Research Explorer

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Researcher

Nozomi Takahashi

51 Results

2022

Executioner caspases 3 and 7 are dispensable for intestinal epithelium turnover and homeostasis at steady state

Farzaneh GhazaviJelle HuysentruytJordy De ConinckStephanie KourulaSofie MartensBehrouz HassanniaTatyana DivertRia RoelandtPeter TougaardTom Vanden BergheMarie JoossensGeert BerxNozomi TakahashiPeter Vandenabeele

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MLKL deficiency in BrafV600EPten-/- melanoma model results in a modest delay of nevi development and reduced lymph node dissemination in male mice

Sofie MartensNozomi TakahashiGillian BlanckeNiels VandammeHanne VerschuereTatyana DivertGeert BerxPeter Vandenabeele

A1 Journal Article in CELL DEATH & DISEASE

Reduced protection of RIPK3-deficient mice against influenza by matrix protein 2 ectodomain targeted active and passive vaccination strategies

Teodora-Eugenia OlteanLorena IbanezTatyana DivertTine YsenbaertHannelore Van EeckhoutteVera GoossensMichael SchotsaertKen BrackeBert SchepensJonathan MaelfaitNozomi TakahashiXavier SaelensPeter Vandenabeele

A1 Journal Article in CELL DEATH & DISEASE

2021

MLKL in cancer : more than a necroptosis regulator

Sofie MartensJolien BridelanceRia RoelandtPeter VandenabeeleNozomi Takahashi

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

2019

Necroptotic proteins in diseases : targeting RIP kinases in inflammatory disorders and exploring the role of MLKL in melanoma development

Sofie MartensPeter VandenabeeleNozomi TakahashiVera Goossens

Survival of single positive thymocytes depends upon developmental control of RIPK1 kinase signaling by the IKK complex independent of NF-κB

Jelle HuysentruytTom Vanden BergheNozomi TakahashiPeter Vandenabeele

A1 Journal Article in IMMUNITY

The ubiquitin-editing enzyme A20 controls NK cell homeostasis through regulation of mTOR activity and TNF

Jessica VettersMary van HeldenSigrid WahlenSimon TavernierArne MartensFarzaneh FayazpourKarl VergoteManon VanheerswynghelsKim DeswarteJustine Van MoorleghemSofie De PrijckNozomi TakahashiPeter VandenabeeleGeert van LooBart LambrechtSophie Janssens

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

2018

Apoptosis of intestinal epithelial cells restricts Clostridium difficile infection in a model of pseudomembranous colitis

Pedro Henrique Viana SaavedraLinyan HuangFarzaneh GhazaviStephanie KourulaTom Vanden BergheNozomi TakahashiPeter VandenabeeleMohamed Lamkanfi

A1 Journal Article in NATURE COMMUNICATIONS

Glucocorticoid receptor dimers control intestinal STAT1 and TNF-induced inflammation in mice

Marlies BallegeerKelly Van LooverenSteven TimmermansMelanie EggermontSofie VandevyverFabien Henri TheryKaren DendonckerJolien SouffriauJolien VandewalleLise Van WyngeneRiet De RyckeNozomi TakahashiPeter VandenabeeleFrancis ImpensRudi BeyaertKarolien De BosscherRoosmarijn VandenbrouckeClaude Libert

A1 Journal Article in JOURNAL OF CLINICAL INVESTIGATION

RIPK1-dependent cell death : a novel target of the Aurora kinase inhibitor Tozasertib (VX-680)

Sofie MartensVera GoossensMarnik VuylstekeNozomi TakahashiPeter Vandenabeele

A1 Journal Article in CELL DEATH & DISEASE

The transcription factor ZEB2 is required to maintain the tissue-specific identities of macrophages

Charlotte ScottWouter T'JonckLiesbet MartensHelena TodorovDorine SichienBieke SoenJohnny BonnardelSofie De PrijckNiels VandammeRobrecht CannoodtWouter SaelensBavo VannesteWendy ToussaintPieter De BleserNozomi TakahashiPeter VandenabeeleBart LambrechtGeert BerxYvan SaeysMartin Guilliams

A1 Journal Article in IMMUNITY

Tozasertib analogues as inhibitors of necroptotic cell death

Sofie MartensTatyana DivertWim NerinckxNozomi TakahashiVera GoossensPeter Vandenabeele

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

2017

Sorafenib tosylate inhibits directly necrosome complex formation and protects in mouse models of inflammation and tissue injury

Sofie MartensVera GoossensNozomi TakahashiPeter Vandenabeele

A1 Journal Article in CELL DEATH & DISEASE

2016

NecroX-7 reduces necrotic core formation in atherosclerotic plaques of Apoe knockout mice

Nozomi TakahashiPeter Vandenabeele

A1 Journal Article in ATHEROSCLEROSIS

The tumor suppressor Hace1 is a critical regulator of TNFR1-mediated cell fate

Mathieu BertrandNozomi TakahashiPeter Vandenabeele

A1 Journal Article in CELL REPORTS

2014

Depletion of RIPK3 or MLKL blocks TNF-driven necroptosis and switches towards a delayed RIPK1 kinase-dependent apoptosis

Quinten RemijsenVera GoossensSasker GrootjansNele VanlangenakkerYves DondelingerRia RoelandtInge BruggemanAmanda GonçalvesMathieu BertrandNozomi TakahashiTom Vanden BerghePeter Vandenabeele

A1 Journal Article in CELL DEATH & DISEASE

Necroptosis, in vivo detection in experimental disease models

Sandrine JouanFranck RiquetLinde DuprezTom Vanden BergheNozomi TakahashiPeter Vandenabeele

A1 Journal Article in SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Necroptosis: a novel way of regulated necrosis with large pathophysiological implications

Peter VandenabeeleTom Vanden BergheNozomi Takahashi

Bookchapter in Pathobiology of human disease : a dynamic encyclopedia of disease mechanisms

RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis

Nozomi TakahashiLars VereeckeMathieu BertrandLinde DuprezTatyana DivertAmanda GonçalvesMozes SzeBarbara GilbertStephanie KourulaVera GoossensSylvie LefebvreWim DeclercqGeert van LooPeter Vandenabeele

A1 Journal Article in NATURE

Simultaneous targeting of IL-1 and IL-18 is required for protection against inflammatory and septic shock

Tom Vanden BergheDieter DemonPieter BogaertBenjamin VandendriesscheAlain GoethalsMarnik VuylstekeRia RoelandtElien Van WonterghemSze Men ChoiEvelyne MeyerWim DeclercqNozomi TakahashiAnje CauwelsPeter Vandenabeele

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The potential role of necroptosis in diseases

Tom Vanden BergheNozomi TakahashiPeter Vandenabeele

Bookchapter in Necrotic cell death

2013

Determination of apoptotic and necrotic cell death in vitro and in vivo

Tom Vanden BergheSasker GrootjansVera GoossensYves DondelingerDmitri KryskoNozomi TakahashiPeter Vandenabeele

A1 Journal Article in METHODS

Necrostatin-1 blocks both RIPK1 and IDO: consequences for the study of cell death in experimental disease models

Peter VandenabeeleSasker GrootjansNico CallewaertNozomi Takahashi

Editorial material

2012

Degradomics reveals that cleavage specificity profiles of caspase-2 and effector caspases are alike

Magdalena WejdaFrancis ImpensNozomi TakahashiPetra Van DammeKris GevaertPeter Vandenabeele

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer

Francesca GrespiNozomi TakahashiPeter VandenabeeleGennaro Melino

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models

Nozomi TakahashiLinde DuprezSasker GrootjansAnje CauwelsWim NerinckxVera GoossensRia RoelandtFilip Van HauwermeirenClaude LibertWim DeclercqNico CallewaertPeter Vandenabeele

A1 Journal Article in CELL DEATH & DISEASE

TRAIL induces necroptosis involving RIPK1/RIPK3-dependent PARP-1 activation

Franky Van HerrewegheNozomi TakahashiPeter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

2011

Dual face apoptotic machinery: from initiator of apoptosis to guardian of necroptosis

Wim DeclercqNozomi TakahashiPeter Vandenabeele

Editorial material

RIP Kinase-dependent necrosis drives lethal systemic inflammatory response syndrome

Linde DuprezNozomi TakahashiFilip Van HauwermeirenBenjamin VandendriesscheVera GoossensTom Vanden BergheWim DeclercqClaude LibertAnje CauwelsPeter Vandenabeele

A1 Journal Article in IMMUNITY

Role of RIP1 in TNF-induced cell death in vitro and in vivo

Linde DuprezPeter VandenabeeleNozomi Takahashi

TLR-2 and TLR-9 are sensors of apoptosis in a mouse model of doxorubicin-induced acute inflammation

Dmitri KryskoAgnieszka KaczmarekOlga KryskoLiesbeth HeyndrickxPieter BogaertAnje CauwelsNozomi TakahashiClaus BachertPeter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

2002

Bioavailability of recombinant tumor necrosis factor determines its lethality in mice.

Paul AmelootNozomi TakahashiBart EveraerdtJeroen HostensWalther FiersPeter Brouckaert

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

1999

Jerusalem of cytokines

Nozomi TakahashiPeter Vandenabeele

Leptin is an endogenous protective protein against the toxicity exerted by Tumor Necrosis Factor

Nozomi TakahashiWim WaelputYves Guisez

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

1996

Inhibition of and sensitization to the lethal effects of tumor necrosis factor

Peter BrouckaertClaude LibertAnje CauwelsPaul AmelootYannick GansemansNozomi TakahashiWalther Fiers

A1 Journal Article in JOURNAL OF INFLAMMATION

TNF receptor p55 plays a major role in centrally mediated increases of serum IL-6 and corticosterone after intracerebroventricular injection of TNF.

Peter VandenabeeleNozomi TakahashiWalther Fiers

A1 Journal Article in JOURNAL OF IMMUNOLOGY

1995

Tolerance as a strategy to broaden the therapeutic margin of tumor necrosis factor (TNF)

Nozomi TakahashiWalther Fiers

1994

Mechanism of induction of tolerance to tumour-necrosis-factor (TNF): No involvement of modulators of TNF bioavailability or receptor-binding.

Nozomi TakahashiPeter BrouckaertWalther Fiers

A1 Journal Article in CYTOKINE

Receptor-selective mutants of tumour necrosis factor in the therapy of cancer : preclinical studies

Peter BrouckaertPaul AmelootAnje CauwelsClaude LibertNozomi TakahashiWalther Fiers

A1 Journal Article in CIRCULATORY SHOCK

Response of interleukin-6-deficient mice to tumor necrosis factor-induced metabolic changes and lethality.

Claude LibertNozomi TakahashiAnje CauwelsPeter BrouckaertWalther Fiers

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

1993

Cyclooxygenase inhibitors prevent the induction of tolerance to the toxic effects of tumor necrosis factor.

Nozomi TakahashiPeter BrouckaertWalther Fiers

A1 Journal Article in JOURNAL OF IMMUNOTHERAPY

Protection against tumor necrosis factor-induced lethality

Claude LibertNozomi TakahashiAnje CauwelsPeter BrouckaertWalther Fiers

Strategies to broaden the therapeutic margin of tumor necrosis factor

Peter BrouckaertClaude LibertNozomi TakahashiAnje CauwelsWalther Fiers

TUMOR-NECROSIS-FACTOR, ITS RECEPTORS AND THE CONNECTION WITH INTERLEUKIN-1 AND INTERLEUKIN-6.

Peter BrouckaertClaude LibertNozomi TakahashiAnje CauwelsWalther Fiers

A1 Journal Article in IMMUNOBIOLOGY

Two pathways of tumor necrosis factor signal transduction: in vitro and in vivo implications

Walther FiersRudi BeyaertPeter BrouckaertAnje CauwelsWim DeclercqDirk De ValckVera GoossensJohan GrootenGuy HaegemanClaude LibertNozomi TakahashiPeter VandenabeeleBart VanhaesebroeckXaveer Van OstadeFrans Van Roy

1992

Tumor necrosis factor : mechanism of action and its potential for anticancer therapy

Rudi BeyaertPeter BrouckaertEls DecosterDirk De ValckJohan GrootenAnne LenaertsClaude LibertNozomi TakahashiCarla Van DorpeBart VanhaesebroeckXaveer Van OstadeFrans Van Roy

Tumor-necrosis-factor : mechanism of action at the molecular, cellular and in vivo level

Walther FiersRudi BeyaertPeter BrouckaertEls DecosterDirk De ValckBart EveraerdtJohan GrootenAnne LenaertsClaude LibertNozomi TakahashiCarla Van DorpeBart VanhaesebroeckXaveer Van OstadeFrans Van Roy

1991

Induction of tolerance allows separation of lethal and antitumor activities of tumor necrosis factor in mice

Nozomi TakahashiPeter BrouckaertWalther Fiers

A1 Journal Article in CANCER RESEARCH

1990

Tumor-necrosis-factor : mechanism of action at the molecular, cellular and in vivo level

Walther FiersRudi BeyaertPeter BrouckaertBart EveraerdtJohan GrootenAnne LenaertsClaude LibertNozomi TakahashiBart VanhaesebroeckXaveer Van OstadeFrans Van Roy

A1 Journal Article in SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION

1989

A role for Interleukin-1 in the invivo actions of tumor necrosis factor

Peter BrouckaertClaude LibertBart EveraerdtNozomi TakahashiWalther Fiers

A1 Journal Article in LYMPHOKINE RESEARCH

Species specificity and involvement of other cytokines in endotoxic shock action of recombinant tumour necrosis factor in mice

Peter BrouckaertClaude LibertNozomi TakahashiWalther Fiers

A1 Journal Article in AGENTS AND ACTIONS