Research Explorer

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Researcher

Pauline Depuydt

27 Results

2021

SOX11 as guardian of epigenetic plasticity in neuroblastoma

Bieke DecaestekerAmber LouwagieSiebe LoontiensSara De BrouwerCarolina de Carvalho NunesGeertrui DeneckerFanny De VloedLisa DepestelJuliette RoelsKaren VerboomEva D'haeneWouter Van LoockeElena AfanasyevaVolodimir OlexioukPauline DepuydtEllen SandersGivani DewynLiselot MusLucia LorenziJo Van DorpeDavid CreytensFrank WestermannRogier VersteegKaat DurinckBjörn MentenNadine Van RoyAnton HenssenJohannes SchulteTim PietersPieter Van VlierbergheSuzanne VanhauwaertChristophe Van NesteSara EkJohan van NesJan KosterKatleen De PreterFranki Speleman

2019

SOX11 as mediator of the adrenergic cell state in NB

Bieke DecaestekerAmber LouwagieSara De BrouwerVolodimir OlexioukGeertrui DeneckerCarolina de Carvalho NunesKaren VerboomMoritz GartlgruberWouter Van LoockeElena AfanasyevaPauline DepuydtFanny De VloedEllen SandersSuzanne VanhauwaertLiselot MusCarl HerrmannSiebe LoontiensBram De WildeGenevieve LaureysBjörn MentenNadine Van RoyJo Van DorpeDavid CreytensChristophe Van NesteJohannes SchulteKaat DurinckFrank WestermannJan KosterRogier VersteegSara EkJohan Van NesKatleen De PreterFranki Speleman

SOX11 is a key epigenetic regulator in the adrenergic MYCN amplified neuroblastoma

Amber LouwagieBieke DecaestekerCarolina de Carvalho NunesGeertrui DeneckerVolodimir OlexioukKaren VerboomMoritz GartlgruberWouter Van LoockeElena AfanasyevaPauline DepuydtFanny De VloedEllen SandersLiselot MusSiebe LoontiensLucia LorenziCarl HerrmannJo Van DorpeDavid CreytensFrank WestermanRogier VersteegBjörn MentenNadine Van RoyKaat DurinckSuzanne VanhauwaertChristophe Van NesteSara EkJohan Van NesJan KosterKatleen De PreterFranki Speleman

SOX11 is a key epigenetic regulator in the adrenergic MYCN amplified neuroblastoma

Amber LouwagieBieke DecaestekerSara De BrouwerGeertrui DeneckerCarolina de Carvalho NunesVolodimir OlexioukKaren VerboomMoritz GartlgruberWouter Van LoockeElena AfanasyevaPauline DepuydtFanny De VloedEllen SandersSuzanne VanhauwaertLiselot MusCarl HerrmannSiebe LoontiensGeneviève LaureysBjörn MentenNadine Van RoyJo VandorpeDavid CreytensChristophe Van NesteKaat DurinckFrank WestermanRogier VersteegJohan Van NesJan KosterSara EkKatleen De PreterFranki Speleman

2018

DNA copy number imbalances with clinical relevance in cancer : rare events in big data

Pauline DepuydtKatleen De PreterFranki Speleman

Data Descriptor: Meta-mining of copy number profiles of high-risk neuroblastoma tumors

Pauline DepuydtJ KosterV BoevaTD HockingFranki SpelemanG SchleiermacherKatleen De Preter

A1 Journal Article in SCIENTIFIC DATA

Genomic amplifications and distal 6q loss : novel markers for poor survival in high-risk neuroblastoma patients

Pauline DepuydtValentina BoevaToby D HockingRobrecht CannoodtInge M AmbrosPeter F AmbrosShahab AsgharzadehEdward F AttiyehValérie CombaretRaffaella DefferrariMatthias FischerBarbara HeroMichael D HogartyMeredith S IrwinJan KosterSusan KreissmanRuth LadensteinEve LapoubleGenevieve LaureysWendy B LondonKatia MazzoccoAkira NakagawaraRosa NogueraMiki OhiraJulie R ParkUlrike PötschgerJessica TheissenGian Paolo ToniniDominique Valteau-CouanetLuigi VaresioRogier VersteegFranki SpelemanJohn M MarisGudrun SchleiermacherKatleen De Preter

A1 Journal Article in JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE

SOX11 is a transcriptional circuit dosage sensitive transcription factor controlling SWI/SNF components

Bieke DecaestekerSara De BrouwerGeertrui DeneckerFanny De VloedWouter Van LoockeSuzanne VanhauwaertPauline DepuydtMoritz GartlgruberJolien De WynGenevieve LaureysBjörn MentenDavid CreytensJo Van DorpeFrank WestermanJan KosterJohan Van NexRogier VersteegSara EkFranki SpelemanKatleen De Preter

TBX2 is a neuroblastoma core regulatory circuitry component enhancing MYCN/FOXM1 reactivation of DREAM targets

Bieke DecaestekerGeertrui DeneckerChristophe Van NesteEmmy M DolmanWouter Van LoockeMoritz GartlgruberCarolina de Carvalho NunesFanny De VloedPauline DepuydtKaren VerboomDries RombautSiebe LoontiensJolien De WynWaleed M KholosyBianca KoopmansAnke HW EssingCarl HerrmannDaniel DreidaxKaat DurinckDieter DeforceFilip Van NieuwerburghAnton HenssenRogier VersteegValentina BoevaGudrun SchleiermacherJohan van NesPieter MestdaghSuzanne VanhauwaertJohannes H SchulteFrank WestermannJan J MolenaarKatleen De PreterFranki Speleman

A1 Journal Article in NATURE COMMUNICATIONS

TBX2 is implicated in cell cycle control and proliferation in neuroblastoma

Bieke DecaestekerGeertrui DeneckerChristophe Van NesteFanny De VloedMoritz GartlgruberPauline DepuydtWouter Van LoockeShana ClaeysDries RombautSiebe LoontiensAnton HenssenDaniel DreidaxSuzanne VanhauwaertValentina BoevaRogier VersteegGudrun SchleiermacherJohan Van NesJohannes SchulteFrank WestermanKatleen De PreterFranki Speleman

The RRM2-PHF6 complex protects neuroblastoma cells from DNA damage accumulation to install a replication stress resistance phenotype

Carolina de Carvalho NunesKaat DurinckLisa DepestelSiebe LoontiensLouis DelhayeSofia ZanottiEmmy DolmanAline EggermontBieke DecaestekerPauline DepuydtJolien De WynGeertrui DeneckerWinnok De VosSven EyckermanMatthias FischerJan MolenaarChristophe Van NesteFranki Speleman

The core regulatory circuit component TBX2 is implicated in cell cycle control and proliferation in neuroblastoma

Bieke DecaestekerGeertrui DeneckerChristophe Van NesteFanny De VloedMoritz GartlgruberPauline DepuydtWouter Van LoockeShana ClaeysDries RombautSiebe LoontiensAnton HenssenDaniel DreidaxSuzanne VanhauwaertValentina BoevaRogier VersteegGudrun SchleiermacherJohan Van NesJohannes SchulteFrank WestermanKatleen De PreterFranki Speleman

The core regulatory circuit component TBX2 is implicated in cell cycle control and proliferation in neuroblastoma

Bieke DecaestekerGeertrui DeneckerWouter Van LoockeMoritz GartlgruberPauline DepuydtFanny De VloedShana ClaeysDries RombautSiebe LoontiensAnton HenssenDaniel DreidaxSuzanne VanhauwaertValentina BoevaRogier VersteegGudrun SchleiermacherJohan Van NesJohannes SchulteFrank WestermanChristophe Van NesteKatleen De PreterFranki Speleman

The mutational landscape of MYCN, Lin28b and ALKF1174L driven murine neuroblastoma mimics human disease

Bram De WildeAnneleen BeckersSven LindnerKristina AlthoffKatleen De PreterPauline DepuydtPieter MestdaghTom SanteSteve LefeverFalk HertwigZhiyu PengLe-ming ShiSangkyun LeeElien VandermarliereLennart MartensBjörn MentenAlexander SchrammMatthias FischerJohannes SchulteJo VandesompeleFranki Speleman

A2 Journal Article in ONCOTARGET

2017

Genomic amplifications and distal 6q loss are novel markers for poor survival in high-risk neuroblastoma patients

Pauline DepuydtValentina BoevaToby D HockingRobrecht CannoodtInge M AmbrosPeter F AmbrosShahab AsgharzadehEdward F AttiyehValérie CombaretRaffaella DefferrariMatthias FischerBarbara HeroMichael D HogartyMeredith S IrwinJan KosterSusan KreissmanRuth LadensteinEve LapoubleGenevieve LaureysWendy B LondonKatia MazzoccoAkira NakagawaraRosa NogueraMiki OhiraJulie R ParkUlrike PJessica TheissenGian Paolo ToniniDominique Valteau-CouanetLuigi VaresioRogier VersteegFranki SpelemanJohn M MarisGudrun SchleiermacherKatleen De Preter

Identification of novel, rare markers for poor survival in high-risk neuroblastoma patients by merging and reanalysing existing datasets

Pauline DepuydtValentina BoevaToby HockingRobrecht CannoodtInge AmbrosPeter AmbrosShahab AsgharzadehEdward AttiyehValérie CombaretRaffaella DefferrariMatthias FischerBarbara HeroMichael HogartyMeredith IrwinJan KosterSusan KreissmanRuth LadensteinEve LapoubleGenevieve LaureysWendy LondonKatia MazzoccoAkira NakagawaraRosa NogueraMiki OhiraJulie ParkUlrike PötschgerJessica TheissenGian Paolo ToniniDominique Valteau-CouanetLuigi VaresioRogier VersteegFranki SpelemanJohn MarisGudrun SchleiermacherKatleen De Preter

RRM2 is an essential and druggable component of the FOXM1 driven replicative stress DNA damage response in neuroblastoma

Carolina de Carvalho NunesSiebe LoontiensPauline DepuydtSuzanne VanhauwaertBieke DecaestekerBram De WildeKatleen De PreterGeertrui DeneckerChristophe Van NesteKaat DurinckFranki Speleman

RRM2 is an essential and druggable component of the FOXM1 driven replicative stress DNA damage response in neuroblastoma

Carolina de Carvalho NunesSiebe LoontiensPauline DepuydtSuzanne VanhauwaertBieke DecaestekerBram De WildeKatleen De PreterGeertrui DeneckerChristophe Van NesteKaat DurinckFranki Speleman

SOX11 acts as part of the MYCN-WEE1 regulatory protein complex implicated in neuroblastoma

Bieke DecaestekerSara De BrouwerFanny De VloedGeertrui DeneckerSuzanne VanhauwaertJolien De WynGenevieve LaureysBjörn MentenPauline DepuydtPatrick ReynoldsJo VandorpeKris GevaertJan KosterSara EkFranki SpelemanKatleen De Preter

SOX11 acts as part of the MYCN-WEE1 regulatory protein complex implicated in neuroblastoma

Bieke DecaestekerSara De BrouwerFanny De VloedGeertrui DeneckerSuzanne VanhauwaertJolien De WynGenevieve LaureysBjörn MentenPauline DepuydtJo VandorpeKris GevaertJan KosterSara EkFranki SpelemanKatleen De Preter

Shallow whole genome sequencing on circulating cell-free DNA allows reliable non-invasive copy number profiling in neuroblastoma patients

Nadine Van RoyMalaïka Van Der LindenPauline DepuydtBjörn MentenAnnelies DheedeneCharlotte VandeputteJo Van DorpeGenevieve LaureysMarjolijn RenardTom SanteTim LammensBram De WildeFranki SpelemanKatleen De Preter

The core regulatory circuit component TBX2 is implicated in cell cycle control and proliferation in neuroblastoma

Bieke DecaestekerGeertrui DeneckerWouter Van LoockeMoritz GartlgruberPauline DepuydtFanny De VloedShana ClaeysDries RombautSiebe LoontiensAnton HenssenDaniel DreidaxSuzanne VanhauwaertValentina BoevaRogier VersteegGudrun SchleiermacherJohan Van NesJohannes SchulteFrank WestermanChristophe Van NesteKatleen De PreterFranki Speleman

The immunophenotypic fingerprint of patients with primary antibody deficiencies is partially present in their asymptomatic first-degree relatives

Delfien BogaertMarieke De BruyneVeronique DebackerPauline DepuydtKatleen De PreterCarolien BonroyJan PhilippéMaria Bordon Cueto De BraemBart LambrechtTessa KerreAndrea CeruttiKarim VermaelenFilomeen HaerynckMelissa Dullaers

A1 Journal Article in HAEMATOLOGICA

The immunophenotypical fingerprint of patients with primary antibody deficiencies is partially present in their asymptomatic first-degree relatives

Delfien BogaertMarieke De BruyneVeronique DebackerPauline DepuydtKatleen De PreterCarolien BonroyJan PhilippéMaria Bordon Cueto De BraemBart LambrechtTessa KerreAndrea CeruttiKarim VermaelenFilomeen HaerynckMelissa Dullaers

2016

Distal chromosome 6q deletion defines a group of ultra-high risk neuroblastoma patients

Pauline DepuydtValentina BoevaToby D HockingPeter F AmbrosShahab AsgharzadehEdward F AttiyehValérie CombaretRaffaella DefferrariMatthias FischerMichael D HogartyMeredith S IrwinSusan KreissmanRuth LadensteinGenevieve LaureysWendy B LondonKatia MazzoccoAkira NakagawaraRosa NogueraJulie R ParkGian Paolo ToniniDominique Valteau-CouanetLuigi VaresioFranki SpelemanJohn M MarisGudrun SchleiermacherKatleen De Preter

The BRIP1/FANCJ DNA helicase is a druggable 17q driver oncogene involved in G-quadruplex induced replicative stress resistance in neuroblastoma

Suzanne VanhauwaertAnnelies FieuwCarina LeonelliBieke DecaestekerJolien De WynPauline DepuydtSara De BrouwerNadine Van RoyShuning HeThomas LookKatleen De PreterFranki Speleman

The immunophenotypical landscape of patients with primary antibody deficiencies and their asymptomatic first-degree relatives : arguments for a multifactorial aetiology

Delfien BogaertPauline DepuydtKatleen De PreterCarolien BonroyJan PhilippéMaria Bordon Cueto De BraemTessa KerreBart LambrechtAndrea CeruttiKarim VermaelenElfride De BaereFilomeen HaerynckMelissa Dullaers