Research Explorer

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Researcher

Orphélie Lootens

Publications & Research Data

Awards & Distinctions

17 Results

2025

Building Sub-Saharan African PBPK populations reveals critical data gaps : a case study on Aflatoxin B1

Orphélie LootensMarthe De BoevreSarah De SaegerJan Van BocxlaerAn Vermeulen

A1 Journal Article in TOXINS

Under the magnifying glass : investigating aflatoxin B1 and efavirenz in mycotoxin-drug interactions

Orphélie LootensSarah De SaegerMarthe De BoevreAn Vermeulen

Under the magnifying glass : investigating aflatoxin B1 and efavirenz in mycotoxin-drug interactions

Orphélie LootensAn VermeulenMarthe De BoevreSarah De Saeger

2024

Aflatoxin B1 and efavirenz : pharmacokinetic parameter determination for the search on their interplay

Orphélie Lootens

Exploration of cytochrome P450-related interactions between aflatoxin B1 and tiamulin in broiler chickens

Pan SunOrphélie LootensTadele Kabeta YadessaDiethard ReckelbusNatalia FurmanXingyuan CaoSuxia ZhangGunther AntonissenSiska CroubelsMarthe De Boevre et al.

A1 Journal Article in TOXINS

Exploring the impact of efavirenz on aflatoxin B1 metabolism : insights from a physiologically based pharmacokinetic model and a human liver microsome study

Orphélie LootensMarthe De BoevreElke GasthuysSarah De SaegerJan Van BocxlaerAn Vermeulen

A1 Journal Article in TOXINS

Unlocking diversity : towards a comprehensive framework for physiologically based pharmacokinetic population qualification in Sub Saharan Africa

Orphélie LootensMarthe De BoevreElke GasthuysJan Van BocxlaerSarah De SaegerAn Vermeulen

2023

Building a human physiologically based pharmacokinetic model for aflatoxin B1 to simulate interactions with drugs

Orphélie LootensMarthe De BoevreJia NingElke GasthuysJan Van BocxlaerSarah De SaegerAn Vermeulen

A1 Journal Article in PHARMACEUTICS

Building a physiologically based pharmacokinetic model for a carcinogenic food contaminant

Orphélie LootensMarthe De BoevreAn VermeulenJia NingElke GasthuysJan Van BocxlaerSarah De Saeger

Building a physiologically based pharmacokinetic model for a carcinogenic food contaminant

Orphélie LootensMarthe De BoevreJia NingElke GasthuysJan Van BocxlaerSarah De SaegerAn Vermeulen

Building a physiologically-based pharmacokinetic model for a carcinogenic food contaminant aflatoxin B1

Orphélie LootensMarthe De BoevreJia NingElke GasthuysJan Van BocxlaerSarah De SaegerAn Vermeulen

2022

Determination of pharmacokinetic parameters of efavirenz an aflatoxin B1 : an approach to unravel possible interactions

Orphélie LootensAn VermeulenElke GasthuysJan Van BocxlaerSarah De SaegerMarthe De Boevre

Determination of pharmacokinetic parameters of efavirenz and aflatoxin B1 : an approach to unravel possible interactions

Orphélie Lootens

Possible mechanisms of the interplay between drugs and mycotoxins : is there a possible impact?

Orphélie LootensAn VermeulenSiska CroubelsSarah De SaegerJan Van BocxlaerMarthe De Boevre

A1 Journal Article in TOXINS

Unravelling the pharmacokinetics of aflatoxin B1 : in vitro determination of Michaelis-Menten constants, intrinsic clearance and the metabolic contribution of CYP1A2 and CYP3A4 in pooled human liver microsomes

Orphélie LootensMarthe De BoevreElke GasthuysJan Van BocxlaerAn VermeulenSarah De Saeger

A1 Journal Article in FRONTIERS IN MICROBIOLOGY

2021

Determination of pharmacokinetic parameters of efavirenz and aflatoxin B1 : an approach to unravel possible interactions

Orphélie LootensAn VermeulenJan Van BocxlaerSarah De SaegerMarthe De Boevre

Mycotoxin-drug interactions at the level of CYP450 enzymes

Orphélie LootensSarah De SaegerMarthe De BoevreAn VermeulenJan Van Bocxlaer