Research Explorer

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Researcher

Piet Herdewijn

Awards & Distinctions

55 Results

2002

5 '-Deoxy congeners of 9-(3-amido-3-deoxy-beta-D-xylofuranosyl)-N-6-cyclopentyladenine: New adenosine A(1) receptor antagonists and inverse agonists.

Serge Van CalenberghA LINKS FUJIKAWAR DE LIGTVeerle VanheusdenA GOLISADENM BLATONJ ROZENSKIAP IJZERMANPiet Herdewijn

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

Amine-modified nucleosides as adenosine A(3) neoceptor ligands

Philippe Van RompaeyK JACOBSONZ GAOA CHEND BARAKS KIMKyooyoung LeeA LINKB LIANGPiet Herdewijn et al.

Synthesis and evaluation of thymidine-5 '-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase.

Veerle VanheusdenH MUNIER-LEHMANNS POCHETPiet HerdewijnSerge Van Calenbergh

A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of homoceramides, novel ceramide analogues, and their lack of effect on the growth of hippocampal neurons

Steven De JongheInge LamoteK VENKATARAMANSA BOLDINUlrik HillaertJ ROZENSKIC HENDRIXR BUSSONDenis De KeukeleireSerge Van Calenbergh et al.

A1 Journal Article in JOURNAL OF ORGANIC CHEMISTRY

Thymidine (monophosphate) analogues as Mycobacterium tuberculosis thymidylate kinase inhibitors

Philippe Van RompaeyV VEERLES POCHETH MUNIER-LEHMANNM FROEYENPiet HerdewijnSerge Van Calenbergh

2001

Identification of the exopolysaccharide amylovoran by NMR

Roger BussonAndré De BruynPiet HerdewijnMartine MaesEric Messens

A1 Journal Article in JOURNAL OF CARBOHYDRATE CHEMISTRY

Influence of amylovoran production on virulence of Erwinia amylovora and a different amylovoran structure in E-amylovora isolates from Rubus

Martine MaesKristien OryeSvetoslav BobevBart DevreeseJozef Van BeeumenAndré De BruynRoger BussonPiet HerdewijnKris MorreelEric Messens

A1 Journal Article in EUROPEAN JOURNAL OF PLANT PATHOLOGY

2000

A heterogeneous collection of novel antiviral pyrimidines.

Serge Van CalenberghPiet Herdewijn

A1 Journal Article in EXPERT OPINION ON THERAPEUTIC PATENTS

Modifications in lignin and accumulation of phenolic glucosides in poplar xylem upon down-regulation of caffeoyl-coenzyme A O-methyltransferase, an enzyme involved in lignin biosynthesis

Hugo MeyermansKris MorreelCatherine LapierreBrigitte PolletAndré De BruynRoger BussonPiet HerdewijnBart DevreeseJozef Van BeeumenJane M Marita et al.

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Synthesis and biological evaluation of ceramide analogues with substituted aromatic rings or an allylic fluoride in the sphingoid moiety.

Ilse Van OvermeireSA BOLDINK VENKATARAMANR ZISLINGSteven De JongheSerge Van CalenberghDenis De KeukeleireAH FUTERMANPiet Herdewijn

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of fluorinated sphinganine and dihydroceramide analogues.

Steven De JongheIlse Van OvermeireSerge Van CalenberghC HENDRIXR BUSSONDenis De KeukeleirePiet Herdewijn

A1 Journal Article in EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

1999

5 '-deoxy congeners of 9-(3-amido-3-deoxy-beta-D-xylofuranosyl)-N-6-cyclopentyladenine: New adenosine A(1) receptor antagonists

Serge Van CalenberghA LINKS FUJIKAWAVeerle VanheusdenDenis De KeukeleireA IJZERMANPiet Herdewijn

Effect of aromatic short-chain analogues of ceramide on axonal growth in hippocampal neurons.

Ilse Van OvermeireSA BOLDINFilip DumontSerge Van CalenberghG SLEGERSDenis De KeukeleireAH FUTERMANPiet Herdewijn

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

Exploration of the effect of sterically demanding 3 '-amido substitution of 3 '-deoxyadenosines towards inhibition of cyclin-dependent kinase 1.

Serge Van CalenberghA LINKC KUNICKPiet Herdewijn

A1 Journal Article in PHARMAZIE

In vivo synthesis of complex N-glycans by expression of human N-acetylglucosaminyltransferase I in the filamentous fungus Trichoderma reesei

Marleen MarasAndré De BruynWouter VerveckenJ UusitaloM PenttiläR BussonPiet HerdewijnRoland Contreras

A1 Journal Article in FEBS LETTERS

Killing illusions by QUIET-NOESY

André De BruynSerge Van CalenberghJan SchramlRoger BussonPiet Herdewijn

Lead optimization of N⁶-cyclopentyl-3'-amido-3'-deoxyxylofuranosyladenines as adenosine A₁ receptor antagonists

Serge Van CalenberghA LinkDenis De KeukeleirePiet Herdewijn

A1 Journal Article in NUCLEOSIDES & NUCLEOTIDES

Structure-activity relationship of short-chain sphingoid bases as inhibitors of sphingosine kinase.

Steven De JongheIlse Van OvermeireS POULTONC HENDRIXR BUSSONSerge Van CalenberghDenis De KeukeleireS SPIEGELPiet Herdewijn

A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and apoptogenic activity of fluorinated ceramide and dihydroceramide analogues

Steven De JongheIlse Van OvermeireJ. GunstAndré De BruynC. HendrixSerge Van CalenberghR. BussonDenis De KeukeleireJan PhilippéPiet Herdewijn

A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and pairing properties of oligonucleotides containing 3-hydroxy-4-hydroxymethyl-1-cyclohexanyl nucleosides.

Y MAURINSHH ROSEMEYERR ESNOUFA MEDVEDOVICIJ WANGG CEULEMANSE LESCRINIERC HENDRIXR BUSSONPatrick Sandra et al.

A1 Journal Article in CHEMISTRY-A EUROPEAN JOURNAL

1998

3'-Amidated 3'-deoxyxylofuranose analogues of N⁶-cyclopentyladenosines: a new class of non-xanthine antagonists at the adenosine A₁ receptor

Serge Van CalenberghAdriaan P IJzermanPiet Herdewijn

A1 Journal Article in NUCLEOSIDES & NUCLEOTIDES

DNA-binding ligands from peptide libraries containing unnatural amino acids.

T LESCRINIERC HENDRIXL KERREMANSJ ROZENSKIA LINKP SAMYNA VAN AERSCHOTE LESCRINIERR ERITJAJozef Van Beeumen et al.

A1 Journal Article in CHEMISTRY-A EUROPEAN JOURNAL

Oligonucleotides composed of 2'-deoxy-1',5'-anhydro-D-mannitol nucleosides with a purine base moiety

N HossainB WroblowskiA Van AerschotJ RozenskiAndré De BruynPiet Herdewijn

A1 Journal Article in JOURNAL OF ORGANIC CHEMISTRY

Practical method for the parallel synthesis of 2 '-amido-2 '-deoxyadenosines.

A LINKSerge Van CalenberghPiet Herdewijn

A1 Journal Article in TETRAHEDRON LETTERS

1997

A versatile NMR technique for the identification of phosphorylation sites in oligosaccharides

J SchramlAndré De BruynRoland ContrerasPiet Herdewijn

A1 Journal Article in JOURNAL OF CARBOHYDRATE CHEMISTRY

Access to a new type of homo-C-nucleosides with a 'split' 8-deazapurine via a 1,3-dipolar cycloaddition reaction

Serge Van CalenberghAndré De BruynJan SchramlNorbert BlatonOswald PeetersDenis De KeukeleireRobert BussonPiet Herdewijn

A1 Journal Article in NUCLEOSIDES & NUCLEOTIDES

Access to sterically confined nucleoside analogues via intramolecular photocycloadditions of arene-alkene trichromophores

Wim SaeyensDenis De KeukeleirePiet HerdewijnAndré De Bruyn

A1 Journal Article in BIOMEDICAL CHROMATOGRAPHY

An efficient synthesis and physico-chemical properties of 2'-O-D-ribofuranosylnucleosides, minor tRNA components

SN MikhailovEV EfimtsevaGV GurskayaMV FomitchevaSV MeshkovVE ZavodnikAndré De BruynG JanssenJ RozenskiPiet Herdewijn

A1 Journal Article in JOURNAL OF CARBOHYDRATE CHEMISTRY

Fully selective intramolecular ortho photocycloaddition of 4-(4-methoxyphenoxy)-3-(N-3-benzoylthymin-1-yl)but-1-ene: An unprecedented benzene-thymine photocycloaddition.

Wim SaeyensR BUSSONJ VANDEREYCKENPiet HerdewijnDenis De Keukeleire

A1 Journal Article in CHEMICAL COMMUNICATIONS

Hadamard 1D 1H TOCSY and its application to oligosaccharides

J SchramlH van HalbeekAndré De BruynRoland ContrerasMarleen MarasPiet Herdewijn

A1 Journal Article in MAGNETIC RESONANCE IN CHEMISTRY

N6-Cyclopentyl-3'-substituted-xylofuranosyladenosines : a new class of non-xanthine adenosine A1 receptor antagonists

Serge Van CalenberghJacobien K von FrijtagDrabbe KünzelNorbert M BlatonOswald M PeetersJef RozenskiArhtur Van AerschotAndré De BruynDenis De KeukeleireAdriaan P IJzeman et al.

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

NMR evidence for a novel asparagine-linked oligosaccharide on cellobiohydrolase I from Trichoderma reesei RUTC 30

André De BruynMarleen MarasJ. SchramlPiet HerdewijnRoland Contreras

A1 Journal Article in FEBS LETTERS

Ortho photocycloaddition of substituted 4-phenoxybut-1-enes. Identification of rearranged photocycloadducts by NMR.

R BUSSONJ SCHRAMLWim SaeyensE VAN DER EYCKENPiet HerdewijnDenis De Keukeleire

A1 Journal Article in BULLETIN DES SOCIETES CHIMIQUES BELGES

Rational development of new sleeping sickness drugs

Serge Van CalenberghPiet Herdewijn

A1 Journal Article in CURRENT MEDICINAL CHEMISTRY

Screening a random pentapeptide library, composed of 14 D-amino acids, against the COOH-terminal sequence of fructose-1,6-bisphosphate aldolase from Trypanosoma brucei

Isabelle SamsonJef RozenskiBart SamynArthur Van AerschotJozef Van BeeumenPiet Herdewijn

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Structural characterization of N-linked oligosaccharides from cellobiohydrolase I secreted by the filamentous fungus Trichoderma reesei RUTC30

Marleen MarasAndré De BruynJ SchramlPiet HerdewijnMarc ClaeyssensWalther FiersRoland Contreras

A1 Journal Article in EUROPEAN JOURNAL OF BIOCHEMISTRY

Structural requirements for antiviral activity in nucleosides

A1 Journal Article in DRUG DISCOVERY TODAY

1995

3'-deoxy-3'-hydroxymethyl-aldopentopyranosyl nucleoside synthesis. Part I

B DoboszewskiN BlatonJ RozenskiAndré De BruynPiet Herdewijn

A1 Journal Article in TETRAHEDRON

Catalitic activity and stability of hammerhead ribozymes containing 2'-acetamido-2'-deoxyribonucleosides

C HENDRICKXM MAHIEUJ ANNESerge Van CalenberghA VAN AERSCHOTJ CONTENTPiet Herdewijn

A2 Journal Article in Biochem. Biophys., Res. Comm. 210

Incorporation of 2'-amido nucleosides in oligodeoxynucleotides and oligoribonucleotides as a model for 2'-linked conjugates.

C. HendrixBart DevreeseJ. RozenskiA. VanaerschotAndré De BruynJozef Van BeeumenPiet Herdewijn

A1 Journal Article in NUCLEIC ACIDS RESEARCH

SYNTHESIS OF 3'-AMINO-3'-DEOXYADENOSINE DERIVATIVES AS POTENTIAL-DRUGS FOR THE TREATMENT OF MALARIA.

J SOENENSG FRANCOISE VANDENEECKHOUTPiet Herdewijn

A1 Journal Article in NUCLEOSIDES & NUCLEOTIDES

Screening of a synthetic pentapeptide library composed of D-amino acids against fructose-1,6-biphosphate aldolase.

I SAMSONJ ROZENSKIA VANAERSCHOTBart SamynJozef Van BeeumenPiet Herdewijn

A1 Journal Article in LETTERS IN PEPTIDE SCIENCE

Screening of a synthetic peptide library against glycosomal phosphoglycerate kinase of Trypanosoma brucei.

I SAMSONA VANAERSCHOTBart SamynJozef Van BeeumenPiet Herdewijn

A1 Journal Article in LETTERS IN PEPTIDE SCIENCE

Synthesis and properties of some 2'-O-D-ribofuranosyl-nucleosides

SN MikhailovAndré De BruynPiet Herdewijn

A1 Journal Article in NUCLEOSIDES & NUCLEOTIDES

Synthesis and structure-activity relationships of analogs of 2'-deoxy-2'-(3-methoxybenzamido)adenosine, a selective inhibitor of trypanosomal glycosomal glyceraldehyde-3-phosphate dehydrogenase

Serge Van CalenberghChristophe LMJ VerlindeJohanna SoenensAndré De BruynMia CallensNorbert M BlatonOswald M PeetersPiet HerdewijnJef RozenskiWim GJ Hol

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

1994

Selective-inhibition of trypanosomal glyceraldehyde-3-phosphate dehydrogenase by protein structure-based design : toward new drugs for the treatment of sleeping sickness

CLMJ VerlindeM CallensSerge Van CalenberghArthur Van AerschotPiet HerdewijnV HannaertPAM MichelsFR OpperdoesWGJ Hol

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and conformational analysis of 2'-deoxy-2'-(3-methoxybenzamido)adenosine, a rational-designed inhibitor of trypanosomal glyceraldehyde phosphate dehydrogenase (GAPDH)

Serge Van CalenberghElfrida Van Den EeckhoutPiet HerdewijnAndré De BruynChristophe VerlindeWim HolMia CallensArthur Van AerschotJef Rozenski

A1 Journal Article in HELVETICA CHIMICA ACTA

Synthesis of 3'-fluoromethylthio-, 3'fluoromethylsulfinyl- and 3'-fluoromethylsulfonyl-substituted 3'-deoxythymidine

Piet HerdewijnAndré De BruynP WigerinckC HendrixL KerremansJ RozenskiR Busson

A1 Journal Article in JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1

1993

2'-Substituted adenosine analogues as trypanosomal glyceraldehyde phosphate dehydrogenase (GAPDH) inhibitors

Serge Van CalenberghChristophe VerlindeAndré De BruynMia CallensElfrida Van Den EeckhoutArthur Van AerschotPaul MichelsFred OpperdoesWim HolPiet Herdewijn

A2 Journal Article in COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS

Gas chromatographic determination of alkyl lysophospholipids after solid-phase extraction from cell culture media

J CoeneE Van den EeckhoutPiet HerdewijnPatrick Sandra

A1 Journal Article in JOURNAL OF CHROMATOGRAPHY B-BIOMEDICAL APPLICATIONS

SYNTHESIS, ENZYMATIC STABILITY AND BASE-PAIRING PROPERTIES OF OLIGOTHYMIDYLATES CONTAINING THYMIDINE DIMERS WITH DIFFERENT N-SUBSTITUTED GUANIDINE LINKAGES.

F VANDENDRIESSCHEA VANAERSCHOTM VOORTMANSG JANSSENR BUSSONA VANOVERBEKEW VANDENBOSSCHEJ HOOGMARTENSPiet Herdewijn

A1 Journal Article in JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1

1991

Capillary GC analysis of alkyl lysophospholipids after derivatization with trimethylsilylbromide

Jan CoenePiet HerdewijnElfrida Van Den EeckhoutWalter Van den BosschePatrick Sandra

A1 Journal Article in HRC-JOURNAL OF HIGH RESOLUTION CHROMATOGRAPHY

Capillary GC analysis of alkyllysophospholipids after derivatization with trimethylsilylbromide

J CoenePiet HerdewijnElfrida Van Den EeckhoutPatrick SandraW Van den Bossche

Protein structure-based inhibitor desighn by cofactor modification towards new drugs for sleeping sickness: sinthesis of MAD-analogs. Journal de Pharmacie de Belgique, XLVIII, n° 2,1993.

Serge Van CalenberghA VAN AERSCHOTC VERLINDEPiet Herdewijn

A2 Journal Article

Protein structure-based inhibitor design: towards new drugs for sleeping sickness. Perspectives in Medicinal Chemistry. Proceedings of the 12th International Symposium of Medicinal Chemistry, Eds.: B. Testa, E. Kyburz, W. Fuhrer, R. Gieger, pp. 135 -148 (1993).

C VERLINDET PIJNINGK KALKSerge Van CalenberghA VAN AERSCHOTPiet HerdewijnM CALLENSP MICHELSF OPPERDOESR WIERINGA et al.