Research Explorer

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Researcher

Pauline Depuydt

27 Results

2021

SOX11 as guardian of epigenetic plasticity in neuroblastoma

Bieke DecaestekerAmber LouwagieSiebe LoontiensCarolina de Carvalho NunesFanny De VloedLisa DepestelJuliette RoelsKaren VerboomEva D'haeneWouter Van LoockeVolodimir OlexioukPauline DepuydtEllen SandersGivani DewynLiselot MusLucia LorenziJo Van DorpeDavid CreytensKaat DurinckBjörn MentenNadine Van RoyTim PietersPieter Van VlierbergheSuzanne VanhauwaertChristophe Van NesteKatleen De PreterFranki Speleman

2019

SOX11 as mediator of the adrenergic cell state in NB

Bieke DecaestekerAmber LouwagieSara De BrouwerVolodimir OlexioukGeertrui DeneckerCarolina de Carvalho NunesKaren VerboomWouter Van LoockePauline DepuydtFanny De VloedEllen SandersSuzanne VanhauwaertLiselot MusSiebe LoontiensBram De WildeGenevieve LaureysBjörn MentenNadine Van RoyJo Van DorpeDavid CreytensChristophe Van NesteKaat DurinckKatleen De PreterFranki Speleman

SOX11 is a key epigenetic regulator in the adrenergic MYCN amplified neuroblastoma

Amber LouwagieBieke DecaestekerSara De BrouwerGeertrui DeneckerCarolina de Carvalho NunesVolodimir OlexioukKaren VerboomWouter Van LoockePauline DepuydtFanny De VloedEllen SandersSuzanne VanhauwaertLiselot MusSiebe LoontiensBjörn MentenNadine Van RoyDavid CreytensKaat DurinckKatleen De PreterFranki Speleman

SOX11 is a key epigenetic regulator in the adrenergic MYCN amplified neuroblastoma

Amber LouwagieBieke DecaestekerCarolina de Carvalho NunesGeertrui DeneckerVolodimir OlexioukKaren VerboomWouter Van LoockePauline DepuydtFanny De VloedEllen SandersLiselot MusSiebe LoontiensLucia LorenziJo Van DorpeDavid CreytensBjörn MentenNadine Van RoyKaat DurinckSuzanne VanhauwaertChristophe Van NesteKatleen De PreterFranki Speleman

2018

DNA copy number imbalances with clinical relevance in cancer : rare events in big data

Pauline DepuydtKatleen De PreterFranki Speleman

Data Descriptor: Meta-mining of copy number profiles of high-risk neuroblastoma tumors

Pauline DepuydtFranki SpelemanKatleen De Preter

A1 Journal Article in SCIENTIFIC DATA

Genomic amplifications and distal 6q loss : novel markers for poor survival in high-risk neuroblastoma patients

Pauline DepuydtRobrecht CannoodtGenevieve LaureysFranki SpelemanKatleen De Preter

A1 Journal Article in JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE

SOX11 is a transcriptional circuit dosage sensitive transcription factor controlling SWI/SNF components

Bieke DecaestekerSara De BrouwerGeertrui DeneckerFanny De VloedWouter Van LoockeSuzanne VanhauwaertPauline DepuydtJolien De WynBjörn MentenDavid CreytensJo Van DorpeFranki SpelemanKatleen De Preter

TBX2 is a neuroblastoma core regulatory circuitry component enhancing MYCN/FOXM1 reactivation of DREAM targets

Bieke DecaestekerGeertrui DeneckerChristophe Van NesteWouter Van LoockeCarolina de Carvalho NunesFanny De VloedPauline DepuydtKaren VerboomDries RombautSiebe LoontiensJolien De WynKaat DurinckDieter DeforceFilip Van NieuwerburghPieter MestdaghSuzanne VanhauwaertKatleen De PreterFranki Speleman

A1 Journal Article in NATURE COMMUNICATIONS

TBX2 is implicated in cell cycle control and proliferation in neuroblastoma

Bieke DecaestekerGeertrui DeneckerChristophe Van NesteFanny De VloedPauline DepuydtWouter Van LoockeShana ClaeysDries RombautSiebe LoontiensSuzanne VanhauwaertKatleen De PreterFranki Speleman

The RRM2-PHF6 complex protects neuroblastoma cells from DNA damage accumulation to install a replication stress resistance phenotype

Carolina de Carvalho NunesKaat DurinckLisa DepestelSiebe LoontiensLouis DelhayeSofia ZanottiAline EggermontBieke DecaestekerPauline DepuydtJolien De WynGeertrui DeneckerWinnok De VosSven EyckermanChristophe Van NesteFranki Speleman

The core regulatory circuit component TBX2 is implicated in cell cycle control and proliferation in neuroblastoma

Bieke DecaestekerGeertrui DeneckerChristophe Van NesteFanny De VloedPauline DepuydtWouter Van LoockeShana ClaeysDries RombautSiebe LoontiensSuzanne VanhauwaertKatleen De PreterFranki Speleman

The core regulatory circuit component TBX2 is implicated in cell cycle control and proliferation in neuroblastoma

Bieke DecaestekerGeertrui DeneckerPauline DepuydtFanny De VloedShana ClaeysDries RombautSiebe LoontiensSuzanne VanhauwaertChristophe Van NesteKatleen De PreterFranki Speleman

The mutational landscape of MYCN, Lin28b and ALKF1174L driven murine neuroblastoma mimics human disease

Bram De WildeAnneleen BeckersKatleen De PreterPauline DepuydtPieter MestdaghTom SanteSteve LefeverElien VandermarliereLennart MartensBjörn MentenJo VandesompeleFranki Speleman

A2 Journal Article in ONCOTARGET

2017

Genomic amplifications and distal 6q loss are novel markers for poor survival in high-risk neuroblastoma patients

Pauline DepuydtRobrecht CannoodtGenevieve LaureysFranki SpelemanKatleen De Preter

Identification of novel, rare markers for poor survival in high-risk neuroblastoma patients by merging and reanalysing existing datasets

Pauline DepuydtRobrecht CannoodtGenevieve LaureysFranki SpelemanKatleen De Preter

RRM2 is an essential and druggable component of the FOXM1 driven replicative stress DNA damage response in neuroblastoma

Carolina de Carvalho NunesSiebe LoontiensPauline DepuydtSuzanne VanhauwaertBieke DecaestekerBram De WildeKatleen De PreterGeertrui DeneckerChristophe Van NesteKaat DurinckFranki Speleman

RRM2 is an essential and druggable component of the FOXM1 driven replicative stress DNA damage response in neuroblastoma

Carolina de Carvalho NunesSiebe LoontiensPauline DepuydtSuzanne VanhauwaertBieke DecaestekerBram De WildeKatleen De PreterGeertrui DeneckerChristophe Van NesteKaat DurinckFranki Speleman

SOX11 acts as part of the MYCN-WEE1 regulatory protein complex implicated in neuroblastoma

Bieke DecaestekerSara De BrouwerFanny De VloedGeertrui DeneckerSuzanne VanhauwaertJolien De WynGenevieve LaureysBjörn MentenPauline DepuydtKris GevaertFranki SpelemanKatleen De Preter

SOX11 acts as part of the MYCN-WEE1 regulatory protein complex implicated in neuroblastoma

Bieke DecaestekerSara De BrouwerFanny De VloedSuzanne VanhauwaertJolien De WynGenevieve LaureysBjörn MentenPauline DepuydtKris GevaertFranki SpelemanKatleen De Preter

Shallow whole genome sequencing on circulating cell-free DNA allows reliable non-invasive copy number profiling in neuroblastoma patients

Nadine Van RoyMalaïka Van der LindenPauline DepuydtBjörn MentenAnnelies DheedeneCharlotte VandeputteJo Van DorpeGenevieve LaureysMarjolijn RenardTom SanteTim LammensBram De WildeFranki SpelemanKatleen De Preter

The core regulatory circuit component TBX2 is implicated in cell cycle control and proliferation in neuroblastoma

Bieke DecaestekerGeertrui DeneckerWouter Van LoockePauline DepuydtFanny De VloedShana ClaeysDries RombautSiebe LoontiensSuzanne VanhauwaertChristophe Van NesteKatleen De PreterFranki Speleman

The immunophenotypic fingerprint of patients with primary antibody deficiencies is partially present in their asymptomatic first-degree relatives

Delfien BogaertMarieke De BruyneVeronique DebackerPauline DepuydtKatleen De PreterCarolien BonroyJan PhilippéVictoria Bordon MariaBart LambrechtTessa KerreKarim VermaelenFilomeen HaerynckMelissa Dullaers

A1 Journal Article in HAEMATOLOGICA

The immunophenotypical fingerprint of patients with primary antibody deficiencies is partially present in their asymptomatic first-degree relatives

Delfien BogaertMarieke De BruyneVeronique DebackerPauline DepuydtKatleen De PreterCarolien BonroyJan PhilippéVictoria Bordon MariaBart LambrechtTessa KerreAndrea CeruttiKarim VermaelenFilomeen HaerynckMelissa Dullaers

2016

Distal chromosome 6q deletion defines a group of ultra-high risk neuroblastoma patients

Pauline DepuydtGenevieve Laureys

The BRIP1/FANCJ DNA helicase is a druggable 17q driver oncogene involved in G-quadruplex induced replicative stress resistance in neuroblastoma

Suzanne VanhauwaertAnnelies FieuwCarina LeonelliBieke DecaestekerJolien De WynPauline DepuydtSara De BrouwerNadine Van RoyKatleen De PreterFranki Speleman

The immunophenotypical landscape of patients with primary antibody deficiencies and their asymptomatic first-degree relatives : arguments for a multifactorial aetiology

Delfien BogaertPauline DepuydtKatleen De PreterCarolien BonroyJan PhilippéVictoria Bordon MariaTessa KerreBart LambrechtAndrea CeruttiKarim VermaelenElfride De BaereFilomeen HaerynckMelissa Dullaers