Research Explorer

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Researcher

Panagiotis Ntziachristos

Publications & Research Data

Awards & Distinctions

49 Results

2025

Depletion of the RNA binding protein QKI and circular RNA dysregulation in T-cell acute lymphoblastic leukemia

Alessia BuratinBruno PalhaisEnrico GaffoJuliette RoelsJulie MorscioJolien Van LaereSilvia OrsiGeertruij Te KronniePieter Van VlierberghePanagiotis Ntziachristos et al.

A1 Journal Article in HAEMATOLOGICA

FTO regulates ELK3-mediated metabolic rewiring and represents a unique therapeutic target in T cell leukemia

Hao HuangXinlu LiJinlian LuoChuan GaoMengjie YangJin XuTing XieZhi ChenDonghai WangYuan Wang et al.

A1 Journal Article in SCIENCE ADVANCES

HNRNPC and m6A RNA methylation control oncogenic transcription and metabolism in T-cell leukemia

Jonas De KeselIgor FijalkowskiTim PietersCristina BorinKasper Thorhauge ChristensenManou WittouckJolien Van LaereLaura GuerreroLindy ReunesMarino Caruso et al.

A1 Journal Article in BLOOD

Underlying biology, challenges and emergent concepts in the treatment of relapsed and refractory pediatric T-cell acute lymphoblastic leukemia

Patrícia AmaralRhona ChristieDaisy O. F. GreshamEmma J. M. LucasLuyao Kevin XuLena BehrmannJonathan BondSofie DegermanFrederik W. van DelftSteven Goossens et al.

A1 Journal Article in LEUKEMIA

2024

A dual role for PSIP1/LEDGF in T cell acute lymphoblastic leukemia

Lisa DemoenFilip MatthijssensLindy ReunesBruno PalhaisBéatrice LintermansSara T'SasIgor FijalkowskiJoachim TaminauMuluembet Z. AkeleSiska Van Belle et al.

A1 Journal Article in SCIENCE ADVANCES

A positive feedback loop regulation between NOTCH1 and USP11 in T-cell leukemia

Igor FijalkowskiJin WangQi JinJolien Van LaereValentina SerafinJohn D. CrispinoPanagiotis Ntziachristos

A1 Journal Article in LEUKEMIA

A succinylation switch to maligancy : SUCLG1, mitochondrial transcription and leukemia

Laura GuerreroPanagiotis Ntziachristos

A1 Journal Article in EMBO JOURNAL

Myb overexpression synergizes with the loss of Pten and is a dependency factor and therapeutic target in T-cell lymphoblastic leukemia

André Pedro Pinto De AlmeidaSara T'SasLuca PagliaroIgor FijalkowskiWouter SleeckxHannah Van SteenbergeRaffaella ZamponiBéatrice LintermansWouter Van LoockeBruno Palhais et al.

A1 Journal Article in HEMASPHERE

PDXGhent : patient derived tumor xenografting mouse core facility Ghent

Liselot MusSteven GoossensTim LammensLindsey DevisscherPanagiotis NtziachristosOlivier De WeverFrédéric Clement

PDXGhent : patient derived tumor xenografting mouse Core Facility Ghent

Liselot MusSteven GoossensTim LammensLindsey DevisscherPanagiotis NtziachristosOlivier De WeverFrédéric Clement

Targeting hyperactive platelet-derived growth factor receptor-β signaling in T-cell acute lymphoblastic leukemia and lymphoma

Stien De ConinckRenate De SmedtBéatrice LintermansLindy ReunesHansen J. KosasihAlexandra ReekmansLauren M. BrownNadine Van RoyBruno PalhaisJuliette Roels et al.

A1 Journal Article in HAEMATOLOGICA

2023

Emerging epigenetic and posttranslational mechanisms controlling resistance to glucocorticoids in acute lymphoblastic leukemia

Cristina BorinTim PietersValentina SerafinPanagiotis Ntziachristos

A1 Journal Article in HEMASPHERE

2022

SF3B1 homeostasis is critical for survival and therapeutic response in T cell leukemia

Cuijuan HanAlireza Khodadadi-JamayranAdam H. LorchQi JinValentina SerafinPing ZhuYuliya PolitanskaLimin SunBlanca T. Gutierrez-DiazMarina Pryzhkova et al.

A1 Journal Article in SCIENCE ADVANCES

Splicing dysregulation in human hematologic malignancies : beyond splicing mutations

Jonas De KeselIgor FijalkowskiJustin TaylorPanagiotis Ntziachristos

A1 Journal Article in TRENDS IN IMMUNOLOGY

2021

LKB1/STK11 Is a tumor suppressor in the progression of myeloproliferative neoplasms

Christian MarinaccioPraveen SuraneniHamza CelikAndrew VolkQiang Jeremy WenTe LingMarinka BulicTerra LashoRichard P. KocheChristopher A. Famulare et al.

A1 Journal Article in CANCER DISCOVERY

NOTCH1-driven UBR7 stimulates nucleotide biosynthesis to promote T cell acute lymphoblastic leukemia

Shashank SrivastavaUmakant SahuYalu ZhouAnn K. HoganKizhakke Mattada SathyanJustin BodnerJiehuan HuangKelvin A. WongNatalia KhalatyanJeffrey N. Savas et al.

A1 Journal Article in SCIENCE ADVANCES

Posttranslational regulation of FOXA1 by Polycomb and BUB3/USP7 deubiquitin complex in prostate cancer

Su H. ParkKa-wing FongJung KimFang WangXiaodong LuYongik LeeLourdes T. BreaKristine WadoskyChunming GuoSarki A. Abdulkadir et al.

A1 Journal Article in SCIENCE ADVANCES

T-ALL and the talented Mr IL7R alpha

Cuijuan HanPanagiotis Ntziachristos

Editorial material

2020

Cancer-specific CTCF binding facilitates oncogenic transcriptional dysregulation

Celestia FangZhenjia WangCuijuan HanStephanie L. SafgrenKathryn A. HelminEmmalee R. AdelmanValentina SerafinGiuseppe BassoKyle P. EagenAlexandre Gaspar-Maia et al.

A1 Journal Article in GENOME BIOLOGY

Determinants and role of chromatin organization in acute leukemia

Celestia FangSridhar RaoJohn D. CrispinoPanagiotis Ntziachristos

A1 Journal Article in LEUKEMIA

Deubiquitinases : pro-oncogenic activity and therapeutic targeting in blood malignancies

Blanca T. Gutierrez-DiazWei GuPanagiotis Ntziachristos

A1 Journal Article in TRENDS IN IMMUNOLOGY

iAMPlified gene expression offers new insights in B cell precursor leukemia subtype

Panagiotis Ntziachristos

Editorial material

2019

Cardiac myocyte KLF5 regulates body weight via alteration of cardiac FGF21

Christine J. PolNina M. PollakMichael J. JurczakEffimia ZachariaIordanes KaragiannidesIoannis D. KyriazisPanagiotis NtziachristosDiego A. ScerboBrett R. BrownIannis Aifantis et al.

A1 Journal Article in BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Global alteration of CTCF binding in the cancer genome

Celestia FangZhenjia WangCarlos A. MartinezPanagiotis NtziachristosChongzhi Zang

Nuclear deubiquitination in the spotlight : the multifaceted nature of USP7 biology in disease

Radhika RawatDaniel T. StarczynowskiPanagiotis Ntziachristos

A1 Journal Article in CURRENT OPINION IN CELL BIOLOGY

PHF6 : it is written in the stem cells

Panagiotis Ntziachristos

Editorial material

2018

Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy

Lu WangZibo ZhaoPatrick A. OzarkDamiano FantiniStacy A. MarshallEmily J. RendlemanKira A. CozzolinoNundia LouisXingyao HeMarc A. Morgan et al.

A1 Journal Article in NATURE MEDICINE

Stratification of TAD boundaries reveals preferential insulation of super-enhancers by strong boundaries

Yixiao GongCharalampos LazarisTheodore SakellaropoulosAurelie LozanoPrabhanjan KambadurPanagiotis NtziachristosIannis AifantisAristotelis Tsirigos

A1 Journal Article in NATURE COMMUNICATIONS

2017

Cardiac myocyte KLF5 regulates adiposity via alteration of cardiac FGF21

Christine J. PolNina M. PollakMichael J. JurczakIordanes KaragiannidesPanagiotis NtziachristosDiego A. ScerboIannis AlfantisGerald I. ShulmanIra J. GoldbergKonstantinos Drosatos

Cardiomyocyte-specific KLF5 deletion accelerates diet-induced obesity via cardiac FGF21

Christine J. PolNina M. PollakMichael J. JurczakIordanes KaragiannidesPanagiotis NtziachristosDiego A. ScerboBrett R. BrownMesele C. ValentiIannis AifantisGerald I. Shulman et al.

HiC-bench : comprehensive and reproducible Hi-C data analysis designed for parameter exploration and benchmarking

Charalampos LazarisStephen KellyPanagiotis NtziachristosIannis AifantisAristotelis Tsirigos

A1 Journal Article in BMC GENOMICS

Opposing functions of H2BK120 ubiquitylation and H3K79 methylation in the regulation of pluripotency by the Paf1 complex

Alexandros StrikoudisCharalampos LazarisPanagiotis NtziachristosAristotelis TsirigosIannis Aifantis

A1 Journal Article in CELL CYCLE

2016

Cardiac myocyte KLF5 regulates Ppara expression and cardiac function

Konstantinos DrosatosNina M. PollakChristine J. PolPanagiotis NtziachristosFlorian WilleckeMesele-Christina ValentiChad M. TrentYunying HuShaodong GuoIannis Aifantis et al.

A1 Journal Article in CIRCULATION RESEARCH

Deregulation of DUX4 and ERG in acute lymphoblastic leukemia

Jinghui ZhangKelly McCastlainHiroki YoshiharaBeisi XuYunchao ChangMichelle L. ChurchmanGang WulYongjin LiLei WeiIlaria Iacobucci et al.

A1 Journal Article in NATURE GENETICS

Emerging concepts of epigenetic dysregulation in hematological malignancies

Panagiotis NtziachristosOmar Abdel-WahabIannis Aifantis

A1 Journal Article in NATURE IMMUNOLOGY

Histone demethylases in physiology and cancer : a tale of two enzymes, JMJD3 and UTX

Kelly Marie ArcipowskiCarlos Alberto MartinezPanagiotis Ntziachristos

A1 Journal Article in CURRENT OPINION IN GENETICS & DEVELOPMENT

Regulation of transcriptional elongation in pluripotency and cell differentiation by the PHD-finger protein Phf5a

Alexandros StrikoudisCharalampos LazarisThomas TrimarchiAntonio L. Galvao NetoYan YangPanagiotis NtziachristosScott RothbartShannon BuckleyIgor DolgalevMatthias Stadtfeld et al.

A1 Journal Article in NATURE CELL BIOLOGY

2014

Control of embryonic stem cell identity by BRD4-dependent transcriptional elongation of super-enhancer-associated pluripotency genes

Raffaella Di MiccoBarbara Fontanals-CireraVivien LowPanagiotis NtziachristosStephanie K. YuenClaudia D. LovellIgor DolgalevYoshiya YonekuboGuangtao ZhangElena Rusinova et al.

A1 Journal Article in CELL REPORTS

From fly wings to targeted cancer therapies : a centennial for notch signaling

Panagiotis NtziachristosJing Shan LimJulien SageIannis Aifantis

A1 Journal Article in CANCER CELL

Genome-wide mapping and characterization of notch-regulated long noncoding RNAs in acute leukemia

Thomas TrimarchiErhan BilalPanagiotis NtziachristosGiulia FabbriRiccardo Dalla-FaveraAristotelis TsirigosIannis Aifantis

A1 Journal Article in CELL

Klf5 is a transcriptional regulator of cardiac Med13 and affects high fat diet-induced obesity

Konstantinos DrosatosNina M. PollakMichael John JurczakPanagiotis NtziachristosChad M. TrentYunying HuIannis AifantisGerald I. ShulmanIra J. Goldberg

Klf5 regulates cardiac Ppar[alpha] and Med13 and affects cardiac fatty acid metabolism and obesity

Konstantinos DrosatosNina PollakPanagiotis NtziachristosChad M. TrentYunying HuShunichi HommaIannis AifantisIra J. Goldberg

2013

A new player SETs in myeloid malignancy

Thomas TrimarchiPanagiotis NtziachristosIannis Aifantis

Editorial material

Higher-order looping and nuclear organization of Tcra facilitate targeted RAG cleavage and regulated rearrangement in recombination centers

Julie ChaumeilMariann MicsinaiPanagiotis NtziachristosLudovic DerianoJoy M. -H. WangYanhong JiElphege P. NoraMatthew J. RodeschJeffrey A. JeddelohIannis Aifantis et al.

A1 Journal Article in CELL REPORTS

Mechanisms of epigenetic regulation of leukemia onset and progression

Panagiotis NtziachristosJasper MullendersThomas TrimarchiIannis Aifantis

A1 Journal Article in ADVANCES IN IMMUNOLOGY

Notch pathway activation targets AML-initiating cell homeostasis and differentiation

Camille LobryPanagiotis NtziachristosDelphine Ndiaye-LobryPhilmo OhLuisa CimminoNan ZhuElisa AraldiWenhuo HuJacquelyn FreundOmar Abdel-Wahab et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

The RAG2 C-terminus and ATM protect genome integrity by controlling antigen receptor gene cleavage

Julie ChaumeilMariann MicsinaiPanagiotis NtziachristosDavid B. RothIannis AifantisYuval KlugerLudovic DerianoJane A. Skok

A1 Journal Article in NATURE COMMUNICATIONS

The ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stability

Bryan KingThomas TrimarchiLinsey ReavieLuyao XuJasper MullendersPanagiotis NtziachristosBeatriz Aranda-OrgillesArianne Perez-GarciaJunwei ShiChristopher Vakoc et al.

A1 Journal Article in CELL

2012

Hijacking T cell differentiation : new insights in TLX function in T-ALL

Bryan KingPanagiotis NtziachristosIannis Aifantis

Editorial material