Research Explorer

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Researcher

Niels Nicolaï

Awards & Distinctions

17 Results

2021

Two-dimensional moisture content and size measurement of pharmaceutical granules after fluid bed drying using near-infrared chemical imaging

Michael GhijsBrecht VanbillemontNiels NicolaïThomas De BeerIngmar Nopens

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

2020

Model-based optimisation and control strategy for the primary drying phase of a lyophilisation process

Brecht VanbillemontNiels NicolaïLaurens LeysThomas De Beer

A1 Journal Article in PHARMACEUTICS

2019

A model predictive control strategy of the dynamic primary drying settings for a batch freeze-drying process

Brecht VanbillemontNiels NicolaïLaurens LeysThomas De Beer

Model-based investigation of the performance of a novel aeration system in the Dommel river

Andreia Neves do AmaralUsman RehmanT. FlamelingNiels NicolaïYouri AmerlinckIngmar Nopens

Process control levels for continuous pharmaceutical tablet manufacturing

Niels NicolaïIngmar NopensMaxim VerstraetenThomas De Beer

Bookchapter in Chemical engineering in the pharmaceutical industry : drug product design, development, and modeling

Supervisory process monitoring, identification and control for continuous pharmaceutical wet granulation

Niels NicolaïIngmar NopensThomas De BeerKrist V Gernaey

2018

A model predictive control strategy of the dynamic primary drying settings for a batch freeze drying process

Brecht VanbillemontNiels NicolaïJos CorverThomas De Beer

Control of three different continuous pharmaceutical manufacturing processes : use of soft sensors

Jakob RehrlAnssi-Pekka KarttunenNiels NicolaïTheresa HoermannMartin HornOssi KorhonenIngmar NopensThomas De BeerJohannes G Khinast

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Liquid-to-solid ratio control as an advanced process control solution for continuous twin-screw wet granulation

Niels NicolaïFien De LeersnyderDana CopotMichiel StockClara-Mihaela IonescuKrist V GernaeyIngmar NopensThomas De Beer

A1 Journal Article in AICHE JOURNAL

2017

Advanced process control practices for continuous pharmaceutical twin-screw wet granulation

Niels NicolaïIngmar NopensKrist V GernaeyThomas De Beer

Applying inline spatial filter velocimetry to improve process robustness of a continuous twin-screw wet granulator

Niels NicolaïIngmar NopensKrist V GernaeyThomas De Beer

Practical implementation of dynamic primary drying settings in a continuous freeze-drying process

Brecht VanbillemontNiels NicolaïPieter-Jan Van BockstalLaurens De MeyerSéverine MortierJos CorverChris VervaetThomas De Beer

2016

Analysis of inline spatial filter velocimetry for granule size feedback control of a continuous pharmaceutical twin-screw granulator

Niels NicolaïIngmar NopensKrist V GernaeyThomas De Beer

Applying supervisory process control practices to continuous pharmaceutical manufacturing

Niels NicolaïIngmar NopensKrist V GernaeyThomas De Beer

Rietvelden en algenvijvers bepalen toekomst van water in het Zuiden

2015

Towards model-based control of granule moisture content during continuous wet granulation

Niels NicolaïKrist V GernaeyIngmar NopensThomas De Beer

2014

Development of critical quality attributes control strategies in a continuous high shear wet granulation process

Niels NicolaïThomas De BeerKrist V GernaeyIngmar Nopens