Research Explorer

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Researcher

Nina Van Opdenbosch

Awards & Distinctions

24 Results

2022

Bacillus anthracis induces NLRP3 inflammasome activation and caspase-8-mediated apoptosis of macrophages to promote lethal anthrax

Filip Van HauwermeirenNina Van OpdenboschHanne Van GorpNathalia de VasconcelosGeert van LooPeter VandenabeeleThirumala-Devi KannegantiMohamed Lamkanfi

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GSDMD drives canonical inflammasome-induced neutrophil pyroptosis and is dispensable for NETosis

Dhruv ChauhanDieter DemonLieselotte Vande WalleOonagh PaerewijckAnnalisa ZecchinLeslie BosselerKarin SantoniRemi PlanesSilvia Ribó GenéAmelie Fossoul et al.

A1 Journal Article in EMBO REPORTS

2020

An apoptotic caspase network safeguards cell death induction in pyroptotic macrophages

Nathalia Moraes de VasconcelosNina Van OpdenboschHanne Van GorpRosa Martin-PerezAnnalisa ZecchinPeter VandenabeeleMohamed Lamkanfi

A1 Journal Article in CELL REPORTS

2019

Caspases in cell death, inflammation, and disease

Nina Van OpdenboschMohamed Lamkanfi

A1 Journal Article in IMMUNITY

DPP8/DPP9 inhibition elicits canonical Nlrp1b inflammasome hallmarks in murine macrophages

Nathalia Moraes de VasconcelosGwendolyn VliegenAmanda GonçalvesEmilie De HertRosa Martín-PérezNina Van OpdenboschAnvesh JallapallyRuth Geiss-FriedlanderAnne-Marie LambeirKoen Augustyns et al.

A2 Journal Article in LIFE SCIENCE ALLIANCE

Inflammasome-dependent cytokines at the crossroads of health and autoinflammatory disease

Hanne Van GorpNina Van OpdenboschMohamed Lamkanfi

A1 Journal Article in COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY

Single-cell analysis of pyroptosis dynamics reveals conserved GSDMD-mediated subcellular events that precede plasma membrane rupture

Nathalia Moraes de VasconcelosNina Van OpdenboschHanne Van GorpEef ParthoensMohamed Lamkanfi

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

2017

Caspase-1 engagement and TLR-induced c-FLIP expression suppress ASC/caspase-8-dependent apoptosis by inflammasome sensors NLRP1b and NLRC4

Nina Van OpdenboschHanne Van GorpMaarten VerdoncktPedro Henrique Viana SaavedraNathalia Moraes de VasconcelosAmanda GonçalvesLieselotte Vande WalleDieter DemonMagdalena MatusiakFilip Van Hauwermeiren et al.

A1 Journal Article in CELL REPORTS

2016

Does caspase-12 suppress inflammasome activation?

Lieselotte Vande WalleDaniel Jiménez FernandezDieter DemonNaomi Van LaethemFilip Van HauwermeirenHanne Van GorpNina Van OpdenboschNobuhiko KayagakiMohamed Lamkanfi

A1 Journal Article in NATURE

Familial Mediterranean fever mutations lift the obligatory requirement for microtubules in Pyrin inflammasome activation

Hanne Van GorpPedro Henrique Viana SaavedraNathalia Moraes de VasconcelosNina Van OpdenboschLieselotte Vande WalleMagdalena MatusiakGiusi PrencipeAntonella InsalacoFilip Van HauwermeirenDieter Demon et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammasomes as polyvalent cell death platforms

Nathalia Moraes de VasconcelosNina Van OpdenboschMohamed Lamkanfi

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

Inflammasomes in inflammatory disease

Hanne Van GorpPedro Henrique Viana SaavedraNathalia Moraes de VasconcelosNina Van OpdenboschLieselotte Vande WalleMagdalena MatusiakFilip Van HauwermeirenG. PrencipeDelfien BogaertMelissa Dullaers et al.

2015

CARD- and pyrin-only proteins regulating inflammasome activation and immunity

Magdalena MatusiakNina Van OpdenboschMohamed Lamkanfi

A1 Journal Article in IMMUNOLOGICAL REVIEWS

Flagellin-induced NLRC4 phosphorylation primes the inflammasome for activation by NAIP5

Magdalena MatusiakNina Van OpdenboschLieselotte Vande WalleJean-Claude SirardThirumala-Devi KannegantiMohamed Lamkanfi

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

2014

Activation of the NLRP1b inflammasome independently of ASC-mediated caspase-1 autoproteolysis and speck formation

Nina Van OpdenboschPrajwal GurungLieselotte Vande WalleAmelie FossoulThirumala-Devi KannegantiMohamed Lamkanfi

A1 Journal Article in NATURE COMMUNICATIONS

FADD and Caspase-8 mediate priming and activation of the canonical and noncanonical Nlrp3 inflammasomes

Prajwal GurungParas K AnandRK Subbarao MalireddiLieselotte Vande WalleNina Van OpdenboschChristopher P DillonRicardo WeinlichDouglas R GreenMohamed LamkanfiThirumala-Devi Kanneganti

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis

Lieselotte Vande WalleNina Van OpdenboschPeggy JacquesAmelie FossoulEveline VerheugenPeter VogelRudi BeyaertDirk ElewautThirumala-Devi KannegantiGeert van Loo et al.

A1 Journal Article in NATURE

2012

Histone modifications in herpesvirus infections

Nina Van OpdenboschHerman FavoreelGerlinde Van de Walle

A1 Journal Article in BIOLOGY OF THE CELL

The IE180 protein of pseudorabies virus suppresses phosphorylation of translation initiation factor eIF2 alpha

Nina Van OpdenboschCeline Van den BroekeNick De ReggeE TabarésHerman Favoreel

A1 Journal Article in JOURNAL OF VIROLOGY

2011

A triple entente? : interplay between alphaherpesviruses and interferon in sensory neuronal cells

Nina Van OpdenboschHerman FavoreelNick De Regge

Effects of interferon on immediate-early mRNA and protein levels in sensory neuronal cells infected with herpes simplex virus type 1 or pseudorabies virus

Nina Van OpdenboschNick De ReggeMario Van PouckeLuc PeelmanHerman Favoreel

A1 Journal Article in VETERINARY MICROBIOLOGY

2010

Alphaherpesvirus use and misuse of cellular actin and cholesterol

Herman FavoreelCeline Van den BroekeAnn DesplanquesMatthias DeruelleG Van MinnebruggenHans NauwynckSarah GlorieuxNina Van OpdenboschNick De Regge

A1 Journal Article in VETERINARY MICROBIOLOGY

Interferon alpha induces establishment of Alphaherpesvirus latency in sensory neurons in vitro

Nick De ReggeNina Van OpdenboschHans NauwynckStacey EfstathiouHerman Favoreel

A1 Journal Article in PLOS ONE

Interferon alpha suppresses alphaherpesvirus immediate early protein levels in sensory neurons, leading to the establishment of a latent infection

Nina Van OpdenboschNick De ReggeMario Van PouckeLuc PeelmanHerman Favoreel