Research Explorer

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Researcher

Niek Sanders

Publications & Research Data

Awards & Distinctions

216 Results

2026

Influence of the administration route and dose on the expression and antibody responses of a reporter and avian influenza self-amplifying mRNA vaccine in poultry

Janne SnoeckXiaole CuiPieter VervaekeNiek SandersAn Garmyn

U Journal Article in Veterinary Quarterly

Mucosal administration of lipid nanoparticles containing self-amplifying mRNA induces local uptake and expression in a pig model as a potential vaccination platform against STIs

Ibe Van de CasteeleMagalie PlovytMagdalena StuchlíkováMichiel LanssensBen VerschuerenQuenten DenonPaul Van der MeerenSéan Mc CaffertyArlieke GitselsPieter Cornillie et al.

A1 Journal Article in DRUG DELIVERY AND TRANSLATIONAL RESEARCH

2025

A f entanyl hapten-displaying lipid nanoparticle vaccine that non-covalently encapsulates a TLR7/8 agonist and T-helper epitope induces protective anti-fentanyl immunity

Zifu ZhongMarie DeventerYong ChenStijn VanheeInés LammensKim DeswarteYi HuangTingting YeHaixiu WangLutz Nuhn et al.

A1 Journal Article in ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Advancing self-amplifying RNA delivery : evaluating novel polyethylenimine-inspired polymers as non-viral carriers

Lisa OpsomerNiek SandersRichard Hoogenboom

Impact of pre-existing anti-replicase immunity on the efficacy of self-amplifying mRNA vaccines

Xiaole CuiLaura AmelinckOriane GillonJoão Paulo Portela CataniYa GaoQing SunElisabeth De SutterPieter VervaekeJanne SnoeckStefan Lienenklaus et al.

U Journal Article in Nature Communications

Optimizing self-amplifying RNA vaccines for poultry : a novel platform to combat emerging avian diseases

Janne SnoeckAn GarmynNiek Sanders

Overcoming cold chain challenges : cryoprotection of self-amplifying mRNA polyplexes for long-term storage at ambient temperature

Lisa OpsomerSomdeb JanaRichard HoogenboomNiek Sanders

U Journal Article in JOURNAL OF CONTROLLED RELEASE

Self-amplifying mRNA platforms for durable expression of therapeutic payloads

Pieter VervaekeNiek SandersFrancis Combes

The efficacy of self-amplifying RNA vaccines against H5N1 influenza and the impact of pre-existing immunity against the replicase of self-amplifying RNA

Xiaole CuiNiek SandersZifu Zhong

The past, present, and future of RNA vaccines

John S. TregoningNiek Sanders

Editorial material

Thioamides adjacent to the ionizable amine headgroup in ionizable lipids reduce the pKa of lipid nanoparticles and enhance mRNA transfection efficiency in vitro and in vivo

Yong ChenEmily De LombaerdeAimee-Rose Bugler-LambZifu ZhongMartijn SchuijsClaudia Mariela Brenis GómezJamie De BaereMark GontsarikHeleen LauwersKim Deswarte et al.

A1 Journal Article in ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Transcriptomic heterogeneity of nine complementary mouse TNBC models based on their comparative in vitro and in vivo characterization

Robbe SalembierCaro De HaesBo WylinKristel DemeyereSteven Van LaereNiek SandersEvelyne MeyerJonas Steenbrugge

Unlocking the potential of thio-substituted cyclic imino ethers : from monomer synthesis to post-polymerization modification and selective hydrolysis

Emiel PattynRichard HoogenboomNiek Sanders

2024

Amplification of protein expression by self-amplifying mRNA delivered in lipid nanoparticles containing a β-aminoester ionizable lipid correlates with reduced innate immune activation

Emily De LombaerdeXiaole CuiYong ChenZifu ZhongJulie DeckersGiulia MencarelliLisa OpsomerHaixiu WangJamie De BaereStefan Lienenklaus et al.

A1 Journal Article in ACS NANO

Chitin-mediated blockade of chitinase-like proteins reduces tumor growth and immunosuppression in a mouse model for TNBC

Robbe SalembierCaro De HaesBo WylinKristel DemeyereNiek SandersEvelyne MeyerJonas Steenbrugge

Chitin-mediated blockade of chitinase-like proteins reduces tumor immunosuppression, inhibits lymphatic metastasis and enhances anti-PD-1 efficacy in complementary TNBC models

Robbe SalembierCaro De HaesJulie BellemansKristel DemeyereWim Van Den BroeckNiek SandersSteven Van LaereTraci R. LyonsEvelyne MeyerJonas Steenbrugge

A1 Journal Article in BREAST CANCER RESEARCH

Chlamydia trachomatis vaccine development : from antigen design to mucosal delivery in porcine models

Celien KiekensDaisy VanrompayNiek Sanders

CO-DELIVERY of glutamic acid-extended peptide antigen and imidazoquinoline TLR7/8 agonist via ionizable lipid nanoparticles induces protective anti-tumor immunity

Tingting YeZifu ZhongFederica CappellessoKim DeswarteYong ChenHeleen LauwersEmily De LombaerdeMark GontsarikStefan LienenklausDorien Van Lysebetten et al.

A1 Journal Article in BIOMATERIALS

Combinatorial screening of biscarbamate ionizable lipids identifies a low reactogenicity lipid for lipid nanoparticle mRNA delivery

Emily De LombaerdeYong ChenTingting YeJulie DeckersGiulia MencarelliKim DeswarteHeleen LauwersRuben De CoenSabah KasmiSanne Bevers et al.

A1 Journal Article in ADVANCED FUNCTIONAL MATERIALS

Efficient in vitro and in vivo transfection of self-amplifying mRNA with linear poly(propylenimine) and poly(ethylenimine-propylenimine) random copolymers as non-viral carriers

Lisa OpsomerSomdeb JanaIne MertensXiaole CuiRichard HoogenboomNiek Sanders

A1 Journal Article in JOURNAL OF MATERIALS CHEMISTRY B

Epidemiology and diagnostics of avian chlamydiae and mRNA vaccination against Chlamydia psittaci in pet birds

Anne De MeystDaisy VanrompayNiek Sanders

Immunogenicity and biodistribution of lipid nanoparticle formulated self-amplifying mRNA vaccines against H5 avian influenza

Xiaole CuiPieter VervaekeYa GaoLisa OpsomerQing SunJanne SnoeckBert DevriendtZifu ZhongNiek Sanders

A1 Journal Article in NPJ VACCINES

Less is more : self-amplifying mRNA becomes self-killing upon dose escalation in immune-competent retinal cells

Helena VanlucheneOriane GillonKaren PeynshaertStefaan De SmedtNiek SandersKoen RaemdonckKatrien Remaut

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Lipid nanoparticle encapsulation empowers poly(I:C) to activate cytoplasmic RLRs and thereby increases its adjuvanticity

Alexander LamootSonia JangraGabriel LaghlaliPrajakta WarangLauren A. ChangSeok‐Chan ParkGagandeep SinghKim DeswarteZifu ZhongBenoit Louage et al.

A1 Journal Article in SMALL

Lipocalin-2 blockade reduces tumor growth and neutrophil infiltration in a mouse model for TNBC

Caro De HaesRobbe SalembierBo WylinKristel DemeyereNiek SandersEvelyne MeyerJonas Steenbrugge

PH-triggered, lymph node focused immunodrug release by polymeric 2-propionic-3-methyl-maleic anhydrides with cholesteryl end groups

Alina G. HeckCarolina Medina-MontanoZifu ZhongKim DeswarteKatharina EigenJudith StickdornJohannes KockelmannMaximilian SchergerNiek SandersStefan Lienenklaus et al.

A1 Journal Article in ADVANCED HEALTHCARE MATERIALS

Self-amplifying mRNA therapy for cystic fibrosis : delivering mRNA instructions for correct CFTR production

Nathalie FrançoisNiek Sanders

2023

Evaluation of a self-amplifying mRNA reporter vaccine in explant models of broiler chickens

Janne SnoeckKoen ChiersYing TamNiek SandersAn Garmyn

A1 Journal Article in POULTRY SCIENCE

Evaluation of potential administration routes of self-amplifying mRNA in chickens using a reporter vaccine

Janne SnoeckKristof HaemsYing TamNiek SandersAn Garmyn

Evaluation of self-amplifying mRNA vaccination in chickens using a luciferase reporter and an H5N1 vaccine

Janne SnoeckXiaole CuiKristof HaemsYing TamNiek SandersAn Garmyn

Immunogenicity versus efficacy of lipid nanoparticle-mediated delivery of mRNA and self-amplifying mRNA to the retina

Helena VanlucheneKatrien RemautNiek SandersKoen Raemdonck

Lipid nanoparticle delivery alters the adjuvanticity of the TLR9 agonist CpG by innate immune activation in lymphoid tissue

Zifu ZhongYong ChenKim DeswarteHeleen LauwersEmily De LombaerdeXiaole CuiSimon Van HerckTingting YeMark GontsarikStefan Lienenklaus et al.

A1 Journal Article in ADVANCED HEALTHCARE MATERIALS

Novel polymers as promising non-viral carriers for self-amplifying mRNA-based applications

Lisa OpsomerSomdeb JanaIne MertensRichard HoogenboomNiek Sanders

Previous and current efforts to develop a mucosal vaccine against periodontal disease : are we close yet?

Victor VaernewyckJanne SnoeckEric CoxNiek SandersBoaz ArziMaria Soltero-RiveraHenriëtte Booij-VrielingBert Devriendt

Stability study of self-amplifying mRNA-based polyplexes

Lisa OpsomerSomdeb JanaRichard HoogenboomNiek Sanders

The impact of hepatocyte-specific deletion of hypoxia-inducible factors on the development of polymicrobial sepsis with focus on GR and PPARα function

Tineke VanderhaeghenSteven TimmermansMelanie EggermontDeepika WattsJolien VandewalleCharlotte WallaeysLouise NuyttensJoyca De TemmermanTino HochepiedSylviane Dewaele et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Visible light conjugation with triazolinediones as a route to degradable poly(ethylene glycol)-lipids for mRNA lipid nanoparticle formulation

Bianka GolbaMatthieu SoeteZifu ZhongNiek SandersFilip Du PrezHannes HouckBruno De Geest

A1 Journal Article in ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Xenogeneic equine stem cells activate anti-tumor adaptive immunity in a 4T1-based intraductal mouse model for triple-negative breast cancer : proof-of-principle

Jonas SteenbruggeGlenn PauwelynKristel DemeyereNausikaa DevriendtHilde De RoosterNiek SandersJan H. SpaasEvelyne Meyer

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

2022

A dual-antigen self-amplifying RNA SARS-CoV-2 vaccine induces potent humoral and cellular immune responses and protects against SARS-CoV-2 variants through T cell-mediated immunity

Séan Mc CaffertyA. K. M. Ashiqul HaqueAster VandierendonckBrian WeidenseeMagalie PlovytMagdalena StuchlikovaNathalie FrançoisSophie ValemboisLeo HeyndrickxJohan Michiels et al.

A1 Journal Article in MOLECULAR THERAPY

A lipid nanoparticle platform for mRNA delivery through repurposing of cationic amphiphilic drugs

Bram BogaertFelix SauvageRoberta GuagliardoCristina Muntean[missing] Van Phuc NguyenEline PottieMike WelsAn-Katrien MinnaertRiet De RyckeQiangbing Yang et al.

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Chitin immunomodulation stimulates anti-PD-1 therapy in an intraductal model for triple-negative breast cancer

Jonas SteenbruggeJulie BellemansKristel DemeyereNiek SandersEvelyne Meyer

Choroid plexus-derived extracellular vesicles exhibit brain targeting characteristics

Marie PauwelsJunhua XieAdam CeroiSriram BalusuJonas CasteleinElien Van WonterghemGriet Van ImschootAndrew WardTrevelyan R. MenheniottOskar Gustafsson et al.

A1 Journal Article in BIOMATERIALS

Molecular therapies and vaccines face the challenges of emerging infectious diseases

Ami PatelDavid WeinerWeidong XiaoAndrew BakerNiek Sanders

Editorial material

Mucosal vaccination against periodontal disease : unexploited potential for veterinary and human oral medicine

Victor VaernewyckMaria Soltero-RiveraBoaz ArziNiek SandersEric CoxBert Devriendt

One cisplatin dose provides durable stimulation of anti-tumor immunity and alleviates anti-PD-1 resistance in an intraductal model for triple-negative breast cancer

Jonas SteenbruggeJulie BellemansNiels Vander ElstKristel DemeyereJosephine De VliegherTimothy PereraOlivier De WeverWim Van Den BroeckWard De SpiegelaereNiek Sanders et al.

A1 Journal Article in ONCOIMMUNOLOGY

One cisplatin dose suffices to maintain anti-tumor immunity and enhances anti-PD-1 efficacy in an intraductal model for triple-negative breast cancer

Jonas SteenbruggeJulie BellemansNiels Vander ElstKristel DemeyereNiek SandersEvelyne Meyer

Regulatory guidelines and preclinical tools to study the biodistribution of RNA therapeutics

Pieter VervaekeS.E. BorgosNiek SandersF. Combes

A1 Journal Article in ADVANCED DRUG DELIVERY REVIEWS

The self-amplifying RNA platform for vaccination and in vivo controllable production of therapeutic proteins

Séan Mc CaffertyNiek Sanders

2021

Antibody-mediated targeting of antigens to intestinal aminopeptidase N elicits gut IgA responses in pigs

Hans Van Der WekenRaquel Sanz GarcíaNiek SandersEric CoxBert Devriendt

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Corticosteroids and cellulose purification improve, respectively, the in vivo translation and vaccination efficacy of sa-mRNAs

Zifu ZhongSéan Mc CaffertyLisa OpsomerHaixiu WangHanne HuysmansJoyca De TemmermanStefan LienenklausJoão Portela CataniFrancis CombesNiek Sanders

A1 Journal Article in MOLECULAR THERAPY

Corticosteroids and mRNA vaccines : a word of caution

Zifu ZhongFrancis CombesNiek Sanders

A1 Journal Article in MOLECULAR THERAPY

In Vivo Validation of a Reversible Small Molecule-Based Switch for Synthetic Self-Amplifying mRNA Regulation

Séan Mc CaffertyJoyca De TemmermanTasuku KitadaJacob R. BecraftRon WeissDarrell J. IrvineMathias DevreeseSiegrid De BaereFrancis CombesNiek Sanders

A1 Journal Article in MOLECULAR THERAPY

Lipid-polyglutamate nanoparticle vaccine platform

Dorien Van LysebettenAlessio MalfantiKim DeswarteKaloian KoynovBianka GolbaTingting YeZifu ZhongSabah KasmiAlexander LamootYong Chen et al.

A1 Journal Article in ACS APPLIED MATERIALS & INTERFACES

Low-dose single-shot COVID-19 mRNA vaccines lie ahead

Editorial material

Mucosal vaccination against periodontal disease : current status and opportunities

Victor VaernewyckBoaz ArziNiek SandersEric CoxBert Devriendt

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

OMO-1 reduces progression and enhances cisplatin efficacy in a 4T1-based non-c-MET addicted intraductal mouse model for triple-negative breast cancer

Jonas SteenbruggeNiels Vander ElstKristel DemeyereOlivier De WeverNiek SandersWim Van Den BroeckEric CiamporceroTimothy PereraEvelyne Meyer

A1 Journal Article in NPJ BREAST CANCER

Squaric ester-based, pH-degradable nanogels : modular nanocarriers for safe, systemic administration of toll-like receptor 7/8 agonistic immune modulators

Anne HuppertsbergLeonard KapsZifu ZhongSascha SchmittJudith StickdornKim DeswarteFrancis CombesChristian CzyschJana De VriezeSabah Kasmi et al.

A1 Journal Article in JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Sterilizing immunity against SARS‐CoV‐2 infection in mice by a single‐shot and lipid amphiphile imidazoquinoline TLR7/8 agonist‐adjuvanted recombinant spike protein vaccine**

Sonia JangraJana De VriezeAngela ChoiRaveen RathnasingheGabriel LaghlaliAnnemiek UvynSimon Van HerckLutz NuhnKim DeswarteZifu Zhong et al.

A1 Journal Article in ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Strategies for controlling the innate immune activity of conventional and self-amplifying mRNA therapeutics : getting the message across

An-Katrien MinnaertHelena VanlucheneRein VerbekeIne LentackerStefaan De SmedtKoen RaemdonckNiek SandersKatrien Remaut

A1 Journal Article in ADVANCED DRUG DELIVERY REVIEWS

Unexpected effects of a selective and potent c-MET inhibitor in an immunocompetent intraductal model for triple-negative breast cancer

Jonas SteenbruggeNiels Vander ElstKristel DemeyereOlivier De WeverNiek SandersWim Van Den BroeckAnnegret Van der AaEric CiamporceroTimothy PereraEvelyne Meyer

2020

Chlamydia : what is on the outside does matter

Arlieke GitselsSarah Van LentNiek SandersDaisy Vanrompay

A1 Journal Article in CRITICAL REVIEWS IN MICROBIOLOGY

Development of a mucosal self-amplifying mRNA vaccine against female Chlamydia trachomatis infections

Arlieke GitselsDaisy VanrompayNiek Sanders

Development of a self-replicating mRNA vaccine against Zika virus

Zifu ZhongNiek Sanders

Imidazoquinoline-conjugated degradable coacervate conjugate for local cancer immunotherapy

Hui LiSimon Van HerckYongjun LiuYanyun HaoXiaochu DingLutz NuhnZifu ZhongFrancis CombesNiek SandersStefan Lienenklaus et al.

A1 Journal Article in ACS BIOMATERIALS SCIENCE & ENGINEERING

Immune cells as tumor drug delivery vehicles

Francis CombesEvelyne MeyerNiek Sanders

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Potent and prolonged innate immune activation by enzyme-responsive imidazoquinoline TLR7/8 agonist prodrug vesicles

Bi WangSimon Van HerckYong ChenXiangyang BaiZifu ZhongKim DeswarteBart LambrechtNiek SandersStefan LienenklausHans W. Scheeren et al.

A1 Journal Article in JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Sterilizing immunity against SARS-CoV-2 infection in mice by a single-shot and modified imidazoquinoline TLR7/8 agonist-adjuvanted recombinant spike protein vaccine

Sonia JangraJana De VriezeAngela ChoiRaveen RathnasingheGabriel LaghlaliAnnemiek UvynSimon Van HerckLutz NuhnKim DeswarteZifu Zhong et al.

The opposing effect of type I IFN on the T cell response by non-modified mRNA-lipoplex vaccines Is determined by the route of administration

Lien Van HoeckeKenny RooseMarlies BallegeerZifu ZhongNiek SandersStefaan De KokerXavier SaelensSandra Van Lint

A1 Journal Article in MOLECULAR THERAPY-NUCLEIC ACIDS

2019

Chlamydial infection from outside to inside

Arlieke GitselsNiek SandersDaisy Vanrompay

A1 Journal Article in FRONTIERS IN MICROBIOLOGY

Comparative profiling of metastatic 4T1- vs. non-metastatic Py230-based mammary tumors in an intraductal model for triple-negative breast cancer

Jonas SteenbruggeNiels Vander ElstKristel DemeyereOlivier De WeverNiek SandersWim Van Den BroeckLuc DirixSteven Van LaereEvelyne Meyer

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Expression kinetics and innate immune response after electroporation and LNP-mediated delivery of a self-amplifying mRNA in the skin

Hanne HuysmansZifu ZhongJoyca De TemmermanBarbara L MuiYing K TamSéan Mc CaffertyArlieke GitselsDaisy VanrompayNiek Sanders

A1 Journal Article in MOLECULAR THERAPY-NUCLEIC ACIDS

Immunogenicity and protection efficacy of a naked self-replicating mRNA-based Zika virus vaccine

Zifu ZhongJoão Paulo Portela CataniSéan Mc CaffertyLiesbeth CouckWim Van Den BroeckNina GorléRoosmarijn VandenbrouckeBert DevriendtSebastian UlbertLieselotte Cnops et al.

A1 Journal Article in VACCINES

Improving the repeatability and efficacy of intradermal electroporated self-replicating mRNA

Hanne HuysmansJoyca De TemmermanZifu ZhongSéan Mc CaffertyFrancis CombesFreddy HaesebrouckNiek Sanders

A1 Journal Article in MOLECULAR THERAPY-NUCLEIC ACIDS

Intradermal delivery strategies of mRNA-based therapeutics in mice and pigs

Hanne HuysmansNiek Sanders

Migration and distribution of systemically injected mononuclear phagocytes in tumor-bearing mice

Francis CombesNiek SandersEvelyne Meyer

Mononuclear but not polymorphonuclear phagocyte depletion increases circulation times and improves mammary tumor-homing efficiency of donor bone marrow-derived monocytes

Francis CombesAlexandros Marios SofiasSéan Mc CaffertyHanne HuysmansJoyca De TemmermanSjoerd HakEvelyne MeyerNiek Sanders

A1 Journal Article in CANCERS

Potent Lymphatic Translocation and Spatial Control Over Innate Immune Activation by Polymer-Lipid Amphiphile Conjugates of Small-Molecule TLR7/8 Agonists

Jana De VriezeBenoit LouageKim DeswarteZifu ZhongRuben De CoenSimon Van HerckLutz NuhnCamilla Kaas FrichAlexander N ZelikinStefan Lienenklaus et al.

A1 Journal Article in ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

2018

Anti-inflammatory signaling by mammary tumor cells mediates prometastatic macrophage polarization in an innovative intraductal mouse model for triple-negative breast cancer

Jonas SteenbruggeKoen BreyneKristel DemeyereOlivier De WeverNiek SandersWim Van Den BroeckCecile ColpaertPeter VermeulenSteven Van LaereEvelyne Meyer

A1 Journal Article in JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Comparison of the expression kinetics and immunostimulatory activity of replicating mRNA, nonreplicating mRNA, and pDNA after intradermal electroporation in pigs

Bregje LeymanHanne HuysmansSéan Mc CaffertyFrancis CombesEric CoxBert DevriendtNiek Sanders

A1 Journal Article in MOLECULAR PHARMACEUTICS

Lymph-node-targeted immune activation by engineered block copolymer amphiphiles-TLR7/8 agonist conjugates

Simon Van HerckKim DeswarteLutz NuhnZifu ZhongJoão Portela CataniYupeng LiNiek SandersStefan LienenklausStefaan De KokerBart Lambrecht et al.

A1 Journal Article in JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

mRNA therapeutics deliver a hopeful message

Zifu ZhongSéan Mc CaffertyFrancis CombesHanne HuysmansJoyca De TemmermanArlieke GitselsDaisy VanrompayJoão Portela CataniNiek Sanders

A1 Journal Article in NANO TODAY

Nanoparticle-conjugate TLR7/8 agonist localized immunotherapy provokes safe antitumoral responses

Lutz NuhnStefaan De KokerSandra Van LintZifu ZhongJoão Portela CataniFrancis CombesKim DeswarteYupeng LiBart LambrechtStefan Lienenklaus et al.

A1 Journal Article in ADVANCED MATERIALS

Off-target and tumor-specific accumulation of monocytes, macrophages and myeloid-derived suppressor cells after systemic injection

Francis CombesSéan Mc CaffertyEvelyne MeyerNiek Sanders

A1 Journal Article in NEOPLASIA

Small-molecule-based regulation of RNA-delivered circuits in mammalian cells

Tyler E WagnerJacob R BecraftKatie BodnerBrian TeagueXin ZhangAmanda WooEly PorterBremy AlburquerqueBrian DoboshOliwia Andries et al.

A1 Journal Article in NATURE CHEMICAL BIOLOGY

Tumor immune profiling and host NF-kappaB activity assessment in a novel Py230-based intraductal model for triple-negative breast cancer

Jonas SteenbruggeNiels Vander ElstKristel DemeyereNiek SandersOlivier De WeverSteven Van LaereEvelyne Meyer

2017

Evaluation of a xenogeneic vascular endothelial growth factor-2 vaccine in two preclinical metastatic tumor models in mice

Sofie DeniesBregje LeymanHanne HuysmansFrancis CombesSéan Mc CaffertyLaetitia CiccheleroMarjan SteppeJoyca De TemmermanNiek Sanders

A1 Journal Article in CANCER IMMUNOLOGY IMMUNOTHERAPY

Immunological and angiogenic markers during metronomic temozolomide and cyclophosphamide in canine cancer patients

Sofie DeniesLaetitia CiccheleroHilde De RoosterSylvie DaminetIngeborgh PolisIsabel Van de MaeleNiek Sanders

A1 Journal Article in VETERINARY AND COMPARATIVE ONCOLOGY

Immunological, anti-angiogenic and clinical effects of intratumoral interleukin 12 electrogene therapy combined with metronomic cyclophosphamide in dogs with spontaneous cancer : a pilot study

Laetitia CiccheleroSofie DeniesKatrien VanderperrenEmmelie StockLeen Van BrantegemHilde De RoosterNiek Sanders

A1 Journal Article in CANCER LETTERS

In vitro exploration of a myeloid-derived suppressor cell line as vehicle for cancer gene therapy

Sofie DeniesFrancis CombesCynthia GhekiereSéan Mc CaffertyLaetitia CiccheleroNiek Sanders

A1 Journal Article in CANCER GENE THERAPY

Intratumoural interleukin 12 gene therapy stimulates the immune system and decreases angiogenesis in dogs with spontaneous cancer

Laetitia CiccheleroSofie DeniesHendrik HaersKatrien VanderperrenEmmelie StockLeen Van BrantegemHilde De RoosterNiek Sanders

A1 Journal Article in VETERINARY AND COMPARATIVE ONCOLOGY

Oral delivery of Escherichia coli persistently infected with M2e-displaying bacteriophages partially protects against influenza A virus

Lei DengKenny RooseEmma JobRiet De RyckeEvelien Van HammeAmanda GonçalvesEef ParthoensLaetitia CiccheleroNiek SandersWalter Fiers et al.

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

The crosstalk between macrophages and 4T1 mammary tumor cells promotes metastasis in a novel intraductal model for breast cancer

Jonas SteenbruggeKoen BreyneLore Vander PlanckenKristel DemeyereNiek SandersCecile ColpaertSteven Van LaereEvelyne Meyer

2016

Aerosolized non-viral nucleic acid delivery in the vaginal tract of pigs

Katrien RemautEvelien De ClercqOliwia AndriesKoen RomboutsMatthias Van GilsLaetitia CiccheleroIan VandenbusscheSarah Van PraetJuan Manuel BenitoJosé Manuel Garcia Fernandéz et al.

A1 Journal Article in PHARMACEUTICAL RESEARCH

Chitinase 3-like 1 as breast cancer metastasis biomarker for differential tumor progression in the intraductal versus the fat pad preclinical model

Jonas SteenbruggeKoen BreyneSofie DeniesMelissa DekimpeKristel DemeyereOlivier De WeverNiek SandersEvelyne Meyer

Coadministration of a plasmid encoding HIV-1 Gag enhances the efficacy of cancer DNA vaccines

Laure LambrichtKevin VanvarenbergAns De BeuckelaerLien Van HoeckeJohan GrootenBernard UcakarPascale LipnikNiek SandersStefan LienenklausVéronique Préat et al.

A1 Journal Article in MOLECULAR THERAPY

Comparison of the adipose and luminal mammary gland compartment as orthotopic inoculation sites in a 4T1-based immunocompetent preclinical model for triple-negative breast cancer

Jonas SteenbruggeKoen BreyneSofie DeniesMelissa DekimpeKristel DemeyereOlivier De WeverPeter VermeulenSteven Van LaereNiek SandersEvelyne Meyer

A1 Journal Article in JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Contrast-enhanced ultrasound imaging of the anti-angiogenitic effects of interleukin-12 in pet dogs with spontaneous malignant tumors

Laetitia CiccheleroKatrien VanderperrenSofie DeniesEmmelie StockHendrik HaersLeen Van BrantegemHilde De RoosterNiek Sanders

De hond als kankermodel in de zoektocht naar nieuwe therapeutische alternatieven

Eline AbmaLaetitia CiccheleroHilde De RoosterSylvie DaminetNiek Sanders

A1 Journal Article in VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT

Immunogenicity and safety of xenogeneic vascular endothelial growth factor receptor-2 DNA vaccination in mice and dogs

Sofie DeniesLaetitia CiccheleroIngeborgh PolisNiek Sanders

A1 Journal Article in ONCOTARGET

Mono- and combination immunotherapy in dogs with spontaneous tumors : stimulation of the adaptive and innate immune system against cancer and suppression of immunosuppressive immune cells

Laetitia CiccheleroNiek SandersHilde De Rooster

Topical imiquimod yields systemic effects due to unintended oral uptake

Lynda GrineSophie SteelandSara Van RyckeghemMarlies BallegeerStefan LienenklausSiegfried WeissNiek SandersRoosmarijn VandenbrouckeClaude Libert

A1 Journal Article in SCIENTIFIC REPORTS

Type I interferons interfere with the capacity of mRNA lipoplex vaccines to elicit cytolytic T cell responses

Ans De BeuckelaerCharlotte PollardSandra Van LintKenny RooseLien Van HoeckeTom NaessensVimal Kumar UdhayakumarMuriel SmetNiek SandersStefan Lienenklaus et al.

A1 Journal Article in MOLECULAR THERAPY

2015

Can dendritic cells improve whole cancer cell vaccines based on immunogenically killed cancer cells?

Laetitia CiccheleroSofie DeniesBert DevriendtHilde De RoosterNiek Sanders

A1 Journal Article in ONCOIMMUNOLOGY

Cancer immunotherapy : tumor vaccination, IL-12 gene therapy and metronomic chemotherapy

Sofie DeniesNiek Sanders

Is intraductal inoculation of tumour cells a more relevant in vivo model for immune-competent breast cancer metastasis than the classical fat pad model?

Koen BreyneSofie DeniesJonas SteenbruggeMelissa DekimpeKristel DemeyereOlivier De WeverNiek SandersEvelyne Meyer

mRNA Modification and delivery strategies towards the establishment of a platform for safe and effective gene therapy

Oliwia AndriesNiek SandersStefaan De SmedtTasuku Kitada

N-1-methylpseudouridine-incorporated mRNA outperforms pseudouridine-incorporated mRNA by providing enhanced protein expression and reduced immunogenicity in mammalian cell lines and mice

Oliwia AndriesSéan Mc CaffertyStefaan De SmedtRon WeissNiek SandersTasuku Kitada

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Synthetic biology devices and circuits for RNA-based 'smart vaccines': a propositional review

Oliwia AndriesTasuku KitadaKatie BodnerNiek SandersRon Weiss

A1 Journal Article in EXPERT REVIEW OF VACCINES

The challenge of West Nile virus in Europe : knowledge gaps and research priorities

A RizzoliMA Jiménez-ClaveroL BarzonP CordioliJ FiguerolaP KorakaB MartinaA MorenoN NowotnyN Pardigon et al.

A1 Journal Article in EUROSURVEILLANCE

2014

Adaptation of an intraductal mouse mastitis model to study the effect of inflammation in breast cancer metastasis

Koen BreyneSofie DeniesDieter DemonNiek SandersEvelyne Meyer

Combination of interleukin-12 gene therapy, metronomic cyclophosphamide and DNA cancer vaccination directs all arms of the immune system towards tumor eradication

Sofie DeniesLaetitia CiccheleroIsabel Van AudenhoveNiek Sanders

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Genital Chlamydia suis and C. trachomatis infections in pigs and optimization of C. trachomatis vaccine delivery

Evelien De ClercqDaisy VanrompayNiek Sanders

Kankercelvaccins op basis van volledige cellen : mogelijkheden en hindernissen

Laetitia CiccheleroHilde De RoosterNiek Sanders

A2 Journal Article in ONCO HEMATO

Non-classical ProIL-1beta activation during mammary gland infection is pathogen-dependent but caspase-1 independent

Koen BreyneSteven CoolDieter DemonKristel DemeyereTom VandenberghePeter VandenabeeleHarald CarlsenWim Van Den BroeckNiek SandersEvelyne Meyer

Non-classical ProIL-1beta activation during mammary gland infection is pathogen-dependent but caspase-1 independent

Koen BreyneSteven CoolDieter DemonKristel DemeyereTom VandenberghePeter VandenabeeleHarald CarlsenWim Van Den BroeckNiek SandersEvelyne Meyer

A1 Journal Article in PLOS ONE

Optimalization and characterization of a novel intraductal mouse mammary tumor model

Koen BreyneSofie DeniesDieter DemonNiek SandersEvelyne Meyer

T Cell epitope mapping of the E-protein of West Nile virus in BALB/c mice

Marina De FiletteStefan ChabierskiOliwia AndriesSebastian UlbertNiek Sanders

A1 Journal Article in PLOS ONE

Vaccination of mice using the West Nile virus E-protein in a DNA prime-protein boost strategy stimulates cell-mediated immunity and protects mice against a lethal challenge

Marina De FiletteSilke SoehleSebastian UlbertJustin RichnerMichael S DiamondAlessandro SinigagliaLuisa BarzonStefan RoelsJulianna LisziewiczOrsolya Lorincz et al.

A1 Journal Article in PLOS ONE

Vaccine-induced protection of Rhesus macaques against plasma viremia after intradermal infection with a European lineage 1 strain of West Nile virus

Babs E VerstrepenHerman OostermeijerZahra FagrouchMelanie van HeterenHenk NiphuisTom HaaksmaIvanela KondovaWilly M BogersMarina De FiletteNiek Sanders et al.

A1 Journal Article in PLOS ONE

Various ways to improve whole cancer cell vaccines

Laetitia CiccheleroHilde De RoosterNiek Sanders

A1 Journal Article in EXPERT REVIEW OF VACCINES

2013

A nanobody targeting the F-actin capping protein CapG restrains breast cancer metastasis

Katrien Van ImpeJonas BethuyneSteven CoolFrancis ImpensDavid Ruano-GallegoOlivier De WeverBerlinda VanlooMarleen Van TroysKathleen LambeinCiska Boucherie et al.

A1 Journal Article in BREAST CANCER RESEARCH

Comparison of in vivo optical systems for bioluminescence and fluorescence imaging

Steven CoolKoen BreyneEvelyne MeyerStefaan De SmedtNiek Sanders

A1 Journal Article in JOURNAL OF FLUORESCENCE

Coupling of drug containing liposomes to microbubbles improves ultrasound triggered drug delivery in mice

Steven CoolBart GeersStefan RoelsStephan StremerschKatrien VanderperrenJimmy SaundersStefaan De SmedtJo DemeesterNiek Sanders

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Enhancing nucleic acid delivery with ultrasound and microbubbles

Steven CoolBart GeersIne LentackerStefaan De SmedtNiek Sanders

Bookchapter in Nanotechnology for nucleic acid delivery : methods and protocols

Innate immune response and programmed cell death following carrier-mediated delivery of unmodified mRNA to respiratory cells

Oliwia AndriesMarina De FiletteStefaan De SmedtJo DemeesterMario Van PouckeLuc PeelmanNiek Sanders

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

The use of unloaded self-made microbubbles for contrast-enhanced ultrasound imaging in dogs: potential for image-guided drug delivery in vivo

Katrien VanderperrenSteven CoolHendrik HaersEmmelie StockCaroline FinaNiek SandersJimmy Saunders

2012

Comparison of the gene transfer efficiency of mRNA/GL67 and pDNA/GL67 complexes in respiratory cells

Oliwia AndriesMarina De FiletteJoanna RejmanStefaan De SmedtJo DemeesterMario Van PouckeLuc PeelmanCindy PelemanTony LahoutteNiek Sanders

A1 Journal Article in MOLECULAR PHARMACEUTICS

Liposome based systems for systemic siRNA delivery: stability in blood sets the requirements for optimal carrier design

Kevin BuyensStefaan De SmedtKevin BraeckmansJo DemeesterLiesbeth PeetersLeo A van GrunsvenXavier de Mollerat du JeuRupa SawantVladimir TorchilinKatarina Farkasova et al.

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Recent progress in canine tumor vaccination: potential applications for human tumor vaccines

Sofie DeniesNiek Sanders

A1 Journal Article in EXPERT REVIEW OF VACCINES

Recent progress in West Nile virus diagnosis and vaccination

Marina De FiletteSebastian UlbertMike DiamondNiek Sanders

A1 Journal Article in VETERINARY RESEARCH

The mechanisms behind sonoporation through the eyes of an AAV-vector

Bart GeersIne LentackerAngelika AlonsoNiek SandersJo DemeesterStephen MeairsStefaan De Smedt

A2 Journal Article in PUBLICATIONS QUARTERLY / AMERICAN CHEMICAL SOCIETY

2011

Absence of inhibition of DNA hydrolysing capacity of dornase alfa by azithromycin in vitro at clinical representative concentrations of azithromycin, dornase alfa and DNA

Erik B WilmsDaniel J TouwHarry GM HeijermanJo DemeesterNiek Sanders

A2 Journal Article in EJHP SCIENCE

Elucidating the mechanisms behind sonoporation with adeno-associated virus-loaded microbubbles

Bart GeersIne LentackerAngelika AlonsoNiek SandersJo DemeesterStephen MeairsStefaan De Smedt

A1 Journal Article in MOLECULAR PHARMACEUTICS

Fluorescence single particle tracking for sizing of nanoparticles in undiluted biological fluids

Kevin BraeckmansKevin BuyensWim Bouquet-GeerardynChris VervaetPhilippe JoyeFilip De VosLaurent PlawinskiLoïc DoeuvreEduardo Angles-CanoNiek Sanders et al.

Lipid-mediated gene delivery to the skin

Barbara GeusensTINE STROBBESTEFANIE BRACKEPeter DynoodtNiek SandersMireille Van GeleJo Lambert

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

mRNA as gene therapeutic: how to control protein expression

Geertrui TavernierOliwia AndriesJo DemeesterNiek SandersStefaan De SmedtJoanna Rejman

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Self-assembled liposome-loaded microbubbles: the missing link for safe and efficient ultrasound triggered drug-delivery

Bart GeersIne LentackerNiek SandersJo DemeesterStephen MeairsStefaan De Smedt

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

2010

Advanced fluorescence microscopy methods illuminate the transfection pathway of nucleic acid nanoparticles

Kevin BraeckmansKevin BuyensBroes NaeyeDries VercauterenHendrik DeschoutKoen RaemdonckKatrien RemautNiek SandersJo DemeesterStefaan De Smedt

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Connexin32 hemichannels contribute to the apoptotic-to-necrotic transition during Fas-mediated hepatocyte cell death

Mathieu VinkenElke DecrockElke De VuystMarijke De BockRoosmarijn VandenbrouckeBruno De GeestJo DemeesterNiek SandersTamara VanhaeckeLuc Leybaert et al.

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

Design and evaluation of doxorubicin-containing microbubbles for ultrasound-triggered doxorubicin delivery: cytotoxicity and mechanisms involved

Ine LentackerBart GeersJo DemeesterStefaan De SmedtNiek Sanders

A1 Journal Article in MOLECULAR THERAPY

Flexible nanosomes (SECosomes) enable efficient siRNA delivery in cultured primary skin cells and in the viable epidermis of ex vivo human skin

Barbara GeusensMireille Van GeleSien BraatStefaan De SmedtMarc CA StuartTarl W ProwWashington SanchezMichael S RobertsNiek SandersJo Lambert

A1 Journal Article in ADVANCED FUNCTIONAL MATERIALS

Monitoring the disassembly of siRNA polyplexes in serum is crucial for predicting their biological efficacy

Kevin BuyensMartin MeyerErnst WagnerJo DemeesterStefaan De SmedtNiek Sanders

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Optimizing siRNA-nanocarriers for systemic delivery by monitoring their behavior in blood

Kevin BuyensStefaan De SmedtNiek Sanders

Pulmonary delivery of mRNA: in vitro and in vivo evaluation

Oliwia AndriesJoanna RejmanCindy PelemanTony LahoutteStefaan De SmedtJo DemeesterNiek Sanders

siRNA containing nanoparticles: stability of encapsulation and particle size

Kevin BuyensKevin BraeckmansJo DemeesterStefaan De SmedtNiek Sanders

Sizing nanomatter in biological fluids by fluorescence single particle tracking

Kevin BraeckmansKevin BuyensWim Bouquet-GeerardynChris VervaetPhilippe JoyeFilip De VosLaurent PlawinskiLoic DoeuvreEduardo Angles-CanoNiek Sanders et al.

A1 Journal Article in NANO LETTERS

Synergistic effects between natural histone mixtures and polyethylenimine in non-viral gene delivery in vitro

Anne SchneeweissKevin BuyensMatthias GieseNiek SandersSebastian Ulbert

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

The use of inhibitors to study endocytic pathways of gene carriers: optimization and pitfalls

Dries VercauterenRoosmarijn VandenbrouckeArwyn T JonesJoanna RejmanJo DemeesterStefaan De SmedtNiek SandersKevin Braeckmans

A1 Journal Article in MOLECULAR THERAPY

Vaccination of turkeys against Chlamydophila psittaci through optimised DNA formulation and administration

Kristel VerminnenDelphine Sylvie Anne BeeckmanNiek SandersStefaan De SmedtDaisy Vanrompay

A1 Journal Article in VACCINE

2009

Cationic polymers to optimize aerosol delivery of a Chlamydophila psittaci DNA vaccine

Kristel VerminnenNiek SandersStefaan De SmedtDaisy Vanrompay

Cutaneous short-interfering RNA therapy

Barbara GeusensNiek SandersTarl ProwMireille Van Gele

A1 Journal Article in EXPERT OPINION ON DRUG DELIVERY

Delivery of mRNA via non-viral carriers

Oliwia AndriesJoanna RejmanStefaan De SmetJo DemeesterMario Van PouckeAlex Van ZeverenLuc PeelmanNiek Sanders

Design and evaluation of drug loaded microbubbles for ultrasound guided cancer therapy

Ine LentackerNiek SandersStefaan De SmedtJo Demeester

Drug loaded microbubble design for ultrasound triggered delivery

Ine LentackerStefaan De SmedtNiek Sanders

A1 Journal Article in SOFT MATTER

Elucidating the Encapsulation of Short Interfering RNA in PEGylated Cationic Liposomes

Kevin BuyensJo DemeesterStefaan De SmedtNiek Sanders

A1 Journal Article in Langmuir

Evaluation of ethosomes for delivery of siRNA into cultured primary melanocytes and skin

Barbara GeusensSien BraatM StuartStefaan De SmedtNiek SandersT ProwM RobertsJo LambertMireille Van Gele

Extracellular barriers in respiratory gene therapy

Niek SandersCarsten RudolphKevin BraeckmansStefaan De SmedtJo Demeester

A1 Journal Article in ADVANCED DRUG DELIVERY REVIEWS

Formulation and process development of (recombinant human) deoxyribonuclease I as a powder for inhalation

Gerrit S ZijlstraBart J PonsioenSylvia A HummelNiek SandersWouter LJ HinrichsAnne H de BoerHenderik W Frijlink

A1 Journal Article in PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY

Stability of siRNA polyplexes from poly(ethylenimine) and poly(ethylenimine)-g-poly(ethylene glycol) under in vivo conditions: Effects on pharmacokinetics and biodistribution measured by Fluorescence Fluctuation Spectroscopy and Single Photon Emission Computed Tomography (SPECT) imaging

OM MerkelD LibrizziA PfestroffT SchurratKevin BuyensNiek SandersStefaan De SmedtM BeheT Kissel

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Ultradeformable cationic liposomes for delivery of small interfering RNA (siRNA) into human primary melanocytes

Barbara GeusensJo LambertStefaan De SmedtKevin BuyensNiek SandersMireille Van Gele

A1 Journal Article in Journal of Controlled Release

Ultrasound exposure of lipoplex loaded microbubbles facilitates direct cytoplasmic entry of the lipoplexes

Ine LentackerNan WangRoosmarijn VandenbrouckeJo DemeesterStefaan De SmedtNiek Sanders

A1 Journal Article in MOLECULAR PHARMACEUTICS

2008

A fast and sensitive method for measuring the integrity of siRNA-carrier complexes in full human serum

Kevin BuyensBart LucasKoen RaemdonckKevin BraeckmansJ VERCAMMENJ HENDRIXY ENGELBORGHSStefaan De SmedtNiek Sanders

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Can ultrasound solve the transport barrier of the neural retina?

Liesbeth PeetersIne LentackerRoosmarijn VandenbrouckeBart LucasJo DemeesterNiek SandersStefaan De Smedt

A1 Journal Article in PHARMACEUTICAL RESEARCH

Cationic polymers to optimize aerosol delivery of a Chlamydophila psittaci DNA vaccine

Kristel VerminnenNiek SandersStefaan De SmedtDaisy Vanrompay

Cationic polymers to optimize aerosol delivery of a Chlamydophila psittaci DNA vaccine

Kristel VerminnenNiek SandersStefaan De SmedtDaisy Vanrompay

Circumventing the endocytotic uptake of highly PEGylated lipoplexes by using lipoplex loaded microbubbles and ultrasound can drastically increase their transfection efficiency

Ine LentackerStefaan De SmedtNiek Sanders

Dextran microgels for time-controlled delivery of siRNA

Koen RaemdonckTinneke Van ThienenRoosmarijn VandenbrouckeNiek SandersJo DemeesterStefaan De Smedt

A1 Journal Article in ADVANCED FUNCTIONAL MATERIALS

Loading of PEGylated siRNA lipoplexes on microbubbles restores their siRNA delivery capacity in the presence of ultrasound

Roosmarijn VandenbrouckeIne LentackerJo DemeesterStefaan De SmedtNiek Sanders

Maintaining the silence: reflections on long-term RNAi

Koen RaemdonckRoosmarijn VandenbrouckeJo DemeesterNiek SandersStefaan De Smedt

A1 Journal Article in DRUG DISCOVERY TODAY

New strategies for nucleic acid delivery to conquer cellular and nuclear membranes

Ine LentackerRoosmarijn VandenbrouckeBart LucasJo DemeesterStefaan De SmedtNiek Sanders

A1 Journal Article in Journal of Controlled Release

Non-viral delivery strategies to guide therapeutic nucleic acids through cellular barriers

Roosmarijn VandenbrouckeNiek SandersJo DemeesterStefaan De Smedt

Prolonged gene silencing in hepatoma cells and primary hepatocytes after siRNA delivery with biodegradable poly(beta-amino esters)

Roosmarijn VandenbrouckeBruno De GeestJo DemeesterStefaan De SmedtNiek Sanders

Prolonged gene silencing in hepatoma cells and primary hepatocytes after small interfering RNA delivery with biodegradable poly(beta-amino esters)

Roosmarijn VandenbrouckeBruno De GeestStefan BonnéM VINKENT VAN HAECKEH HEIMBERGE WAGNERV ROGIERSStefaan De SmedtJo Demeester et al.

A1 Journal Article in JOURNAL OF GENE MEDICINE

Ultrasound assisted siRNA delivery using PEG-siPlex loaded microbubbles

Roosmarijn VandenbrouckeIne LentackerJo DemeesterStefaan De SmedtNiek Sanders

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Vitreous and neural retina are barriers for non-viral ocular gene therapy

Liesbeth PeetersNiek SandersStefaan De SmedtJo Demeester

2007

Cellular entry pathway and gene transfer capacity of TAT-modified lipoplexes

Roosmarijn VandenbrouckeStefaan De SmedtJo DemeesterNiek Sanders

A1 Journal Article in BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Challenges in non-viral ocular gene transfer

Liesbeth PeetersNiek SandersJo DemeesterStefaan De Smedt

A1 Journal Article in BIOCHEMICAL SOCIETY TRANSACTIONS

Lipoplex-loaded microbubbles for gene delivery: A Trojan horse controlled by ultrasound

Ine LentackerStefaan De SmedtJo DemeesterVeerle Van MarckMarc BrackeNiek Sanders

A1 Journal Article in ADVANCED FUNCTIONAL MATERIALS

Mucolytic activity of bacterial and human chitinases

Niek SandersVGH EIJSLNKPS VAN DEN PANGAARTRJJ VAN NEERVENPJ SIMONSStefaan De SmedtJo Demeester

A1 Journal Article in BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Nuclear accumulation of plasmid DNA can be enhanced by non-selective gating of the nuclear pore

Roosmarijn VandenbrouckeBart LucasJo DemeesterStefaan De SmedtNiek Sanders

Nuclear accumulation of plasmid DNA can be enhanced by non-selective gating of the nuclear pore

Roosmarijn VandenbrouckeBart LucasJo DemeesterStefaan De SmedtNiek Sanders

A1 Journal Article in NUCLEIC ACIDS RESEARCH

Nucleic acid delivery: Where material sciences and bio-sciences meet

Katrien RemautNiek SandersBruno De GeestKevin BraeckmansJo DemeesterStefaan De Smedt

A1 Journal Article in MATERIALS SCIENCE & ENGINEERING R-REPORTS

Post-pegylated lipoplexes are promising vehicles for gene delivery in RPE cells

Liesbeth PeetersNiek SandersA JONESJo DemeesterStefaan De Smedt

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Release mechanisms for polyelectrolyte capsules

Bruno De GeestNiek SandersGB SUKHORUKOVJo DemeesterStefaan De Smedt

A1 Journal Article in CHEMICAL SOCIETY REVIEWS

Sensitive spectroscopic detection of large and denatured protein aggregates in solution by use of the fluorescent dye Nile red

M SUTTERS OLIVEIRANiek SandersBart LucasA VAN HOEKMA HINKAJWG VISSERStefaan De SmedtWE HENNINKW JISKOOT

A1 Journal Article in JOURNAL OF FLUORESCENCE

Wanted and unwanted properties of surface PEGylated nucleic acid nanoparticles in ocular gene transfer

Niek SandersLiesbeth PeetersIne LentackerJo DemeesterStefaan De Smedt

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

2006

Delivery of phosphodiester oligonucleotides: Can DOTAP/DOPE liposomes do the trick?

Katrien RemautBart LucasKevin BraeckmansNiek SandersJo DemeesterStefaan De Smedt

A1 Journal Article in BIOCHEMISTRY

Detection of Aspergillus fumigatus hyphae in respiratory secretions by membrane filtration, fluorescent labelling and laser scanning

MM DE VOSNiek SandersHans Nelis

A1 Journal Article in JOURNAL OF MICROBIOLOGICAL METHODS

In situ analysis of single-stranded and duplex siRNA integrity in living cells

Koen RaemdonckKatrien RemautBart LucasNiek SandersJo DemeesterStefaan De Smedt

A1 Journal Article in BIOCHEMISTRY

Influence of plasmid DNA topology on the transfection properties of DOTAP/DOPE lipoplexes

Katrien RemautNiek SandersFarzaneh FayazpourJo DemeesterStefaan De Smedt

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Intracellularly degradable polyelectrolyte microcapsules

Bruno De GeestRoosmarijn VandenbrouckeAM GUENTHERGB SUKHORUKOVWE HENNINKNiek SandersJo DemeesterStefaan De Smedt

A1 Journal Article in ADVANCED MATERIALS

Microbubbles which bind and protect DNA against nucleases

Ine LentackerStefaan De SmedtJo DemeesterNiek Sanders

Physicochemical and transfection properties of cationic hydroxyethylcellulose/DNA nanoparticles

Farzaneh FayazpourBart LucasC ALVAREZ-LORENZONiek SandersJo DemeesterStefaan De Smedt

A1 Journal Article in BIOMACROMOLECULES

Role of magnesium in the failure of rhDNase therapy in patients with cystic fibrosis

Niek SandersH FRANCKXK DE BOECKJurgen HaustraeteStefaan De SmedtJo Demeester

A1 Journal Article in THORAX

The choice of a suitable oligosaccharide to prevent aggregation of PEGylated nanoparticles during freeze thawing and freeze drying

WLJ HINRICHSFA MANCENIDONiek SandersKevin BraeckmansStefaan De SmedtJo DemeesterHW FRIJLINK

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

The internalization route resulting in successful gene expression depends on polyethylenimine both cell line and polyplex type

K VON GERSDORFFNiek SandersRoosmarijn VandenbrouckeStefaan De SmedtE WAGNERM OGRIS

A1 Journal Article in MOLECULAR THERAPY

Ultrasound-responsive polymer-coated microbubbles that bind and protect DNA

Ine LentackerBruno De GeestRoosmarijn VandenbrouckeLiesbeth PeetersJo DemeesterStefaan De SmedtNiek Sanders

A1 Journal Article in LANGMUIR

2005

Fluorescence energy transfer to study the degradation of double-labeled oligonucleotides

Katrien RemautBart LucasKevin BraeckmansNiek SandersStefaan De SmedtJo Demeester

FRET-FCS as a tool to evaluate the stability of oligonucleotide drugs after intracellular delivery

Katrien RemautBart LucasKevin BraeckmansNiek SandersStefaan De SmedtJo Demeester

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Inulin is a promising cryo- and lyoprotectant for PEGylated lipoplexes

WLJ HINRICHSNiek SandersStefaan De SmedtJo DemeesterHW FRIJLINK

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Protection of oligonucleotides against nucleases by pegylated and non-pegylated liposomes as studied by fluorescence correlation spectroscopy

Katrien RemautBart LucasKevin BraeckmansNiek SandersJo DemeesterStefaan De Smedt

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Studying biophysical barriers to DNA delivery by advanced light microscopy

Stefaan De SmedtKatrien RemautBart LucasKevin BraeckmansNiek SandersJo Demeester

A1 Journal Article in ADVANCED DRUG DELIVERY REVIEWS

Studying the intracellular dissociation of polymer-oligonucleotide complexes by dual color fluorescence fluctuation spectroscopy and confocal imaging

Bart LucasKatrien RemautNiek SandersKevin BraeckmansStefaan De SmedtJo Demeester

A1 Journal Article in BIOCHEMISTRY

Towards a better understanding of the dissociation behavior of liposome-oligonucleotide complexes in the cytosol of cells

Bart LucasKatrien RemautNiek SandersKevin BraeckmansStefaan De SmedtJo Demeester

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Vitreous: a barrier to nonviral ocular gene therapy

Liesbeth PeetersNiek SandersKevin BraeckmansKoen BousseryJohan Van de VoordeStefaan De SmedtJo Demeester

A1 Journal Article in INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

2004

Enhancement of nuclear uptake of therapeutic genes and macromolecules by using NLS and PTD containing viral peptides

Roosmarijn VandenbrouckeEls VanderleydenStefaan De SmedtNiek SandersJo Demeester

On the biological activity of anti-ICAM-1 oligonucleotides complexed to non-viral carriers

Bart LucasElsa Van RompaeyKatrien RemautNiek SandersStefaan De SmedtJo Demeester

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

2003

Mobility and stability of gene complexes in biogels

Niek SandersStefaan De SmedtJo Demeester

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Three-dimensional fluorescence recovery after photobleaching with the confocal scanning laser microscope

Kevin BraeckmansLiesbeth PeetersNiek SandersStefaan De SmedtJo Demeester

A1 Journal Article in BIOPHYSICAL JOURNAL

2002

On the transport of lipoplexes through cystic fibrosis sputum.

Niek SandersElsa Van RompaeyStefaan De SmedtJo Demeester

A1 Journal Article in PHARMACEUTICAL RESEARCH

Pegylated GL67 lipoplexes retain their gene transfection activity after exposure to components of CF mucus.

Niek SandersStefaan De SmedtSH CHENGJo Demeester

A1 Journal Article in GENE THERAPY

2001

Interactions between oligonucleotides and cationic polymers investigated by fluorescence correlation spectroscopy.

Elsa Van RompaeyY ENGELBORGHSNiek SandersStefaan De SmedtJo Demeester

A1 Journal Article in PHARMACEUTICAL RESEARCH

Structural alterations of gene complexes by cystic fibrosis sputum.

Niek SandersElsa Van RompaeyStefaan De SmedtJo Demeester

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

2000

Complex formation between cationic polymethacrylates and oligonucleotides.

Elsa Van RompaeyNiek SandersStefaan De SmedtJo DemeesterE VAN CRAENENBROECKY ENGELBORGHS

A1 Journal Article in MACROMOLECULES

Cystic fibrosis sputum. A barrier to the transport of nanospheres.

Niek SandersStefaan De SmedtElsa Van RompaeyPaul SimoensFrans De BaetsJo Demeester

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The physical properties of biogels and their permeability for macromolecular drugs and colloidal drug carriers.

Niek SandersStefaan De SmedtJo Demeester

A1 Journal Article in JOURNAL OF PHARMACEUTICAL SCIENCES