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Researcher
Philip Meuleman
Profile
Projects
Publications & Research Data
Activities
Awards & Distinctions
Patents
170
Results
2026
Fluorescent virus lights up on a new drug for chronic hepatitis E
Jérôme Gouttenoire
Philip Meuleman
Editorial material
2026
In vivo determinants of hepatitis C virus adaptation and escape from neutralizing antibody AR5A
Rodrigo Velázquez-Moctezuma
Rani Burm
Lieven Verhoye
Laura Collignon
Kenn Holmbeck
Erick Giang
Mansun Law
Jens Bukh
Philip Meuleman
Jannick Prentoe
A1
Journal Article
in
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
2026
2025
A novel in vitro system for simultaneous infections with hepatitis B, C, D and E viruses
Roxanne Fouillé
Eloi R. Verrier
Amse De Meyer
Lieven Verhoye
Maud Michelet
Romain Barnault
Caroline Pons
Olivier Diaz
Michel Rivoire
Guillaume Passot
et al.
A1
Journal Article
in
JHEP REPORTS
2025
Broadly neutralizing antibodies isolated from HEV convalescents confer protective effects in human liver-chimeric mice
George Ssebyatika
Katja Dinkelborg
Luisa J. Ströh
Florian Hinte
Laura Corneillie
Lucas Hueffner
Elina M. Guzman
Prossie L. Nankya
Nina Plückebaum
Lukas Fehlau
et al.
A1
Journal Article
in
NATURE COMMUNICATIONS
2025
Higher hepatitis E seroprevalence in workers in the pig sector in Flanders, Belgium : results from a seroprevalence case‐control study
Heidi Janssens
Lies Delameillieure
Stijn Jonckheere
Freya Van Houtte
Philip Meuleman
Tom Geens
A1
Journal Article
in
ZOONOSES AND PUBLIC HEALTH
2025
IFN-β production promotes metabolic rewiring and protection against oxidative stress in hepatitis delta virus-infected hepatocyte cultures
Olga A. Khomich
Patrick Giavalisco
Romain Parent
George S. Krasnov
Peter Tessarz
Philip Meuleman
Rani Burm
Natalia F. Zakirova
Jennifer Molle
Enkhtuul Batbold
et al.
A1
Journal Article
in
CELL DEATH & DISEASE
2025
2024
A critical role for HNF4α in polymicrobial sepsis-associated metabolic reprogramming and death
Céline Van Dender
Steven Timmermans
Ville Paakinaho
Tineke Vanderhaeghen
Jolien Vandewalle
Maarten Claes
Bruno Garcia
Bart Roman
Jan De Waele
Siska Croubels
et al.
A1
Journal Article
in
EMBO MOLECULAR MEDICINE
2024
High-throughput single-cell screening of viable hybridomas and patient-derived antibody-secreting cells using punchable microwells
Kaat Rubben
Ann-Sophie Vander Plaetsen
Ruben Almey
Olivier Tytgat
Koen Deserranno
Jamie De Baere
Delphine Acar
Philip Meuleman
Dieter Deforce
Filip Van Nieuwerburgh
A1
Journal Article
in
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
2024
Highlights from the 2023 International Meeting on the Molecular Biology of Hepatitis B virus
Lena Allweiss
Chari Cohen
Joao Dias
Valeria Fumagalli
Haitao Guo
James M Harris
Jianming Hu
Matteo Iannacone
Masanori Isogawa
Wen-Juei Jeng
et al.
A1
Journal Article
in
JOURNAL OF GENERAL VIROLOGY
2024
JFH1-based Core-NS2 genotype variants of HCV with genetic stability in vivo and in vitro : important tools in the evaluation of virus neutralization
Laura Collignon
Kenn Holmbeck
Ashley Just
Lieven Verhoye
Rodrigo Velázquez-Moctezuma
Ulrik Fahnøe
Thomas H R Carlsen
Mansun Law
Jannick Prentoe
Troels K H Scheel
et al.
A1
Journal Article
in
HEPATOLOGY
2024
Microbiological evaluation of ultraviolet C light-emitting diodes for disinfection of medical instruments
Hannah Siwe
Annelies Aerssens
Mieke V. Flour
Silke Ternest
Leen Van Simaey
Duncan Verstraeten
Alain Kalmar
Isabel Leroux-Roels
Philip Meuleman
Piet Cools
A1
Journal Article
in
HELIYON
2024
Phosphatidylinositol 4-kinase III alpha governs cytoskeletal organization for invasiveness of liver cancer cells
Cong Si Tran
Julia Kersten
Jingyi Yan
Marco Breinig
Thorben Huth
Tanja Poth
Ombretta Colasanti
Tobias Riedl
Suzanne Faure-Dupuy
Stefan Diehl
et al.
A1
Journal Article
in
GASTROENTEROLOGY
2024
Preclinical animal models to evaluate therapeutic antiviral antibodies
Amse De Meyer
Philip Meuleman
A1
Journal Article
in
ANTIVIRAL RESEARCH
2024
TIM1, un récepteur de la phosphatidylsérine essentiel pour l’infection par le virus de l’hépatite E
Laura Corneillie
Philip Meuleman
Laurence Cocquerel
Editorial material
2024
2023
A human monoclonal antibody against HBsAg for the prevention and treatment of chronic HBV and HDV infection
Rani Burm
Freya Van Houtte
Lieven Verhoye
Ahmed Atef Ahmed Abouzeid Mesalam
S Ciesek
P Roingeard
H Wedemeyer
Geert Leroux-Roels
Philip Meuleman
A1
Journal Article
in
JHEP REPORTS
2023
Adeno-associated virus serotype 2 capsid variants for improved liver-directed gene therapy
N Meumann
M Cabanes-Creus
M Ertelt
RG Navarro
J Lucifora
Q Yuan
K Nien-Huber
A Abdelrahman
XK Vu
L Zhang
et al.
A1
Journal Article
in
HEPATOLOGY
2023
Comparison of HAV and HCV infections in vivo and in vitro reveals distinct patterns of innate immune evasion and activation
Ombretta Colasanti
Rani Burm
Hao-En Huang
Tobias Riedl
Jannik Traut
Nadine Gillich
Teng-Feng Li
Laura Corneillie
Suzanne Faure-Dupuy
Oliver Grünvogel
et al.
A1
Journal Article
in
JOURNAL OF HEPATOLOGY
2023
Identification and characterization of protein interactions between the hepatitis E virus and its host
Laura Corneillie
Philip Meuleman
Dissertation
2023
Novel prime-boost immune-based therapy inhibiting both hepatitis B and D virus infections
Rani Burm
Panagiota Maravelia
Gustaf Ahlen
Sandra Ciesek
Noelia Caro Perez
Anna Pasetto
Stephan Urban
Freya Van Houtte
Lieven Verhoye
Heiner Wedemeyer
et al.
A1
Journal Article
in
GUT
2023
The phosphatidylserine receptor TIM1 promotes infection of enveloped hepatitis E virus
Laura Corneillie
Irma Lemmens
Claire Montpellier
Martin Ferrié
Karin Weening
Freya Van Houtte
Xavier Hanoulle
Laurence Cocquerel
Ali Amara
Jan Tavernier
et al.
A1
Journal Article
in
CELLULAR AND MOLECULAR LIFE SCIENCES
2023
Virus-host protein interaction network of the hepatitis E virus ORF2-4 by mammalian two-hybrid assays
Laura Corneillie
Irma Lemmens
Karin Weening
Amse De Meyer
Freya Van Houtte
Jan Tavernier
Philip Meuleman
A1
Journal Article
in
VIRUSES-BASEL
2023
2022
A Hepatitis C virus genotype 1b post-transplant isolate with high replication efficiency in cell culture and its adaptation to infectious virus production in vitro and in vivo
Christian Heuss
Paul Rothhaar
Rani Burm
Ji-Young Lee
Philipp Ralfs
Uta Haselmann
Luisa J. Ströh
Ombretta Colasanti
Cong Si Tran
Noemi Schäfer
et al.
A1
Journal Article
in
PLOS PATHOGENS
2022
A ribavirin-induced ORF2 single-nucleotide variant produces defective hepatitis E virus particles with immune decoy function
TL Meister
Y Brüggemann
MK Nocke
RG Ulrich
J Schuhenn
K Sutter
A Gömer
V Bader
KF Winklhofer
R Broering
et al.
A1
Journal Article
in
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
2022
Development and evaluation of a chimeric recombinant vaccine against hepatitis E virus and hepatitis B virus infection
Laura Collignon
Philip Meuleman
Dissertation
2022
Human hepatocyte PNPLA3-148M exacerbates rapid non-alcoholic fatty liver disease development in chimeric mice
M Kabbani
E Michailidis
S Steensels
CG Fulmer
JM Luna
J Le Pen
M Tardelli
B Razooky
I Ricardo-Lax
C Zou
et al.
A1
Journal Article
in
CELL REPORTS
2022
Preventive and therapeutic approaches to eliminate both hepatitis B and D virus infections
Rani Burm
Philip Meuleman
Dissertation
2022
Study of hepatitis E virus-4 infection in human liver-chimeric, immunodeficient, and immunocompetent mice
Laura Collignon
Lieven Verhoye
Renate Hakze-Van der Honing
Wim H. M. Van der Poel
Philip Meuleman
A1
Journal Article
in
FRONTIERS IN MICROBIOLOGY
2022
Viral interference of hepatitis C and E virus replication in novel experimental co-infection systems
T Burkard
N Proske
K Resner
Laura Collignon
L Knegendorf
M Friesland
Lieven Verhoye
IM Sayed
Y Brüggemann
MK Nocke
et al.
A1
Journal Article
in
CELLS
2022
2021
A role for B cells to transmit hepatitis C virus infection
Isabelle Desombere
Freya Van Houtte
Aliasghar Farhoudi Moghadam
Lieven Verhoye
Caroline Buysschaert
Yvonne Gijbels
Sibyl Couvent
W Swinnen
Hans Van Vlierberghe
André Elewaut
et al.
A1
Journal Article
in
FRONTIERS IN IMMUNOLOGY
2021
Blocking entry of hepatitis B and D viruses to hepatocytes as a novel immunotherapy for treating chronic infections
P Maravelia
L Frelin
Y Ni
NC Pérez
G Ahlén
N Jagya
G Verch
Lieven Verhoye
L Pater
M Johansson
et al.
A1
Journal Article
in
JOURNAL OF INFECTIOUS DISEASES
2021
2020
Expansion, in vivo-ex vivo cycling, and genetic manipulation of primary human hepatocytes
Eleftherios Michailidis
Koen Vercauteren
Liliana Mancio-Silva
Linda Andrus
Cyprien Jahan
Inna Ricardo-Lax
Chenhui Zou
Mohammad Kabbani
Paul Park
Corrine Quirk
et al.
A1
Journal Article
in
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
2020
Experimental variables that affect human hepatocyte MV transduction in liver chimeric mice
Chenhui Zou
Koen O.A. Vercauteren
Eleftherios Michailidis
Mohammad Kabbani
Irene Zoluthkin
Corrine Quirk
Luis Chiriboga
Mustafa Yazicioglu
Xavier M. Anguela
Philip Meuleman
et al.
A1
Journal Article
in
MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT
2020
Inflammation alters the secretome and immunomodulatory properties of human skin-derived precursor cells
Joery De Kock
Robim Marcelino Rodrigues
Steven Branson
Lieven Verhoye
Haaike Colemonts-Vroninks
Matthias Rombaut
Joost Boeckmans
Jessie Neuckermans
Sien Lequeue
Karolien Buyl
et al.
A1
Journal Article
in
CELLS
2020
Liver-expressed Cd302 and Cr1l limit hepatitis C virus cross-species transmission to mice
Richard J. P. Brown
Birthe Tegtmeyer
Julie Sheldon
Tanvi Khera
[missing] Anggakusuma
Daniel Todt
Gabrielle Vieyres
Romy Weller
Sebastian Joecks
Yudi Zhang
et al.
A1
Journal Article
in
SCIENCE ADVANCES
2020
Robust hepatitis E virus infection and transcriptional response in human hepatocytes
Daniel Todt
Martina Friesland
Nora Moeller
Dimas Praditya
Volker Kinast
Yannick Brüggemann
Leonard Knegendorf
Thomas Burkard
Joerg Steinmann
Rani Burm
et al.
A1
Journal Article
in
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
2020
Updates in hepatitis E virus (HEV) field : lessons learned from human liver chimeric mice
Ibrahim M Sayed
Philip Meuleman
A1
Journal Article
in
REVIEWS IN MEDICAL VIROLOGY
2020
2019
A central hydrophobic E1 region controls the pH range of hepatitis C virus membrane fusion and susceptibility to fusion inhibitors
Banda H Dominic
Paula M Perin
Richard JP Brown
Daniel Todt
Wladimir Solodenko
Patrick Hoffmeyer
Kamlesh Kumar Sahu
Michael Houghton
Philip Meuleman
Rolf Muller
et al.
A1
Journal Article
in
JOURNAL OF HEPATOLOGY
2019
Animal models for hepatitis E virus
Laura Corneillie
Dominic Banda
Philip Meuleman
A1
Journal Article
in
VIRUSES-BASEL
2019
Hepatitis E virus (HEV) open reading frame 2 antigen kinetics in human-liver chimeric mice and its impact on HEV diagnosis
Ibrahim Ibrahim Mahmoud Sayed
Lieven Verhoye
Claire Montpellier
Florence Abravanel
Jacques Izopet
Laurence Cocquerel
Philip Meuleman
A1
Journal Article
in
JOURNAL OF INFECTIOUS DISEASES
2019
Hepatitis E virus prevalence in Flemish blood donors
Ann-Sofie Vercouter
Freya Van Houtte
Lieven Verhoye
Isabel González Fraile
Lydia Blanco
Veerle Compernolle
Philip Meuleman
A1
Journal Article
in
JOURNAL OF VIRAL HEPATITIS
2019
Infectivity and stability of hepatitis C virus in different perfusion solutions
Fabian A Helfritz
Verena Wanders
Denisa Bojkova
Nina Kuklinski
Sandra Westhaus
Sandra Swoboda
Thomas Minor
Philip Meuleman
Andreas Paul
Eike Steinmann
et al.
A1
Journal Article
in
TRANSPLANT INFECTIOUS DISEASE
2019
New insights into the ORF2 capsid protein, a key player of the hepatitis E virus lifecycle
Maliki Ankavay
Claire Montpellier
Ibrahim Ibrahim Mahmoud Sayed
Jean-Michel Saliou
Czeslaw Wychowski
Laure Saas
Sandrine Duvet
Cécile-Marie Aliouat-Denis
Rayan Farhat
Valentin de Masson d’Autume
et al.
A1
Journal Article
in
SCIENTIFIC REPORTS
2019
Prevalence of hepatitis E virus in Flanders and evaluation of a potential novel reservoir
Ann-Sofie Vercouter
Philip Meuleman
Dissertation
2019
2018
Absence of zoonotic hepatitis E virus infection in Flemish dairy cows
Ann-Sofie Vercouter
Ibrahim Ibrahim Mahmoud Sayed
Zyncke Lipkens
Koen De Bleecker
Sarne De Vliegher
Roos Colman
Marco Koppelman
Karlien Supré
Philip Meuleman
A1
Journal Article
in
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
2018
Animal models to study hepatitis C virus infection
Rani Burm
Laura Collignon
Ahmed Atef Ahmed Abouzeid Mesalam
Philip Meuleman
A1
Journal Article
in
FRONTIERS IN IMMUNOLOGY
2018
Development and characterization of a human monoclonal antibody targeting the N-terminal region of hepatitis C virus envelope glycoprotein E1
Ahmed Atef Ahmed Abouzeid Mesalam
Isabelle Desombere
Aliasghar Farhoudi Moghadam
Freya Van Houtte
Lieven Verhoye
Jonathan Ball
Jean Dubuisson
Steven KH Foung
Arvind H Patel
Mats AA Persson
et al.
A1
Journal Article
in
VIROLOGY
2018
Elucidating the differences in pathogenicity between hepatitis E virus genotypes : the quest continues
Ann-Sofie Vercouter
Philip Meuleman
Editorial material
2018
Functional study of the C-terminal part of the hepatitis C virus E1 ectodomain
Rehab I Moustafa
Juliano G Haddad
Lydia Linna
Xavier Hanoulle
Véronique Descamps
Ahmed Atef Ahmed Abouzeid Mesalam
Thomas F Baumert
Gilles Duverlie
Philip Meuleman
Jean Dubuisson
et al.
A1
Journal Article
in
JOURNAL OF VIROLOGY
2018
Hepatitis E virus lifecycle and identification of 3 forms of the ORF2 capsid protein
Claire Montpellier
Czeslaw Wychowski
Ibrahim Ibrahim Mahmoud Sayed
Jean-Christophe Meunier
Jean-Michel Saliou
Maliki Ankavay
Anne Bull
André Pillez
Florence Abravanel
François Helle
et al.
A1
Journal Article
in
GASTROENTEROLOGY
2018
Immunological responses following administration of a genotype 1a/1b/2/3a quadrivalent HCV VLP vaccine
D Christiansen
L Earnest-Silveira
B Chua
Philip Meuleman
I Boo
B Grubor-Bauk
DC Jackson
ZY Keck
SKH Foung
HE Drummer
et al.
A1
Journal Article
in
SCIENTIFIC REPORTS
2018
Methylene blue treatment of grafts during cold ischemia time reduces the risk of hepatitis C virus transmission
Fabian A Helfritz
Denisa Bojkova
Verena Wanders
Nina Kuklinski
Sandra Westhaus
Charlotte von Horn
Ursula Rauen
Anja Gallinat
Hideo A Baba
Andreas Skyschally
et al.
A1
Journal Article
in
JOURNAL OF INFECTIOUS DISEASES
2018
Monoclonal antibodies as a new strategy for prevention and treatment of hepatitis C virus infection
Ahmed Atef Ahmed Abouzeid Mesalam
Philip Meuleman
Dissertation
2018
The natural compound silvestrol inhibits hepatitis E virus (HEV) replication in vitro and in vivo
Daniel Todt
Nora Moeller
Dimas Praditya
Volker Kinast
Martina Friesland
Michael Engelmann
Lieven Verhoye
Ibrahim Ibrahim Mahmoud Sayed
Patrick Behrendt
Viet Loan Dao Thi
et al.
A1
Journal Article
in
ANTIVIRAL RESEARCH
2018
2017
A novel neutralizing human monoclonal antibody broadly abrogates hepatitis C virus infection in vitro and in vivo
Isabelle Desombere
Ahmed Atef Ahmed Abouzeid Mesalam
Richard A Urbanowicz
Freya Van Houtte
Lieven Verhoye
Zhen-Yong Keck
Aliasghar Farhoudi Moghadam
Koen Vercauteren
Karin Weening
Thomas F Baumert
et al.
A1
Journal Article
in
ANTIVIRAL RESEARCH
2017
Characterization of a novel monoclonal antibody targeting epitope II within hepatitis C virus E2 envelope glycoprotein
Philip Meuleman
Ahmed Atef Ahmed Abouzeid Mesalam
Isabelle Desombere
Richard Urbanowicz
Freya Van Houtte
Lieven Verhoye
Zhen-Yong Keck
Aliasghar Farhoudi Moghadam
Koen Vercauteren
Karin Weening
et al.
C3
Conference
2017
Development and characterization of a human monoclonal antibody for prevention of HCV recurrence in liver transplant patients
Ahmed Atef Ahmed Abouzeid Mesalam
Isabelle Desombere
Richard Urbanowicz
Daniel X Johansson
Koen Vercauteren
Aliasghar Farhoudi Moghadam
Freya Van Houtte
Lieven Verhoye
Mats Persson
Jonathan Ball
et al.
C3
Conference
2017
Effect of hepatitis E virus infection on the human hepatic innate immune response in human liver chimeric mice
Ibrahim Mahmoud Sayed Ibrahim
Lieven Verhoye
Laurance Cocquerel
Florence Abravanel
Lander Foquet
Claire Montpellier
Yannick Debing
Aliasghar Farhoudi Moghadam
Czeslaw Wychowski
Jean Dubuisson
et al.
C3
Conference
2017
Humanized mice as a model for the study of hepatitis E virus infection
Ibrahim Mahmoud Sayed Ibrahim
Philip Meuleman
Dissertation
2017
Impact of HEV infection on the human hepatic innate immune response in human liver chimeric mice
Ibrahim Mahmoud Sayed Ibrahim
Lieven Verhoye
Lander Foquet
Florence Abravanel
Aliasghar Farhoudi Moghadam
Geert Leroux-Roels
Jacques Izopet
Philip Meuleman
C3
Conference
2017
Murine tissues of human liver chimeric mice are not susceptible to hepatitis E virus genotypes 1 and 3
Ibrahim M Sayed
Philip Meuleman
A1
Journal Article
in
JOURNAL OF INFECTIOUS DISEASES
2017
Pentagalloylglucose, a highly bioavailable polyphenolic compound present in Cortex moutan, efficiently blocks hepatitis C virus entry
Patrick Behrendt
Paula Perin
Nicolas Menzel
Dominic Banda
Stephanie Pfaender
Marco P Alves
Volker Thiel
Philip Meuleman
Che C Colpitts
Luis M Schang
et al.
A1
Journal Article
in
ANTIVIRAL RESEARCH
2017
Study of hepatitis E virus infection of genotype 1 and 3 in mice with humanised liver
Ibrahim Mahmoud Sayed Ibrahim
Lieven Verhoye
Laurence Cocquerel
Florence Abravanel
Lander Foquet
Claire Montpellier
Yannick Debing
Aliasghar Farhoudi Moghadam
Czeslaw Wychowski
Jean Dubuisson
et al.
A1
Journal Article
in
GUT
2017
Successful engraftment of human hepatocytes in uPA-SCID and FRG® KO mice
Lander Foquet
Elizabeth M Wilson
Lieven Verhoye
Markus Grompe
Geert Leroux-Roels
John Bial
Philip Meuleman
Bookchapter
in
Hepatocyte transplantation : methods and protocols
2017
Tracking HCV protease population diversity during transmission and susceptibility of founder populations to antiviral therapy
Tanvi Khera
Daniel Todt
Koen Vercauteren
C Patrick McClure
Lieven Verhoye
Aliasghar Farhoudi Moghadam
Sabin Bhuju
Robert Geffers
Thomas F Baumert
Eike Steinmann
et al.
A1
Journal Article
in
ANTIVIRAL RESEARCH
2017
Transmission of hepatitis E virus infection to human-liver chimeric FRG mice using patient plasma
Ibrahim Mahmoud Sayed Ibrahim
Lander Foquet
Lieven Verhoye
Aliasghar Farhoudi Moghadam
Floresence Abravanel
Geert Leroux-Roels
Jacques Izopet
Philip Meuleman
A1
Journal Article
in
ANTIVIRAL RESEARCH
2017
2016
Apolipoprotein E mediates evasion from hepatitis C virus neutralizing antibodies
Catherine Fauvelle
Daniel J Felmlee
Emilie Crouchet
JiYoung Lee
Laura Heydmann
Mathieu Lefèvre
Andrea Magri
Marie-Sophie Hiet
Isabel Fofana
François Habersetzer
et al.
A1
Journal Article
in
GASTROENTEROLOGY
2016
Characterisation of a hepatitis C virus-like particle vaccine produced in a human hepatocyte-derived cell line
L Earnest-Silveira
B Chua
R Chin
D Christiansen
D Johnson
S Herrmann
SA Ralph
Koen Vercauteren
Ahmed Atef Ahmed Abouzeid Mesalam
Philip Meuleman
et al.
A1
Journal Article
in
JOURNAL OF GENERAL VIROLOGY
2016
Characterization of a novel human monoclonal antibody targeting the hepatitis C virus envelope protein
Ahmed Atef Ahmed Abouzeid Mesalam
Isabelle Desombere
Richard Urbanowicz
Daniel X Johansson
Koen Vercauteren
Aliasghar Farhoudi Moghadam
Freya Van Houtte
Lieven Verhoye
Mats Persson
Jonathan Ball
et al.
C3
Conference
2016
Effect of hepatitis E virus infection on the human hepatic innate immune response in human liver chimeric mice
Ibrahim Mahmoud Sayed Ibrahim
Lieven Verhoye
Laurance Cocquerel
Florence Abravanel
Lander Foquet
Claire Montpellier
Yannick Debing
Aliasghar Farhoudi Moghadam
Czeslaw Wychowski
Jean Dubuisson
et al.
C3
Conference
2016
Expanding the host range of hepatitis C virus through viral adaptation
Markus von Schaewen
Marcus Dorner
Kathrin Hueging
Lander Foquet
Sherif Gerges
Gabriela Hrebikova
Brigitte Heller
Julia Bitzegeio
Juliane Doerrbecker
Joshua A Horwitz
et al.
A1
Journal Article
in
MBIO
2016
Flunarizine prevents hepatitis C virus membrane fusion in a genotype-dependent manner by targeting the potential fusion peptide within E1
Paula M Perin
Sibylle Haid
Richard JP Brown
Juliane Doerrbecker
Kai Schulze
Carsten Zeilinger
Markus von Schaewen
Brigitte Heller
Koen Vercauteren
Eva Luxenburger
et al.
A1
Journal Article
in
HEPATOLOGY
2016
Hepatitis E virus in acute liver failure : an unusual suspect?
Ibrahim Mahmoud Sayed Ibrahim
Ann-Sofie Vercouter
Philip Meuleman
Editorial material
2016
Host cell mTORC1 is required for HCV RNA replication
Stefanie Stöhr
Rui Costa
Lisa Sandmann
Sandra Westhaus
Stephanie Pfaender
- Anggakusuma
Eva Dazert
Philip Meuleman
Florian WR Vondran
Michael P Manns
et al.
A1
Journal Article
in
GUT
2016
HVR1-mediated antibody evasion of highly infectious in vivo adapted HCV in humanised mice
Jannick Prentoe
Lieven Verhoye
Rodrigo Velázquez Moctezuma
Caroline Buysschaert
Aliasghar Farhoudi Moghadam
Richard Wang
Harvey Alter
Philip Meuleman
Jens Bukh
A1
Journal Article
in
GUT
2016
Identification of a new benzimidazole derivative as an antiviral against hepatitis C virus
Thibaut Vausselin
Karin Séron
Muriel Lavie
Ahmed Atef Ahmed Abouzeid Mesalam
Matthieu Lemasson
Sandrine Belouzard
Lucie Fénéant
Adeline Danneels
Yves Rouillé
Laurence Cocquerel
et al.
A1
Journal Article
in
JOURNAL OF VIROLOGY
2016
In vitro and in vivo metabolism studies of dimethazine
Lore Geldof
Eva Tudela Palomar
Leen Lootens
Jasper Van Lysebeth
Philip Meuleman
Geert Leroux-Roels
Peter Van Eenoo
Koen Deventer
A1
Journal Article
in
BIOMEDICAL CHROMATOGRAPHY
2016
Metabolic studies of prostanozol with the uPA-SCID chimeric mouse model and human liver microsomes
Lore Geldof
Leen Lootens
Lieselot Decroix
Philip Meuleman
Francesco Botrè
Geert Leroux-Roels
Koen Deventer
Peter Van Eenoo
A1
Journal Article
in
STEROIDS
2016
Monoclonal anti-envelope antibody AP33 protects humanized mice against a patient-derived hepatitis C virus challenge
Isabelle Desombere
Samira Fafi-Kremer
Freya Van Houtte
Patrick Pessaux
Aliasghar Farhoudi Moghadam
Laura Heydmann
Lieven Verhoye
Sarah Cole
Jane A McKeating
Geert Leroux-Roels
et al.
A1
Journal Article
in
HEPATOLOGY
2016
Mouse systems to model hepatitis C virus treatment and associated resistance
Ahmed Atef Ahmed Abouzeid Mesalam
Koen Vercauteren
Philip Meuleman
A1
Journal Article
in
VIRUSES-BASEL
2016
Targeting a host-cell entry factor barricades antiviral-resistant HCV variants from on-therapy breakthrough in human-liver mice
Koen Vercauteren
Richard JP Brown
Ahmed Atef Ahmed Abouzeid Mesalam
Juliane Doerrbecker
Sabin Bhuju
Robert Geffers
Naomi Van den Eede
C Patrick McClure
Fulvia Troise
Lieven Verhoye
et al.
A1
Journal Article
in
GUT
2016
Tuning a cellular lipid kinase activity adapts hepatitis C virus to replication in cell culture
Christian Harak
Max Meyrath
Inés Romero-Brey
Christian Schenk
Claire Gondeau
Philipp Schult
Katharina Esser-Nobis
Mohsan Saeed
Petra Neddermann
Paul Schnitzler
et al.
A1
Journal Article
in
NATURE MICROBIOLOGY
2016
2015
A broadly neutralizing monoclonal antibody targeting hepatitis C virus prevents viral infection in vitro and in uPA/SCID mice with humanized liver
Ahmed Atef Ahmed Abouzeid Mesalam
Isabelle Desombere
Richard Urbanowicz
Daniel X Johansson
Koen Vercauteren
Aliasghar Farhoudi Moghadam
Freya Van Houtte
Lieven Verhoye
Karin Weening
Mats Persson
et al.
C3
Conference
2015
A broadly neutralizing monoclonal antibody targeting hepatitis C virus prevents viral infection in vitro and in uPA/SCID mice with humanized liver
Ahmed Atef Ahmed Abouzeid Mesalam
Isabelle Desombere
Richard Urbanowicz
Daniel X Johansson
Aliasghar Farhoudi Moghadam
Freya Van Houtte
Lieven Verhoye
Mats Persson
Jonathan Ball
Geert Leroux-Roels
et al.
C3
Conference
2015
A broadly neutralizing monoclonal antibody targeting hepatitis C virus prevents viral infection in vitro and in uPA/SCID mice with humanized liver
Ahmed Atef Ahmed Abouzeid Mesalam
Isabelle Desombere
Richard Urbanowicz
Daniel X Johansson
Aliasghar Farhoudi Moghadam
Freya Van Houtte
Lieven Verhoye
Mats Persson
Jonathan Ball
Geert Leroux-Roels
et al.
C3
Conference
2015
A humanized mouse model for the study of infection with Plasmodium falciparum : development and applications
Lander Foquet
Geert Leroux-Roels
Philip Meuleman
Dissertation
2015
Animal models for the study of HCV
Koen Vercauteren
Ype P de Jong
Philip Meuleman
A1
Journal Article
in
CURRENT OPINION IN VIROLOGY
2015
Anti-CD81 but not anti-SR-BI blocks Plasmodium falciparum liver infection in a humanized mouse model
Lander Foquet
Cornelus C Hermsen
Lieven Verhoye
Geert-Jan van Gemert
Riccardo Cortese
Alfredo Nicosia
Robert W Sauerwein
Geert Leroux-Roels
Philip Meuleman
A1
Journal Article
in
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
2015
Assessment of parasite liver-stage burden in human-liver chimeric mice
Lander Foquet
Philip Meuleman
Cornelus C Hermsen
Robert Sauerwein
Geert Leroux-Roels
Bookchapter
in
Malaria vaccines
2015
Clearance of persistent hepatitis C virus infection in humanized mice using a claudin-1-targeting monoclonal antibody
Laurent Mailly
Fei Xiao
Joachim Lupberger
Garrick K Wilson
Philippe Aubert
François HT Duong
Diego Calabrese
Céline Leboeuf
Isabel Fofana
Christine Thumann
et al.
A1
Journal Article
in
NATURE BIOTECHNOLOGY
2015
Generation and characterization of small single domain antibodies inhibiting human tumor necrosis factor receptor 1
Sophie Steeland
Leen Puimège
Roosmarijn Vandenbroucke
Filip Van Hauwermeiren
Jurgen Haustraete
Nick Devoogdt
Paco Hulpiau
Geert Leroux-Roels
Debby Laukens
Philip Meuleman
et al.
A1
Journal Article
in
JOURNAL OF BIOLOGICAL CHEMISTRY
2015
Human liver chimeric mice as a novel model for the study of hepatitis E virus infections
Ibrahim Mahmoud Sayed Ibrahim
Lieven Verhoye
Laurence Cocquerel
Florence Abbravanel
Lander Foquet
Yannick Debing
Aliasghar Farhoudi Moghadam
Czeslaw Wychowski
Jean Dubuisson
Geert Leroux-Roels
et al.
C3
Conference
2015
Human liver chimeric mice as a novel model for the study of hepatitis E virus infections
Ibrahim Mahmoud Sayed Ibrahim
Lieven Verhoye
Aliasghar Farhoudi Moghadam
Yannick Debing
Johan Neyts
Geert Leroux-Roels
Robert Purcell
Suzanne Emerson
Philip Meuleman
C3
Conference
2015
Human liver chimeric mice as a novel model for the study of hepatitis E virus infections
Ibrahim Mahmoud Sayed Ibrahim
Lieven Verhoye
Y Debing
F Abbravanel
Aliasghar Farhoudi Moghadam
Geert Leroux-Roels
J Neyts
J Izopet
R Purcell
S Emerson
et al.
C3
Conference
2015
Is hepatitis E virus an emerging problem in industrialized countries?
Ibrahim Mahmoud Sayed Ibrahim
Ann-Sofie Vercouter
Sayed F Abdelwahab
Koen Vercauteren
Philip Meuleman
A1
Journal Article
in
HEPATOLOGY
2015
Polyphenols inhibit hepatitis C virus entry by a new mechanism of action
Noémie Calland
Marie-Emmanuelle Sahuc
Sandrine Belouzard
Véronique Pène
Pierre Bonnafous
Ahmed Atef Ahmed Abouzeid Mesalam
Gaspard Deloison
Véronique Descamps
Sevser Sahpaz
Czeslaw Wychowski
et al.
A1
Journal Article
in
JOURNAL OF VIROLOGY
2015
Targeting a host-cell entry factor barricades antiviral-resistant HCV variants from on-therapy breakthrough in human-liver mice
Koen Vercauteren
Richard JP Brown
Ahmed Atef Ahmed Abouzeid Mesalam
Juliane Doerrbecker
Sabin Bhuju
Robert Geffers
Naomi Van den Eede
Fulvia Troise
Lieven Verhoye
Thomas Baumert
et al.
C3
Conference
2015
The emergence of hepatitis E virus in Europe
Ibrahim Mahmoud Sayed Ibrahim
Koen Vercauteren
Sayed F Abdelwahab
Philip Meuleman
A1
Journal Article
in
FUTURE VIROLOGY
2015
2014
A genetically attenuated malaria vaccine candidate based on P. falciparum b9/slarp gene-deficient sporozoites
Ben CL van Schaijk
Ivo HJ Ploemen
Takeshi Annoura
Martijn W Vos
Lander Foquet
Geert-Jan van Gemert
Severine Chevalley-Maurel
Marga van de Vegte-Bolmer
Mohammed Sajid
Jean-Francois Franetich
et al.
A1
Journal Article
in
eLIFE
2014
Combined adenovirus vector and hepatitis C virus envelope protein prime-boost regimen elicits T cell and neutralizing antibody immune responses
Alicja M Chmielewska
Mariarosaria Naddeo
Stefania Capone
Virginia Ammendola
Ke Hu
Luke Meredith
Lieven Verhoye
Malgorzata Rychlowska
Rino Rappuoli
Jeffrey B Ulmer
et al.
A1
Journal Article
in
JOURNAL OF VIROLOGY
2014
HCV animal models and liver disease
Koen Vercauteren
Ype P de Jong
Philip Meuleman
A1
Journal Article
in
JOURNAL OF HEPATOLOGY
2014
Human but not mouse hepatocytes respond to interferon-lambda in vivo
Pascale Hermant
Céline Demarez
Tanel Mahlakõiv
Peter Staeheli
Philip Meuleman
Thomas Michiels
A1
Journal Article
in
PLOS ONE
2014
Human liver chimeric mice as a novel model for the study of hepatitis E virus infections
Ibrahim Mahmoud Sayed Ibrahim
Lieven Verhoye
Aliasghar Farhoudi Moghadam
Yannick Debing
Johan Neyts
Geert Leroux-Roels
Robert Purcell
Suzanne Emerson
Philip Meuleman
C3
Conference
2014
Human skin-derived precursor cells are poorly immunogenic and modulate the allogeneic immune response
Joery De Kock
Philip Meuleman
Gordana Raicevic
Robim M Rodrigues
Steven Branson
Kesavan Meganathan
Veerle De Boe
Agapios Sachinidis
Geert Leroux-Roels
Tamara Vanhaecke
et al.
A1
Journal Article
in
STEM CELLS
2014
Impact of lipids and lipoproteins on hepatitis C virus infection and virus neutralization
Koen Vercauteren
Ahmed Atef Ahmed Abouzeid Mesalam
Geert Leroux-Roels
Philip Meuleman
A1
Journal Article
in
WORLD JOURNAL OF GASTROENTEROLOGY
2014
Metabolic study of a steroid product containing dimethazine using human liver microsomes and a chimeric mouse model
Lore Geldof
Eva Tudela
Leen Lootens
Jasper Van Lysebeth
Philip Meuleman
Geert Leroux-Roels
Koen Deventer
Peter Van Eenoo
C3
Conference
2014
Metabolism of methylstenbolone studied with human liver microsomes and the uPA+/+-SCID chimeric mouse model
Lore Geldof
Leen Lootens
Michaël Polet
Daniel Eichner
Thane Campbell
Vinod Nair
Francesco Botrè
Philip Meuleman
Geert Leroux-Roels
Koen Deventer
et al.
A1
Journal Article
in
BIOMEDICAL CHROMATOGRAPHY
2014
Sporozoite immunization of human volunteers under chemoprophylaxis induces functional antibodies against pre-erythrocytic stages of Plasmodium falciparum
Marije C Behet
Lander Foquet
Geert-Jan van Gemert
Else M Bijker
Philip Meuleman
Geert Leroux-Roels
Cornelus C Hermsen
Anja Scholzen
Robert W Sauerwein
A1
Journal Article
in
MALARIA JOURNAL
2014
Successful anti-scavenger receptor class B type I (SR-BI) monoclonal antibody therapy in humanized mice after challenge with HCV variants with in vitro resistance to SR-BI-targeting agents
Koen Vercauteren
Naomi Van den Eede
Ahmed Atef Ahmed Abouzeid Mesalam
Sandrine Belouzard
Maria Teresa Catanese
Dorothea Bankwitz
Flossie Wong-Staal
Riccardo Cortese
Jean Dubuisson
Charles M Rice
et al.
A1
Journal Article
in
HEPATOLOGY
2014
Targeting SR-BI for the prevention and treatment of hepatitis C virus infections
Koen Vercauteren
Philip Meuleman
Geert Leroux-Roels
Dissertation
2014
Turmeric curcumin inhibits entry of all hepatitis C virus genotypes into human liver cells
- Anggakusuma
Che C Colpitts
Luis M Schang
Heni Rachmawati
Anne Frentzen
Stephanie Pfaender
Patrick Behrendt
Richard JP Brown
Dorothea Bankwitz
Joerg Steinmann
et al.
A1
Journal Article
in
GUT
2014
Vaccine-induced monoclonal antibodies targeting circumsporozoite protein prevent Plasmodium falciparum infection
Lander Foquet
Cornelus C Hermsen
Geert-Jan van Gemert
Eva Van Braeckel
Karin Weening
Robert Sauerwein
Philip Meuleman
Geert Leroux-Roels
A1
Journal Article
in
JOURNAL OF CLINICAL INVESTIGATION
2014
2013
99mTc-mebrofenin disposition in chimeric mice with a humanized liver
Sara Neyt
Philip Meuleman
Lieven Verhoye
Christian Vanhove
Geert Mannens
Filip De Vos
C3
Conference
2013
Artemisinin analogues as potent inhibitors of in vitro hepatitis C virus replication
Susan Obeid
Jo Alen
Van Hung Nguyen
Van Cuong Pham
Philip Meuleman
Christophe Pannecouque
Thanh Nguyen Le
Johan Neyts
Wim Dehaen
Jan Paeshuyse
A1
Journal Article
in
PLOS ONE
2013
Hepatitis C virus infection and related liver disease: the quest for the best animal model
Laurent Mailly
Eric Robinet
Philip Meuleman
Thomas F Baumert
Mirjam Zeisel
A1
Journal Article
in
FRONTIERS IN MICROBIOLOGY
2013
In vitro and in vivo metabolism studies of a nutritional supplement containing methylstenbolone
Lore Geldof
Leen Lootens
Koen Deventer
Michaël Polet
Daniel Eichner
Francesco Botrè
Philip Meuleman
Geert Leroux-Roels
Peter Van Eenoo
C3
Conference
2013
In vitro and in vivo metabolisms of 1-pentyl-3-(4-methyl-1-naphthoyl)indole (JWH-122)
Nik De Brabanter
Simone Esposito
Lore Geldof
Leen Lootens
Philip Meuleman
Geert Leroux-Roels
Koen Deventer
Peter Van Eenoo
A1
Journal Article
in
FORENSIC TOXICOLOGY
2013
In vivo and in vitro metabolism of the synthetic cannabinoid JWH-200
Nik De Brabanter
Simone Esposito
Eva Tudela Palomar
Leen Lootens
Philip Meuleman
Geert Leroux-Roels
Koen Deventer
Peter Van Eenoo
A1
Journal Article
in
RAPID COMMUNICATIONS IN MASS SPECTROMETRY
2013
Molecular detection and quantification of Plasmodium falciparum-infected human hepatocytes in chimeric immune-deficient mice
Lander Foquet
Cornelus C Hermsen
Geert-Jan van Gemert
Louis Libbrecht
Robert Sauerwein
Philip Meuleman
Geert Leroux-Roels
A1
Journal Article
in
MALARIA JOURNAL
2013
The Sin3a repressor complex regulates the balance between the activities of different STAT proteins
Laura Icardi
Raffaele Mori
Viola Gesellchen
Sven Eyckerman
Judith Verhelst
Koen Vercauteren
Xavier Saelens
Philip Meuleman
Karolien De Bosscher
M Boutros
et al.
C3
Conference
2013
Thermostability of seven hepatitis C virus genotypes in vitro and in vivo
J Doerrbecker
Philip Meuleman
J Kang
N Riebesehl
C Wilhelm
M Friesland
S Pfaender
J Steinmann
T Pietschmann
E Steinmann
A1
Journal Article
in
JOURNAL OF VIRAL HEPATITIS
2013
Turmeric curcumin inhibits entry of all hepatitis C virus genotypes into human liver cells
A Kusuma
CC Colpitts
LM Schang
H Rachmawati
A Frentzen
S Pfaender
P Behrendt
RJP Brown
D Bankwitz
J Steinmann
et al.
C3
Conference
2013
2012
A human monoclonal antibody targeting scavenger receptor class B type I precludes hepatitis C virus infection and viral spread in vitro and in vivo
Philip Meuleman
Maria Teresa Catanese
Lieven Verhoye
Isabelle Desombere
Aliasghar Farhoudi Moghadam
Christopher T Jones
Timothy Sheahan
Katarzyna Grzyb
Riccardo Cortese
Charles M Rice
et al.
A1
Journal Article
in
HEPATOLOGY
2012
Blocking HCV entry as potential antiviral therapy
Koen Vercauteren
Geert Leroux-Roels
Philip Meuleman
A1
Journal Article
in
FUTURE VIROLOGY
2012
Metabolic study of prostanozol using human liver licrosomes and humanized mice
Leen Lootens
Lore Geldof
Lieselot Decroix
Koen Deventer
Francesco Botrè
Geert Leroux-Roels
Philip Meuleman
Peter Van Eenoo
C1
Conference
2012
Mitochondrial cardiotoxicity of a prototype HCV NS3-protease inhibitor is characterized by a specific electrocardiographic signature in mice
THOMAS VANWOLLEGHEM
Eva Van Braeckel
Joél Smet
Bi-Sheng Liu
Philip Meuleman
Harry L Janssen
Tania Roskams
Rudy Van Coster
Rita De Vos
Geert Leroux-Roels
C3
Conference
2012
Novel human SR-BI antibodies prevent infection and dissemination of HCV in vitro and in humanized mice
Krzysztof Lacek
Koen Vercauteren
Katarzyna Grzyb
Mariarosaria Naddeo
Lieven Verhoye
Marek Patryk Słowikowski
Samira Fafi-Kremer
Arvind H Patel
Thomas F Baumert
Antonella Folgori
et al.
A1
Journal Article
in
JOURNAL OF HEPATOLOGY
2012
The Sin3a repressor complex is a master regulator of STAT transcriptional activity
Laura Icardi
Raffaele Mori
Viola Gesellchen
Sven Eyckerman
Lode De Cauwer
Judith Verhelst
Koen Vercauteren
Xavier Saelens
Philip Meuleman
Geert Leroux-Roels
et al.
A1
Journal Article
in
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
2012
2011
Development and application of hepatitis C reporter viruses with genotype 1 to 7 core-nonstructural protein 2 (NS2) expressing fluorescent proteins or luciferase in modified JFH1 NS5A
Judith M Gottwein
Tanja B Jensen
Christian K Mathiesen
Philip Meuleman
Stephanie BN Serre
Jacob B Lademann
Lubna Ghanem
Troels KH Scheel
Geert Leroux-Roels
Jens Bukh
A1
Journal Article
in
JOURNAL OF VIROLOGY
2011
Discovery of (7R)-14-cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl) amino}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylic acid (MK-3281), a potent and orally bioavailable finger-loop inhibitor of the hepatitis C virus NS5B polymerase
Frank Narjes
Benedetta Crescenzi
Marco Ferrara
Jörg Habermann
Stefania Colarusso
Maria del Rosario Ferreira
Ian Stansfield
Angela Claire Mackay
Immacolata Conte
Caterina Ercolani
et al.
A1
Journal Article
in
JOURNAL OF MEDICINAL CHEMISTRY
2011
Griffithsin has antiviral activity against hepatitis C virus
Philip Meuleman
Anna Albecka
Sandrine Belouzard
Koen Vercauteren
Lieven Verhoye
Czeslaw Wychowski
Geert Leroux-Roels
Kenneth E Palmer
Jean Dubuisson
A1
Journal Article
in
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
2011
Hypervariable region 1 differentially impacts viability of hepatitis C virus strains of genotypes 1 to 6 and impairs virus neutralization
Jannick Prentoe
Tanja B Jensen
Philip Meuleman
Stephanie BN Serre
Troels KH Scheel
Geert Leroux-Roels
Judith M Gottwein
Jens Bukh
A1
Journal Article
in
JOURNAL OF VIROLOGY
2011
In vivo evaluation of the cross-genotype neutralizing activity of polyclonal antibodies against hepatitis C virus
Philip Meuleman
Jens Bukh
Lieven Verhoye
Aliasghar Farhoudi Moghadam
THOMAS VANWOLLEGHEM
Richard Y Wang
Isabelle Desombere
Harvey Alter
Robert H Purcell
Geert Leroux-Roels
A1
Journal Article
in
HEPATOLOGY
2011
Lipoprotein lipase inhibits hepatitis C virus (HCV) infection by blocking virus cell entry
Patrick Maillard
Marine Walic
Philip Meuleman
Farzin Roohvand
Thierry Huby
Wilfried Le Goff
Geert Leroux-Roels
Eve-Isabelle Pécheur
Agata Budkowska
A1
Journal Article
in
PLOS ONE
2011
Metabolic studies with promagnon, methylclostebol and methasterone in the uPA+/+-SCID chimeric mice
Leen Lootens
Philip Meuleman
Geert Leroux-Roels
Peter Van Eenoo
A1
Journal Article
in
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
2011
The green tea polyphenol, epigallocatechin-3-gallate, inhibits hepatitis C virus entry
Sandra Ciesek
Thomas von Hahn
Che C Colpitts
Luis M Schang
Martina Friesland
Jürg Steinmann
Michael P Manns
Michael Ott
Heiner Wedemeyer
Philip Meuleman
et al.
A1
Journal Article
in
HEPATOLOGY
2011
2010
Challenge pools of hepatitis C virus genotypes 1-6 prototype strains: replication fitness and pathogenicity in chimpanzees and human liver-chimeric mouse models
Jens Bukh
Philip Meuleman
Raymond Tellier
Ronald E Engle
Stephen M Feinstone
Gerald Eder
William C Satterfield
Sugantha Govindarajan
Krzysztof Krawczynski
Roger H Miller
et al.
A1
Journal Article
in
JOURNAL OF INFECTIOUS DISEASES
2010
Factors determining successful engraftment of hepatocytes and susceptibility to hepatitis B and C virus infection in uPA-SCID mice
THOMAS VANWOLLEGHEM
Louis Libbrecht
Bettina E Hansen
Isabelle Desombere
Tania Roskams
Philip Meuleman
Geert Leroux-Roels
A1
Journal Article
in
JOURNAL OF HEPATOLOGY
2010
Viral entry and escape from antibody-mediated neutralization influence hepatitis C virus reinfection in liver transplantation
Samira Fafi-Kremer
Isabel Fofana
Eric Soulier
Patric Carolla
Philip Meuleman
Geert Leroux-Roels
Arvind H Patel
François-Loic Cosset
Patrick Pessaux
Michel Doffoel
et al.
A1
Journal Article
in
JOURNAL OF EXPERIMENTAL MEDICINE
2010
2009
Combination of liquid-chromatography tandem mass spectrometry in different scan modes with human and chimeric mouse urine for the study of steroid metabolism
Oscar Juan Pozo Mendoza
Leen Lootens
Peter Van Eenoo
Koen Deventer
Philip Meuleman
Geert Leroux-Roels
MK Parr
W Schanzer
Frans Delbeke
A1
Journal Article
in
DRUG TESTING AND ANALYSIS
2009
Detection and characterization of a new metabolite of 17 α-methyltestosterone
Oscar Juan Pozo Mendoza
Peter Van Eenoo
Koen Deventer
Leen Lootens
Wim Van Thuyne
Maria Parr
Wilhelm Schanzer
Juan Sancho
Felix Hernandez
Philip Meuleman
et al.
A1
Journal Article
in
DRUG METABOLISM AND DISPOSITION
2009
Detection and structural investigation of metabolites of stanozolol in human urine by liquid chromatography tandem mass spectrometry
Oscar Juan Pozo Mendoza
Peter Van Eenoo
Koen Deventer
Leen Lootens
Grimalt Susana
Juan V Sancho
Felix Hernández
Philip Meuleman
Geert Leroux-Roels
Frans Delbeke
A1
Journal Article
in
STEROIDS
2009
HCV animal models : a journey of more than 30 years
Philip Meuleman
Geert Leroux-Roels
A1
Journal Article
in
VIRUSES-BASEL
2009
Production of infectious genotype 1b virus particles in cell culture and impairment by replication enhancing mutations
T. Pietschmann
M. Zayas
Philip Meuleman
G. Long
N. Appel
G. Koutsoudakis
S. Kallis
Geert Leroux-Roels
V. Lohmann
R. Bartenschlager
A1
Journal Article
in
PLOS PATHOGENS
2009
Steroid metabolism in chimeric mice with humanized liver
Leen Lootens
Peter Van Eenoo
Philip Meuleman
Oscar Juan Pozo Mendoza
Pieter Van Renterghem
Geert Leroux-Roels
Frans Delbeke
A1
Journal Article
in
Drug Testing and Analysis
2009
The uPA(+/+)-SCID mouse with humanized liver as a model for in vivo metabolism of 4-androstene-3,17-dione
Leen Lootens
Peter Van Eenoo
Philip Meuleman
Geert Leroux-Roels
Frans Delbeke
A1
Journal Article
in
DRUG METABOLISM AND DISPOSITION
2009
uPA+/+-SCID mouse with humanized liver as a model for in vivo metabolism of exogenous steroids: methandienone as a case study
Leen Lootens
Philip Meuleman
Oscar Juan Pozo Mendoza
Peter Van Eenoo
Geert Leroux-Roels
Frans Delbeke
A1
Journal Article
in
CLINICAL CHEMISTRY
2009
2008
ANTI-CD81 ANTIBODIES CAN PREVENT A HEPATITIS C VIRUS INFECTION IN VIVO
Philip Meuleman
Joseph Hesselgesser
Matthew Paulson
THOMAS VANWOLLEGHEM
Isabelle Desombere
Hans Reiser
Geert Leroux-Roels
C3
Conference
2008
Anti-CD81 Antibodies Can Prevent a Hepatitis C Virus Infection In Vivo
Philip Meuleman
Joseph Hesselgesser
Matthew Paulson
THOMAS VANWOLLEGHEM
Isabelle Desombere
Ilans Reiser
Geert Leroux-Roels
A1
Journal Article
in
HEPATOLOGY
2008
Development and validation of a quantitative gas chromatography-mass spectrometry method for the detection of endogenous androgens in mouse urine
Leen Lootens
Peter Van Eenoo
Philip Meuleman
Geert Leroux-Roels
Wim Van Thuyne
Frans Delbeke
A1
Journal Article
in
JOURNAL OF CHROMATOGRAPHY A
2008
Polyclonal immunoglobulins from a chronic hepatitis C virus patient protect human liver-chimeric mice from infection with a homologous hepatitis C virus strain
THOMAS VANWOLLEGHEM
J BUKH
Philip Meuleman
Isabelle Desombere
JC MEUNIER
H ALTER
RH PURCELL
Geert Leroux-Roels
A1
Journal Article
in
HEPATOLOGY
2008
Role of the Hepatitis C Virus Core+1 Open Reading Frame and Core cis-Acting RNA Elements in Viral RNA Translation and Replication
Niki Vassilaki
Peter Friebe
Philip Meuleman
Stephanie Kallis
Arthur Kaul
Glaucia Paranhos-Bacala
Geert Leroux-Roels
Penelope Mavromara
Ralf Bartenschlager
A1
Journal Article
in
JOURNAL OF VIROLOGY
2008
The human liver-uPA-SCID mouse: A model for the evaluation of antiviral compounds against HBV and HCV
Philip Meuleman
Geert Leroux-Roels
A1
Journal Article
in
ANTIVIRAL RESEARCH
2008
Validation of the metabolism of steroids in uPA+/+-SCID mice with humanized liver
Leen Lootens
Peter Van Eenoo
Oscar Juan Pozo Mendoza
Philip Meuleman
Geert Leroux-Roels
Frans Delbeke
C1
Conference
2008
2007
Cell culture adaptation of hepatitis c virus and in vivo viability of an adapted variant
A KAUL
I WOERZ
Philip Meuleman
Geert Leroux-Roels
R BARTENSCHLAGER
A1
Journal Article
in
JOURNAL OF VIROLOGY
2007
Scavenger receptor BI and BII expression levels modulate hepatitis C virus infectivity
J GROVE
T HUBY
Z STAMATAKI
THOMAS VANWOLLEGHEM
Philip Meuleman
M FARQUHAR
A SCHWARZ
M MOREAU
JS OWEN
Geert Leroux-Roels
et al.
A1
Journal Article
in
JOURNAL OF VIROLOGY
2007
Ultra-rapid cardiotoxicity of the hepatitis C virus protease inhibitor BILN 2061 in the urokinase-type plasminogen activator mouse
THOMAS VANWOLLEGHEM
Philip Meuleman
Louis Libbrecht
Tania Roskams
Rita De Vos
Geert Leroux-Roels
A1
Journal Article
in
GASTROENTEROLOGY
2007
2006
Cell culture-grown hepatitis C virus is infectious in vivo and can be recultured in vitro
BD LINDENBACH
Philip Meuleman
A PLOSS
THOMAS VANWOLLEGHEM
AJ SYDER
JA MCKEATING
RE LANFORD
SM FEINSTONE
ME MAJOR
Geert Leroux-Roels
et al.
A1
Journal Article
in
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
2006
Human hepatocytes secrete soluble CD14, a process not directly influenced by HBV and HCV infection
Philip Meuleman
Sophia Steyaert
Louis Libbrecht
Sibyl Couvent
Freya Van Houtte
Filip Clinckspoor
Bernard de Hemptinne
Tania Roskams
Peter Vanlandschoot
Geert Leroux-Roels
A1
Journal Article
in
CLINICA CHIMICA ACTA
2006
Immune suppression uncovers endogenous cytopathic effects of the hepatitis B virus
Philip Meuleman
Louis Libbrecht
Stefan Wieland
Rita De Vos
Nagy Habib
Anna Kramvis
Tania Roskams
Geert Leroux-Roels
A1
Journal Article
in
JOURNAL OF VIROLOGY
2006
The Human Liver-uPA-SCID Mouse. A Small Animal Model for the study of viral hepatitis.
Philip Meuleman
G Leroux-roels
Dissertation
2006
2005
Morphological and biochemical characterization of a human liver in a uPA-SCID mouse chimera
Philip Meuleman
Louis Libbrecht
Rita De Vos
Bernard de Hemptinne
Kris Gevaert
Joël Vandekerckhove
Tania Roskams
Geert Leroux-Roels
A1
Journal Article
in
HEPATOLOGY
2005
2004
Cytopathic effects of hepatitis B virus infection in long-term infected chimeric uPA-SCID mice
Philip Meuleman
L LIBBRECHT
R DE VOS
T ROSKAMS
Geert Leroux-Roels
C3
Conference
2004
Morphological and biochemical characterization of a human liver in uPA-SCID mouse chimera
Philip Meuleman
Louis Libbrecht
Rita De Vos
Tania Roskams
Geert Leroux-Roels
C3
Conference
2004
The interferon gamma secretion assay: a reliable tool to study interferon gamma production at the single cell level
Isabelle Desombere
Philip Meuleman
Hanne Rigole
Annick Willems
J IRSCH
Geert Leroux-Roels
A1
Journal Article
in
JOURNAL OF IMMUNOLOGICAL METHODS
2004
Virological and morphological characterization of HBV and HCV infections in human liver-UPA-SCID mice
Philip Meuleman
L LIBBRECHT
R DE VOS
T ROSKAMS
Geert Leroux-Roels
C3
Conference
2004
2003
A simple and rapid method to determine the zygosity of uPA-transgenic SCID mice
Philip Meuleman
Peter Vanlandschoot
Geert Leroux-Roels
A1
Journal Article
in
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2003
2001
In vivo inhibition of anti-HBcIgG production by HBcAg-specific CD4+Th1-type T cell clones in a hu-PBL-NOD/SCID mice model
TH CAO
Philip Meuleman
Isabelle Desombere
M SALLBERG
Geert Leroux-Roels
C3
Conference
2001
In vivo inhibition of anti-hepatitis B virus core antigen (HBcAg) immunoglobulin G production by HBcAg-specific CD4(+) Th1-type T-cell clones in a hu-PBL-NOD/SCID mouse model.
Tinghua Cao
Philip Meuleman
Isabelle Desombere
M SALLBERG
Geert Leroux-Roels
A1
Journal Article
in
JOURNAL OF VIROLOGY
2001
Prevention of hepatitis B infections: Vaccination and its limitations
Geert Leroux-Roels
T CAO
A DE KNIBBER
Philip Meuleman
A ROOBROUCK
A FARHOUDI
Peter Vanlandschoot
Isabelle Desombere
A1
Journal Article
in
ACTA CLINICA BELGICA
2001
1998
Murine IL-2 receptor beta chain blockade improves human leukocyte engraftment in SCID mice
Kurt Tournoy
Stany Depraetere
Philip Meuleman
Geert Leroux-Roels
Romain Pauwels
A1
Journal Article
in
EUROPEAN JOURNAL OF IMMUNOLOGY
1998