Research Explorer

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Researcher

Pedro Henrique Viana Saavedra

Awards & Distinctions

13 Results

2021

Escherichia coli Rho GTPase-activating toxin CNF1 mediates NLRP3 inflammasome activation via p21-activated kinases-1/2 during bacteraemia in mice

Oceane DufiesAnne DoyeJohan CourjonCedric TorreGregory MichelCeline LoubatierArnaud JacquelPaul ChaintreuilAlissa MajoorRodolphe R. Guinamard et al.

A1 Journal Article in NATURE MICROBIOLOGY

IL1 beta promotes immune suppression in the tumor microenvironment independent of the inflammasome and gasdermin D

Mate KissLieselotte Vande WallePedro Henrique Viana SaavedraEls LebeggeHelena Van DammeAleksandar MurgaskiJunbin QianManuel EhlingSamantha PrettoEvangelia Bolli et al.

A1 Journal Article in CANCER IMMUNOLOGY RESEARCH

2020

Blood-based test for diagnosis and functional subtyping of familial Mediterranean fever

Hanne Van GorpLinyan HuangPedro Henrique Viana SaavedraMarnik VuylstekeTomoko AsaokaGiusi PrencipeAntonella InsalacoBenson OgunjimiJerold JeyaratnamIlaria Cataldo et al.

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

2019

MCC950/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibition

Lieselotte Vande WalleIrma B StowePavel SachaBettina L LeeDieter DemonAmelie FossoulFilip Van HauwermeirenPedro Henrique Viana SaavedraPetr SimonVladimir Subrt et al.

A1 Journal Article in PLOS BIOLOGY

Miconazole loaded chitosan-based nanoparticles for local treatment of vulvovaginal candidiasis fungal infections

Andre Correa AmaralPedro Henrique Viana SaavedraAna Camila Oliveira SouzaMaryanne Trafani de MeloAntonio Claudio TedescoPaulo Cesar MoraisMaria Sueli Soares FelipeAnamelia Lorenzetti Bocca

A1 Journal Article in COLLOIDS AND SURFACES B-BIOINTERFACES

2018

Apoptosis of intestinal epithelial cells restricts Clostridium difficile infection in a model of pseudomembranous colitis

Pedro Henrique Viana SaavedraLinyan HuangFarzaneh GhazaviStephanie KourulaTom Vanden BergheNozomi TakahashiPeter VandenabeeleMohamed Lamkanfi

A1 Journal Article in NATURE COMMUNICATIONS

GSDMD is critical for autoinflammatory pathology in a mouse model of Familial Mediterranean Fever

Apurva KannegantiRK Subbarao MalireddiPedro Henrique Viana SaavedraLieselotte Vande WalleHanne Van GorpHiroto KambaraHeather TillmanPeter VogelHongbo R LuoRamnik J Xavier et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Mechanism and functions of the cytosolic receptor Pyrin

Pedro Henrique Viana SaavedraAndy WullaertMohamed Lamkanfi

2017

Caspase-1 engagement and TLR-induced c-FLIP expression suppress ASC/caspase-8-dependent apoptosis by inflammasome sensors NLRP1b and NLRC4

Nina Van OpdenboschHanne Van GorpMaarten VerdoncktPedro Henrique Viana SaavedraNathalia Moraes de VasconcelosAmanda GonçalvesLieselotte Vande WalleDieter DemonMagdalena MatusiakFilip Van Hauwermeiren et al.

A1 Journal Article in CELL REPORTS

Gut sensor halts viral attack

Pedro Henrique Viana SaavedraMohamed Lamkanfi

Editorial material

2016

Familial Mediterranean fever mutations lift the obligatory requirement for microtubules in Pyrin inflammasome activation

Hanne Van GorpPedro Henrique Viana SaavedraNathalia Moraes de VasconcelosNina Van OpdenboschLieselotte Vande WalleMagdalena MatusiakGiusi PrencipeAntonella InsalacoFilip Van HauwermeirenDieter Demon et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammasomes in inflammatory disease

Hanne Van GorpPedro Henrique Viana SaavedraNathalia Moraes de VasconcelosNina Van OpdenboschLieselotte Vande WalleMagdalena MatusiakFilip Van HauwermeirenG. PrencipeDelfien BogaertMelissa Dullaers et al.

2015

Protective and detrimental roles of inflammasomes in disease

Pedro Henrique Viana SaavedraDieter DemonHanne Van GorpMohamed Lamkanfi

A1 Journal Article in SEMINARS IN IMMUNOPATHOLOGY