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Researcher
Peter Delputte
Profile
Projects
Publications
Activities
Awards & Distinctions
56
Results
2013
Development of a recombinant antibody to target peptides and proteins to sialoadhesin-expressing macrophages
Karen Ooms
Hanne Van Gorp
Tim Van Gaever
Hans Nauwynck
Peter Delputte
A1
Journal Article
in
BMC BIOTECHNOLOGY
2013
Evaluation of viral peptide targeting to porcine sialoadhesin using a porcine reproductive and respiratory syndrome virus vaccination-challenge model
Karen Ooms
Hanne Van Gorp
Sara Botti
Tim Van Gaever
Peter Delputte
Hans Nauwynck
A1
Journal Article
in
VIRUS RESEARCH
2013
Targeting antigens to sialoadhesin-expressing macrophages as a vaccination strategy
Karen Ooms
Peter Delputte
Hans Nauwynck
Dissertation
2013
2012
Interaction of the European genotype porcine reproductive and respiratory syndrome virus (PRRSV) with sialoadhesin (CD169/Siglec-1) inhibits alveolar macrophage phagocytosis
Miet De Baere
Hanne Van Gorp
Peter Delputte
Hans Nauwynck
A1
Journal Article
in
VETERINARY RESEARCH
2012
Novel insights in the physiological function of sialoadhesin as a downregulator of macrophage phagocytosis and its implications for viral infection
Miet De Baere
Hans Nauwynck
Peter Delputte
Dissertation
2012
Porcine sialoadhesin: a newly identified xenogeneic innate immune receptor
LG Brock
Peter Delputte
JP Waldman
Hans Nauwynck
MA Rees
A1
Journal Article
in
AMERICAN JOURNAL OF TRANSPLANTATION
2012
Single amino acid mutations in the capsid switch the neutralization phenotype of porcine circovirus 2
Dipongkor Saha
David Lefebvre
Karen Ooms
Liping Huang
Peter Delputte
Jan Van Doorsselaere
Hans Nauwynck
A1
Journal Article
in
JOURNAL OF GENERAL VIROLOGY
2012
2011
Antibody binding to porcine sialoadhesin reduces phagocytic capacity without affecting other macrophage effector functions
Miet De Baere
Hanne Van Gorp
Hans Nauwynck
Peter Delputte
A1
Journal Article
in
CELLULAR IMMUNOLOGY
2011
Characterization of a circulating PRRSV strain by means of random PCR cloning and full genome sequencing
Joris Van Doorsselaere
Marc Geldhof
Hans Nauwynck
Peter Delputte
A1
Journal Article
in
VIROLOGY JOURNAL
2011
Interaction of the porcine reproductive and respiratory syndrome virus with the macrophage-specific lectin sialoadhesin
Wander Van Breedam
Hans Nauwynck
Peter Delputte
Dissertation
2011
Mapping of neutralizing epitopes in the capsid protein of porcine circovirus 2
Dipongkor Saha
David Lefebvre
Karen Ooms
Peter Delputte
J Van Doorsselaere
Hans Nauwynck
C3
Conference
2011
PRRSV binding to and/or internalization by its receptor sialoadhesin on macrophages is sufficient to compromise phagocytosis
Miet De Baere
Hanne Van Gorp
Peter Delputte
Hans Nauwynck
C3
Conference
2011
Porcine sialoadhesin (CD169/Siglec-1) is an endocytic receptor that allows targeted delivery of toxins and antigens to macrophages
Peter Delputte
Hanne Van Gorp
Herman Favoreel
Inge Hoebeke
Iris Delrue
Hannah Dewerchin
Frederik Verdonck
Bruno Verhasselt
Eric Cox
Hans Nauwynck
A1
Journal Article
in
PLOS ONE
2011
2010
Detection of truncated circular DNA species in Escherichia coli with a PCV2-containing plasmid with a single PCV2 origin of replication
Jan Van Doorsselaere
David Lefebvre
Hans Nauwynck
Peter Delputte
A1
Journal Article
in
INTERVIROLOGY
2010
Development of a new inactivated porcine reproductive and respiratory syndrome virus (PRRSV) vaccine
Iris Delrue
Hans Nauwynck
Peter Delputte
Dissertation
2010
GP4 of porcine reproductive and respiratory syndrome virus contains a neutralizing epitope that is susceptible to immunoselection in vitro
Sarah Costers
David Lefebvre
Jan Van Doorsselaere
Merijn Vanhee
Peter Delputte
Hans Nauwynck
A1
Journal Article
in
ARCHIVES OF VIROLOGY
2010
Identification of the CD163 protein domains involved in infection of the porcine reproductive and respiratory syndrome virus
Hanne Van Gorp
Wander Van Breedam
Jan Van Doorsselaere
Peter Delputte
Hans Nauwynck
C3
Conference
2010
Identification of the CD163 protein domains involved in infection of the porcine reproductive and respiratory syndrome virus
Hanne Van Gorp
Wander Van Breedam
Jan Van Doorsselaere
Peter Delputte
Hans Nauwynck
A1
Journal Article
in
JOURNAL OF VIROLOGY
2010
Porcine reproductive and respiratory syndrome virus entry into the porcine macrophage
Wander Van Breedam
Peter Delputte
Hanne Van Gorp
Gerald Misinzo
Nathalie Vanderheijden
XiaoBo Duan
Hans Nauwynck
A1
Journal Article
in
JOURNAL OF GENERAL VIROLOGY
2010
Scavenger receptor CD163, a Jack-of-all-trades and potential target for cell-directed therapy
Hanne Van Gorp
Peter Delputte
Hans Nauwynck
A1
Journal Article
in
MOLECULAR IMMUNOLOGY
2010
Sialoadhesin and CD163, a dynamic duo involved in porcine reproductive and respiratory syndrome virus entry in macrophages and possible targeting molecules
Hanne Van Gorp
Hans Nauwynck
Peter Delputte
Dissertation
2010
Susceptible cell lines for the production of porcine reproductive and respiratory syndrome virus by stable transfection of sialoadhesin and CD163
Iris Delrue
Hanne Van Gorp
J Van Doorsselaere
Peter Delputte
Hans Nauwynck
A1
Journal Article
in
BMC BIOTECHNOLOGY
2010
The M/GP(5) glycoprotein complex of porcine reproductive and respiratory syndrome virus binds the sialoadhesin receptor in a sialic acid-dependent manner
Wander Van Breedam
Hanne Van Gorp
Jiquan Q Zhang
Paul R Crocker
Peter Delputte
Hans Nauwynck
A1
Journal Article
in
PLOS PATHOGENS
2010
2009
Assessing the functionality of viral entry-associated domains of porcine reproductive and respiratory syndrome virus during inactivation procedures, a potential tool to optimize inactivated vaccines
Iris Delrue
Peter Delputte
Hans Nauwynck
A1
Journal Article
in
VETERINARY RESEARCH
2009
Development of an experimental inactivated PRRSV vaccine that induces virus-neutralizing antibodies
Merijn Vanhee
Peter Delputte
Iris Delrue
Marc Geldhof
Hans Nauwynck
A1
Journal Article
in
VETERINARY RESEARCH
2009
Functional impairment of PRRSV-specific peripheral CD3(+)CD8(high) cells
Sarah Costers
David Lefebvre
Bruno Goddeeris
Peter Delputte
Hans Nauwynck
A1
Journal Article
in
VETERINARY RESEARCH
2009
Porcine circovirus 2 infection of epithelial cells is clathrin-, caveolae- and dynamin-independent, actin and Rho-GTPase-mediated, and enhanced by cholesterol depletion
Gerald Misinzo
Peter Delputte
David Lefebvre
Hans Nauwynck
A1
Journal Article
in
VIRUS RESEARCH
2009
Recombination of two porcine circovirus type 2 strains
David Lefebvre
J Van Doorsselaere
Peter Delputte
Hans Nauwynck
A1
Journal Article
in
ARCHIVES OF VIROLOGY
2009
The porcine reproductive and respiratory syndrome virus requires trafficking through CD163-positive early endosomes, but not late endosomes, for productive infection
Hanne Van Gorp
Wander Van Breedam
Peter Delputte
Hans Nauwynck
A1
Journal Article
in
ARCHIVES OF VIROLOGY
2009
2008
Gene expression profiling of porcine alveolar macrophages after antibody-mediated cross-linking of sialoadhesin (Sn, Siglec-1)
S GENINI
R MALINVERNI
Peter Delputte
S FIORENTINI
A STELLA
S BOTTI
Hans Nauwynck
E GIUFFRA
A1
Journal Article
in
JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION
2008
Genome-wide transcriptional response of primary alveolar macrophages following infection with porcine reproductive and respiratory syndrome virus
S GENINI
Peter Delputte
R MALINVERNI
M CECERE
A STELLA
Hans Nauwynck
E GIUFFRA
A1
Journal Article
in
JOURNAL OF GENERAL VIROLOGY
2008
Increased yield of porcine circovirus-2 by a combined treatment of PK-15 cells with interferon-gamma and inhibitors of endosomal-lysosomal system acidification
Gerald Misinzo
Peter Delputte
David Lefebvre
Hans Nauwynck
A1
Journal Article
in
ARCHIVES OF VIROLOGY
2008
Inhibition of endosome-lysosome system acidification enhances porcine circovirus 2 infection of porcine epithelial cells
Gerald Misinzo
Peter Delputte
Hans Nauwynck
A1
Journal Article
in
JOURNAL OF VIROLOGY
2008
Involvement of proteases in porcine reproductive and respiratory syndrome virus uncoating upon internalization in primary macrophages
Gerald Misinzo
Peter Delputte
Hans Nauwynck
A1
Journal Article
in
VETERINARY RESEARCH
2008
Porcine reproductive and respiratory syndrome virus modulates apoptosis during replication in alveolar macrophages
Sarah Costers
David Lefebvre
Peter Delputte
Hans Nauwynck
A1
Journal Article
in
ARCHIVES OF VIROLOGY
2008
Sialoadhesin and CD163 join forces during entry of the porcine reproductive and respiratory syndrome virus
Hanne Van Gorp
Wander Van Breedam
Peter Delputte
Hans Nauwynck
A1
Journal Article
in
JOURNAL OF GENERAL VIROLOGY
2008
Strategies exhibited by PRRSV allowing evasion of immune detection and/or clearance in the infected pig
Sarah Costers
Hans Nauwynck
Peter Delputte
Dissertation
2008
2007
IFN-α treatment enhances porcine Arterivirus infection of monocytes via upregulation of the porcine Arterivirus receptor sialoadhesin
Peter Delputte
Wander Van Breedam
Filip Barbé
Kristien Van Reeth
Hans Nauwynck
A1
Journal Article
in
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
2007
Interferon alpha dependent enhancement of porcine reproductive and respiratory syndrome virus infection of monocytes
Peter Delputte
Wander Van Breedam
Merijn Vanhee
Filip Barbé
Kristien Van Reeth
Hans Nauwynck
C1
Conference
2007
Porcine arterivirus attachment to the macrophage-specific receptor sialoadhesin is dependent on the sialic acid-binding activity of the N-terminal immunoglobulin domain of sialoadhesin
Peter Delputte
Wander Van Breedam
Iris Delrue
Cornelia Oetke
Paul R Crocker
Hans Nauwynck
A1
Journal Article
in
JOURNAL OF VIROLOGY
2007
Porcine macrophage binding of human erythrocytes is mediated by sialoadhesin
L GODING
Peter Delputte
Hans Nauwynck
M REES
C3
Conference
2007
Receptor mediated porcine arterivirus entry in macrophages
Peter Delputte
Hanne Van Gorp
Wander Van Breedam
Gerald Misinzo
Iris Delrue
Hans Nauwynck
C1
Conference
2007
Receptor-determined resistance of preimplantation embryos to porcine reproductive and respiratory syndrome virus
Hans Nauwynck
Bart Mateusen
Dominiek Maes
Peter Delputte
Ann Van Soom
C1
Conference
2007
Sialoadhesin (Siglec-1), a unique macrophage entry portal for targeted delivery of antigens and drugs
Sven Arnouts
Hans Nauwynck
Hanne Van Gorp
Peter Delputte
C3
Conference
2007
2006
Efficacy of an inactivated PRRSV vaccine - Induction of virus-neutralizing antibodies and partial virological protection upon challenge
Gerald Misinzo
Peter Delputte
P MEERTS
C DREXLER
Hans Nauwynck
A1
Journal Article
in
NIDOVIRUSES: TOWARD CONTROL OF SARS AND OTHER NIDOVIRUS DISEASES
2006
Porcine circovirus 2 uses heparan sulfate and chondroitin sulfate B glycosaminoglycans as receptors for its attachment to host cells
Gerald Misinzo
Peter Delputte
Peter Meerts
David Lefebvre
Hans Nauwynck
A1
Journal Article
in
JOURNAL OF VIROLOGY
2006
Porcine reproductive and respiratory syndrome virus (PRRSV) entry in macrophages. Proceedings of the 19th International Pig Veterinary Society Congress, Copenhagen, Denmark, 17
Peter Delputte
Gerald Misinzo
Hans Nauwynck
C1
Conference
2006
Porcine reproductive and respiratory syndrome virus-infected alveolar macrophages contain no detectable levels of viral proteins in their plasma membrane and are protected against antibody-dependent, complement-mediated cell lysis
Sarah Costers
Peter Delputte
Hans Nauwynck
A1
Journal Article
in
JOURNAL OF GENERAL VIROLOGY
2006
Protection of PRRSV-infected macrophages against antibody-dependent, complement-mediated cell lysis due to absence of surface expression of viral proteins. Proceedings of the 19th International Pig Veterinary Society Congress, Copenhagen, Denmark
Sarah Costers
Peter Delputte
Hans Nauwynck
C1
Conference
2006
2005
Analysis of porcine reproductive and respiratory syndrome virus attachment and internalization: distinctive roles for heparan sulphate and sialoadhesin
Peter Delputte
Sarah Costers
Hans Nauwynck
A1
Journal Article
in
JOURNAL OF GENERAL VIROLOGY
2005
Sialoadhesin: a macrophage receptor involved in binding sialic acid-bearing xenogeneic cells and viruses
L GODING
Peter Delputte
Hans Nauwynck
M REES
C3
Conference
2005
2004
Back fat measurements in sows from three commercial pig herds: relationship with reproductive efficiency and correlation with visual body condition scores
Dominiek Maes
Geert Janssens
Peter Delputte
A LAMMERTYN
Aart de Kruif
A1
Journal Article
in
LIVESTOCK PRODUCTION SCIENCE
2004
2003
Entry process of porcine reproductive and respiratory syndrome virus in porcine alveolar macrophages
Hans Nauwynck
N VANDERHEIJDEN
Peter Delputte
Maurice Pensaert
C1
Conference
2003
Involvement of sialoadhesin in entry of porcine reproductive and respiratory syndrome virus into porcine alveolar macrophages
Nathalie Vanderheijden
Peter Delputte
Herman Favoreel
Joël Vandekerckhove
Jozef Van Damme
PA VAN WOENSEL
Hans Nauwynck
A1
Journal Article
in
JOURNAL OF VIROLOGY
2003
2002
Involvement of the matrix protein in attachment of porcine reproductive and respiratory syndrome virus to a heparinlike receptor on porcine alveolar macrophages.
Peter Delputte
Nathalie Vanderheijden
Hans Nauwynck
Maurice Pensaert
A1
Journal Article
in
JOURNAL OF VIROLOGY
2002
2001
Effects of heparin on the entry of porcine reproductive and respiratory syndrome virus into alveolar macrophages
Nathalie Vanderheijden
Peter Delputte
Hans Nauwynck
Maurice Pensaert
A1
Journal Article
in
ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY
2001