Research Explorer

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Researcher

Philip Meuleman

Awards & Distinctions

153 Results

2023

A human monoclonal antibody against HBsAg for the prevention and treatment of chronic HBV and HDV infection

Rani BurmFreya Van HoutteLieven VerhoyeAhmed Atef Ahmed Abouzeid MesalamS CiesekP RoingeardH WedemeyerGeert Leroux-RoelsPhilip Meuleman

A1 Journal Article in JHEP REPORTS

Adeno-associated virus serotype 2 capsid variants for improved liver-directed gene therapy

N MeumannM Cabanes-CreusM ErteltRG NavarroJ LuciforaQ YuanK Nien-HuberA AbdelrahmanXK VuL Zhang et al.

A1 Journal Article in HEPATOLOGY

Identification and characterization of protein interactions between the hepatitis E virus and its host

Laura CorneilliePhilip Meuleman

Novel prime-boost immune-based therapy inhibiting both hepatitis B and D virus infections

Rani BurmPanagiota MaraveliaGustaf AhlenSandra CiesekNoelia Caro PerezAnna PasettoStephan UrbanFreya Van HoutteLieven VerhoyeHeiner Wedemeyer et al.

A1 Journal Article in GUT

2022

A Hepatitis C virus genotype 1b post-transplant isolate with high replication efficiency in cell culture and its adaptation to infectious virus production in vitro and in vivo

Christian HeussPaul RothhaarRani BurmJi-Young LeePhilipp RalfsUta HaselmannLuisa J. StröhOmbretta ColasantiCong Si TranNoemi Schäfer et al.

A1 Journal Article in PLOS PATHOGENS

A ribavirin-induced ORF2 single-nucleotide variant produces defective hepatitis E virus particles with immune decoy function

TL MeisterY BrüggemannMK NockeRG UlrichJ SchuhennK SutterA GömerV BaderKF WinklhoferR Broering et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Development and evaluation of a chimeric recombinant vaccine against hepatitis E virus and hepatitis B virus infection

Laura CollignonPhilip Meuleman

Human hepatocyte PNPLA3-148M exacerbates rapid non-alcoholic fatty liver disease development in chimeric mice

M KabbaniE MichailidisS SteenselsCG FulmerJM LunaJ Le PenM TardelliB RazookyI Ricardo-LaxC Zou et al.

A1 Journal Article in CELL REPORTS

Preventive and therapeutic approaches to eliminate both hepatitis B and D virus infections

Rani BurmPhilip Meuleman

Study of hepatitis E virus-4 infection in human liver-chimeric, immunodeficient, and immunocompetent mice

Laura CollignonLieven VerhoyeRenate Hakze-Van der HoningWim H. M. Van der PoelPhilip Meuleman

A1 Journal Article in FRONTIERS IN MICROBIOLOGY

Viral interference of hepatitis C and E virus replication in novel experimental co-infection systems

T BurkardN ProskeK ResnerLaura CollignonL KnegendorfM FrieslandLieven VerhoyeIM SayedY BrüggemannMK Nocke et al.

A1 Journal Article in CELLS

2021

A role for B cells to transmit hepatitis C virus infection

Isabelle DesombereFreya Van HoutteAliasghar Farhoudi MoghadamLieven VerhoyeCaroline BuysschaertYvonne GijbelsSibyl CouventW SwinnenHans Van VlierbergheAndré Elewaut et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Blocking entry of hepatitis B and D viruses to hepatocytes as a novel immunotherapy for treating chronic infections

P MaraveliaL FrelinY NiNC PérezG AhlénN JagyaG VerchLieven VerhoyeL PaterM Johansson et al.

A1 Journal Article in JOURNAL OF INFECTIOUS DISEASES

2020

Expansion, in vivo-ex vivo cycling, and genetic manipulation of primary human hepatocytes

Eleftherios MichailidisKoen VercauterenLiliana Mancio-SilvaLinda AndrusCyprien JahanInna Ricardo-LaxChenhui ZouMohammad KabbaniPaul ParkCorrine Quirk et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Experimental variables that affect human hepatocyte MV transduction in liver chimeric mice

Chenhui ZouKoen O.A. VercauterenEleftherios MichailidisMohammad KabbaniIrene ZoluthkinCorrine QuirkLuis ChiribogaMustafa YaziciogluXavier M. AnguelaPhilip Meuleman et al.

A1 Journal Article in MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT

Inflammation alters the secretome and immunomodulatory properties of human skin-derived precursor cells

Joery De KockRobim Marcelino RodriguesSteven BransonLieven VerhoyeHaaike Colemonts-VroninksMatthias RombautJoost BoeckmansJessie NeuckermansSien LequeueKarolien Buyl et al.

A1 Journal Article in CELLS

Liver-expressed Cd302 and Cr1l limit hepatitis C virus cross-species transmission to mice

Richard J. P. BrownBirthe TegtmeyerJulie SheldonTanvi Khera[missing] AnggakusumaDaniel TodtGabrielle VieyresRomy WellerSebastian JoecksYudi Zhang et al.

A1 Journal Article in SCIENCE ADVANCES

Robust hepatitis E virus infection and transcriptional response in human hepatocytes

Daniel TodtMartina FrieslandNora MoellerDimas PradityaVolker KinastYannick BrüggemannLeonard KnegendorfThomas BurkardJoerg SteinmannRani Burm et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Updates in hepatitis E virus (HEV) field : lessons learned from human liver chimeric mice

Ibrahim M SayedPhilip Meuleman

A1 Journal Article in REVIEWS IN MEDICAL VIROLOGY

2019

A central hydrophobic E1 region controls the pH range of hepatitis C virus membrane fusion and susceptibility to fusion inhibitors

Banda H DominicPaula M PerinRichard JP BrownDaniel TodtWladimir SolodenkoPatrick HoffmeyerKamlesh Kumar SahuMichael HoughtonPhilip MeulemanRolf Muller et al.

A1 Journal Article in JOURNAL OF HEPATOLOGY

Animal models for hepatitis E virus

Laura CorneillieDominic BandaPhilip Meuleman

A1 Journal Article in VIRUSES-BASEL

Hepatitis E virus (HEV) open reading frame 2 antigen kinetics in human-liver chimeric mice and its impact on HEV diagnosis

Ibrahim Ibrahim Mahmoud SayedLieven VerhoyeClaire MontpellierFlorence AbravanelJacques IzopetLaurence CocquerelPhilip Meuleman

A1 Journal Article in JOURNAL OF INFECTIOUS DISEASES

Hepatitis E virus prevalence in Flemish blood donors

Ann-Sofie VercouterFreya Van HoutteLieven VerhoyeIsabel González FraileLydia BlancoVeerle CompernollePhilip Meuleman

A1 Journal Article in JOURNAL OF VIRAL HEPATITIS

Infectivity and stability of hepatitis C virus in different perfusion solutions

Fabian A HelfritzVerena WandersDenisa BojkovaNina KuklinskiSandra WesthausSandra SwobodaThomas MinorPhilip MeulemanAndreas PaulEike Steinmann et al.

A1 Journal Article in TRANSPLANT INFECTIOUS DISEASE

New insights into the ORF2 capsid protein, a key player of the hepatitis E virus lifecycle

Maliki AnkavayClaire MontpellierIbrahim Ibrahim Mahmoud SayedJean-Michel SaliouCzeslaw WychowskiLaure SaasSandrine DuvetCécile-Marie Aliouat-DenisRayan FarhatValentin de Masson d’Autume et al.

A1 Journal Article in SCIENTIFIC REPORTS

Prevalence of hepatitis E virus in Flanders and evaluation of a potential novel reservoir

Ann-Sofie VercouterPhilip Meuleman

2018

Absence of zoonotic hepatitis E virus infection in Flemish dairy cows

Ann-Sofie VercouterIbrahim Ibrahim Mahmoud SayedZyncke LipkensKoen De BleeckerSarne De VliegherRoos ColmanMarco KoppelmanKarlien SupréPhilip Meuleman

A1 Journal Article in INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY

Animal models to study hepatitis C virus infection

Rani BurmLaura CollignonAhmed Atef Ahmed Abouzeid MesalamPhilip Meuleman

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Development and characterization of a human monoclonal antibody targeting the N-terminal region of hepatitis C virus envelope glycoprotein E1

Ahmed Atef Ahmed Abouzeid MesalamIsabelle DesombereAliasghar Farhoudi MoghadamFreya Van HoutteLieven VerhoyeJonathan BallJean DubuissonSteven KH FoungArvind H PatelMats AA Persson et al.

A1 Journal Article in VIROLOGY

Elucidating the differences in pathogenicity between hepatitis E virus genotypes : the quest continues

Ann-Sofie VercouterPhilip Meuleman

Editorial material

Functional study of the C-terminal part of the hepatitis C virus E1 ectodomain

Rehab I MoustafaJuliano G HaddadLydia LinnaXavier HanoulleVéronique DescampsAhmed Atef Ahmed Abouzeid MesalamThomas F BaumertGilles DuverliePhilip MeulemanJean Dubuisson et al.

A1 Journal Article in JOURNAL OF VIROLOGY

Hepatitis E virus lifecycle and identification of 3 forms of the ORF2 capsid protein

Claire MontpellierCzeslaw WychowskiIbrahim Ibrahim Mahmoud SayedJean-Christophe MeunierJean-Michel SaliouMaliki AnkavayAnne BullAndré PillezFlorence AbravanelFrançois Helle et al.

A1 Journal Article in GASTROENTEROLOGY

Immunological responses following administration of a genotype 1a/1b/2/3a quadrivalent HCV VLP vaccine

D ChristiansenL Earnest-SilveiraB ChuaPhilip MeulemanI BooB Grubor-BaukDC JacksonZY KeckSKH FoungHE Drummer et al.

A1 Journal Article in SCIENTIFIC REPORTS

Methylene blue treatment of grafts during cold ischemia time reduces the risk of hepatitis C virus transmission

Fabian A HelfritzDenisa BojkovaVerena WandersNina KuklinskiSandra WesthausCharlotte von HornUrsula RauenAnja GallinatHideo A BabaAndreas Skyschally et al.

A1 Journal Article in JOURNAL OF INFECTIOUS DISEASES

Monoclonal antibodies as a new strategy for prevention and treatment of hepatitis C virus infection

Ahmed Atef Ahmed Abouzeid MesalamPhilip Meuleman

The natural compound silvestrol inhibits hepatitis E virus (HEV) replication in vitro and in vivo

Daniel TodtNora MoellerDimas PradityaVolker KinastMartina FrieslandMichael EngelmannLieven VerhoyeIbrahim Ibrahim Mahmoud SayedPatrick BehrendtViet Loan Dao Thi et al.

A1 Journal Article in ANTIVIRAL RESEARCH

2017

A novel neutralizing human monoclonal antibody broadly abrogates hepatitis C virus infection in vitro and in vivo

Isabelle DesombereAhmed Atef Ahmed Abouzeid MesalamRichard A UrbanowiczFreya Van HoutteLieven VerhoyeZhen-Yong KeckAliasghar Farhoudi MoghadamKoen VercauterenKarin WeeningThomas F Baumert et al.

A1 Journal Article in ANTIVIRAL RESEARCH

Characterization of a novel monoclonal antibody targeting epitope II within hepatitis C virus E2 envelope glycoprotein

Philip MeulemanAhmed Atef Ahmed Abouzeid MesalamIsabelle DesombereRichard UrbanowiczFreya Van HoutteLieven VerhoyeZhen-Yong KeckAliasghar Farhoudi MoghadamKoen VercauterenKarin Weening et al.

Development and characterization of a human monoclonal antibody for prevention of HCV recurrence in liver transplant patients

Ahmed Atef Ahmed Abouzeid MesalamIsabelle DesombereRichard UrbanowiczDaniel X JohanssonKoen VercauterenAliasghar Farhoudi MoghadamFreya Van HoutteLieven VerhoyeMats PerssonJonathan Ball et al.

Effect of hepatitis E virus infection on the human hepatic innate immune response in human liver chimeric mice

Ibrahim Mahmoud Sayed IbrahimLieven VerhoyeLaurance CocquerelFlorence AbravanelLander FoquetClaire MontpellierYannick DebingAliasghar Farhoudi MoghadamCzeslaw WychowskiJean Dubuisson et al.

Humanized mice as a model for the study of hepatitis E virus infection

Ibrahim Mahmoud Sayed IbrahimPhilip Meuleman

Impact of HEV infection on the human hepatic innate immune response in human liver chimeric mice

Ibrahim Mahmoud Sayed IbrahimLieven VerhoyeLander FoquetFlorence AbravanelAliasghar Farhoudi MoghadamGeert Leroux-RoelsJacques IzopetPhilip Meuleman

Murine tissues of human liver chimeric mice are not susceptible to hepatitis E virus genotypes 1 and 3

Ibrahim M SayedPhilip Meuleman

A1 Journal Article in JOURNAL OF INFECTIOUS DISEASES

Pentagalloylglucose, a highly bioavailable polyphenolic compound present in Cortex moutan, efficiently blocks hepatitis C virus entry

Patrick BehrendtPaula PerinNicolas MenzelDominic BandaStephanie PfaenderMarco P AlvesVolker ThielPhilip MeulemanChe C ColpittsLuis M Schang et al.

A1 Journal Article in ANTIVIRAL RESEARCH

Study of hepatitis E virus infection of genotype 1 and 3 in mice with humanised liver

Ibrahim Mahmoud Sayed IbrahimLieven VerhoyeLaurence CocquerelFlorence AbravanelLander FoquetClaire MontpellierYannick DebingAliasghar Farhoudi MoghadamCzeslaw WychowskiJean Dubuisson et al.

A1 Journal Article in GUT

Successful engraftment of human hepatocytes in uPA-SCID and FRG® KO mice

Lander FoquetElizabeth M WilsonLieven VerhoyeMarkus GrompeGeert Leroux-RoelsJohn BialPhilip Meuleman

Bookchapter in Hepatocyte transplantation : methods and protocols

Tracking HCV protease population diversity during transmission and susceptibility of founder populations to antiviral therapy

Tanvi KheraDaniel TodtKoen VercauterenC Patrick McClureLieven VerhoyeAliasghar Farhoudi MoghadamSabin BhujuRobert GeffersThomas F BaumertEike Steinmann et al.

A1 Journal Article in ANTIVIRAL RESEARCH

Transmission of hepatitis E virus infection to human-liver chimeric FRG mice using patient plasma

Ibrahim Mahmoud Sayed IbrahimLander FoquetLieven VerhoyeAliasghar Farhoudi MoghadamFloresence AbravanelGeert Leroux-RoelsJacques IzopetPhilip Meuleman

A1 Journal Article in ANTIVIRAL RESEARCH

2016

Apolipoprotein E mediates evasion from hepatitis C virus neutralizing antibodies

Catherine FauvelleDaniel J FelmleeEmilie CrouchetJiYoung LeeLaura HeydmannMathieu LefèvreAndrea MagriMarie-Sophie HietIsabel FofanaFrançois Habersetzer et al.

A1 Journal Article in GASTROENTEROLOGY

Characterisation of a hepatitis C virus-like particle vaccine produced in a human hepatocyte-derived cell line

L Earnest-SilveiraB ChuaR ChinD ChristiansenD JohnsonS HerrmannSA RalphKoen VercauterenAhmed Atef Ahmed Abouzeid MesalamPhilip Meuleman et al.

A1 Journal Article in JOURNAL OF GENERAL VIROLOGY

Characterization of a novel human monoclonal antibody targeting the hepatitis C virus envelope protein

Ahmed Atef Ahmed Abouzeid MesalamIsabelle DesombereRichard UrbanowiczDaniel X JohanssonKoen VercauterenAliasghar Farhoudi MoghadamFreya Van HoutteLieven VerhoyeMats PerssonJonathan Ball et al.

Effect of hepatitis E virus infection on the human hepatic innate immune response in human liver chimeric mice

Ibrahim Mahmoud Sayed IbrahimLieven VerhoyeLaurance CocquerelFlorence AbravanelLander FoquetClaire MontpellierYannick DebingAliasghar Farhoudi MoghadamCzeslaw WychowskiJean Dubuisson et al.

Expanding the host range of hepatitis C virus through viral adaptation

Markus von SchaewenMarcus DornerKathrin HuegingLander FoquetSherif GergesGabriela HrebikovaBrigitte HellerJulia BitzegeioJuliane DoerrbeckerJoshua A Horwitz et al.

A1 Journal Article in MBIO

Flunarizine prevents hepatitis C virus membrane fusion in a genotype-dependent manner by targeting the potential fusion peptide within E1

Paula M PerinSibylle HaidRichard JP BrownJuliane DoerrbeckerKai SchulzeCarsten ZeilingerMarkus von SchaewenBrigitte HellerKoen VercauterenEva Luxenburger et al.

A1 Journal Article in HEPATOLOGY

HVR1-mediated antibody evasion of highly infectious in vivo adapted HCV in humanised mice

Jannick PrentoeLieven VerhoyeRodrigo Velázquez MoctezumaCaroline BuysschaertAliasghar Farhoudi MoghadamRichard WangHarvey AlterPhilip MeulemanJens Bukh

A1 Journal Article in GUT

Hepatitis E virus in acute liver failure : an unusual suspect?

Ibrahim Mahmoud Sayed IbrahimAnn-Sofie VercouterPhilip Meuleman

Editorial material

Host cell mTORC1 is required for HCV RNA replication

Stefanie StöhrRui CostaLisa SandmannSandra WesthausStephanie Pfaender- AnggakusumaEva DazertPhilip MeulemanFlorian WR VondranMichael P Manns et al.

A1 Journal Article in GUT

Identification of a new benzimidazole derivative as an antiviral against hepatitis C virus

Thibaut VausselinKarin SéronMuriel LavieAhmed Atef Ahmed Abouzeid MesalamMatthieu LemassonSandrine BelouzardLucie FénéantAdeline DanneelsYves RouilléLaurence Cocquerel et al.

A1 Journal Article in JOURNAL OF VIROLOGY

In vitro and in vivo metabolism studies of dimethazine

Lore GeldofEva Tudela PalomarLeen LootensJasper Van LysebethPhilip MeulemanGeert Leroux-RoelsPeter Van EenooKoen Deventer

A1 Journal Article in BIOMEDICAL CHROMATOGRAPHY

Metabolic studies of prostanozol with the uPA-SCID chimeric mouse model and human liver microsomes

Lore GeldofLeen LootensLieselot DecroixPhilip MeulemanFrancesco BotrèGeert Leroux-RoelsKoen DeventerPeter Van Eenoo

A1 Journal Article in STEROIDS

Monoclonal anti-envelope antibody AP33 protects humanized mice against a patient-derived hepatitis C virus challenge

Isabelle DesombereSamira Fafi-KremerFreya Van HouttePatrick PessauxAliasghar Farhoudi MoghadamLaura HeydmannLieven VerhoyeSarah ColeJane A McKeatingGeert Leroux-Roels et al.

A1 Journal Article in HEPATOLOGY

Mouse systems to model hepatitis C virus treatment and associated resistance

Ahmed Atef Ahmed Abouzeid MesalamKoen VercauterenPhilip Meuleman

A1 Journal Article in VIRUSES-BASEL

Targeting a host-cell entry factor barricades antiviral-resistant HCV variants from on-therapy breakthrough in human-liver mice

Koen VercauterenRichard JP BrownAhmed Atef Ahmed Abouzeid MesalamJuliane DoerrbeckerSabin BhujuRobert GeffersNaomi Van den EedeC Patrick McClureFulvia TroiseLieven Verhoye et al.

A1 Journal Article in GUT

Tuning a cellular lipid kinase activity adapts hepatitis C virus to replication in cell culture

Christian HarakMax MeyrathInés Romero-BreyChristian SchenkClaire GondeauPhilipp SchultKatharina Esser-NobisMohsan SaeedPetra NeddermannPaul Schnitzler et al.

A1 Journal Article in NATURE MICROBIOLOGY

2015

A broadly neutralizing monoclonal antibody targeting hepatitis C virus prevents viral infection in vitro and in uPA/SCID mice with humanized liver

Ahmed Atef Ahmed Abouzeid MesalamIsabelle DesombereRichard UrbanowiczDaniel X JohanssonAliasghar Farhoudi MoghadamFreya Van HoutteLieven VerhoyeMats PerssonJonathan BallGeert Leroux-Roels et al.

A broadly neutralizing monoclonal antibody targeting hepatitis C virus prevents viral infection in vitro and in uPA/SCID mice with humanized liver

Ahmed Atef Ahmed Abouzeid MesalamIsabelle DesombereRichard UrbanowiczDaniel X JohanssonKoen VercauterenAliasghar Farhoudi MoghadamFreya Van HoutteLieven VerhoyeKarin WeeningMats Persson et al.

A broadly neutralizing monoclonal antibody targeting hepatitis C virus prevents viral infection in vitro and in uPA/SCID mice with humanized liver

Ahmed Atef Ahmed Abouzeid MesalamIsabelle DesombereRichard UrbanowiczDaniel X JohanssonAliasghar Farhoudi MoghadamFreya Van HoutteLieven VerhoyeMats PerssonJonathan BallGeert Leroux-Roels et al.

A humanized mouse model for the study of infection with Plasmodium falciparum : development and applications

Lander FoquetGeert Leroux-RoelsPhilip Meuleman

Animal models for the study of HCV

Koen VercauterenYpe P de JongPhilip Meuleman

A1 Journal Article in CURRENT OPINION IN VIROLOGY

Anti-CD81 but not anti-SR-BI blocks Plasmodium falciparum liver infection in a humanized mouse model

Lander FoquetCornelus C HermsenLieven VerhoyeGeert-Jan van GemertRiccardo CorteseAlfredo NicosiaRobert W SauerweinGeert Leroux-RoelsPhilip Meuleman

A1 Journal Article in JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Assessment of parasite liver-stage burden in human-liver chimeric mice

Lander FoquetPhilip MeulemanCornelus C HermsenRobert SauerweinGeert Leroux-Roels

Bookchapter in Malaria vaccines

Clearance of persistent hepatitis C virus infection in humanized mice using a claudin-1-targeting monoclonal antibody

Laurent MaillyFei XiaoJoachim LupbergerGarrick K WilsonPhilippe AubertFrançois HT DuongDiego CalabreseCéline LeboeufIsabel FofanaChristine Thumann et al.

A1 Journal Article in NATURE BIOTECHNOLOGY

Generation and characterization of small single domain antibodies inhibiting human tumor necrosis factor receptor 1

Sophie SteelandLeen PuimègeRoosmarijn VandenbrouckeFilip Van HauwermeirenJurgen HaustraeteNick DevoogdtPaco HulpiauGeert Leroux-RoelsDebby LaukensPhilip Meuleman et al.

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Human liver chimeric mice as a novel model for the study of hepatitis E virus infections

Ibrahim Mahmoud Sayed IbrahimLieven VerhoyeAliasghar Farhoudi MoghadamYannick DebingJohan NeytsGeert Leroux-RoelsRobert PurcellSuzanne EmersonPhilip Meuleman

Human liver chimeric mice as a novel model for the study of hepatitis E virus infections

Ibrahim Mahmoud Sayed IbrahimLieven VerhoyeLaurence CocquerelFlorence AbbravanelLander FoquetYannick DebingAliasghar Farhoudi MoghadamCzeslaw WychowskiJean DubuissonGeert Leroux-Roels et al.

Human liver chimeric mice as a novel model for the study of hepatitis E virus infections

Ibrahim Mahmoud Sayed IbrahimLieven VerhoyeY DebingF AbbravanelAliasghar Farhoudi MoghadamGeert Leroux-RoelsJ NeytsJ IzopetR PurcellS Emerson et al.

Is hepatitis E virus an emerging problem in industrialized countries?

Ibrahim Mahmoud Sayed IbrahimAnn-Sofie VercouterSayed F AbdelwahabKoen VercauterenPhilip Meuleman

A1 Journal Article in HEPATOLOGY

Polyphenols inhibit hepatitis C virus entry by a new mechanism of action

Noémie CallandMarie-Emmanuelle SahucSandrine BelouzardVéronique PènePierre BonnafousAhmed Atef Ahmed Abouzeid MesalamGaspard DeloisonVéronique DescampsSevser SahpazCzeslaw Wychowski et al.

A1 Journal Article in JOURNAL OF VIROLOGY

Targeting a host-cell entry factor barricades antiviral-resistant HCV variants from on-therapy breakthrough in human-liver mice

Koen VercauterenRichard JP BrownAhmed Atef Ahmed Abouzeid MesalamJuliane DoerrbeckerSabin BhujuRobert GeffersNaomi Van den EedeFulvia TroiseLieven VerhoyeThomas Baumert et al.

The emergence of hepatitis E virus in Europe

Ibrahim Mahmoud Sayed IbrahimKoen VercauterenSayed F AbdelwahabPhilip Meuleman

A1 Journal Article in FUTURE VIROLOGY

2014

A genetically attenuated malaria vaccine candidate based on P. falciparum b9/slarp gene-deficient sporozoites

Ben CL van SchaijkIvo HJ PloemenTakeshi AnnouraMartijn W VosLander FoquetGeert-Jan van GemertSeverine Chevalley-MaurelMarga van de Vegte-BolmerMohammed SajidJean-Francois Franetich et al.

A1 Journal Article in eLIFE

Combined adenovirus vector and hepatitis C virus envelope protein prime-boost regimen elicits T cell and neutralizing antibody immune responses

Alicja M ChmielewskaMariarosaria NaddeoStefania CaponeVirginia AmmendolaKe HuLuke MeredithLieven VerhoyeMalgorzata RychlowskaRino RappuoliJeffrey B Ulmer et al.

A1 Journal Article in JOURNAL OF VIROLOGY

HCV animal models and liver disease

Koen VercauterenYpe P de JongPhilip Meuleman

A1 Journal Article in JOURNAL OF HEPATOLOGY

Human but not mouse hepatocytes respond to interferon-lambda in vivo

Pascale HermantCéline DemarezTanel MahlakõivPeter StaeheliPhilip MeulemanThomas Michiels

A1 Journal Article in PLOS ONE

Human liver chimeric mice as a novel model for the study of hepatitis E virus infections

Ibrahim Mahmoud Sayed IbrahimLieven VerhoyeAliasghar Farhoudi MoghadamYannick DebingJohan NeytsGeert Leroux-RoelsRobert PurcellSuzanne EmersonPhilip Meuleman

Human skin-derived precursor cells are poorly immunogenic and modulate the allogeneic immune response

Joery De KockPhilip MeulemanGordana RaicevicRobim M RodriguesSteven BransonKesavan MeganathanVeerle De BoeAgapios SachinidisGeert Leroux-RoelsTamara Vanhaecke et al.

A1 Journal Article in STEM CELLS

Impact of lipids and lipoproteins on hepatitis C virus infection and virus neutralization

Koen VercauterenAhmed Atef Ahmed Abouzeid MesalamGeert Leroux-RoelsPhilip Meuleman

A1 Journal Article in WORLD JOURNAL OF GASTROENTEROLOGY

Metabolic study of a steroid product containing dimethazine using human liver microsomes and a chimeric mouse model

Lore GeldofEva TudelaLeen LootensJasper Van LysebethPhilip MeulemanGeert Leroux-RoelsKoen DeventerPeter Van Eenoo

Metabolism of methylstenbolone studied with human liver microsomes and the uPA+/+-SCID chimeric mouse model

Lore GeldofLeen LootensMichaël PoletDaniel EichnerThane CampbellVinod NairFrancesco BotrèPhilip MeulemanGeert Leroux-RoelsKoen Deventer et al.

A1 Journal Article in BIOMEDICAL CHROMATOGRAPHY

Sporozoite immunization of human volunteers under chemoprophylaxis induces functional antibodies against pre-erythrocytic stages of Plasmodium falciparum

Marije C BehetLander FoquetGeert-Jan van GemertElse M BijkerPhilip MeulemanGeert Leroux-RoelsCornelus C HermsenAnja ScholzenRobert W Sauerwein

A1 Journal Article in MALARIA JOURNAL

Successful anti-scavenger receptor class B type I (SR-BI) monoclonal antibody therapy in humanized mice after challenge with HCV variants with in vitro resistance to SR-BI-targeting agents

Koen VercauterenNaomi Van den EedeAhmed Atef Ahmed Abouzeid MesalamSandrine BelouzardMaria Teresa CataneseDorothea BankwitzFlossie Wong-StaalRiccardo CorteseJean DubuissonCharles M Rice et al.

A1 Journal Article in HEPATOLOGY

Targeting SR-BI for the prevention and treatment of hepatitis C virus infections

Koen VercauterenPhilip MeulemanGeert Leroux-Roels

Turmeric curcumin inhibits entry of all hepatitis C virus genotypes into human liver cells

- AnggakusumaChe C ColpittsLuis M SchangHeni RachmawatiAnne FrentzenStephanie PfaenderPatrick BehrendtRichard JP BrownDorothea BankwitzJoerg Steinmann et al.

A1 Journal Article in GUT

Vaccine-induced monoclonal antibodies targeting circumsporozoite protein prevent Plasmodium falciparum infection

Lander FoquetCornelus C HermsenGeert-Jan van GemertEva Van BraeckelKarin WeeningRobert SauerweinPhilip MeulemanGeert Leroux-Roels

A1 Journal Article in JOURNAL OF CLINICAL INVESTIGATION

2013

99mTc-mebrofenin disposition in chimeric mice with a humanized liver

Sara NeytPhilip MeulemanLieven VerhoyeChristian VanhoveGeert MannensFilip De Vos

Artemisinin analogues as potent inhibitors of in vitro hepatitis C virus replication

Susan ObeidJo AlenVan Hung NguyenVan Cuong PhamPhilip MeulemanChristophe PannecouqueThanh Nguyen LeJohan NeytsWim DehaenJan Paeshuyse

A1 Journal Article in PLOS ONE

Hepatitis C virus infection and related liver disease: the quest for the best animal model

Laurent MaillyEric RobinetPhilip MeulemanThomas F BaumertMirjam Zeisel

A1 Journal Article in FRONTIERS IN MICROBIOLOGY

In vitro and in vivo metabolism studies of a nutritional supplement containing methylstenbolone

Lore GeldofLeen LootensKoen DeventerMichaël PoletDaniel EichnerFrancesco BotrèPhilip MeulemanGeert Leroux-RoelsPeter Van Eenoo

In vitro and in vivo metabolisms of 1-pentyl-3-(4-methyl-1-naphthoyl)indole (JWH-122)

Nik De BrabanterSimone EspositoLore GeldofLeen LootensPhilip MeulemanGeert Leroux-RoelsKoen DeventerPeter Van Eenoo

A1 Journal Article in FORENSIC TOXICOLOGY

In vivo and in vitro metabolism of the synthetic cannabinoid JWH-200

Nik De BrabanterSimone EspositoEva Tudela PalomarLeen LootensPhilip MeulemanGeert Leroux-RoelsKoen DeventerPeter Van Eenoo

A1 Journal Article in RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Molecular detection and quantification of Plasmodium falciparum-infected human hepatocytes in chimeric immune-deficient mice

Lander FoquetCornelus C HermsenGeert-Jan van GemertLouis LibbrechtRobert SauerweinPhilip MeulemanGeert Leroux-Roels

A1 Journal Article in MALARIA JOURNAL

The Sin3a repressor complex regulates the balance between the activities of different STAT proteins

Laura IcardiRaffaele MoriViola GesellchenSven EyckermanJudith VerhelstKoen VercauterenXavier SaelensPhilip MeulemanKarolien De BosscherM Boutros et al.

Thermostability of seven hepatitis C virus genotypes in vitro and in vivo

J DoerrbeckerPhilip MeulemanJ KangN RiebesehlC WilhelmM FrieslandS PfaenderJ SteinmannT PietschmannE Steinmann

A1 Journal Article in JOURNAL OF VIRAL HEPATITIS

Turmeric curcumin inhibits entry of all hepatitis C virus genotypes into human liver cells

A KusumaCC ColpittsLM SchangH RachmawatiA FrentzenS PfaenderP BehrendtRJP BrownD BankwitzJ Steinmann et al.

2012

A human monoclonal antibody targeting scavenger receptor class B type I precludes hepatitis C virus infection and viral spread in vitro and in vivo

Philip MeulemanMaria Teresa CataneseLieven VerhoyeIsabelle DesombereAliasghar Farhoudi MoghadamChristopher T JonesTimothy SheahanKatarzyna GrzybRiccardo CorteseCharles M Rice et al.

A1 Journal Article in HEPATOLOGY

Blocking HCV entry as potential antiviral therapy

Koen VercauterenGeert Leroux-RoelsPhilip Meuleman

A1 Journal Article in FUTURE VIROLOGY

Metabolic study of prostanozol using human liver licrosomes and humanized mice

Leen LootensLore GeldofLieselot DecroixKoen DeventerFrancesco BotrèGeert Leroux-RoelsPhilip MeulemanPeter Van Eenoo

Mitochondrial cardiotoxicity of a prototype HCV NS3-protease inhibitor is characterized by a specific electrocardiographic signature in mice

Thomas VanwolleghemEva Van BraeckelJoél SmetBi-Sheng LiuPhilip MeulemanHarry L JanssenTania RoskamsRudy Van CosterRita De VosGeert Leroux-Roels

Novel human SR-BI antibodies prevent infection and dissemination of HCV in vitro and in humanized mice

Krzysztof LacekKoen VercauterenKatarzyna GrzybMariarosaria NaddeoLieven VerhoyeMarek Patryk SłowikowskiSamira Fafi-KremerArvind H PatelThomas F BaumertAntonella Folgori et al.

A1 Journal Article in JOURNAL OF HEPATOLOGY

The Sin3a repressor complex is a master regulator of STAT transcriptional activity

Laura IcardiRaffaele MoriViola GesellchenSven EyckermanLode De CauwerJudith VerhelstKoen VercauterenXavier SaelensPhilip MeulemanGeert Leroux-Roels et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

2011

Development and application of hepatitis C reporter viruses with genotype 1 to 7 core-nonstructural protein 2 (NS2) expressing fluorescent proteins or luciferase in modified JFH1 NS5A

Judith M GottweinTanja B JensenChristian K MathiesenPhilip MeulemanStephanie BN SerreJacob B LademannLubna GhanemTroels KH ScheelGeert Leroux-RoelsJens Bukh

A1 Journal Article in JOURNAL OF VIROLOGY

Discovery of (7R)-14-cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl) amino}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylic acid (MK-3281), a potent and orally bioavailable finger-loop inhibitor of the hepatitis C virus NS5B polymerase

Frank NarjesBenedetta CrescenziMarco FerraraJörg HabermannStefania ColarussoMaria del Rosario FerreiraIan StansfieldAngela Claire MackayImmacolata ConteCaterina Ercolani et al.

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

Griffithsin has antiviral activity against hepatitis C virus

Philip MeulemanAnna AlbeckaSandrine BelouzardKoen VercauterenLieven VerhoyeCzeslaw WychowskiGeert Leroux-RoelsKenneth E PalmerJean Dubuisson

A1 Journal Article in ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Hypervariable region 1 differentially impacts viability of hepatitis C virus strains of genotypes 1 to 6 and impairs virus neutralization

Jannick PrentoeTanja B JensenPhilip MeulemanStephanie BN SerreTroels KH ScheelGeert Leroux-RoelsJudith M GottweinJens Bukh

A1 Journal Article in JOURNAL OF VIROLOGY

In vivo evaluation of the cross-genotype neutralizing activity of polyclonal antibodies against hepatitis C virus

Philip MeulemanJens BukhLieven VerhoyeAliasghar Farhoudi MoghadamThomas VanwolleghemRichard Y WangIsabelle DesombereHarvey AlterRobert H PurcellGeert Leroux-Roels

A1 Journal Article in HEPATOLOGY

Lipoprotein lipase inhibits hepatitis C virus (HCV) infection by blocking virus cell entry

Patrick MaillardMarine WalicPhilip MeulemanFarzin RoohvandThierry HubyWilfried Le GoffGeert Leroux-RoelsEve-Isabelle PécheurAgata Budkowska

A1 Journal Article in PLOS ONE

Metabolic studies with promagnon, methylclostebol and methasterone in the uPA+/+-SCID chimeric mice

Leen LootensPhilip MeulemanGeert Leroux-RoelsPeter Van Eenoo

A1 Journal Article in JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

The green tea polyphenol, epigallocatechin-3-gallate, inhibits hepatitis C virus entry

Sandra CiesekThomas von HahnChe C ColpittsLuis M SchangMartina FrieslandJürg SteinmannMichael P MannsMichael OttHeiner WedemeyerPhilip Meuleman et al.

A1 Journal Article in HEPATOLOGY

2010

Challenge pools of hepatitis C virus genotypes 1-6 prototype strains: replication fitness and pathogenicity in chimpanzees and human liver-chimeric mouse models

Jens BukhPhilip MeulemanRaymond TellierRonald E EngleStephen M FeinstoneGerald EderWilliam C SatterfieldSugantha GovindarajanKrzysztof KrawczynskiRoger H Miller et al.

A1 Journal Article in JOURNAL OF INFECTIOUS DISEASES

Factors determining successful engraftment of hepatocytes and susceptibility to hepatitis B and C virus infection in uPA-SCID mice

Thomas VanwolleghemLouis LibbrechtBettina E HansenIsabelle DesombereTania RoskamsPhilip MeulemanGeert Leroux-Roels

A1 Journal Article in JOURNAL OF HEPATOLOGY

Viral entry and escape from antibody-mediated neutralization influence hepatitis C virus reinfection in liver transplantation

Samira Fafi-KremerIsabel FofanaEric SoulierPatric CarollaPhilip MeulemanGeert Leroux-RoelsArvind H PatelFrançois-Loic CossetPatrick PessauxMichel Doffoel et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

2009

Combination of liquid-chromatography tandem mass spectrometry in different scan modes with human and chimeric mouse urine for the study of steroid metabolism

Pozo Mendoza Pozo MendozaLeen LootensPeter Van EenooKoen DeventerPhilip MeulemanGeert Leroux-RoelsMK ParrW SchanzerFrans Delbeke

A1 Journal Article in DRUG TESTING AND ANALYSIS

Detection and characterization of a new metabolite of 17 α-methyltestosterone

Pozo Mendoza Pozo MendozaPeter Van EenooKoen DeventerLeen LootensWim Van ThuyneMaria ParrWilhelm SchanzerJuan SanchoFelix HernandezPhilip Meuleman et al.

A1 Journal Article in DRUG METABOLISM AND DISPOSITION

Detection and structural investigation of metabolites of stanozolol in human urine by liquid chromatography tandem mass spectrometry

Pozo Mendoza Pozo MendozaPeter Van EenooKoen DeventerLeen LootensGrimalt SusanaJuan V SanchoFelix HernándezPhilip MeulemanGeert Leroux-RoelsFrans Delbeke

A1 Journal Article in STEROIDS

HCV animal models : a journey of more than 30 years

Philip MeulemanGeert Leroux-Roels

A1 Journal Article in VIRUSES-BASEL

Production of infectious genotype 1b virus particles in cell culture and impairment by replication enhancing mutations

T. PietschmannM. ZayasPhilip MeulemanG. LongN. AppelG. KoutsoudakisS. KallisGeert Leroux-RoelsV. LohmannR. Bartenschlager

A1 Journal Article in PLOS PATHOGENS

Steroid metabolism in chimeric mice with humanized liver

Leen LootensPeter Van EenooPhilip MeulemanPozo Mendoza Pozo MendozaPieter Van RenterghemGeert Leroux-RoelsFrans Delbeke

A1 Journal Article in Drug Testing and Analysis

The uPA(+/+)-SCID mouse with humanized liver as a model for in vivo metabolism of 4-androstene-3,17-dione

Leen LootensPeter Van EenooPhilip MeulemanGeert Leroux-RoelsFrans Delbeke

A1 Journal Article in DRUG METABOLISM AND DISPOSITION

uPA+/+-SCID mouse with humanized liver as a model for in vivo metabolism of exogenous steroids: methandienone as a case study

Leen LootensPhilip MeulemanPozo Mendoza Pozo MendozaPeter Van EenooGeert Leroux-RoelsFrans Delbeke

A1 Journal Article in CLINICAL CHEMISTRY

2008

ANTI-CD81 ANTIBODIES CAN PREVENT A HEPATITIS C VIRUS INFECTION IN VIVO

Philip MeulemanJoseph HesselgesserMatthew PaulsonThomas VanwolleghemIsabelle DesombereHans ReiserGeert Leroux-Roels

Anti-CD81 Antibodies Can Prevent a Hepatitis C Virus Infection In Vivo

Philip MeulemanJoseph HesselgesserMatthew PaulsonThomas VanwolleghemIsabelle DesombereIlans ReiserGeert Leroux-Roels

A1 Journal Article in HEPATOLOGY

Development and validation of a quantitative gas chromatography-mass spectrometry method for the detection of endogenous androgens in mouse urine

Leen LootensPeter Van EenooPhilip MeulemanGeert Leroux-RoelsWim Van ThuyneFrans Delbeke

A1 Journal Article in JOURNAL OF CHROMATOGRAPHY A

Polyclonal immunoglobulins from a chronic hepatitis C virus patient protect human liver-chimeric mice from infection with a homologous hepatitis C virus strain

Thomas VanwolleghemJ BUKHPhilip MeulemanIsabelle DesombereJC MEUNIERH ALTERRH PURCELLGeert Leroux-Roels

A1 Journal Article in HEPATOLOGY

Role of the Hepatitis C Virus Core+1 Open Reading Frame and Core cis-Acting RNA Elements in Viral RNA Translation and Replication

Niki VassilakiPeter FriebePhilip MeulemanStephanie KallisArthur KaulGlaucia Paranhos-BacalaGeert Leroux-RoelsPenelope MavromaraRalf Bartenschlager

A1 Journal Article in JOURNAL OF VIROLOGY

The human liver-uPA-SCID mouse: A model for the evaluation of antiviral compounds against HBV and HCV

Philip MeulemanGeert Leroux-Roels

A1 Journal Article in ANTIVIRAL RESEARCH

Validation of the metabolism of steroids in uPA+/+-SCID mice with humanized liver

Leen LootensPeter Van EenooPozo Mendoza Pozo MendozaPhilip MeulemanGeert Leroux-RoelsFrans Delbeke

2007

Cell culture adaptation of hepatitis c virus and in vivo viability of an adapted variant

A KAULI WOERZPhilip MeulemanGeert Leroux-RoelsR BARTENSCHLAGER

A1 Journal Article in JOURNAL OF VIROLOGY

Scavenger receptor BI and BII expression levels modulate hepatitis C virus infectivity

J GROVET HUBYZ STAMATAKIThomas VanwolleghemPhilip MeulemanM FARQUHARA SCHWARZM MOREAUJS OWENGeert Leroux-Roels et al.

A1 Journal Article in JOURNAL OF VIROLOGY

Ultra-rapid cardiotoxicity of the hepatitis C virus protease inhibitor BILN 2061 in the urokinase-type plasminogen activator mouse

Thomas VanwolleghemPhilip MeulemanLouis LibbrechtTania RoskamsRita De VosGeert Leroux-Roels

A1 Journal Article in GASTROENTEROLOGY

2006

Cell culture-grown hepatitis C virus is infectious in vivo and can be recultured in vitro

BD LINDENBACHPhilip MeulemanA PLOSSThomas VanwolleghemAJ SYDERJA MCKEATINGRE LANFORDSM FEINSTONEME MAJORGeert Leroux-Roels et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human hepatocytes secrete soluble CD14, a process not directly influenced by HBV and HCV infection

Philip MeulemanSophia SteyaertLouis LibbrechtSibyl CouventFreya Van HoutteFilip ClinckspoorBernard de HemptinneTania RoskamsPeter VanlandschootGeert Leroux-Roels

A1 Journal Article in CLINICA CHIMICA ACTA

Immune suppression uncovers endogenous cytopathic effects of the hepatitis B virus

Philip MeulemanLouis LibbrechtStefan WielandRita De VosNagy HabibAnna KramvisTania RoskamsGeert Leroux-Roels

A1 Journal Article in JOURNAL OF VIROLOGY

The Human Liver-uPA-SCID Mouse. A Small Animal Model for the study of viral hepatitis.

Philip MeulemanG Leroux-roels

2005

Morphological and biochemical characterization of a human liver in a uPA-SCID mouse chimera

Philip MeulemanLouis LibbrechtRita De VosBernard de HemptinneKris GevaertJoël VandekerckhoveTania RoskamsGeert Leroux-Roels

A1 Journal Article in HEPATOLOGY

2004

Cytopathic effects of hepatitis B virus infection in long-term infected chimeric uPA-SCID mice

Philip MeulemanL LIBBRECHTR DE VOST ROSKAMSGeert Leroux-Roels

Morphological and biochemical characterization of a human liver in uPA-SCID mouse chimera

Philip MeulemanLouis LibbrechtRita De VosTania RoskamsGeert Leroux-Roels

The interferon gamma secretion assay: a reliable tool to study interferon gamma production at the single cell level

Isabelle DesomberePhilip MeulemanHanne RigoleAnnick WillemsJ IRSCHGeert Leroux-Roels

A1 Journal Article in JOURNAL OF IMMUNOLOGICAL METHODS

Virological and morphological characterization of HBV and HCV infections in human liver-UPA-SCID mice

Philip MeulemanL LIBBRECHTR DE VOST ROSKAMSGeert Leroux-Roels

2003

A simple and rapid method to determine the zygosity of uPA-transgenic SCID mice

Philip MeulemanPeter VanlandschootGeert Leroux-Roels

A1 Journal Article in BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

2001

In vivo inhibition of anti-HBcIgG production by HBcAg-specific CD4+Th1-type T cell clones in a hu-PBL-NOD/SCID mice model

TH CAOPhilip MeulemanIsabelle DesombereM SALLBERGGeert Leroux-Roels

In vivo inhibition of anti-hepatitis B virus core antigen (HBcAg) immunoglobulin G production by HBcAg-specific CD4(+) Th1-type T-cell clones in a hu-PBL-NOD/SCID mouse model.

Tinghua CaoPhilip MeulemanIsabelle DesombereM SALLBERGGeert Leroux-Roels

A1 Journal Article in JOURNAL OF VIROLOGY

Prevention of hepatitis B infections: Vaccination and its limitations

Geert Leroux-RoelsT CAOA DE KNIBBERPhilip MeulemanA ROOBROUCKA FARHOUDIPeter VanlandschootIsabelle Desombere

A1 Journal Article in ACTA CLINICA BELGICA

1998

Murine IL-2 receptor beta chain blockade improves human leukocyte engraftment in SCID mice

Kurt TournoyStany DepraeterePhilip MeulemanGeert Leroux-RoelsRomain Pauwels

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY