Research Explorer

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Researcher

Niels Geudens

Publications & Research Data

Awards & Distinctions

63 Results

2025

Structural and dynamic insights into the loss of activity of Tolaasin I, an antimicrobial cyclic lipopeptide

Durga PrasadJosé MartinsBenjámin KovácsNiels GeudensMonica Höfte

Temperature-dependent production of cyclic lipopeptides by Pseudomonas fuscovaginae UPB0736 and its impact on Rhizoctonia solani suppression

Jasmine De RopDurga PrasadNiels GeudensLu ZhouBishnu MarahattaPieter SpanogheJosé MartinsMonica Höfte

A2 Journal Article in MICROBE

2024

Breaking cycles : saponification‐enhanced NMR fingerprint matching for the identification and stereochemical evaluation of cyclic lipodepsipeptides from natural sources

Penthip MuangkaewDurga PrasadVic De RooYentl VerleysenLu ZhouRené De MotMonica HöfteAnnemieke MadderNiels GeudensJosé Martins

A1 Journal Article in CHEMISTRY-A EUROPEAN JOURNAL

Time-resolved fluorescence of tryptophan characterizes membrane perturbation by cyclic lipopeptides

Iulia CarabadjacJessica SteigenbergerNiels GeudensVic De RooPenthip MuangkaewAnnemieke MadderJosé MartinsHeiko Heerklotz

A1 Journal Article in BIOPHYSICAL JOURNAL

2023

Charting the lipopeptidome of nonpathogenic Pseudomonas

Catherine Cesa-LunaNiels GeudensLea GirardVic De RooHassan R. MakladJosé MartinsMonica HöfteRene De Mot

A1 Journal Article in MSYSTEMS

Complex electrostatic effects on the selectivity of membrane-permeabilizing cyclic lipopeptides

Jessica SteigenbergerYentl VerleysenNiels GeudensAnnemieke MadderJosé MartinsHeiko Heerklotz

A1 Journal Article in BIOPHYSICAL JOURNAL

Stereomeric lipopeptides from a single non-ribosomal peptide synthetase as an additional source of structural and functional diversification in pseudomonas lipopeptide biosynthesis

Penthip MuangkaewVic De RooLu ZhouLéa GirardCatherine Cesa-LunaMonica HöfteRené De MotAnnemieke MadderNiels GeudensJosé Martins

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Structural and dynamic insights into the loss of activity of tolaasin I : an exploration of helical dynamics

Durga PrasadBenjámin KovácsNiels GeudensJosé Martins

2022

Altering in vivo membrane sterol composition affects the activity of the cyclic lipopeptides tolaasin and sessilin against Pythium

Enrico FerrariniVic De RooNiels GeudensJosé MartinsMonica Höfte

A1 Journal Article in BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

An nuclear magnetic resonance fingerprint matching approach for the identification and structural re-evaluation of Pseudomonas lipopeptides

Vic De RooYentl VerleysenBenjámin KovácsMatthias De VleeschouwerPenthip MuangkaewLéa GirardMonica HöfteRené De MotAnnemieke MadderNiels Geudens et al.

A1 Journal Article in MICROBIOLOGY SPECTRUM

Structure-function relationships of membrane permeabilizing cyclic lipopeptides : be prepared for surprises

Jessica SteigenbergerYentl VerleysenNiels GeudensVic De RooJosé MartinsHeiko Heerklotz

The effect of membrane thickness on the membrane permeabilizing activity of the cyclic lipopeptide tolaasin II

Jessica SteigenbergerCatherine MergenVic De RooNiels GeudensJosé MartinsHeiko Heerklotz

A1 Journal Article in FRONTIERS IN MOLECULAR BIOSCIENCES

The impact of macrocycle formation on the conformation of Tolaasin I as revealed by NMR spectroscopy

Durga PrasadBenjámin KovácsDries RoelandtNiels GeudensJosé Martins

Towards a molecular understanding of the membrane altering properties of viscosin, a cyclic lipodepsipeptide

Vic De RooNiels GeudensYentl VerleysenTzong Hsien LeeAnnemieke MadderMarie-Isabel AguilarJosé Martins

Transporter gene-mediated typing for detection and genome mining of lipopeptide-producing Pseudomonas

Lea GirardNiels GeudensBrent PauwelsMonica HöfteJosé MartinsRene De Mot

A1 Journal Article in APPLIED AND ENVIRONMENTAL MICROBIOLOGY

2021

Exploring the environment of a cyclic lipopeptide by time-resolved-fluorescence of tryptophan

J. SteigenbergerNiels GeudensBenjámin KovácsVic De RooYentl VerleysenJosé MartinsH. Heerklotz

The optimal lipid chain length of a membrane-permeabilizing lipopeptide results from the balance of membrane partitioning and local damage

Jessica SteigenbergerYentl VerleysenNiels GeudensJosé MartinsHeiko Heerklotz

A1 Journal Article in FRONTIERS IN MICROBIOLOGY

2020

Biosynthesis and antimicrobial activity of pseudodesmin and viscosinamide cyclic lipopeptides produced by pseudomonads associated with the cocoyam rhizosphere

Feyisara Eyiwumi OniNiels GeudensAmayana AdioboOlumide Owolabi OmoboyeElsie Ayamoh EnowJoseph T. OnyekaAyodeji E. SalamiRene De MotJosé MartinsMonica Höfte

A1 Journal Article in MICROORGANISMS

Cyclic lipopeptide‐producing Pseudomonas koreensis group strains dominate the cocoyam rhizosphere of a Pythium root rot suppressive soil contrasting with P. putida prominence in conducive soils

Feyisara Eyiwumi OniNiels GeudensJoseph T. OnyekaOluwatoyin Faith OlorunlekeAyodeji Ekundayo SalamiOlumide Owolabi OmoboyeAnthony Arguelles AriasAmayana AdioboStefaan De NeveMarc Ongena et al.

A1 Journal Article in ENVIRONMENTAL MICROBIOLOGY

2019

Conformation and dynamics of the cyclic lipopeptide viscosinamide at the water-lipid interface

Niels GeudensBenjámin KovácsDavy SinnaeveFeyisara Eyiwumi OniMonica HöfteJosé Martins

A1 Journal Article in MOLECULES

Cyclic lipodepsipeptides across the globe

Niels GeudensYentl VerleysenBenjámin KovácsRené De MotMonica HöfteAnnemieke MadderVic De RooJosé Martins

Fluorescent Pseudomonas and cyclic lipopeptide diversity in the rhizosphere of cocoyam (Xanthosoma sagittifolium)

Feyisara Eyiwumi OniNiels GeudensOlumide Owolabi OmoboyeLien BertierHoang Gia Khuong HuaAmayana AdioboDavy SinnaeveJosé MartinsMonica Höfte

A1 Journal Article in ENVIRONMENTAL MICROBIOLOGY

Pseudomonas sp. COW3 Produces New Bananamide-Type Cyclic Lipopeptides with Antimicrobial Activity against Pythium myriotylum and Pyricularia oryzae

Olumide Owolabi OmoboyeNiels GeudensMatthieu DubanMickael ChevalierChristophe FlahautJosé MartinsValerie LeclereFeyisara Eyiwumi OniMonica Höfte

A1 Journal Article in MOLECULES

The 1,3-diyne linker as a rigid 'i,i+7' staple for α-helix stabilization : stereochemistry at work

Steven VerlindenNiels GeudensKevin Van holsbeeckMorgane MannesJosé MartinsGuido VerniestSteven Ballet

A1 Journal Article in JOURNAL OF PEPTIDE SCIENCE

2018

A full structure analysis of MDN-0066, a recently described cyclic lipodepsipeptide produced by Pseudomonas sp. bacteria

Vic De RooNiels GeudensYentl VerleysenBenjámin KovácsFeyisara Eyiwumi OniMonica HöfteAnnemieke MadderJosé Martins

Breaking the limits of NMR spectroscopy in peptide-membrane interaction studies using isotope labelling

Benjámin KovácsNiels GeudensJosé Martins

Concerted biophysical and biological evaluation of Pseudomonas lipopeptides as a premise to unlock their application potential

José MartinsYentl VerleysenBenjámin KovácsVic De RooChristophe AmpeAnnemieke MadderMarleen Van TroysNiels Geudens

Cyclic lipodepsipeptides : time for a concerted action to unlock their application potential?

Niels GeudensDavy SinnaeveJosé Martins

Editorial material

Cyclic lipodepsipeptides from Pseudomonas spp. : biological Swiss-army knives

Niels GeudensJosé Martins

A1 Journal Article in FRONTIERS IN MICROBIOLOGY

Direct detection of N-H...O=C H-bonds in a 13C- and 15N-labelled cyclic lipodepsipeptide and the investigation of its self-assembly

Benjámin KovácsNiels GeudensJosé Martins

Exploration of CLP antitumor potential

Yentl VerleysenMatthias De VleeschouwerNiels GeudensMarleen Van TroysChristophe AmpeAnnemieke MadderJosé Martins

Form and function : structural variations of natural cyclic lipodepsipeptides

Niels GeudensBenjámin KovácsVic De RooFeyisara Eyiwumi OniMaarten GhequireRené De MotMonica HöfteJosé Martins

Influence of CLP structure on antitumor potential

Yentl VerleysenMatthias De VleeschouwerNiels GeudensTim Van KersavondArend MandelingsMarleen Van TroysChristophe AmpeAnnemieke MadderJosé Martins

Membrane interactions of cyclic lipodepsipeptides

Niels GeudensMehmet Nail NasirJean-Marc CrowetLaurence LinsMagali DeleuDavy SinnaeveJosé Martins

Membrane interactions of natural cyclic lipodepsipeptides

Niels GeudensBenjámin KovácsDavy SinnaeveJosé Martins

2017

Form and function : structural variations of natural cyclic lipodepsipeptides

Niels GeudensBenjámin KovácsVic De RooFeyisara Eyiwumi OniMaarten GhequireRené De MotMonica HöfteJosé Martins

Insights in the structure-function and membrane interactions of natural cyclic lipodepsipeptides

Niels GeudensJosé MartinsDavy Sinnaeve

Membrane interactions of natural cyclic lipodepsipeptides of the viscosin group

Niels GeudensMehmet Nail NasirJean-Marc CrowetJos M RaaijmakersKrisztina FehérTom CoenyeJosé MartinsLaurence LinsDavy SinnaeveMagali Deleu

A1 Journal Article in BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Role of cyclic lipopeptides produced by Pseudomonas spp. in biocontrol

Monica HöfteFeyisara Eyiwumi OniOlumide Owolabi OmoboyeNiels GeudensZongwang MaAnthony Argüelles AriasMarc OngenaJosé Martins

2016

Biosynthesis, chemical structure, and structure-activity relationship of orfamide lipopeptides produced by Pseudomonas protegens and related species

Zongwang MaNiels GeudensNam Kieu PhuongDavy SinnaeveMarc OngenaJosé MartinsMonica Höfte

A1 Journal Article in FRONTIERS IN MICROBIOLOGY

Membrane interactions of natural cyclic lipodepsipeptides

Niels GeudensMehmet Nail NasirJean-Marc CrowetLaurence LinsMagali DeleuJosé MartinsDavy Sinnaeve

Rhizosphere diversity of fluorescent pseudomonads and cyclic lipopeptides correlates with cocoyam (Xanthosoma sagittifolium) resilience to the Pythium root rot disease

Feyisara Eyiwumi OniNiels GeudensOlumide Owolabi OmoboyeLien BertierAmayana AdioboJoseph OnyekaAyodeji SalamiDavy SinnaeveJosé MartinsMonica Höfte

2015

Diversity of fluorescent Pseudomonas sp. associated with the cocoyam rhizosphere and its influence on soil suppressiveness to the root rot disease caused by P. myriotylum

Feyisara Eyiwumi OniNiels GeudensJosé MartinsMonica Höfte

Fluorescent Pseudomonas spp. and cyclic lipopeptide diversity in the cocoyam rhizosphere and their relation with soil suppressiveness against the root rot disease

Feyisara Eyiwumi OniNiels GeudensOluwatoyin Faith OlorunlekeOlumide Owolabi OmoboyeAmayana AdioboDavy SinnaeveJosé MartinsMonica Höfte

Fluorescent Pseudomonas spp. and cyclic lipopeptides diversity in the cocoyam rhizosphere and their relation with soil suppressiveness against the root rot disease caused by P. myriotylum

Feyisara Eyiwumi OniNiels GeudensJosé MartinsMonica Höfte

Membrane interactions of cyclic lipodepsipeptides

Niels GeudensMehmet Nail NasirJean-Marc CrowetKrisztina FehérTom CoenyeLaurence LinsMagali DeleuJosé MartinsDavy Sinnaeve

Membrane interactions of cyclic lipodepsipeptides

Niels GeudensMehmet Nail NasirJean-Marc CrowetKrisztina FehérLaurence LinsMagali DeleuJosé MartinsDavy Sinnaeve

Membrane Interactions of Cyclic Lipodepsipeptides

Niels GeudensMehmet Nail NasirJean-Marc CrowetKrisztina FehérTom CoenyeLaurence LinsMagali DeleuJosé MartinsDavy Sinnaeve

Oxidative α,ω-diyne coupling as an approach towards novel peptidic macrocycles

Steven VerlindenNiels GeudensJosé MartinsDirk TourwéSteven BalletGuido Verniest

A1 Journal Article in ORGANIC & BIOMOLECULAR CHEMISTRY

2014

Diversity and bioactivity of biosurfactant-producing pseudomonads isolated from cocoyam rhizosphere in Nigeria and Cameroon

Feyisara Eyiwumi OniNiels GeudensJoseph OnyekaLien BertierNam Kieu PhuongChien-Jui HuangMarc OngenaMonica Höfte

Exploration of the structure-activity relation of natural, self-assembling cyclic lipodepsipeptides

Niels GeudensKrisztina FehérMatthias De VleeschouwerJean-Marc CrowetMehmet Nail NasirHassen Rokni-ZadehRené De MotAnnemieke MadderLaurence LinsJosé Martins et al.

Impact of a stereocentre inversion in cyclic lipodepsipeptides from the viscosin group: a comparative study of the viscosinamide and pseudodesmin conformation and self-assembly

Niels GeudensMatthias De VleeschouwerKrisztina FehérHassan Rokni-ZadehMaarten GK GhequireAnnemieke MadderRené De MotJosé MartinsDavy Sinnaeve

A1 Journal Article in CHEMBIOCHEM

Membrane interactions of natural cyclic lipodepsipeptides

Niels GeudensKrisztina FehérMatthias De VleeschouwerJean-Marc CrowetMehmet Nail NasirAnnemieke MadderLaurence LinsJosé MartinsDavy Sinnaeve

Membrane interactions of natural cyclic lipodepsipeptides

Niels GeudensKrisztina FehérJean-Marc CrowetMehmet Nail NasirAnnemieke MadderLaurence LinsJosé MartinsDavy Sinnaeve

Membrane interactions of natural cyclic lipodepsipeptides

Niels GeudensKrisztina FehérMatthias De VleeschouwerJean-Marc CrowetMehmet Nail NasirHassan Rokni-ZadehRené De MotAnnemieke MadderLaurence LinsJosé Martins et al.

Pseudomonas cyclic lipodepsipeptides from the viscosin group: insight into their self-assembly and membrane interaction

Davy SinnaeveMatthias De VleeschouwerNiels GeudensKrisztina FehérJean-Marc CrowetAnnemieke MadderLaurence LinsJosé Martins

Self‐assembling cyclic lipodepsipeptides

Davy SinnaeveMatthias De VleeschouwerNiels GeudensJean-Marc CrowetAnnemieke MadderLaurence LinsJosé Martins

Unravelling the self-assembly of bacterial cyclic lipopeptides by 13C relaxation, PFGSTE and MD simulation studies

Davy SinnaeveMatthias De VleeschouwerJean-Marc CrowetNiels GeudensKrisztina FehérAnnemieke MadderLaurence LinsJosé Martins

2013

Exploration of the structure-activity relation of natural, self-assembling cyclic lipodepsipeptides

Niels GeudensKrisztina FehérMatthias De VleeschouwerHassan Rokni-ZadehRené De MotAnnemieke MadderJosé MartinsDavy Sinnaeve

Exploration of the structure-activity relation of natural, self-assembling cyclic lipodepsipeptides

Niels GeudensKrisztina FehérMatthias De VleeschouwerJean-Marc CrowetMehmet Nail NasirHassen Rokni-ZadehRené De MotAnnemieke MadderLaurence LinsJosé Martins et al.

NMR approaches to characterize the structure and self-assembly of bacterial cyclic lipodepsipeptides

Davy SinnaeveMatthias De VleeschouwerNiels GeudensKrisztina FehérMarc-André DelsucBruno KiefferJosé Martins

2012

Conformational and self-assembly properties of cyclic lipodepsipeptides of the viscosin group

Davy SinnaeveNiels GeudensMatthias De VleeschouwerKrisztina FehérHassan Rokni-ZadehJos M RaaijmakersRené De MotAnnemieke MadderJosé Martins

Conformational and self-assembly properties of cyclic lipodepsipeptides of the viscosin group

Niels GeudensKrisztina FehérMatthias De VleeschouwerHassan Rokni-ZadehRené De MotAnnemieke MadderJosé MartinsDavy Sinnaeve