Research Explorer

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Researcher

Nozomi Takahashi

Awards & Distinctions

54 Results

2025

RIPK1 ablation in T cells results in spontaneous enteropathy and TNF-driven villus atrophy

Jelle HuysentruytWolf SteelsMario Ruiz PérezBruno VerstraetenTatyana DivertKayleigh FliesKelly LemeireNozomi TakahashiElke De BruynMarie Joossens et al.

A1 Journal Article in EMBO REPORTS

2024

RIPK1 protects naive and regulatory T cells from TNFR1-induced apoptosis

Jelle HuysentruytWolf SteelsMario Ruiz PérezBruno VerstraetenMike VadiTatyana DivertKayleigh FliesNozomi TakahashiBart LambrechtWim Declercq et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Type 1 immunity enables neonatal thymic ILC1 production

Peter TougaardMario Ruiz PérezWolf SteelsJelle HuysentruytBruno VerstraetenJessica VettersTatyana DivertAmanda GonçalvesRia RoelandtNozomi Takahashi et al.

A1 Journal Article in SCIENCE ADVANCES

2022

Executioner caspases 3 and 7 are dispensable for intestinal epithelium turnover and homeostasis at steady state

Farzaneh GhazaviJelle HuysentruytJordy De ConinckStephanie KourulaSofie MartensBehrouz HassanniaTim WartewigTatyana DivertRia RoelandtBastian Popper et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MLKL deficiency in BrafV600EPten-/- melanoma model results in a modest delay of nevi development and reduced lymph node dissemination in male mice

Sofie MartensNozomi TakahashiGillian BlanckeNiels VandammeHanne VerschuereTatyana DivertMarnik VuylstekeGeert BerxPeter Vandenabeele

A1 Journal Article in CELL DEATH & DISEASE

Reduced protection of RIPK3-deficient mice against influenza by matrix protein 2 ectodomain targeted active and passive vaccination strategies

Teodora-Eugenia OlteanLorena IbanezTatyana DivertTine YsenbaertHannelore Van EeckhoutteVera GoossensMichael SchotsaertKen BrackeBert SchepensJonathan Maelfait et al.

A1 Journal Article in CELL DEATH & DISEASE

2021

MLKL in cancer : more than a necroptosis regulator

Sofie MartensJolien BridelanceRia RoelandtPeter VandenabeeleNozomi Takahashi

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

2019

Necroptotic proteins in diseases : targeting RIP kinases in inflammatory disorders and exploring the role of MLKL in melanoma development

Sofie MartensPeter VandenabeeleNozomi TakahashiVera Goossens

Survival of single positive thymocytes depends upon developmental control of RIPK1 kinase signaling by the IKK complex independent of NF-κB

Louise V WebbAlessandro BarbaruloJelle HuysentruytTom Vanden BergheNozomi TakahashiSteven LeyPeter VandenabeeleBenedict Seddon

A1 Journal Article in IMMUNITY

The ubiquitin-editing enzyme A20 controls NK cell homeostasis through regulation of mTOR activity and TNF

Jessica VettersMary van HeldenSigrid WahlenSimon TavernierArne MartensFarzaneh FayazpourKarl VergoteManon VanheerswynghelsKim DeswarteJustine Van Moorleghem et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

2018

Apoptosis of intestinal epithelial cells restricts Clostridium difficile infection in a model of pseudomembranous colitis

Pedro Henrique Viana SaavedraLinyan HuangFarzaneh GhazaviStephanie KourulaTom Vanden BergheNozomi TakahashiPeter VandenabeeleMohamed Lamkanfi

A1 Journal Article in NATURE COMMUNICATIONS

Glucocorticoid receptor dimers control intestinal STAT1 and TNF-induced inflammation in mice

Marlies BallegeerKelly Van LooverenSteven TimmermansMelanie EggermontSofie VandevyverFabien Henri TheryKaren DendonckerJolien SouffriauJolien VandewalleLise Van Wyngene et al.

A1 Journal Article in JOURNAL OF CLINICAL INVESTIGATION

RIPK1-dependent cell death : a novel target of the Aurora kinase inhibitor Tozasertib (VX-680)

Sofie MartensVera GoossensLars DevisscherSam HofmansPolien ClaeysMarnik VuylstekeNozomi TakahashiKoen AugustynsPeter Vandenabeele

A1 Journal Article in CELL DEATH & DISEASE

The transcription factor ZEB2 is required to maintain the tissue-specific identities of macrophages

Charlotte ScottWouter T'JonckLiesbet MartensHelena TodorovDorine SichienBieke SoenJohnny BonnardelSofie De PrijckNiels VandammeRobrecht Cannoodt et al.

A1 Journal Article in IMMUNITY

Tozasertib analogues as inhibitors of necroptotic cell death

Sam HofmansLars DevisscherSofie MartensDries Van RompaeyKenneth GoossensTatyana DivertWim NerinckxNozomi TakahashiHans De WinterPieter Van der Veken et al.

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

2017

Sorafenib tosylate inhibits directly necrosome complex formation and protects in mouse models of inflammation and tissue injury

Sofie MartensManhyung JeongWulf TonnusFriederike FeldmannSam HofmansVera GoossensNozomi TakahashiJan Hinrich BraesenEun-Woo LeePieter Van der Veken et al.

A1 Journal Article in CELL DEATH & DISEASE

2016

NecroX-7 reduces necrotic core formation in atherosclerotic plaques of Apoe knockout mice

Mandy OJ GrootaertDorien M SchrijversHanne Van SpaendonkAnnelies BreynaertNina HermansViviane O Van HoofNozomi TakahashiPeter VandenabeeleSoon Ha KimGuido RY De Meyer et al.

A1 Journal Article in ATHEROSCLEROSIS

The tumor suppressor Hace1 is a critical regulator of TNFR1-mediated cell fate

Luigi TortolaRoberto NitschMathieu BertrandMelanie KoglerYounes RedouaneIvona KozieradzkiIris UribesalgoLilian M FennellMads DaugaardHelene Klug et al.

A1 Journal Article in CELL REPORTS

2014

Depletion of RIPK3 or MLKL blocks TNF-driven necroptosis and switches towards a delayed RIPK1 kinase-dependent apoptosis

Quinten RemijsenVera GoossensSasker GrootjansC Van den HauteNele VanlangenakkerYves DondelingerRia RoelandtInge BruggemanAmanda GonçalvesMathieu Bertrand et al.

A1 Journal Article in CELL DEATH & DISEASE

Necroptosis, in vivo detection in experimental disease models

Sandrine Jouan-LanhouetFranck RiquetLinde DuprezTom Vanden BergheNozomi TakahashiPeter Vandenabeele

A1 Journal Article in SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Necroptosis: a novel way of regulated necrosis with large pathophysiological implications

Peter VandenabeeleTom Vanden BergheNozomi Takahashi

Bookchapter in Pathobiology of human disease : a dynamic encyclopedia of disease mechanisms

RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis

Nozomi TakahashiLars VereeckeMathieu BertrandLinde DuprezScott B BergerTatyana DivertAmanda GonçalvesMozes SzeBarbara GilbertStephanie Kourula et al.

A1 Journal Article in NATURE

Simultaneous targeting of IL-1 and IL-18 is required for protection against inflammatory and septic shock

Tom Vanden BergheDieter DemonPieter BogaertBenjamin VandendriesscheAlain GoethalsBart DepuydtMarnik VuylstekeRia RoelandtElien Van WonterghemJill Vandenbroecke et al.

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The potential role of necroptosis in diseases

Andreas LinkermannTom Vanden BergheNozomi TakahashiUlrich KunzendorfStefan KrautwaldPeter Vandenabeele

Bookchapter in Necrotic cell death

2013

Determination of apoptotic and necrotic cell death in vitro and in vivo

Tom Vanden BergheSasker GrootjansVera GoossensYves DondelingerDmitri KryskoNozomi TakahashiPeter Vandenabeele

A1 Journal Article in METHODS

Necrostatin-1 blocks both RIPK1 and IDO: consequences for the study of cell death in experimental disease models

Peter VandenabeeleSasker GrootjansNico CallewaertNozomi Takahashi

Editorial material

2012

Degradomics reveals that cleavage specificity profiles of caspase-2 and effector caspases are alike

Magdalena WejdaFrancis ImpensNozomi TakahashiPetra Van DammeKris GevaertPeter Vandenabeele

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer

Paola TucciMassimiliano AgostiniFrancesca GrespiElke K MarkertAlessandro TerrinoniKaren H VousdenPatricia AJ MullerVolker DötschSebastian KehrloesserBerna S Sayan et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models

Nozomi TakahashiLinde DuprezSasker GrootjansAnje CauwelsWim NerinckxJB DuHadawayVera GoossensRia RoelandtFilip Van HauwermeirenClaude Libert et al.

A1 Journal Article in CELL DEATH & DISEASE

TRAIL induces necroptosis involving RIPK1/RIPK3-dependent PARP-1 activation

S Jouan-LanhouetMI ArshadC Piquet-PellorceC Martin-ChoulyG Le Moigne-MullerFranky Van HerrewegheNozomi TakahashiO SergentD Lagadic-GossmannPeter Vandenabeele et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

2011

Dual face apoptotic machinery: from initiator of apoptosis to guardian of necroptosis

Wim DeclercqNozomi TakahashiPeter Vandenabeele

Editorial material

RIP Kinase-dependent necrosis drives lethal systemic inflammatory response syndrome

Linde DuprezNozomi TakahashiFilip Van HauwermeirenBenjamin VandendriesscheVera GoossensTom Vanden BergheWim DeclercqClaude LibertAnje CauwelsPeter Vandenabeele

A1 Journal Article in IMMUNITY

Role of RIP1 in TNF-induced cell death in vitro and in vivo

Linde DuprezPeter VandenabeeleNozomi Takahashi

TLR-2 and TLR-9 are sensors of apoptosis in a mouse model of doxorubicin-induced acute inflammation

Dmitri KryskoAgnieszka KaczmarekOlga KryskoLiesbeth HeyndrickxJerzy WoznickiPieter BogaertAnje CauwelsNozomi TakahashiS MagezClaus Bachert et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

2002

Bioavailability of recombinant tumor necrosis factor determines its lethality in mice.

Paul AmelootNozomi TakahashiBart EveraerdtJeroen HostensHP EUGSTERWalter FiersPeter Brouckaert

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

1999

Jerusalem of cytokines

Ben-Zion LeviAntonio SicaGerhard Müller-NewenNozomi TakahashiPeter VandenabeeleEleanor Fish

Leptin is an endogenous protective protein against the toxicity exerted by Tumor Necrosis Factor

Nozomi TakahashiWim WaelputYves Guisez

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

1996

Inhibition of and sensitization to the lethal effects of tumor necrosis factor

Peter BrouckaertClaude LibertAnje CauwelsBart EveraerdtWim Van MollePaul AmelootYannick GansemansBernardo GrijalbaNozomi TakahashiMarie-José Truong et al.

A1 Journal Article in JOURNAL OF INFLAMMATION

TNF receptor p55 plays a major role in centrally mediated increases of serum IL-6 and corticosterone after intracerebroventricular injection of TNF.

F BENIGNIR FAGGIONIM SIRONIG FANTUZZIPeter VandenabeeleNozomi TakahashiS SACCOWalter FiersWA BUURMANP GHEZZI

A1 Journal Article in JOURNAL OF IMMUNOLOGY

1995

Tolerance as a strategy to broaden the therapeutic margin of tumor necrosis factor (TNF)

Nozomi TakahashiWalter Fiers

1994

Mechanism of induction of tolerance to tumour-necrosis-factor (TNF): No involvement of modulators of TNF bioavailability or receptor-binding.

Nozomi TakahashiPeter BrouckaertMHA BEMELMANSWA BUURMANWalter Fiers

A1 Journal Article in CYTOKINE

Receptor-selective mutants of tumour necrosis factor in the therapy of cancer : preclinical studies

Peter BrouckaertPaul AmelootAnje CauwelsBart EveraerdtClaude LibertNozomi TakahashiWim Van MolleWalter Fiers

A1 Journal Article in CIRCULATORY SHOCK

Response of interleukin-6-deficient mice to tumor necrosis factor-induced metabolic changes and lethality.

Claude LibertNozomi TakahashiAnje CauwelsPeter BrouckaertH BLUETHMANNWalter Fiers

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

1993

Cyclooxygenase inhibitors prevent the induction of tolerance to the toxic effects of tumor necrosis factor.

Nozomi TakahashiPeter BrouckaertWalter Fiers

A1 Journal Article in JOURNAL OF IMMUNOTHERAPY

Protection against tumor necrosis factor-induced lethality

Claude LibertBart EveraerdtNozomi TakahashiAnje CauwelsPeter BrouckaertWalter Fiers

Strategies to broaden the therapeutic margin of tumor necrosis factor

Peter BrouckaertBart EveraerdtClaude LibertNozomi TakahashiAnje CauwelsWalter Fiers

TUMOR-NECROSIS-FACTOR, ITS RECEPTORS AND THE CONNECTION WITH INTERLEUKIN-1 AND INTERLEUKIN-6.

Peter BrouckaertClaude LibertB EVERAERDTNozomi TakahashiAnje CauwelsWalter Fiers

A1 Journal Article in IMMUNOBIOLOGY

Two pathways of tumor necrosis factor signal transduction: in vitro and in vivo implications

Walter FiersRudi BeyaertPeter BrouckaertAnje CauwelsWim DeclercqDirk De ValckB EveraerdtVera GoossensJohan GrootenGuy Haegeman et al.

1992

Tumor necrosis factor : mechanism of action and its potential for anticancer therapy

W HersRudi BeyaertPeter BrouckaertEls DecosterDirk De ValckB EveraerdtJohan GrootenAnne LenaertsClaude LibertK Schulze-Osthoff et al.

Tumor-necrosis-factor : mechanism of action at the molecular, cellular and in vivo level

Walter FiersRudi BeyaertPeter BrouckaertEls DecosterDirk De ValckBart EveraerdtJohan GrootenAnne LenaertsClaude LibertK. Schulzeosthoff et al.

1991

Induction of tolerance allows separation of lethal and antitumor activities of tumor necrosis factor in mice

Nozomi TakahashiPeter BrouckaertWalter Fiers

A1 Journal Article in CANCER RESEARCH

1990

Tumor-necrosis-factor : mechanism of action at the molecular, cellular and in vivo level

Walter FiersRudi BeyaertPeter BrouckaertBart EveraerdtJohan GrootenAnne LenaertsClaude LibertP. SuffysNozomi TakahashiJan Tavernier et al.

A1 Journal Article in SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION

1989

A role for Interleukin-1 in the invivo actions of tumor necrosis factor

Peter BrouckaertClaude LibertBart EveraerdtNozomi TakahashiWalter Fiers

A1 Journal Article in LYMPHOKINE RESEARCH

Species specificity and involvement of other cytokines in endotoxic shock action of recombinant tumour necrosis factor in mice

Peter BrouckaertBart EveraerdtClaude LibertNozomi TakahashiWalter Fiers

A1 Journal Article in AGENTS AND ACTIONS