Research Explorer

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Researcher

Paco Hulpiau

Publications & Research Data

Awards & Distinctions

48 Results

2026

Digging deeper : computational and functional screening for iminosugar natural product enzymes in soil bacteria (meta)genomes

Anne-Sofie De RopKato SarensYaren ÜnverJeltien RombautMarieke MispelaereSofie De MaeseneirePaco HulpiauWim SoetaertMaarten De Mol

2025

MariClus : your one-stop platform for information on marine natural products, their gene clusters and producing organisms

Maarten De MolCedric HermansMarieke MispelaereAnne-Sofie De RopJeltien RombautTesneem NusayrRebecca CreamerSofie De MaeseneireWim SoetaertPaco Hulpiau

Novel iminosugar enzymes and products through metagenomics

Anne-Sofie De RopMaarten De MolSofie De MaeseneireInari WillemsMarieke MispelaerePaco HulpiauWim Soetaert

Screening for iminosugar enzymes through (meta)genomic analysis of actinomycetes

Anne-Sofie De RopJeltien RombautMaarten De MolSofie De MaeseneireMarieke MispelaerePaco HulpiauWim Soetaert

Unravelling Listeria monocytogenes persistence in frozen potato processing : insights from whole genome sequencing analysis

Tessa TuytschaeverMarieke MispelaereCharlotte PeetersEvelien De CanckPeter VandammeKatleen RaesPaco HulpiauImca Sampers

A1 Journal Article in INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY

2024

Average nucleotide identity and digital DNA-DNA hybridization analysis following PromethION nanopore-based whole genome sequencing allows for accurate prokaryotic typing

Nick VersmessenMarieke MispelaereMarjolein VandekerckhoveCedric HermansJerina BoelensKatleen VranckxFilip Van NieuwerburghMario VaneechouttePaco HulpiauPiet Cools

A1 Journal Article in DIAGNOSTICS

2023

Functions of the RIP kinase family members in the skin

Corinne UrwylerGiel TangheMichael DevosPaco HulpiauYvan SaeysWim Declercq

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

2022

Modifying PCDH19 levels affects cortical interneuron migration

Anna PanchoManuela D. D. MitsogiannisTania AertsMarco Dalla VecchiaLena K. K. EbertLieve GeenenLut NoterdaemeRia VanlaerAnne StulensPaco Hulpiau et al.

A1 Journal Article in FRONTIERS IN NEUROSCIENCE

2021

Characteristic ERK1/2 signaling dynamics distinguishes necroptosis from apoptosis

François SipieterBenjamin CappeAymeric LerayElke De SchutterJolien BridelancePaco HulpiauGuy Van CampWim DeclercqLaurent HeliotPierre Vincent et al.

A1 Journal Article in ISCIENCE

RyR2 regulates Cx43 hemichannel intracellular Ca2+-dependent activation in cardiomyocytes

Alessio LissoniPaco HulpiauTânia Martins-MarquesNan WangGeert BultynckRainer SchulzKatja WitschasHenrique GiraoMaarten De SmetLuc Leybaert

A1 Journal Article in CARDIOVASCULAR RESEARCH

2020

Functional exploration of the GH29 fucosidase family

Hendrik GrootaertLinde Van LanduytPaco HulpiauNico Callewaert

A1 Journal Article in GLYCOBIOLOGY

Mouse strain-dependent difference toward the staphylococcus aureus allergen serine protease-like protein D reveals a novel regulator of IL-33

Andrea Renate TeufelbergerSharon Van NevelPaco HulpiauMaria NordengrünSavvas SavvidesSarah De GraeveSrinivas AkulaGabriële HoltappelsNatalie De RuyckWim Declercq et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

2019

Armc8 is a evolutionarily conserved armadillo protein involved in cell-cell adhesion complexes through multiple molecular interactions

Ismail Sahin GülPaco HulpiauEllen SandersFrans Van RoyJolanda van Hengel

A1 Journal Article in BIOSCIENCE REPORTS

2018

Ancient origin of the CARD-coiled coil/Bcl10/MALT1-like paracaspase signaling complex indicates unknown critical functions

Jens StaalYasmine DriegeMira HaegmanAlice BorghiPaco HulpiauLaurens LievensIsmail Sahin GülSrividhya Sundararaman IyerAmanda GonçalvesIneke Dhondt et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Cx43 hemichannel opening in ventricular cardiomyocytes necessitates simultaneous ryanodine receptor activation and elevation of intracellular Ca2+

Alessio LissoniMaarten De SmetPaco HulpiauTania Martins-MarquesNan WangHenrique GiraoLuc Leybaert

GC content of Early Metazoan genes and its impact on gene expression levels in mammalian cell lines

Ismail Sahin GülJens StaalPaco HulpiauEvi De KeuckelaereKai KammTom DerooEllen SandersKatrien StaesYasmine DriegeYvan Saeys et al.

A1 Journal Article in GENOME BIOLOGY AND EVOLUTION

Nanos genes and their role in development and beyond

Evi De KeuckelaerePaco HulpiauYvan SaeysGeert BerxFrans Van Roy

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

Neutralization of Junín virus by single domain antibodies targeted against the nucleoprotein

Florencia LineroClaudia SepúlvedaIoanna ChristopoulouPaco HulpiauLuis ScolaroXavier Saelens

A1 Journal Article in SCIENTIFIC REPORTS

RyR2 regulates Cx43 hemichannel [Ca2+]i-dependent activation in cardiomyocytes

Alessio LissoniMaarten De SmetTania Martins-MarquesNan WangHenrique GiraoPaco HulpiauLuc Leybaert

RyR2 regulates Cx43 hemichannel [Ca2+]i-dependent activation in cardiomyocytes

Alessio LissoniMaarten De SmetTania Martins-MarquesNan WangHenrique GiraoPaco HulpiauLuc Leybaert

RyR2 regulates Cx43 hemichannel [Ca2+]i-dependent activation in cardiomyocytes

Alessio LissoniMaarten De SmetTania Martins-MarquesHerique GiraoNan WangPaco HulpiauLuc Leybaert

2017

ConTra v3 : a tool to identify transcription factor binding sites across species, update 2017

Lukasz KreftArne SoetePaco HulpiauAlexander BotzkiYvan SaeysPieter De Bleser

A1 Journal Article in NUCLEIC ACIDS RESEARCH

Evolution and diversity of cadherins and catenins

Ismail Sahin GülPaco HulpiauYvan SaeysFrans Van Roy

A1 Journal Article in EXPERIMENTAL CELL RESEARCH

Metazoan evolution of the armadillo repeat superfamily

Ismail Sahin GülPaco HulpiauYvan SaeysFrans Van Roy

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

The EMT transcription factor Zeb2 controls adult murine hematopoietic differentiation by regulating cytokine signaling

Jin LiTamara RiedtSteven GoossensCarmen Carrillo GarciaSabrina SzczepanskiMaria BrandesTim PietersLinne DobroschInes GuetgemannNatalie Farla et al.

A1 Journal Article in BLOOD

2016

An evolutionary perspective on the necroptotic pathway

Yves DondelingerPaco HulpiauYvan SaeysMathieu BertrandPeter Vandenabeele

A1 Journal Article in TRENDS IN CELL BIOLOGY

Development and validation of a small single-domain antibody that effectively inhibits matrix metalloproteinase 8

Delphine DemeestereEline DejonckheereSophie SteelandPaco HulpiauJurgen HaustraeteNick DevoogdtRielana WichertChristoph Becker-PaulyElien Van WonterghemSylviane Dewaele et al.

A1 Journal Article in MOLECULAR THERAPY

Efficient analysis of mouse genome sequences reveal many nonsense variants

Sophie SteelandSteven TimmermansSara Van RyckeghemPaco HulpiauYvan SaeysMarc Van MontaguRoosmarijn VandenbrouckeClaude Libert

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evolution of cadherins and associated catenins

Paco HulpiauIsmail Sahin GülFrans Van Roy

Bookchapter in The cadherin superfamily : key regulators of animal development and physiology

Formin is associated with left-right asymmetry in the pond snail and the frog

Angus DavisonGary S McDowellJennifer M HoldenHarriet F JohnsonGeorgios D KoutsovoulosM Maureen LiuPaco HulpiauFrans Van RoyChristopher M WadeRuby Banerjee et al.

A1 Journal Article in CURRENT BIOLOGY

MALT1 is not alone after all : identification of novel paracaspases

Paco HulpiauYasmine DriegeJens StaalRudi Beyaert

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

2015

Generation and characterization of small single domain antibodies inhibiting human tumor necrosis factor receptor 1

Sophie SteelandLeen PuimègeRoosmarijn VandenbrouckeFilip Van HauwermeirenJurgen HaustraeteNick DevoogdtPaco HulpiauGeert Leroux-RoelsDebby LaukensPhilip Meuleman et al.

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Passenger mutations confound interpretation of all genetically modified congenic mice

Tom Vanden BerghePaco HulpiauLiesbet MartensRoosmarijn VandenbrouckeElien Van WonterghemSeth W PerryInge BruggemanTatyana DivertSze Men ChoiMarnik Vuylsteke et al.

A1 Journal Article in IMMUNITY

2014

MLKL compromises plasma membrane integrity by binding to phosphatidylinositol phosphates

Yves DondelingerWim DeclercqSylvie MontessuitRia RoelandtAmanda GonçalvesInge BruggemanPaco HulpiauKathrin WeberClark A SehonRobert W Marquis et al.

A1 Journal Article in CELL REPORTS

2013

Paco HulpiauFrans Van Roy

Bookchapter in Encyclopedia of metalloproteins

Mutations in the area composita protein T-catenin are associated with arrhythmogenic right ventricular cardiomyopathy

Jolanda van HengelMartina CaloreBarbara BauceEmanuela DazzoElisa MazzottiMarzia De BortoliAlessandra LorenzonIlena EA Li MuraGiorgia BeffagnaIlaria Rigato et al.

A1 Journal Article in EUROPEAN HEART JOURNAL

Mx proteins: antiviral gatekeepers that restrain the uninvited

Judith VerhelstPaco HulpiauXavier Saelens

A1 Journal Article in MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

New insights into the evolution of metazoan cadherins and catenins

Paco HulpiauIsmail Sahin GülFrans Van Roy

A1 Journal Article in Progress in Molecular Biology and Translational Science

p53 promotes VEGF expression and angiogenesis in the absence of an intact p21-Rb pathway

Morvarid Farhang GhahremaniSteven GoossensD NittnerX BisteauSona BartunkovaA ZwolinskaPaco HulpiauKatharina HaighLieven HaenebalckeBenjamin Drogat et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

2012

A bacterial glycosidase enables mannose-6-phosphate modification and improved cellular uptake of yeast-produced recombinant human lysosomal enzymes

Petra TielsEkaterina BaranovaKathleen PiensCharlotte De VisscherGwenda PynaertWim NerinckxJan StoutFranck FudalejPaco HulpiauSimon Tännler et al.

A1 Journal Article in NATURE BIOTECHNOLOGY

Evolutionary functional analysis and molecular regulation of the ZEB transcription factors

Alexander GheldofPaco HulpiauFrans Van RoyBram De CraeneGeert Berx

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

2011

ConTra v2 : a tool to identify transcription factor binding sites across species, update 2011

Stefan BroosPaco HulpiauJeroen GalleBart HoogheFrans Van RoyPieter De Bleser

A1 Journal Article in NUCLEIC ACIDS RESEARCH

New insights into the evolution of metazoan cadherins

Paco HulpiauFrans Van Roy

A1 Journal Article in MOLECULAR BIOLOGY AND EVOLUTION

2009

Molecular evolution of the cadherin superfamily

Paco HulpiauFrans Van Roy

A1 Journal Article in INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

2008

ConTra: a promoter alignment analysis tool for identification of transcription factor binding sites across species

Bart HooghePaco HulpiauFrans Van RoyPieter De Bleser

A1 Journal Article in NUCLEIC ACIDS RESEARCH

Text-mining assisted regulatory annotation

S AERTSM HAEUSSLERS VAN VOORENOL GRIFFITHPaco HulpiauSJM JONESSB MONTGOMERYCM BERGMAN

A1 Journal Article in GENOME BIOLOGY

2007

Structural investigation of cold activity and regulation of aspartate carbamoyltransferase from the extreme psychrophilic bacterium Moritella profunda

D DE VOSX XUPaco HulpiauBjorn VergauwenJozef Van Beeumen

A1 Journal Article in JOURNAL OF MOLECULAR BIOLOGY

2005

Expression, purification, crystallization and preliminary X-ray crystallographic studies of a cold-adapted aspartate carbamoyltransferase from Moritella profunda

Dirk De VosPaco HulpiauBjorn VergauwenSavvas SavvidesJozef Van Beeumen

A1 Journal Article in ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS