Research Explorer

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Researcher

Nathalie Bracke

Awards & Distinctions

53 Results

2020

Blood-brain barrier transport kinetics of NOTA-modified proteins : the somatropin case

Nathalie BrackeYorick JanssensEvelien WynendaeleLiesa TackAlex MaesChristophe Van De WieleMike SathekgeBart De Spiegeleer

A1 Journal Article in QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

LC-MS compatible antiadsorption diluent for peptide analysis

Frederick VerbekeNathalie BrackeNathan DebunneEvelien WynendaeleBart De Spiegeleer

A1 Journal Article in ANALYTICAL CHEMISTRY

MEK1/2 inhibition in murine heart and aorta after oral administration of refametinib supplemented drinking water

Felke SteijnsNathalie BrackeMarjolijn RenardJulie De BackerPatrick SipsNathan DebunneEvelien WynendaeleFrederick VerbekeBart De SpiegeleerLaurence Campens

A1 Journal Article in FRONTIERS IN PHARMACOLOGY

2019

Biological characterisation of somatropin-derived cryptic peptides

Liesa TackNathalie BrackeFrederick VerbekeEvelien WynendaeleEwald PauwelsAlex MaesChristophe Van de WieleMike SathekgeBart De Spiegeleer

A1 Journal Article in INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS

2017

Hydrophilic interaction liquid chromatography method development and validation for the assay of HEPES zwitterionic buffer

Xiaolong XuBert GevaertNathalie BrackeHan YaoEvelien WynendaeleBart De Spiegeleer

A1 Journal Article in JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

In vitro functional quality characterization of NOTA-modified somatropins

Nathalie BrackeHan YaoEvelien WynendaeleFrederick VerbekeXiaolong XuBert GevaertAlex MaesChristophe Van De WieleMike SathekgeSarah De Saeger et al.

A1 Journal Article in ANALYTICAL CHEMISTRY

2016

An analytical quality by design (aQbD) approach for a L-asparaginaseactivity method

Han YaoJochem VancoillieMatthias D'HondtEvelien WynendaeleNathalie BrackeBart De Spiegeleer

A1 Journal Article in JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Blood-brain barrier transport kinetics of the cyclic depsipeptide mycotoxins beauvericin and enniatins

Lien TaevernierNathalie BrackeLieselotte VeryserEvelien WynendaeleBert GevaertKathelijne PeremansBart De Spiegeleer

A1 Journal Article in TOXICOLOGY LETTERS

Blood-brain barrier transport kinetics of the neuromedin peptides NMU, NMN, NMB and NT

Bert GevaertEvelien WynendaeleSofie StalmansNathalie BrackeMatthias D'HondtIlse SmoldersAnn Van EeckhautBart De Spiegeleer

A1 Journal Article in NEUROPHARMACOLOGY

Do cyclic depsipeptide mycotoxins beauvericin and enniatins cross the blood-brain barrier?

Lien TaevernierNathalie BrackeLieselotte VeryserEvelien WynendaeleBart De Spiegeleer

Exploration of the medicinal peptide space

Bert GevaertSofie StalmansEvelien WynendaeleLien TaevernierNathalie BrackeMatthias D'HondtBart De Spiegeleer

A1 Journal Article in PROTEIN AND PEPTIDE LETTERS

Functional quality of somatropin derivatives : NOTA-modifications and peptides

Nathalie BrackeBart De Spiegeleer

Hydrophilic interaction liquid chromatography method development and validation for the assay of HEPES zwitterionic buffer

Xiaolong XuBert GevaertNathalie BrackeHan YaoEvelien WynendaeleBart De Spiegeleer

Impurity profiling of L-asparaginase preparation

Han YaoNathalie BrackeBert GevaertXiaolong XuEvelien WynendaeleRob HaselbergGovert SomsenBart De Spiegeleer

Mucosal and blood-brain barrier transport kinetics of the plant N-alkylamide spilanthol using in vitro and in vivo models

Lieselotte VeryserLien TaevernierTanmayee JoshiPratima TatkeEvelien WynendaeleNathalie BrackeSofie StalmansKathelijne PeremansChristian BurvenichMartijn Risseeuw et al.

A1 Journal Article in BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE

Pharmaceutical regulatory framework in Ethiopia : a critical evaluation of its legal basis and implementation

Sultan Suleman WegaAbdulkadir WoliyiKifle WoldemichaelKora TushuneLuc DuchateauAgnes DegrooteRoy VancauwenbergheNathalie BrackeBart De Spiegeleer

A2 Journal Article in ETHIOPIAN JOURNAL OF HEALTH SCIENCES

Quality control of cationic cell-penetrating peptides

Sofie StalmansBert GevaertFrederick VerbekeMatthias D'HondtNathalie BrackeEvelien WynendaeleBart De Spiegeleer

A1 Journal Article in JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Quantitative in vitro and in vivo evaluation of intestinal and blood-brain barrier transport kinetics of the plant N-alkylamide pellitorine

Lieselotte VeryserNathalie BrackeEvelien WynendaeleTanmayee JoshiPratima TatkeLien TaevernierBart De Spiegeleer

A1 Journal Article in BIOMED RESEARCH INTERNATIONAL

Regulatory development of geriatric medicines : to GIP or not to GIP?

Bart De SpiegeleerEvelien WynendaeleNathalie BrackeLieselotte VeryserLien TaevernierAgnes DegrooteSofie Stalmans

A1 Journal Article in AGEING RESEARCH REVIEWS

2015

An analytical quality-by-design (aQbD) approach for a L-asparaginase activity method

Han YaoJochem VancoillieMatthias D'HondtEvelien WynendaeleNathalie BrackeBart De Spiegeleer

Blood–brain transfer and antinociception of linear and cyclic N-methyl-guanidine and thiourea-enkephalins

Mathieu VerbekenEvelien WynendaeleElodie MauchaufféeNathalie BrackeSofie StalmansEngin BojnikSandor BenyheKathelijne PeremansIngeborgh PolisChristian Burvenich et al.

A1 Journal Article in PEPTIDES

Cell-penetrating peptides selectively cross the blood-brain barrier in vivo

Sofie StalmansNathalie BrackeEvelien WynendaeleBert GevaertKathelijne PeremansChristian BurvenichIngeborgh PolisBart De Spiegeleer

A1 Journal Article in PLOS ONE

Evaluation of local tolerance of a plant extract by the slug mucosal irritation (SMI) assay

Lieselotte VeryserJoke LenoirJente BoonenNathalie BrackeEvelien WynendaeleEls AdriaensHans NelisBram De WeverJean Paul RemonBart De Spiegeleer

A2 Journal Article in JOURNAL OF TOXICOLOGICAL EDUCATION

Peptide profiling of internet obtained Cerebrolysin using HPLC-ESI-IT & UHPLC-Q-IM-TOF mass spectrometry

Bert GevaertMatthias D'HondtNathalie BrackeHan YaoEvelien WynendaeleJohannes Petrus Cornelis VissersMartin De CeccoJan ClaereboudtBart De Spiegeleer

Peptide profiling of internet-obtained cerebrolysin using high performance liquid chromatography–electrospray ionization ion trap and ultra high performance liquid chromatography–ion mobility–quadrupole time of flight mass spectrometry

Bert GevaertMatthias D'HondtNathalie BrackeHan YaoEvelien WynendaeleJohannes Petrus Cornelis VissersMartin De CeccoJan ClaereboudtBart De Spiegeleer

A1 Journal Article in DRUG TESTING AND ANALYSIS

Surface acoustic wave biosensor as a functional quality method in pharmaceutics

Nathalie BrackeSophia BarhdadiEvelien WynendaeleBert GevaertMatthias D'HondtBart De Spiegeleer

A1 Journal Article in SENSORS AND ACTUATORS B-CHEMICAL

The blood-brain barrier (BBB) permeability properties of plant N-alkylamides

Lieselotte VeryserEvelien WynendaeleNathalie BrackeBart De Spiegeleer

2014

Analytical characterisation of NOTA-modified somatropins

Nathalie BrackeEvelien WynendaeleMatthias D'HondtRob HaselbergGovert W SomsenEwald PauwelsChristophe Van De WieleBart De Spiegeleer

A1 Journal Article in JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Blood-brain barrier transport of short proline-rich antimicrobial peptides

Sofie StalmansEvelien WynendaeleNathalie BrackeDaniel KnappeRalf HoffmannKathelijne PeremansIngeborgh PolisChristian BurvenichBart De Spiegeleer

A1 Journal Article in PROTEIN AND PEPTIDE LETTERS

Development of geriatric medicines: to GIP or not to GIP?

Sofie StalmansNathalie BrackeBart De Spiegeleer

Development of peptide and protein based radiopharmaceuticals

Evelien WynendaeleNathalie BrackeSofie StalmansBart De Spiegeleer

A1 Journal Article in CURRENT PHARMACEUTICAL DESIGN

Do cell-penetrating peptides cross the blood-brain barrier

Sofie StalmansEvelien WynendaeleNathalie BrackeBart De Spiegeleer

Identification of a microscopically selected microorganism in milk samples

Nathalie BrackeMario Van PouckeBram BaertEvelien WynendaeleLobke De BelsWim Van Den BroeckLuc PeelmanChristian BurvenichBart De Spiegeleer

A1 Journal Article in JOURNAL OF DAIRY SCIENCE

Related impurities in peptide medicines

Matthias D'HondtNathalie BrackeLien TaevernierBert GevaertFrederick VerbekeEvelien WynendaeleBart De Spiegeleer

A1 Journal Article in JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Similars for biologics and ATMPs: quo vadis?

Nathalie BrackeBart De Spiegeleer

Surface acoustic wave biosensor as a functional-quality method in pharmaceutics

Nathalie BrackeEvelien WynendaeleBert GevaertBart De Spiegeleer

Surface acoustic wave biosensor as an analytical tool in pharmaceutics : a quality by design approach

Nathalie BrackeEvelien WynendaeleBert GevaertBart De Spiegeleer

The moving boundaries in starting materials: from small molecules to biopharma and ATMPs

Matthias D'HondtNathalie BrackeBart De Spiegeleer

The possible role of somatropin derivatives as a theranostic in oncology

Nathalie BrackeEvelien WynendaeleSophia BarhdadiChristophe Van De WieleBart De Spiegeleer

2013

A rapid stability-indicating, fused-core HPLC method for simultaneous determination of β-artemether and lumefantrine in anti-malarial fixed dose combination products

Sultan Suleman WegaKirsten VandercruyssenEvelien WynendaeleMatthias D'HondtNathalie BrackeLuc DuchateauChristian BurvenichKathelijne PeremansBart De Spiegeleer

A1 Journal Article in MALARIA JOURNAL

Chemical-functional diversity in cell-penetrating peptides

Sofie StalmansEvelien WynendaeleNathalie BrackeBert GevaertMatthias D'HondtKathelijne PeremansChristian BurvenichBart De Spiegeleer

A1 Journal Article in PLOS ONE

Human IL-34 and CSF-1 establish structurally similar extracellular assemblies with their common hematopoietic receptor

Jan FélixJonathan ElegheertIrina GutscheAlexander ShkumatovYurong WenNathalie BrackeErwin PannecouckeIsabel VandenbergheBart DevreeseDmitri Svergun et al.

A1 Journal Article in STRUCTURE

Quorumpeps database : chemical space, microbial origin and functionality of quorum sensing peptides

Evelien WynendaeleAntoon BronselaerJoachim NielandtMatthias D'HondtSofie StalmansNathalie BrackeFrederick VerbekeChristophe Van De WieleGuy De TréBart De Spiegeleer

A1 Journal Article in NUCLEIC ACIDS RESEARCH

Somatropin (rhGH) functional quality characterization by LC/CE-MS and SAW (Surface Acoustic Wave) biosensor techniques

Nathalie BrackeEvelien WynendaeleRob HaselbergGovert SomsenSophia BarhdadiBart De Spiegeleer

Surface acoustic wave technology as a tool for functional quality characterization of new compounds and biosimilars

Nathalie BrackeEvelien WynendaeleChristophe Van De WieleBart De Spiegeleer

2012

Allosteric competitive inactivation of hematopoietic CSF-1 signaling by the viral decoy receptor BARF1

Jonathan ElegheertNathalie BrackePhilippe PouliotIrina GutscheAlexander V ShkumatovNicolas TarbouriechKenneth VerstraeteAnaïs BekaertWim P BurmeisterDmitri I Svergun et al.

A1 Journal Article in NATURE STRUCTURAL & MOLECULAR BIOLOGY

Exploring the Brainpeps database

Sofie StalmansMatthias D'HondtEvelien WynendaeleNathalie BrackeBart De Spiegeleer

Functional quality of peptide drugs

Mathieu VerbekenNathalie BrackeBart De Spiegeleer

Receptor and blood-brain barrier characterisation of opioid peptides in drug research and early development

Bart De SpiegeleerSofie StalmansEvelien WynendaeleNathalie BrackeMathieu VerbekenKathelijne PeremansIngeborgh PolisChristian Burvenich

Receptor and blood-brain barrier characterization of opioid peptides in drug research and early development

Mathieu VerbekenSofie StalmansEvelien WynendaeleNathalie BrackeBert GevaertKathelijne PeremansIngeborgh PolisChristian BurvenichBart De Spiegeleer

Surface acoustic wave technology as a tool for functional characterization of new compounds

Nathalie BrackeLaurens DeneveBart De Spiegeleer

Variation of the net charge, lipophilicity, and side chain flexibility in Dmt¹-DALDA: effect on opioid activity and biodistribution

Alexandre NovoaSylvia Van DorpeEvelien WynendaeleMariana SpeteaNathalie BrackeSofie StalmansCecilia BettiNga N ChungCarole LemieuxJohannes Zuegg et al.

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

2011

Extracellular complexes of the hematopoietic human and mouse CSF-1 receptor are driven by common assembly principles

Jonathan ElegheertAmbroise DesfossesAlexander V ShkumatovXiongwu WuNathalie BrackeKenneth VerstraeteKathleen Van CraenenbroeckBernard R BrooksDmitri I SvergunBjorn Vergauwen et al.

A1 Journal Article in STRUCTURE