Research Explorer

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Researcher

Olivier Zwaenepoel

Publications & Research Data

Awards & Distinctions

31 Results

2026

High sensitivity perovskite-tagged nanobody electrochemiluminescent immunosensor for spike (S1) protein biomarker-based persistent viral reservoir detection

Jaymi JanuaryOlivier ZwaenepoelNelia SangaJan GettemansEmmanuel Iwuoha

A1 Journal Article in BIOELECTROCHEMISTRY

2025

BioID reveals that NR2E3 mediates transcriptional repression through the AP-1 complex

dr. Edith De BruyckerOlivier ZwaenepoelManon BouckaertGeorgios MoschonasDelphine De SutterLouis DelhayeFrauke CoppietersSven EyckermanJan GettemansElfride De Baere

Cell-specific mRNA delivery via nanobody-functionalized lipid nanoparticles

Linglong ChenHans Van Der WekenOlivier ZwaenepoelIrina OkkelmanJustine AelvoetEmma Van DenbergheJan GettemansRuslan DmitrievBruno De GeestEric Cox et al.

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Development of 'furan warhead'-equipped antagonistic nanobodies for covalent cross-linking to the epidermal growth factor receptor

Laure TackLaia Miret CasalsOlivier ZwaenepoelEnrico CadoniMarleen Van TroysJan GettemansAnnemieke Madder

A1 Journal Article in BIOCONJUGATE CHEMISTRY

Highly sensitive nanobody-immunosensor for macrophage-capping protein

Jaymi JanuaryOlivier ZwaenepoelJan GettemansEmmanuel Iwuoha

A1 Journal Article in BIOSENSORS & BIOELECTRONICS

Thiol-thiol cross-clicking using bromo-ynone reagents

Marvin NicqueJan H. MeffertDiederick MaesKevin BevernaegeMehwish IftikharOlivier ZwaenepoelJan GettemansAnnemieke MadderJohan Winne

A1 Journal Article in NATURE COMMUNICATIONS

TurboID proximity interactome mapping reveals NR2E3 association with AP-1 and retinal developmental complexes

Edith De BruyckerOlivier ZwaenepoelGeorgios MoschonasDelphine De SutterEva D'haeneCharlotte MattonLaure VandeveldeJULIE VAN DE VELDEQuinten MahieuSara Dufour et al.

Unravelling the proxisome of photoreceptor-specific nuclear receptor NR2E3 reveals a potential molecular link between transcriptional regulation and splicing in human retina

Edith De BruyckerOlivier ZwaenepoelManon BouckaertGeorgios MoschonasDelphine De SutterLouis DelhayeFrauke CoppietersSven EyckermanJan GettemansElfride De Baere

2024

Development of nanobodies against the coat protein of maize chlorotic mottle virus

Faith NjeruOlivier ZwaenepoelGeert HaesaertGerald MisinzoKris De JongheJan Gettemans

A1 Journal Article in FEBS OPEN BIO

Single domain antibodies to tackle autosomal dominant retinitis pigmentosa caused by NR2E3 mutation G56R

Edith De BruyckerOlivier ZwaenepoelFrauke CoppietersJan GettemansElfride De Baere

Unravelling the interactome of nuclear receptors through proximity dependent biotin labelling

Edith De BruyckerOlivier ZwaenepoelManon BouckaertLaure VandeveldeDelphine De SutterLouis DelhayeFrauke CoppietersSven EyckermanElfride De BaereJan Gettemans

2023

Single domain antibodies to study orphan receptors and tackle their mutant counterpart with dominant-negative effect

Edith De BruyckerOlivier ZwaenepoelFrauke CoppietersElfride De BaereJan Gettemans

2022

Triazolinedione protein modification : from an overlooked off-target effect to a tryptophan-based bioconjugation strategy

Klaas DecoeneKamil ÜnalAn StaesOlivier ZwaenepoelJan GettemansKris GevaertJohan WinneAnnemieke Madder

A1 Journal Article in CHEMICAL SCIENCE

2021

An AKT2-specific nanobody that targets the hydrophobic motif induces cell cycle arrest, autophagy and loss of focal adhesions in MDA-MB-231 cells

Tijs MerckaertOlivier ZwaenepoelKris GevaertJan Gettemans

A1 Journal Article in BIOMEDICINE & PHARMACOTHERAPY

2020

Development and characterization of protein kinase B/AKT isoform-specific nanobodies

Tijs MerckaertOlivier ZwaenepoelKris GevaertJan Gettemans

A1 Journal Article in PLOS ONE

Nanobody click chemistry for convenient site-specific fluorescent labelling, single step immunocytochemistry and delivery into living cells by photoporation and live cell imaging

Tim HebbrechtJing LiuOlivier ZwaenepoelGaelle BoddinChloé Van LeeneKlaas DecoeneAnnemieke MadderKevin BraeckmansJan Gettemans

A1 Journal Article in NEW BIOTECHNOLOGY

2019

Nb-induced stabilisation of p53 in HPV-infected cells

Anneleen SteelsLaura VannevelOlivier ZwaenepoelJan Gettemans

A1 Journal Article in SCIENTIFIC REPORTS

PET imaging of distinct brain uptake of a nanobody and similarly-sized PAMAM dendrimers after intra-arterial administration

Wojciech G. LesniakChengyan ChuAnna JablonskaBabak Behnam AzadOlivier ZwaenepoelMichal ZawadzkiAla LisokMartin G. PomperPiotr WalczakJan Gettemans et al.

A1 Journal Article in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

2018

Intracellular displacement of p53 using transactivation domain (p53 TAD) specific nanobodies

Anneleen SteelsAdriaan VerhelleOlivier ZwaenepoelJan Gettemans

A1 Journal Article in MABS

Nanobodies targeting cortactin proline rich, helical and actin binding regions downregulate invadopodium formation and matrix degradation in SCC-61 cancer cells

Laurence BertierTim HebbrechtElien MettepenningenNatasja De WitOlivier ZwaenepoelAdriaan VerhelleJan Gettemans

A1 Journal Article in BIOMEDICINE & PHARMACOTHERAPY

2017

AAV9 delivered bispecific nanobody attenuates amyloid burden in the gelsolin amyloidosis mouse model

Adriaan VerhelleNair NishaInge EveraertWouter Van OverbekeLynn SupplyOlivier ZwaenepoelCindy PelemanJo Van DorpeTony LahoutteNick Devoogdt et al.

A1 Journal Article in HUMAN MOLECULAR GENETICS

Inhibitory cortactin nanobodies delineate the role of NTA- and SH3-domain-specific functions during invadopodium formation and cancer cell invasion

Laurence BertierCiska BoucherieOlivier ZwaenepoelBerlinda VanlooMarleen Van TroysIsabel Van AudenhoveJan Gettemans

A1 Journal Article in FASEB JOURNAL

VCA nanobodies target N-WASp to reduce invadopodium formation and functioning

Tim HebbrechtIsabel Van AudenhoveOlivier ZwaenepoelAdriaan VerhelleJan Gettemans

A1 Journal Article in PLOS ONE

2016

A new survivin tracer tracks, delocalizes and captures endogenous survivin at different subcellular locations and in distinct organelles

Els BegheinIsabel Van AudenhoveOlivier ZwaenepoelAdriaan VerhelleAriane De GanckJan Gettemans

A1 Journal Article in SCIENTIFIC REPORTS

Non-invasive imaging of amyloid deposits in a mouse model of AGel using 99mTc-modified nanobodies and SPECT/CT

Adriaan VerhelleWouter Van OverbekeCindy PelemanRebecca De SmetOlivier ZwaenepoelTony LahoutteJo Van DorpeNick DevoogdtJan Gettemans

A1 Journal Article in MOLECULAR IMAGING AND BIOLOGY

2015

An ER-directed gelsolin nanobody targets the first step in amyloid formation in a gelsolin amyloidosis mouse model

Wouter Van OverbekeJantana WongsantichonInge EveraertAdriaan VerhelleOlivier ZwaenepoelAnantasak LoonchantaLeslie D BurtnickAriane De GanckTino HochepiedJody Haigh et al.

A1 Journal Article in HUMAN MOLECULAR GENETICS

2014

A nanobody modulates the p53 transcriptional program without perturbing its functional architecture

Jonas BethuyneSteven De GieterOlivier ZwaenepoelAbel Garcia-PinoKaat DurinckAdriaan VerhelleGholamreza Hassanzadeh-GhassabehFranki SpelemanRemy LorisJan Gettemans

A1 Journal Article in NUCLEIC ACIDS RESEARCH

Chaperone nanobodies protect gelsolin against MT1-MMP degradation and alleviate amyloid burden in the gelsolin amyloidosis mouse model

Wouter Van OverbekeAdriaan VerhelleInge EveraertOlivier ZwaenepoelJoël VandekerckhoveClaude CuvelierWim DeraveJan Gettemans

A1 Journal Article in MOLECULAR THERAPY

Stratifying fascin and cortactin function in invadopodium formation using inhibitory nanobodies and targeted subcellular delocalization

Isabel Van AudenhoveCiska BoucherieLeen PietersOlivier ZwaenepoelBerlinda VanlooEvelien MartensCharlotte VerbruggeGholamreza Hassanzadeh-GhassabehJoël VandekerckhoveMaria Cornelissen et al.

A1 Journal Article in FASEB JOURNAL

2013

A nanobody targeting the F-actin capping protein CapG restrains breast cancer metastasis

Katrien Van ImpeJonas BethuyneSteven CoolFrancis ImpensDavid Ruano-GallegoOlivier De WeverBerlinda VanlooMarleen Van TroysKathleen LambeinCiska Boucherie et al.

A1 Journal Article in BREAST CANCER RESEARCH

Nanobody-induced perturbation of LFA-1/L-plastin phosphorylation impairs MTOC docking, immune synapse formation and T cell activation

Sarah De ClercqOlivier ZwaenepoelEvelien MartensJoël VandekerckhoveAude GuillabertJan Gettemans

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES