Research Explorer

Your browser does not support JavaScript or JavaScript is not enabled. Without JavaScript some functions of this webapplication may be disabled or cause error messages. To enable JavaScript, please consult the manual of your browser or contact your system administrator.

Researcher

Nan Wang

Awards & Distinctions

69 Results

2021

Cx43 hemichannel microdomain signaling at the intercalated disc enhances cardiac excitability

Maarten De SmetAlessio LissoniTimur NezlobinskiiNan WangEef DriesMarta Pérez-HernándezXianming LinMatthew AmoniTim VervlietKatja Witschas et al.

A1 Journal Article in JOURNAL OF CLINICAL INVESTIGATION

RyR2 regulates Cx43 hemichannel intracellular Ca2+-dependent activation in cardiomyocytes

Alessio LissoniPaco HulpiauTânia Martins-MarquesNan WangGeert BultynckRainer SchulzKatja WitschasHenrique GiraoMaarten De SmetLuc Leybaert

A1 Journal Article in CARDIOVASCULAR RESEARCH

2020

Gap19, a Cx43 hemichannel inhibitor, acts as a gating modifier that decreases main state opening while increasing substate gating

Alessio LissoniNan WangTimur NezlobinskiiMaarten De SmetAlexander PanfilovNele VandersickelLuc LeybaertKatja Witschas

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

2019

Targeting MAPK phosphorylation of Connexin43 provides neuroprotection in stroke

Moises Freitas-AndradeNan WangJohn F BechbergerMarijke De BockPaul D LampeLuc LeybaertChristian C Naus

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

2018

Cx43 hemichannel opening in ventricular cardiomyocytes necessitates simultaneous ryanodine receptor activation and elevation of intracellular Ca2+

Alessio LissoniMaarten De SmetPaco HulpiauTania Martins-MarquesNan WangHenrique GiraoLuc Leybaert

The SH3-binding domain of Cx43 participates in loop/tail interactions critical for Cx43-hemichannel activity

Jegan IyyathuraiNan WangCatheleyne D'hondtJean X. JiangLuc LeybaertGeert Bultynck

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

2017

Activation, regulation and arrhythmogenic implications of Cx43 hemichannels in ventricular cardiomyocytes

Maarten De SmetAlessio LissoniNan WangEef DriesKarin SipidoLuc Leybaert

At the cross-point of connexins, calcium, and ATP : blocking hemichannels inhibits vasoconstriction of rat small mesenteric arteries

Mélissa BolNan WangMarijke De BockBenjamin WacquierElke DecrockAshish GadicherlaKatrijn DecaluweBert VanheelHarold Victor Maria van RijenDmitri Krysko et al.

A1 Journal Article in CARDIOVASCULAR RESEARCH

Calcium, oxidative stress and connexin channels, a harmonious orchestra directing the response to radiotherapy treatment?

Elke DecrockDelphine HoorelbekeRaghda RamadanTinneke DelvaeyeMarijke De BockNan WangDmitri KryskoSarah BaatoutGeert BultynckAn Aerts et al.

A1 Journal Article in BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Contribution of astroglial Cx43 hemichannels to the modulation of glutamatergic currents by D-serine in the mouse prefrontal cortex

Claire MeunierNan WangChenju YiGlenn DalleracPascal EzanAnnette KoulakoffLuc LeybaertChristian Giaume

A1 Journal Article in JOURNAL OF NEUROSCIENCE

Cx43 hemichannel opening in ventricular cardiomyocytes necessitates simultaneous ryanodine receptor activation and elevation of intracellular Ca2+

Alessio LissoniMaarten De SmetTânia Martins-MarquesNan WangHenrique GirãoLuc Leybaert

Cx43 hemichannel opening in ventricular cardiomyocytes necessitates simultaneous ryanodine receptor activation and elevation of intracellular Ca2+, and is modulated by CaMKII and p38MAPK

Alessio LissoniMaarten De SmetNan WangLuc Leybaert

Cx43 hemichannel opening in ventricular cardiomyocytes necessitates simultaneous ryanodine receptor activation and elevation of intracellular Ca2+, and is modulated by CaMKII and p38MAPK

Alessio LissoniMaarten De SmetNan WangLuc Leybaert

Mitochondrial Cx43 hemichannels contribute to mitochondrial calcium entry and cell death in the heart

Ashish GadicherlaNan WangMarco BulicEsperanza Agullo-PascualAlessio LissoniMaarten De SmetMario DelmarGeert BultynckDmitri KryskoAmadou Camara et al.

A1 Journal Article in BASIC RESEARCH IN CARDIOLOGY

Role of Cx43 hemichannels in ventricular arrhythmia associated with abnormal Ca2+ homeostasis

Maarten De SmetAlessio LissoniNan WangLuc Leybaert

2016

Activation, regulation and arrhythmogenic implications of Cx43 hemichannels in ventricular cardiomyocytes

Maarten De SmetAlessio LissoniNan WangLuc Leybaert

Connexines in the horse heart

Kimberley VandeveldeWim Van Den BroeckNan WangTim VandecasteeleGunther van Loon

Connexins and their channels in inflammation

Joost WillebrordsSara Crespo YanguasMichael MaesElke DecrockNan WangLuc LeybaertBrenda R KwakColin R GreenBruno CogliatiMathieu Vinken

A1 Journal Article in CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Cx43 hemichannel opening in ventricular cardiomyocytes necessitates simultaneous ryanodine receptor activation and elevation of intracellular Ca2+, and is modulated by CaMKII

Alessio LissoniMaarten De SmetNan WangLuc Leybaert

Cx43 hemichannels in ventricular cardiomyocytes can be activated by an elevation of cytoplasmic Ca2+ through a CaM-dependent signaling cascade and are a potent contributor to cardiac arrhythmogenesis

Maarten De SmetAlessio LissoniNan WangLuc Leybaert

Cx43 hemichannels in ventricular cardiomyocytes can be activated by an elevation of cytoplasmic Ca2+ through a CaM-dependent signaling cascade and are a potent contributor to cardiac arrhythmogenesis

Maarten De SmetAlessio LissoniNan WangLuc Leybaert

Electroporation loading and dye transfer : a safe and robust method to probe gap junctional coupling

Elke DecrockMarijke De BockDiego De BaereDelphine HoorelbekeNan WangLuc Leybaert

Bookchapter in Gap junction protocols

Into rather unexplored terrain : transcellular transport across the blood-brain barrier

Marijke De BockValérie Van HaverRoosmarijn VandenbrouckeElke DecrockNan WangLuc Leybaert

A1 Journal Article in GLIA

Whole-cell patch clamp recordings of unitary connexin 43 hemichannel currents

Nan WangAlessio LissoniMaarten De SmetKarin R SipidoLuc Leybaert

Bookchapter in Gap junction channels and hemichannels

2015

Connexin and pannexin signaling pathways, an architectural blueprint for CNS physiology and pathology?

Elke DecrockMarijke De BockNan WangGeert BultynckChristian GiaumeChristian C NausColin R GreenLuc Leybaert

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

Electroporation loading and flash photolysis to investigate intra- and intercellular Ca2+ signaling

Elke DecrockMarijke De BockNan WangMélissa BolAshish GadicherlaLuc Leybaert

A2 Journal Article in COLD SPRING HARBOR PROTOCOLS

Electroporation loading of membrane-impermeable molecules to investigate intra- and intercellular Ca2+ signaling

Elke DecrockMarijke De BockNan WangMélissa BolAshish GadicherlaLuc Leybaert

A2 Journal Article in COLD SPRING HARBOR PROTOCOLS

Flash photolysis of caged IP3 to trigger intercellular Ca2+ waves

Elke DecrockMarijke De BockNan WangMélissa BolAshish GadicherlaLuc Leybaert

A2 Journal Article in COLD SPRING HARBOR PROTOCOLS

Intracellular cleavage of the Cx43 C-terminal domain by matrix-metalloproteases : a novel contributor to inflammation?

Marijke De BockNan WangElke DecrockGeert BultynckLuc Leybaert

A1 Journal Article in MEDIATORS OF INFLAMMATION

Structure, regulation and function of gap junctions in liver

Joost WillebrordsSara Crespo YanguasMichaël MaesElke DecrockNan WangLuc LeybaertTereza Cristina da SilvaIsabel Veloso Alves PereiraHartmut JaeschkeBruno Cogliati et al.

A1 Journal Article in CELL COMMUNICATION AND ADHESION

2014

The connexin43 mimetic peptide Gap19 inhibits hemichannels without altering gap junctional communication in astrocytes

Verónica AbudaraJohn BechbergerMoises Freitas-AndradeMarijke De BockNan WangGeert BultynckChristian C NausLuc LeybaertChristian Giaume

A1 Journal Article in FRONTIERS IN CELLULAR NEUROSCIENCE

The dual face of connexin-based astroglial Ca2+ communication: a key player in brain physiology and a prime target in pathology

Marijke De BockElke DecrockNan WangMélissa BolMathieu VinkenGeert BultynckLuc Leybaert

A1 Journal Article in BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

2013

Connexin targeting peptides as inhibitors of voltage- and intracellular Ca2+-triggered Cx43 hemichannel opening

Nan WangMarijke De BockElke DecrockMélissa BolAshish GadicherlaGeert BultynckLuc Leybaert

A1 Journal Article in NEUROPHARMACOLOGY

Endothelial calcium dynamics, connexin channels and blood-brain barrier function

Marijke De BockNan WangElke DecrockMélissa BolAshish GadicherlaMaxime CulotRomeo CecchelliGeert BultynckLuc Leybaert

A1 Journal Article in PROGRESS IN NEUROBIOLOGY

IP₃, a small molecule with a powerful message

Elke DecrockMarijke De BockNan WangAshish GadicherlaMélissa BolTinneke DelvaeyePeter VandenabeeleMathieu VinkenGeert BultynckDmitri Krysko et al.

A1 Journal Article in BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Inhibiting connexin channels protects against cryopreservation-induced cell death in human blood vessels

Mélissa BolCaroline Van GeytSaskia BaertElke DecrockNan WangMarijke De BockAshish GadicherlaCaren RandonWH EvansHilde Beele et al.

A1 Journal Article in EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY

Negatively charged residues (Asp378 and Asp379) in the last ten amino acids of the C-terminal tail of Cx43 hemichannels are essential for loop/tail interactions

Catheleyne D'HondtJegan IyyathuraiNan WangRobert G GourdieBernard HimpensLuc LeybaertGeert Bultynck

A1 Journal Article in BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Neurological manifestations of oculodentodigital dysplasia: a Cx43 channelopathy of the central nervous system?

Marijke De BockMarianne KerrebrouckNan WangLuc Leybaert

A1 Journal Article in FRONTIERS IN PHARMACOLOGY

Peptides and peptide-derived molecules targeting the intracellular domains of Cx43: gap junctions versus hemichannels

Jegan IyyathuraiCatheleyne D'hondtNan WangMarijke De BockBernard HimpensMauricio A RetamalJimmy StehbergLuc LeybaertGeert Bultynck

A1 Journal Article in NEUROPHARMACOLOGY

Selective inhibition of Cx43 hemichannels by Gap19 and its impact on myocardial ischemia/reperfusion injury

Nan WangElke De VuystRaf PonsaertsKerstin BoenglerNicolás Palacios-PradoJoris WaumanCharles P LaiMarijke De BockElke DecrockMélissa Bol et al.

A1 Journal Article in BASIC RESEARCH IN CARDIOLOGY

Single channel studies on the modulation of connexin hemichannels by Cx43 targeting peptides and cytoplasmic Ca2+ in the context of heart disease

Nan WangLuc Leybaert

2012

Connexin 43 hemichannels contribute to cytoplasmic Ca2+ oscillations by providing a bimodal Ca2+-dependent Ca2+ entry pathway

Marijke De BockNan WangMélissa BolElke DecrockRaf PonsaertsGeert BultynckGnenviève DupontLuc Leybaert

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Connexin mimetic peptides inhibit Cx43 hemichannel opening triggered by voltage and intracellular Ca2+ elevation

Nan WangMarijke De BockGudrun AntoonsAshish GadicherlaMélissa BolElke DecrockWilliam Howard EvansKarin R SipidoFeliksas F BukauskasLuc Leybaert

A1 Journal Article in BASIC RESEARCH IN CARDIOLOGY

Is chronic exposure of the blood-brain barrier to relatively low L-β-ODAP concentrations a possible entry point of L-β-ODAP into the central nervous system?

Marijke Van MoorhemM CulotM KuntzElke DecrockMarijke De BockNan WangKatharina D'HerdeFernand LambeinLuc Leybaert

Low extracellular Ca2+ conditions induce an increase in brain endothelial permeability that involves intercellular Ca2+ waves

Marijke De BockMaxime CulotNan WangAnaelle da CostaElke DecrockMélissa BolGeert BultynckRomeo CecchelliLuc Leybaert

A1 Journal Article in BRAIN RESEARCH

Pannexin 1 ohnologs in the teleost lineage

Steven R BondNan WangLuc LeybaertChristian C Naus

A1 Journal Article in JOURNAL OF MEMBRANE BIOLOGY

Paracrine signaling through plasma membrane hemichannels

Nan WangMarijke De BockElke DecrockMélissa BolAshish GadicherlaMathieu VinkenVera RogiersFeliksas F BukauskasGeert BultynckLuc Leybaert

A1 Journal Article in BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The contractile system as a negative regulator of the connexin 43 hemichannel

Raf PonsaertsNan WangBernard HimpensLuc LeybaertGeert Bultynck

A1 Journal Article in BIOLOGY OF THE CELL

Transfer of IP3 through gap junctions is critical, but not sufficient, for the spread of apoptosis

Elke DecrockDmitri KryskoMathieu VinkenAgnieszka KaczmarekGiulia CrispinoMélissa BolNan WangMarijke De BockElke De VuystChristian C Naus et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

2011

Connexin channels provide a target to manipulate brain endothelial calcium dynamics and blood brain barrier permeability

Marijke De BockMaxime CulotNan WangMélissa BolElke DecrockElke De VuystAnaelle Da CostaIne DauweMathieu VinkenAlexander Simon et al.

A1 Journal Article in JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

L-β-N-oxalyl-α,β-diaminopropionic acid toxicity in motor neurons

Marijke Van MoorhemElke DecrockElke De VuystMarijke De BockNan WangFernand LambeinLudo Van Den BoschLuc Leybaert

A1 Journal Article in NEUROREPORT

Memichannels contribute to Ca2+ dynamics and contractility of smooth muscle cells in acutely isolated small mesenteric arteries

Mélissa BolMarijke De BockNan WangElke DecrockBert Vanheel

Pannexin channels in ATP release and beyond: an unexpected rendezvous at the endoplasmic reticulum

Catheleyne D'hondtRaf PonsaertsHumbert De SmedtMathieu VinkenElke De VuystMarijke De BockNan WangVera RogiersLuc LeybaertBernard Himpens et al.

A1 Journal Article in CELLULAR SIGNALLING

2010

Hemichannel involvement in CA2+ dynamics and contractility of smooth muscle cells in acutely isolated small mesenteric arteries

Mélissa BolMarijke De BockElke De VuystNan WangElke DecrockJhon Jairo Monsalvo CastaKelly DecaluwéBert VanheelJohan Van de VoordeLuc Leybaert

Intramolecular loop/tail interactions are essential for connexin 43-hemichannel activity

Raf PonsaertsElke De VuystMauricio RetamalCatheleyne D'hondtDieter VermeireNan WangHumbert De SmedtPascale ZimmermannBernard HimpensJohan Vereecke et al.

A1 Journal Article in FASEB JOURNAL

L-β-ODAP alters mitochondrial Ca2+ handling as an early event in excitotoxicity

Marijke Van MoorhemElke DecrockEvelyne CousseeLiesbeth FaesElke De VuystKatleen VranckxMarijke De BockNan WangKatharina D'HerdeFernand Lambein et al.

A1 Journal Article in CELL CALCIUM

2009

Ca2+ regulation of connexin 43 hemichannels in C6 glioma and glial cells

Elke De VuystNan WangElke DecrockMarijke De BockMathieu VinkenMarijke Van MoorhemCharles LaiMaxime CulotVera RogiersRomeo Cecchelli et al.

A1 Journal Article in Cell Calcium

Calcium regulation of connexin-43 hemichannel-mediated ATP release in glial cells

Elke De VuystMarijke De BockNan WangElke DecrockMathieu VinkenMarijke Van MoorhemVera RogiersChristian NausHoward EvansLuc Leybaert

Cell death communication via connexin channels investigated in a C6 glioma cell model

Elke DecrockMarijke Van MoorhemElke De VuystNan WangMarijke De BockMathieu VinkenVera RogiersCC NausC ErneuxLuc Leybaert

Cell-cell communication of apoptosis via connexin channels in a C6 glioma cell model.

Elke DecrockMarijke Van MoorhemElke De VuystNan WangMarijke De BockMélissa BolKatharina D'HerdeC ErneuxLuc Leybaert

Connexin 43 hemichannels contribute to the propagation of apoptotic cell death in a rat C6 glioma cell model.

Elke DecrockElke De VuystMathieu VinkenMarijke Van MoorhemKatleen VranckxNan WangLaura Van LaekenMarijke De BockKatharina D'HerdeCharles Lai et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Hemichannels contribute to Ca2+ dynamics in smooth muscle cells in acutely isolated small mesenteric arteries

Mélissa BolMarijke De BockElke De VuystNan WangElke DecrockMarijke Van MoorhemBert VanheelLuc Leybaert

Inhibition of connexin 43 hemichannel responses with high cytoplasmic calcium concentrations is mediated by mechanisms different from calcium activation of hemichannel responses

Nan WangElke De VuystMarijke De BockElke DecrockMarijke Van MoorhemLuc Leybaert

Involvement of connexin hemichannels in dynamic calcium changes and permeability of blood-brain barrier endothelial cells

Marijke De BockElke De VuystNan WangElke DecrockMarijke Van MoorhemMaxime CulotAM SimonRomeo CecchelliLuc Leybaert

Neuro- and gliotoxicity of the excitatory amino acid beta-ODAP involves impaired free radical defence

Marijke Van MoorhemElke DecrockMarijke De BockNan WangElke De VuystGeert CallewaertLudo Van Den BoschFernand LambeinLuc Leybaert

Neuro- and gliotoxicity of the excitatory amino acid beta-ODAP involves impaired free radical difference

Marijke Van MoorhemElke DecrockMarijke De BockNan WangElke De VuystGeert CallewaertLudo Van den BoschFernand LambeinLuc Leybaert

Ultrasound exposure of lipoplex loaded microbubbles facilitates direct cytoplasmic entry of the lipoplexes

Ine LentackerNan WangRoosmarijn VandenbrouckeJo DemeesterStefaan De SmedtNiek Sanders

A1 Journal Article in MOLECULAR PHARMACEUTICS

2008

Gliotransmitter release via Connexin 43 hemichannels: role of cytoplasmic changes

Elke De VuystMarijke De BockNan WangMarijke Van MoorhemElke Decrock

Inhibition of Cx43 hemichannel responses with High Ca2+i is mediated by mechanisms different from calcium activation of hemichannel responses

Nan WangElke De VuystMarijke De BockElke Decrock