Research Explorer

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Researcher

Nico Mertens

Awards & Distinctions

31 Results

2010

PH1-derived bivalent bibodies and trivalent tribodies bind differentially to shed and tumour cell-associated MUC1

Steve SchoonoogheIngrid BurvenichLiesbet VervoortFilip De VosNico MertensJohan Grooten

A1 Journal Article in PROTEIN ENGINEERING DESIGN & SELECTION

2009

Efficient production of human bivalent and trivalent anti-MUC1 Fab-scFv antibodies in Pichia pastoris

Steve SchoonoogheVladimir KaigorodovMonika ZawiszaCaroline DumolynJurgen HaustraeteJohan GrootenNico Mertens

A1 Journal Article in BMC BIOTECHNOLOGY

2008

Monoclonal antibody 14C5 targets integrin alpha(v)beta(3)

Ingrid BurvenichSteve SchoonoogheLiesbet VervoortCaroline DumolynElisabeth CoeneLieve VANWALLEGHEMJacques Van HuysseMarleen PraetClaude CuvelierNico Mertens et al.

A1 Journal Article in MOLECULAR CANCER THERAPEUTICS

2007

Biodistribution and planar gamma camera imaging of I-123- and I-131-labeled F(ab ')(2) and Fab fragments of monoclonal antibody 14C5 in nude mice bearing an A549 lung tumor

Ingrid BurvenichSteve SchoonooghePeter BlanckaertKlaus BacherLiesbet VervoortElisabeth CoeneNico MertensFilip De VosGuido Slegers

A1 Journal Article in NUCLEAR MEDICINE AND BIOLOGY

In vivo cellular uptake, degradation, and biocompatibility of polyelectrolyte microcapsules

Stefaan De KokerBruno De GeestClaude CuvelierLiesbeth FerdinandeWies DeckersWE HENNINKStefaan De SmedtNico Mertens

A1 Journal Article in ADVANCED FUNCTIONAL MATERIALS

2006

Angiogenesis enhances factor IX delivery and persistence from retrievable human bioengineered muscle implants

L THORREZH VANDENBURGHNico CallewaertNico MertensJ SHANSKYL WANGJ ARNOUTD COLLENM CHUAHT VANDENDRIESSCHE

A1 Journal Article in MOLECULAR THERAPY

2005

50 Ways to get your protein. Multiparallel screening of optimal gene expression strategies

A2 Journal Article in Screening - Trends in Drug Discovery

CD3 x CD28 cross-interacting bispecific antibodies improve tumor cell dependent T-cell activation

An WillemsSteve SchoonoogheDominique EeckhoutGeert De JaegerJohan GrootenNico Mertens

A1 Journal Article in CANCER IMMUNOLOGY IMMUNOTHERAPY

In vitro and in vivo targeting properties of iodine-123- or iodine-131-labeled monoclonal antibody 14C5 in a non-small cell lung cancer and colon carcinoma model

Ingrid BurvenichSteve SchoonoogheBart CornelissenPeter BlanckaertElisabeth CoeneClaude CuvelierNico MertensGuido Slegers

A1 Journal Article in CLINICAL CANCER RESEARCH

Treatment of motoneuron degeneration by intracerebroventricular delivery of VEGF in a rat model of ALS

E STORKEBAUMD LAMBRECHTSM DEWERCHINMP MORENO-MURCIANOS APPELMANSH OHP VAN DAMMEB RUTTENWY MANM DE MOL et al.

A1 Journal Article in NATURE NEUROSCIENCE

2004

123I-labelled monoclonal antibody 14C5 for SPECT tumour imaging: In vivo evaluation of athymic mice bearing a LoVo tumour

Ingrid BurvenichBart CornelissenPeter BlanckaertElisabeth CoeneClaude CuvelierGuido SlegersSteve SchoonoogheNico Mertens

Improved targeting with F(ab)2 fragments of monoclonal antibody 14C5 for imaging and therapy of metastatic disease

Ingrid BurvenichKaren JanssenPeter BlanckaertSteve SchoonoogheElisabeth CoeneClaude CuvelierNico MertensGuido Slegers

Molecular aspects of G-protein coupled receptor signalling of relevance for nuclear medicine imaging in psychiatry

Christophe Van De WieleIngeborg GoethalsKurt AudenaertAndreas OtteNico Mertens

Bookchapter in Nuclear medicine in psychiatry

New strategies in polypeptide and antibody synthesis: An overview

Nico MertensF DEVOSJannick LeoenEls Van DeynseAn WillemsSteve SchoonoogheIngrid BurvenichStefaan De KokerDominique VliegheJohan Grooten et al.

A1 Journal Article in CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

Radioimmunoimaging. Advances and prospects

Christophe Van De WieleH REVETSNico Mertens

A2 Journal Article in The Quarterly Journal of Nuclear Medicine and Molecular Imaging

Radiolabeled annexin-V for monitoring treatment response in oncology

Christophe Van De WieleHubert VermeerschDavid LooseA SIGNORENico MertensRudi Dierckx

A1 Journal Article in CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

Targeting properties of radiolabelled monoclonal antibody 14c5 directed against a cell substrate adhesion molecule

Ingrid BurvenichSteve SchoonooghePeter BlanckaertElisabeth CoeneBart CornelissenClaude CuvelierNico MertensGuido Slegers

2003

Optimizing expression and purification from cell culture medium of trispecific recombinant antibody derivatives

An WillemsJannick LeoenSteve SchoonoogheJohan GrootenNico Mertens

A1 Journal Article in JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

2001

A new model for intermediate molecular weight recombinant bispecific and trispecific antibodies by efficient heterodimerization of single chain variable domains through fusion to a Fab-chain.

Reinhilde SchoonjansAn WillemsSteve SchoonoogheJ LEOENJohan GrootenNico Mertens

A1 Journal Article in BIOMOLECULAR ENGINEERING

Expression in Escherichia coli of the death domain of the human p55 tumor necrosis factor receptor.

Gert De WildeNico MertensElke BooneB DE VREESEJozef Van BeeumenWalther FiersGuy Haegeman

A1 Journal Article in PROTEIN EXPRESSION AND PURIFICATION

New recombinant bi- and trispecific antibody derivatives

Nico MertensReinhilde SchoonjansAn WillemsSteve SchoonoogheJannick LeoenJohan Grooten

2000

Efficient heterodimerization of recombinant bi- and trispecific antibodies.

Reinhilde SchoonjansAn WillemsJohan GrootenNico Mertens

A1 Journal Article in BIOSEPARATION

Fab chains as an efficient heterodimerization scaffold for the production of recombinant bispecific and trispecific antibody derivatives.

Reinhilde SchoonjansAn WillemsSteve SchoonoogheWalther FiersJohan GrootenNico Mertens

A1 Journal Article in JOURNAL OF IMMUNOLOGY

1999

An advanced vector system for high-level recombinant gene expression in Escherichia coli

Nico MertensWalther FiersErik Remaut

Bookchapter in Biotechnology international II

1996

Increased stability of phage T7g10 mRNA is mediated by either a 5'- or a 3'-terminal stem-loop structure.

Nico MertensErik RemautWalther Fiers

A1 Journal Article in BIOLOGICAL CHEMISTRY

Optimization of heterologous gene expression in Escherichia coli

Nico MertensWalther Fiers

1995

TIGHT TRANSCRIPTIONAL CONTROL MECHANISM ENSURES STABLE HIGH-LEVEL EXPRESSION FROM T7 PROMOTER-BASED EXPRESSION PLASMIDS.

Nico MertensErik RemautWalther Fiers

A1 Journal Article in BIO-TECHNOLOGY

VERSATILE, MULTI-FEATURED PLASMIDS FOR HIGH-LEVEL EXPRESSION OF HETEROLOGOUS GENES IN ESCHERICHIA-COLI - OVERPRODUCTION OF HUMAN AND MURINE CYTOKINES.

Nico MertensErik RemautWalther Fiers

A1 Journal Article in GENE

1993

HIGH-LEVEL EXPRESSION, PURIFICATION, AND RENATURATION OF RECOMBINANT MURINE INTERLEUKIN-2 FROM ESCHERICHIA-COLI

Yves GuisezJan DemolderNico MertensAlex RaeymaekersGeert PlaetinckJohan RobbensJoël VandekerckhoveErik RemautWalther Fiers

A1 Journal Article in PROTEIN EXPRESSION AND PURIFICATION

T7-RNA-polymerase terminates at poly-A regions on plasmids.

Nico MertensErik RemautWalther Fiers

Translational coupling: the importance of the translational efficiency of the first cistron.

Nico MertensErik RemautWalther Fiers