDaniel HealyPieter De CockKarel AllegaertCatherine Sherwin

A1 Journal Article in THERAPEUTIC DRUG MONITORING

Pharmacokinetic model development for total and free vancomycin in critically ill children

Ferran GonzalezPieter De CockEvelyn DhontSophie VanhaesebrouckDominique BiarentFrank KloproggePeter De PaepeJoe Standing

Piglets as animal model to assess the contribution of fluid therapy to the development of augmented renal clearance in children

Laura DhondtSiska CroubelsPeter De PaepePieter De CockMathias Devreese

Retrospective evaluation of teicoplanin dosing, therapeutic drug monitoring practices and target attainment in a Belgian tertiary hospital

Franky BuyleJasmien Van de WalBarbara ClausDirk VogelaersPieter De Cock

Target attainment of amikacin therapy in critically ill children

Joery VerbruggenKamilya JakipbayevaEvelyn DhontLaura DhondtTatjana Van Der HeggenIngrid HerckJohan Vande WallePeter De PaepePieter De Cock

The juvenile pig as animal model for unraveling renal drug elimination processes in children

Laura DhondtSiska CroubelsPeter De PaepePieter De CockMathias Devreese

Untangling maturation functions for kidney transporters using a combined population pharmacokinetics and physiology-based pharmacokinetics approach

Sinzea CristeaElke KrekelsPieter De CockPeter De PaepeKarel AllegaertCatherijne Knibbe

Volumetric absorptive microsampling as an alternative sampling strategy for the determination of paracetamol in blood and cerebrospinal fluid

Lisa DelahayeEvelyn DhontPieter De CockPeter De PaepeChristophe Stove

A1 Journal Article in ANALYTICAL AND BIOANALYTICAL CHEMISTRY

2018

Antibiotic PK/PD research in critically ill neonates and children : how do we proceed?

Anne SmitsPieter De Cock

Editorial material

Antibiotic dosing in pediatric critically ill patients

Pieter De CockKarel AllegaertMatthew W LinakisCatherine MT Sherwin

Bookchapter in Antibiotic pharmacokinetic/pharmacodynamic considerations in the critically ill

Disease condition affects amikacin pharmacokinetics and dosing in children

Anne SmitsXiaoxi LiuYuhuan WangMarleen RenardStephanie WeadRichard KaganDaniel HealyPieter De CockCatherine SherwinKarel Allegaert

Dosing renally cleared drugs in critically ill children : mind the trap of glomerular hyperfiltration!

Pieter De CockTatjana Van Der HeggenEvelyn DhontNicky BoeykensKarlien RoelandtBenjamin LeenknegtHarlinde PeperstraeteJoris DelangheJohan Vande WallePeter De Paepe

Glomerular hyperfiltration : a new concept in critically ill children

Tatjana Van Der HeggenEvelyn DhontHarlinde PeperstraeteJoris DelangheJohan Vande WallePeter De PaepePieter De Cock

Simultaneous determination of creatinine, iohexol and p-aminohippuric acid in animal plasma by ultra-high-performance liquid chromatography-tandem mass spectrometry

Laura DhondtSiska CroubelsPieter De CockPeter De PaepeMathias Devreese

Subtherapeutic antimicrobial plasma concentrations with standard amoxicillin-clavulanate dosing regimens in paediatric cardiac surgery patients

Evelyn DhontJef WillemsWim VandenbergheMieke CarlierAlain VerstraeteJohan Vande WallePeter De PaepePieter De Cock

Teicoplanin therapy in critically ill children : an observational study on protein binding and target attainment

MARGOT WOLLAERTSarah DesmetBrett McWhinneyJacobus UngererAnnik de JaegerJohan Vande WallePeter De PaepePieter De Cock

The development of a juvenile porcine augmented renal clearance model for paediatric drug research during sepsis : the effect of different continuously administered LPS doses on the renal function

Laura DhondtSiska CroubelsPieter De CockPeter De PaepeMathias Devreese

2017

An observational study on plasma protein binding and target attainment of teicoplanin in critically ill children

Pieter De Cock. WollaertSanne DesmetAnnick De JaegerJohan Vande WallePeter De Paepe

Antibiotic dosing in ICU children : so you think you can prescribe?

Pieter De CockEvelyn DhontPeter De Paepe

Editorial material

Dose optimization of piperacillin/tazobactam in critically ill children

Pieter De CockSven C van DijkmanAnnik de JaegerJef WillemsMieke CarlierAlain VerstraeteJoris DelangheHugo RobaysJohan Vande WalleOscar E Della PasquaPeter De Paepe

A1 Journal Article in JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Hyperfiltration in the paediatric intensive care unit (HYPIC) : a pilot study

Tatjana Van Der Heggen. Leenkneght. Roelandt. De JaegerIngrid HerckJoris DelangheJohan Vande WallePeter De PaepePieter De Cock

Hyperfiltration in the pediatric intensive care unit : a pilot study

Tatjana Van Der HeggenBenjamin LeenknegtKarlien RoelandtAnnik de Jaeger. Van HerckJoris DelangheJohan Vande WallePeter De PaepePieter De Cock

Impact of critical illness and cardiopulmonary bypass on antibiotic disposition in children

Pieter De CockPeter De PaepeJohan Vande WalleOscar Della Pasqua

Impact of vancomycin protein binding on target attainment in critically ill children : back to the drawing board?

Pieter De CockSarah DesmetAnnik de JaegerDominique BiarentEVELYN DHONTIngrid HerckDaphné VensSofie ColmanVeronique StoveSabrina CommeyneJohan Vande WallePeter De Paepe

A1 Journal Article in JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Participating in pediatric drug research : identifying the burden

Fien DewolfThierry Christiaens. De BruynePieter De CockJohan Vande Walle

Population pharmacokinetics of cefazolin before, during and after cardiopulmonary bypass to optimize dosing regimens for children undergoing cardiac surgery

Pieter De CockHussain MullaSarah DesmetFilip De SomerBrett C McWhinneyJacobus PJ UngererAnneliese MoermanSABRINA COMMEYNEJohan Vande WalleKatrien FrancoisJohan GC Van HasseltPeter De Paepe

A1 Journal Article in JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Teicoplanin therapy in critically ill children : a plea for more dedicated research on optimal pharmacokinetic-pharmacodynamic indices

MARGOT WOLLAERTSarah DesmetB McWhinneyAnnik de JaegerJohan Vande WallePeter De PaepePieter De Cock

2016

Piperacollin-tazobactam pharmacokinetis- pharmacodynamics implies a need for higher dosing in critically ill children

Pieter De CockSven Van DijckmanAnnick De JaegerJef WillemsMieke CarlierAlain VerstraeteJoris DelangheHugo RobaysJohan Vande WalleOscar Della PasquaPeter De Paepe

2015

Augmented renal clearance implies a need for increased amoxicillin-clavulanic acid dosing in critically ill children

Pieter De CockJoseph F StandingCharlotte IS BarkerANNIK DE JAEGEREVELYN DHONTMieke CarlierAlain VerstraeteJoris DelangheHugo RobaysPeter De Paepe

A1 Journal Article in ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Population cefazolin pharmacokinetics before, during and after cardiopulmonary bypass in children undergoing cardiac surgery

Pieter De CockHussain MullaKaren JacobsKim VanderburghtSarah DesmetBrett McWhinneyJacobus UngererFilip De SomerAnneliese MoermanHugo RobaysKatrien FrançoisPeter De Paepe

Population cefazolin pharmacokinetics before, during and after cardiopulmonary bypass in children undergoing cardiac surgery

Pieter De CockHussain MullaKaren JacobsKim VanderburghtSarah DesmetBrett McWhinneyJacobus UngererFilip De SomerAnneliese MoermanHugo RobaysKatrien FrancoisPeter De Paepe

2014

The clinical relevance of pediatric formulations

Karel AllegaertPieter De CockJohannes N van den Anker

Bookchapter in Pediatric formulations : a roadmap

2013

A pilot qualitative analysis of vancomycin dosing and monitoring in children at a Belgian teaching hospital

Pieter De CockEVELIEN HAEGEMANNele GoerlandtVeronique StoveAlain VerstraetePiet VanhaesebrouckPetra SchelstraeteHugo Robays

2012

Geneesmiddelenformulering, klinische farmacologie en de zuigeling: over de relevantie van pediatrische formuleringen

Pieter De CockAnne SmitsRoosmarijn De CockKatrien CosaertHugo RobaysKarel Allegaert

A4 Journal Article in PERCENTIEL (NEDERLANDSE ED.)

2011

Pharmacokinetics of two formulations of omeprazole administered through a gastrostomy tube in patients with severe neurodevelopmental problems

Koen BousseryJulie De SmetPieter De CockSaskia Vande VeldeEls MehuysPeter De PaepeJean Paul RemonJan Van BocxlaerMyriam Van Winckel

A1 Journal Article in BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

2010

A bio-analytical hydrophilic interaction LC-MS/MS method for the simultaneous quantification of omeprazole and lansoprazole in human plasma in support of a pharmacokinetic omeprazole study in children

Julie De SmetKoen BousseryPieter De CockPeter De PaepeJean Paul RemonMyriam Van WinckelJan Van Bocxlaer

A1 Journal Article in JOURNAL OF SEPARATION SCIENCE

2009

Safety of short-acting nifedipine in children: a literature review

Pieter De CockLucas Van BortelAnn RaesJohan Vande WalleAnnik de JaegerHugo Robays

Tacrolimus-clarithromycin interaction in a paediatric liver transplant with severe diarrhea: a case report

Pieter De CockMyriam Van WinckelANN VERRIJCKTANNIK DE JAEGERMARIJKE VAN HOOREWEGHEHugo Robays

2006

Clinical pharmacy and pediatrics : why focus on antibiotics?

Tieneke BautersBT NguyenFranky BuylePetra SchelstraetePieter De CockANNIK DE JAEGERANN VERRIJCKTHugo Robays

Editorial material