Research Explorer

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Researcher

Nincy Debeuf

Publications & Research Data

Awards & Distinctions

20 Results

2025

GM-CSF and specific type 2 cytokines induce CD103+and CD301b+cell states in cDC1s and cDC2s

Lukas AmonDamir VurnekAnna SeichterGiorgi TchitashviliTomasz KaszubowskiMarkus MrozNincy DebeufTina VoglerNicole KuepperKaushikk Ravi Rengarajan et al.

A1 Journal Article in CELL REPORTS

Maternal allergy and neonatal RSV infection synergize via FcR-mediated allergen uptake to promote the development of asthma in early life

Elisabeth De LeeuwJosefine F. JustesenCedric BosteelsNincy DebeufManon VanheerswynghelsLeander JonckheereCaroline De WolfAlysia WayenbergKarel Van DammeStijn Vanhee et al.

A1 Journal Article in SCIENCE IMMUNOLOGY

Ultrapotent SARS coronavirus-neutralizing single-domain antibodies that clamp the spike at its base

Sieglinde De CaeInge Van MolleLoes van SchieSophie R. ShoemakerJulie DeckersNincy DebeufSahine LameireWim NerinckxKenny RooseDaria Fijalkowska et al.

A1 Journal Article in NATURE COMMUNICATIONS

2024

Inhaled GM-CSF administered during ongoing pneumovirus infection alters myeloid and CD8 T cell immunity without affecting disease outcome

Nincy DebeufJulie DeckersSahine LameireCedric BosteelsHamida HammadBart Lambrecht

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

TCR transgenic clone selection guided by immune receptor analysis and single-cell RNA expression of polyclonal responders

Nincy DebeufSahine LameireManon VanheerswynghelsJulie DeckersCaroline De WolfWendy ToussaintRein VerbekeKevin VerstaenHamida HammadStijn Vanhee et al.

A2 Journal Article in ELIFE

2023

A Complement Atlas identifies interleukin 6 dependent alternative pathway dysregulation as a key druggable feature of COVID-19

Karel Van DammeLevi HosteJozefien DeclercqElisabeth De LeeuwBastiaan MaesLiesbet MartensRoos ColmanRobin BrowaeysCedric BosteelsStijn Verwaerde et al.

A complement atlas identifies interleukin-6-dependent alternative pathway dysregulation as a key druggable feature of COVID-19

Karel Van DammeLevi HosteJozefien DeclercqElisabeth De LeeuwBastiaan MaesLiesbet MartensRoos ColmanRobin BrowaeysCedric BosteelsStijn Verwaerde et al.

A1 Journal Article in SCIENCE TRANSLATIONAL MEDICINE

2022

Efficacy and safety of the investigational complement C5 inhibitor zilucoplan in patients hospitalized with COVID-19 : an open-label randomized controlled trial

Elisabeth De LeeuwKarel Van DammeJozefien DeclercqCedric BosteelsBastiaan MaesSimon TavernierLaurent DetalleTrevor SmartSophie GlattNincy Debeuf et al.

A1 Journal Article in RESPIRATORY RESEARCH

Emerging paradigms in type 2 immunity

Hamida HammadNincy DebeufHelena Catharine AegerterAndrew BrownBart Lambrecht

A1 Journal Article in ANNUAL REVIEW OF IMMUNOLOGY

Loss of GM-CSF-dependent instruction of alveolar macrophages in COVID-19 provides a rationale for inhaled GM-CSF treatment

Cedric BosteelsKarel Van DammeElisabeth De LeeuwJozefien DeclercqBastiaan MaesVictor BosteelsLevi HosteLeslie NaesensNincy DebeufJulie Deckers et al.

A1 Journal Article in CELL REPORTS MEDICINE

The STE20 kinase TAOK3 controls the development of house dust mite-induced asthma in mice

Bastiaan MaesUrsula SmoleMatthias VanderkerkenKim DeswarteJustine Van MoorleghemKarl VergoteManon VanheerswynghelsCaroline De WolfSofie De PrijckNincy Debeuf et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

2021

IRE1 beta does not affect mucus secretion during allergic asthma development in a house dust mite murine model

Eva ClootsNincy DebeufKim DeswarteFarzaneh FayazpourManon VanheerswynghelsCaroline De WolfEvelien Van de VeldeHamida HammadBart LambrechtSven Eyckerman et al.

A1 Journal Article in ALLERGY

2020

Inflammatory type 2 cDCs acquire features of cDC1s and macrophages to orchestrate immunity to respiratory virus infection

Cedric BosteelsKatrijn NeytManon VanheerswynghelsMary van HeldenDorine SichienNincy DebeufSofie De PrijckVictor BosteelsNiels VandammeLiesbet Martens et al.

A1 Journal Article in IMMUNITY

2019

ORMDL3 in the regulation of sphingolipid synthesis and in the pathogenesis of allergic asthma

Nincy DebeufBart LambrechtSophie Janssens

The ORMDL3 asthma susceptibility gene regulates systemic ceramide levels without altering key asthma features in mice

Nincy DebeufAssem ZhakupovaRegula SteinerSofie Van GassenKim DeswarteFarzaneh FayazpourJustine Van MoorleghemKarl VergoteBenjamin PavieKelly Lemeire et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

2018

Eicosanoid control over antigen presenting cells in asthma

Nincy DebeufBart Lambrecht

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

2017

Murine models of allergic asthma

Eline HaspeslaghNincy DebeufHamida HammadBart Lambrecht

Bookchapter in Inflammation : methods and protocols

2016

Mouse models of asthma

Nincy DebeufEline HaspeslaghMary van HeldenHamida HammadBart Lambrecht

Bookchapter in Current protocols in mouse biology

ORMDL3 expression levels have no influence on the activity of serine palmitoyltransferase

Assem ZhakupovaNincy DebeufMichiel KrolsWendy ToussaintLeen VanhoutteIrina AlecuZoltán KutalikPeter VollenweiderDaniela ErnstArnold von Eckardstein et al.

A1 Journal Article in FASEB JOURNAL

2015

Fascin actin bundling controls podosome turnover and disassembly while cortactin is involved in podosome assembly by its SH3 domain in THP-1 macrophages and dendritic cells

Isabel Van AudenhoveNincy DebeufCiska BoucherieJan Gettemans

A1 Journal Article in BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH