Research Explorer

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Researcher

Natalie De Ruyck

Publications & Research Data

Awards & Distinctions

66 Results

2026

Chitin is a potent inducer of type 2 airway inflammation independent of endogenous chitinolytic activity

Jozefien DeclercqHelena Catharine AegerterUrsula SmoleKarel Van DammeEllen KetelaereInés LammensCaroline De WolfKarl VergoteManon VanheerswynghelsSofie De Prijck et al.

A1 Journal Article in ALLERGY

Mechanisms and kinetics of wound healing in chronic rhinosinusitis patients after complete sinus surgery and its improvement by doxycycline therapy

Elke VandewalleEls De SchryverLien CalusManon BlauwblommePauline JanssenEllen KetelaereSharon Van NevelAnne-Sophie EeckelsNatalie De RuyckGabriële Holtappels et al.

A1 Journal Article in INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY

2025

Distinct effects of biological treatments on eosinophils and neutrophils in chronic rhinosinusitis with nasal polyp patients

Sharon Van NevelNan ZhangZhaofeng XuManon BlauwblommeElke VandewalleGabriële HoltappelsNatalie De RuyckFilip Van NieuwerburghStijn VanheePhilippe Gevaert et al.

A1 Journal Article in CLINICAL AND TRANSLATIONAL ALLERGY

Nasal mucosal brushings could be used to define the endotype in nasal inflammatory diseases

Elke VandewalleGabriële HoltappelsNatalie De RuyckLara DeryckeManon BlauwblommeEllen KetelaereAnne-Sophie EeckelsThibaut Van ZeleStijn VanheePhilippe Gevaert

Real-life effectiveness of mepolizumab and omalizumab in sever uncontrolled chronic rhinosinusitis with nasal polyps : a prospective study

Manon BlauwblommePhilippe GevaertGuy BrusselleGeert De VosAnne-Sophie EeckelsStijn VanheeElke VandewalleGabriële HoltappelsNatalie De RuyckEllen Ketelaere et al.

2024

Case report : dual monoclonal antibody therapy in chronic rhinosinusitis with nasal polyps and severe eosinophilic asthma : a proteome analysis

Manon BlauwblommePhilippe GevaertSharon Van NevelSebastian RiemannElke VandewalleGabriële HoltappelsNatalie De RuyckLara DeryckeAnne-Sophie EeckelsStijn Vanhee et al.

A2 Journal Article in FRONTIERS IN ALLERGY

Repeated COVID-19 mRNA-based vaccination contributes to SARS-CoV-2 neutralizing antibody responses in the mucosa

Jozefien DeclercqSarah GerloSharon Van NevelNatalie De RuyckGabriële HoltappelsLiesbeth DelesieEls TobbackInés LammensNikita GerebtsovKoen Sedeyn et al.

A1 Journal Article in SCIENCE TRANSLATIONAL MEDICINE

2023

Differential protease content of mast cells and the processing of IL-33 in Alternaria alternata induced allergic airway inflammation in mice

Olga KryskoDarya KorsakovaAndrea Renate TeufelbergerAmse De MeyerJill SteelsNatalie De RuyckJudith van OvostSharon Van NevelGabriële HoltappelsFrauke Coppieters et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Effects of biologics treatment in type 2-high chronic rhinosinusitis with nasal polyp patients

Sharon Van NevelTim MeeseGabriële HoltappelsNatalie De RuyckStijn VanheeNan ZhangFilip Van NieuwerburghClaus Bachert

The multi-omics single-cell landscape of sinus mucosa in uncontrolled severe chronic rhinosinusitis with nasal polyps

Zhaofeng XuYanran HuangTim MeeseSharon Van NevelGabriële HoltappelsStijn VanheeBarbara M. BrökerZhengqi LiEllen De MeesterNatalie De Ruyck et al.

A1 Journal Article in CLINICAL IMMUNOLOGY

2022

COVID‐19 vaccination with BNT162b2 and ChAdOx1 vaccines has the potential to induce nasal neutralizing antibodies

Jozefien DeclercqEls TobbackStijn VanheeNatalie De RuyckSarah GerloPhilippe GevaertLinos Vandekerckhove

A1 Journal Article in ALLERGY

Novel antibody cocktail targeting Bet v 1 rapidly and sustainably treats birch allergy symptoms in a Phase 1 study

Philippe GevaertJarno De CraemerNatalie De RuyckSylvie RotteyJan de HoonPeter W. HellingsBram VolckaertKristof LesneuckJamie M. OrengoAmanda Atanasio et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

2021

A substantial neutrophilic inflammation as regular part of severe type 2 chronic rhinosinusitis with nasal polyps

Tim DelemarreGabriële HoltappelsNatalie De RuyckNan ZhangHans NauwynckClaus BachertElien Gevaert

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Neutrophils affect IL-33 processing in response to the respiratory allergen Alternaria alternata

Sharon Van NevelJudith van OvostGabriële HoltappelsNatalie De RuyckNan ZhangHarald BraunTania MaesClaus BachertOlga Krysko

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

2020

An underestimated predictive role for Type 2 inflammation in CRSsNP

Tim DelemarreGabriële HoltappelsNatalie De RuyckClaus BachertElien Gevaert

Anti-Bet v_1 MABs reduced basophil responsiveness to birch pollen stimulation ex-vivo in birch allergic patients

Jarno De CraemerPhilippe GevaertNatalie De RuyckO. HerreraM. DeveauxD. RameshL. PerleeM. O'BrienC. Wang

Charcot-Leyden crystals promote neutrophilic inflammation in patients with nasal polyposis

Elien GevaertTim DelemarreJoyceline De VolderNan ZhangGabriële HoltappelsNatalie De RuyckEmma PerssonInes HeyndrickxKenneth VerstraeteHelena Catharine Aegerter et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Chronic rhinosinusitis : assessment of changes in nociceptive neurons

Stijn BogaertKoen Van CrombruggenGabriële HoltappelsNatalie De RuyckNicole SuchonosJonas Jae-Hyun ParkClaus Bachert

A1 Journal Article in INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY

Differential response of C57BL/6 and BALB/c mice in Alternaria alternata-induced allergic airway inflammation

Sharon Van NevelNatalie De RuyckGabriële HoltappelsClaus BachertOlga Krysko

Mouse strain-dependent difference toward the staphylococcus aureus allergen serine protease-like protein D reveals a novel regulator of IL-33

Andrea Renate TeufelbergerSharon Van NevelPaco HulpiauMaria NordengrünSavvas SavvidesSarah De GraeveSrinivas AkulaGabriële HoltappelsNatalie De RuyckWim Declercq et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Type 2 inflammation in chronic rhinosinusitis without nasal polyps : another relevant endotype

Tim DelemarreGabriële HoltappelsNatalie De RuyckNan ZhangHans NauwynckClaus BachertElien Gevaert

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Unravelling the expression of interleukin-9 in chronic rhinosinusitis : a possible role for Staphylococcus aureus

Tim DelemarreNatalie De RuyckGabriële HoltappelsClaus BachertElien Gevaert

A1 Journal Article in CLINICAL AND TRANSLATIONAL ALLERGY

2019

Differentiating eosinophil and neutrophil inflammation in chronic rhinosinusitis with and without nasal polyps

Tim DelemarreGabriële HoltappelsNatalie De RuyckClaus BachertElien Gevaert

2018

FcεRI expression and IgE binding by dendritic cells and basophils in allergic rhinitis and upon allergen immunotherapy

Margot BeringsPhilippe GevaertNatalie De RuyckLara DeryckeGabriële HoltappelsC PiletteClaus BachertBart LambrechtMelissa Dullaers

A1 Journal Article in CLINICAL AND EXPERIMENTAL ALLERGY

Staphylococcus aureus induces a mucosal type 2 immune response via epithelial cell-derived cytokines

Feng LanNan ZhangGabriële HoltappelsNatalie De RuyckOlga KryskoKoen Van CrombruggenHarald BraunSebastian L JohnstonNikos G PapadopoulosLuo Zhang et al.

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

2017

Extracellular eosinophilic traps in association with Staphylococcus aureus at the site of epithelial barrier defects in patients with severe airway inflammation

Elien GevaertNan ZhangOlga KryskoFeng LanGabriële HoltappelsNatalie De RuyckHans NauwynckShida YousefiHans-Uwe SimonClaus Bachert

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IL-21 is increased in nasal polyposis and after stimulation with Staphylococcus aureus enterotoxin B

Lien CalusLara DeryckeMelissa DullaersThibaut Van ZeleNatalie De RuyckClaudina Perez NovoGabriële HoltappelsGeert De VosBart LambrechtClaus Bachert et al.

A1 Journal Article in INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Probiotics-impregnated bedding covers for house dust mite allergic rhinitis : a pilot randomized clinical trial

Margot BeringsAnton JultHanne VermeulenNatalie De RuyckLara DeryckeH UcarP GhekiereR TemmermanJ EllisClaus Bachert et al.

A1 Journal Article in CLINICAL AND EXPERIMENTAL ALLERGY

Probiotics-impregnated bedding covers in house dust mite allergic rhinitis patients : a double-blind, randomised, placebo-controlled, crossover clinical trial

Margot BeringsAnton JultHans VermeulenNatalie De RuyckLara DeryckeH. UcarP. GhekiereR. TemmermanJ. EllisClaus Bachert et al.

Reliable mite-specific IgE testing in nasal secretions by means of allergen microarray

Margot BeringsStefania ArasiNatalie De RuyckSerena PernaYvonne ReschChristian LupinekKuan-Wei ChenSusanne VrtalaGiovanni Battista PajnoClaus Bachert et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Suppression of allergen-induced basophil activation upon treatment with subcutaneous house dust mite immunotherapy: a prospective study

Margot BeringsNatalie De RuyckLara DeryckeGabriële HoltappelsClaus BachertBart LambrechtMelissa DullaersPhilippe Gevaert

2016

Detection of IgE to house dust mite components in nasal secretions with a microarray chip : can it predict serum IgE response?

Margot BeringsS. ArasiNatalie De RuyckY. ReschC. LupinekK-W ChenS. VrtalaR. ValentaP. MatricardiPhilippe Gevaert

Inflammatory endotypes of chronic rhinosinusitis based on cluster analysis of biomarkers

Peter TomassenGRIET VANDEPLASThibaut Van ZeleLars-Olaf CardellJulia ArebroHeidi OlzeUlrike Förster-RuhrmannMarek L KowalskiAgnieszka Olszewska-ZiąberGabriële Holtappels et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Systemic expression of inflammatory mediators in patients with chronic rhinosinusitis and nasal polyps with and without Aspirin Exacerbated Respiratory Disease

Rogerio PezatoMonika Świerczyńska-KrępaEwa Niżankowska-MogilnickaGabriële HoltappelsNatalie De RuyckMarek SanakLara DeryckeKoen Van CrombruggenClaus BachertClaudina Perez Novo

A1 Journal Article in CYTOKINE

The response to nasal allergen provocation with grass pollen is reduced in patients with chronic rhinosinusitis with nasal polyposis and grass sensitization

LIEN CALUSLIEN DEVUYSTThibaut Van ZeleNatalie De RuyckLara DeryckeClaus BachertPhilippe Gevaert

A1 Journal Article in CLINICAL AND EXPERIMENTAL ALLERGY

2015

Calcineurin inhibitors dampen humoral immunity by acting directly on naive B cells

Ruth De BruyneDelfien BogaertNatalie De RuyckBart LambrechtMyriam Van WinckelPhilippe GevaertMelissa Dullaers

A1 Journal Article in CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Immunological characterization of pediatric liver transplant associated food allergy

Ruth De BruynePhilippe GevaertMyriam Van WinckelNatalie De RuyckAurelie MinneDelfien BogaertStephanie Van BiervlietSaskia Vande VeldeFrançoise SmetsEtienne Sokal et al.

Raised immunoglobulin A and circulating T follicular helper cells are linked to the development of food allergy in paediatric liver transplant patients

Ruth De BruynePhilippe GevaertMyriam Van WinckelNatalie De RuyckAurelie MinneDelfien BogaertStephanie Van BiervlietSaskia Vande VeldeFrancoise SmetsEtienne Sokal et al.

A1 Journal Article in CLINICAL AND EXPERIMENTAL ALLERGY

Raised immunoglobulin A and circulating T follicular helper cells are linked to the development of food allergy in pediatric liver transplant patients

Ruth De BruyneMyriam Van WinckelPhilippe GevaertNatalie De RuyckDelfien BogaertBart LambrechtMelissa DullaersFrancoise SmetsEtienne SokalFréderic Gottrand et al.

Staphyloccoccus aureus induces a Th2 response via TSLP and IL-33 release in human airway mucosa

Feng LanNan ZhangGabriële HoltappelsNatalie De RuyckNikolaos G PapadopoulosSebastian L JohnstonClaus Bachert

Use of filter disks or sinus packs for single and repeated measurement of total and house dust mite specific IgE in nasal secretions

Margot BeringsNatalie De RuyckGabriële HoltappelsClaus BachertPhilippe Gevaert

2014

Mixed T helper cell signatures in chronic rhinosinusitis with and without polyps

Lara DeryckeStefanie EyerichKoen Van CrombruggenClaudina Perez NovoGabriële HoltappelsNatalie De RuyckPhilippe GevaertClaus Bachert

A1 Journal Article in PLOS ONE

The expression of dendritic cell subsets in severe chronic rhinosinusitis with nasal polyps is altered

Rogerio PezatoClaudina Perez NovoGabriële HoltappelsNatalie De RuyckKoen Van CrombruggenGeert De VosClaus BachertLara Derycke

A1 Journal Article in IMMUNOBIOLOGY

Use of paper filter discs for measurement of local biomarkers of nasal mucosal inflammation

Margot BeringsLIEN CALUSLIEN DEVUYSTThibaut Van ZeleNatalie De RuyckClaus BachertPhilippe Gevaert

2013

Inflammatory patterns in upper airway disease in the same geographical area may change over time

Michail KatotomichelakisPongsakorn TantilipikornGabriële HoltappelsNatalie De RuyckFeng LanThibaut Van ZeleSoranart MuangsomboonPerapun JareonchasriChaweewan BunnagVassilios Danielides et al.

A1 Journal Article in AMERICAN JOURNAL OF RHINOLOGY & ALLERGY

Local receptor revision and class switching to IgE in chronic rhinosinusitis with nasal polyps

Philippe GevaertKayhan T Nouri-AriaHuiFen WuClaire E HarperPooja TakharDavid J FearFrederic AckeNatalie De RuyckGraham BanfieldHarsha H Kariyawasam et al.

A1 Journal Article in ALLERGY

Nasal allergen provocation test in nasal polyposis with and without allergy

LIEN CALUSLIEN DEVUYSTNatalie De RuyckThibaut Van ZeleClaus BachertPhilippe Gevaert

Omalizumab is effective in allergic and nonallergic patients with nasal polyps and asthma

Philippe GevaertLIEN CALUSThibaut Van ZeleKatrien BlommeNatalie De RuyckWOUTER BAUTERSPeter HellingsGuy BrusselleDirk De BacquerPaul Van Cauwenberge et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

2012

IL-21 is increased in nasal polyposis and after stimulation with Staphylococus aureus enterotoxins

LIEN CALUSIne DeryckeNatalie De RuyckGabriële HoltappelsMelissa DullaersBart LambrechtClaus BachertPhilippe Gevaert

Inflammation and remodelling patterns in early stage chronic rhinosinusitis

NICHOLAS VAN BRUAENEClaudina Perez NovoKoen Van CrombruggenNatalie De RuyckGabriële HoltappelsPaul Van CauwenbergePhilippe GevaertClaus Bachert

A1 Journal Article in CLINICAL AND EXPERIMENTAL ALLERGY

Local free light chain expression is increased in chronic rhinosinusitis with nasal polyps

T Groot KormelinkLIEN CALUSNatalie De RuyckGabriële HoltappelsClaus BachertFA RedegeldPhilippe Gevaert

A1 Journal Article in ALLERGY

Omalizumab is effective in allergic and non-allergic patients with nasal polyps and asthma

Philippe GevaertLIEN CALUSThibaut Van ZeleKatrien BlommeNatalie De RuyckWOUTER BAUTERSP HellingsDirk De BacquerGuy BrussellePaul Van Cauwenberge et al.

RAGE processing in chronic airway conditions: involvement of Staphylococcus aureus and ECP

Koen Van CrombruggenGabriële HoltappelsNatalie De RuyckLara DeryckePeter TomassenClaus Bachert

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

2011

European view on the pathology of chronic rhinosinusitis, nasal polyposis and the impact of staphylococcal enterotoxins: first results of the Ga2len sinusitis cohort study

Peter TomassenLars-Olaf CardellNatalie De RuyckUlrike FoersterWytske FokkensPhilippe GevaertPeter HellingsValérie HoxElina KatainenMarek Kowalski et al.

European view on the pathology of chronic rhinosinusitis, nasal polyposis and the impact of staphylococcal enterotoxins: first results of the Ga2len sinusitis cohort study

Peter TomassenLars-Olaf CardellNatalie De RuyckUlrike FoersterWytske FokkensPhilippe GevaertPeter HellingsValérie HoxElina KatainenMarek Kowalski et al.

Mepolizumab, a humanized anti-IL-5 mAb, as a treatment option for severe nasal polyposis

Philippe GevaertNICHOLAS VAN BRUAENETom CattaertKristel Van SteenThibaut Van ZeleFrederic AckeNatalie De RuyckKatrien BlommeAnna SousaRichard Marshall et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Nasal secretion assays predict superantigen involvement in nasal polyposis

Peter TomassenLars-Olaf CardellNatalie De RuyckUlrike FoersterWytske FokkensPhilippe GevaertPeter HellingsValérie HoxElina KatainenMarek Kowalski et al.

Staphylococcal enterotoxin specific IgE in serum is linked to severe asthma and nasal polyposis

Peter TomassenLars-Olaf CardellNatalie De RuyckUlrike FörsterWytske FokkensPhilippe GevaertPeter HellingsValérie HoxElina KatainenMarek Kowalski et al.

2010

Different regulation of cigarette smoke induced inflammation in upper versus lower airways

Wouter HuvenneClaudina Perez NovoLara DeryckeNatalie De RuyckOlga KryskoTania MaesNele PauwelsLander RobaysKen BrackeGuy Joos et al.

A1 Journal Article in RESPIRATORY RESEARCH

2009

Different regulation of cigarette smoke induced inflammation in upper versus lower airways: findings from a mouse model

Wouter HuvenneClaudina Perez NovoNatalie De RuyckNele PauwelsLander RobaysTania MaesPaul Van CauwenbergeGuy JoosGuy BrusselleClaus Bachert

TGF-beta signaling and collagen deposition in chronic rhinosinusitis

NICHOLAS VAN BRUAENELara DeryckeClaudina Perez NovoPhilippe GevaertGabriële HoltappelsNatalie De RuyckClaude CuvelierPaul Van CauwenbergeClaus Bachert

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

2008

Different types of T-effector cells orchestrate mucosal inflammation in chronic sinus disease

Nan ZhangThibaut Van ZeleClaudina Perez NovoNICHOLAS VAN BRUAENEGabriële HoltappelsNatalie De RuyckPaul Van CauwenbergeClaus Bachert

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

T-cell regulation in chronic paranasal sinus disease

NICHOLAS VAN BRUAENEClaudina Perez NovoTomasz M BasinskiThibaut Van ZeleGabriële HoltappelsNatalie De RuyckCarsten Schmidt-WeberCezmi AkdisPaul Van CauwenbergeClaus Bachert et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

TGF-beta isoforms and receptors in chronic sinus disease

NICHOLAS VAN BRUAENEClaudina Perez NovoPhilippe GevaertGabriële HoltappelsNatalie De RuyckPaul Van CauwenbergeClaus Bachert

2007

T cell regulation in chronic sinus disease

NICHOLAS VAN BRUAENEClaudina Perez NovoThibaut Van ZeleGabriële HoltappelsNatalie De RuyckPaul Van CauwenbergeClaus BachertPhilippe Gevaert

2004

TetraThymosin beta is required for actin dynamics in Caenorhabditis elegans and acts via functionally different actin-binding repeats

Marleen Van TroysK ONODaisy DewitteVeronique JonckheereNatalie De RuyckJoël VandekerckhoveS ONOChristophe Ampe

A1 Journal Article in MOLECULAR BIOLOGY OF THE CELL