Research Explorer

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Researcher

Monique Willart

Awards & Distinctions

57 Results

2017

House dust mite-driven asthma and allergen-specific T cells depend on B cells when the amount of inhaled allergen is limiting

Melissa DullaersMartijn SchuijsMonique WillartKaat FierensJustine Van MoorleghemHamida HammadBart Lambrecht

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Inflammatory monocytes regulate Th1 oriented immunity to CpG adjuvanted protein vaccines through production of IL-12

Stefaan De KokerLien Van HoeckeAns De BeuckelaerKenny RooseKim DeswarteMonique WillartPieter BogaertThomas NaessensBruno De GeestXavier Saelens et al.

A1 Journal Article in SCIENTIFIC REPORTS

2016

A20 deficiency in lung epithelial cells protects against influenza A virus infection

Jonathan MaelfaitKenny RooseLars VereeckeConor Mc GuireMozes SzeMartijn SchuijsMonique WillartLorena IbanezHamida HammadBart Lambrecht et al.

A1 Journal Article in PLOS PATHOGENS

Cholesterol-sensing liver X receptors stimulate Th2-driven allergic eosinophilic asthma in mice

Muriel SmetLien Van HoeckeAns De BeuckelaerSeppe Vander BekenThomas NaessensKarl VergoteMonique WillartBart LambrechtJan-Ake GustafssonKnut R Steffensen et al.

A2 Journal Article in IMMUNITY INFLAMMATION AND DISEASE

GM-CSF treatment prevents respiratory syncytial virus– induced pulmonary exacerbation responses in postallergic mice by stimulating alveolar macrophage maturation

Thomas NaessensBert SchepensMuriel SmetCharlotte PollardLien Van HoeckeAns De BeuckelaerMonique WillartBart LambrechtStefaan De KokerXavier Saelens et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Perinatal activation of the interleukin-33 pathway promotes type 2 immunity in the developing lung

Ismé De KleerMirjam KoolMarjolein JW de BruijnMonique WillartJustine Van MoorleghemMartijn SchuijsMaud PlantingaRudi BeyaertEmily HamsPadraic G Fallon et al.

A1 Journal Article in IMMUNITY

2015

Farm dust and endotoxin protect against allergy through A20 induction in lung epithelial cells

Martijn SchuijsMonique WillartKarl VergoteDelphine GrasKim DeswarteMarkus J EgeFilipe Branco MadeiraRudi BeyaertGeert van LooFranz Bracher et al.

A1 Journal Article in SCIENCE

Neutralizing TNFα restores glucocorticoid sensitivity in a mouse model of neutrophilic airway inflammation

Lien DejagerKaren DendonckerMelanie EggermontJolien SouffriauFilip Van HauwermeirenMonique WillartElien Van WonterghemThomas NaessensMarlies BallegeerSofie Vandevyver et al.

A1 Journal Article in MUCOSAL IMMUNOLOGY

2013

Cytokine targets in airway inflammation

Martijn SchuijsMonique WillartHamida HammadBart Lambrecht

A1 Journal Article in CURRENT OPINION IN PHARMACOLOGY

Immune activation at the lung epithelial barrier

Monique WillartHamida HammadBart Lambrecht

PAMPs and DAMPs in allergy exacerbation models

Monique WillartPhilippe PoulliotBart LambrechtMirjam Kool

Bookchapter in Mouse models in allergic disease : methods and protocols

The mucosal adjuvant cholera toxin B instructs non-mucosal dendritic cells to promote IgA production via retinoic acid and TGF-β

Anouk K GloudemansMaud PlantingaMartin GuilliamsMonique WillartArifa Ozir-FazalalikhanAlwin van der HamLouis BoonNicola L HarrisHamida HammadHenk C Hoogsteden et al.

A1 Journal Article in PLOS ONE

2012

Contribution of regulatory T cells to alleviation of experimental allergic asthma after specific immunotherapy

H MaaziS ShirinbakMonique WillartHamida HammadM CabanskiL BoonV GaneshAM BaruG HansenBart Lambrecht et al.

A1 Journal Article in CLINICAL AND EXPERIMENTAL ALLERGY

Interleukin-1α controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33

Monique WillartKim DeswartePhilippe PouliotHarald BraunRudi BeyaertBart LambrechtHamida Hammad

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Polymeric multilayer capsule-mediated vaccination induces protective immunity against cancer and viral infection

Bruno De GeestMonique WillartHamida HammadBart LambrechtCharlotte PollardPieter BogaertMarina De FiletteXavier SaelensChris VervaetJean Paul Remon et al.

A1 Journal Article in ACS NANO

Surface-engineered polyelectrolyte multilayer capsules: synthetic vaccines mimicking microbial structure and function

Bruno De GeestMonique WillartBart LambrechtCharlotte PollardChris VervaetJean Paul RemonJohan GrootenStefaan De Koker

A1 Journal Article in ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ursodeoxycholic acid suppresses eosinophilic airway inflammation by inhibiting the function of dendritic cells through the nuclear farnesoid X receptor

Monique WillartM van NimwegenA GrefhorstHamida HammadL MoonsHC HoogstedenBart LambrechtA KleinJan

A1 Journal Article in ALLERGY

2011

An unexpected role for uric Acid as an inducer of T helper 2 cell immunity to inhaled antigens and inflammatory mediator of allergic asthma

Mirjam KoolMonique WillartMenno van NimwegenIngrid BergenPhilippe PouliotJ Christian VirchowNeil RogersFabiola OsorioCaetano Reis E SousaHamida Hammad et al.

A1 Journal Article in IMMUNITY

Designing polymeric particles for antigen delivery

Stefaan De KokerBart LambrechtMonique WillartYvette van KooykJohan GrootenChris VervaetJean Paul RemonBruno De Geest

A1 Journal Article in CHEMICAL SOCIETY REVIEWS

Disruption of the SapM locus in Mycobacterium bovis BCG improves its protective efficacy as a vaccine against M. tuberculosis

Nele FestjensPieter BogaertAnjana BatniErica HouthuysEvelyn PletsDieter VanderschaegheBram LaukensBob AsselberghEef ParthoensRiet De Rycke et al.

A1 Journal Article in EMBO MOLECULAR MEDICINE

Dual role of IL-22 in allergic airway inflammation and its cross-talk with IL-17A

Anne-Gaelle BesnardRobert SabatLaure DumoutierJean-Christophe RenauldMonique WillartBart LambrechtMauro M TeixeiraSabine CharronLizette FickFrancois Erard et al.

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Lung dendritic cell-epithelial cell crosstalk in Th2 responses to allergens

Monique WillartHamida Hammad

A1 Journal Article in CURRENT OPINION IN IMMUNOLOGY

Novel anti-inflammatory drugs based on targeting lung dendritic cells and airway epithelial cells

Bart LambrechtMaud PlantingaMonique WillartHamida Hammad

Bookchapter in Inflammation and allergy drug design

Persistent activation of dendritic cells after resolution of allergic airway inflammation breaks tolerance to inhaled allergens in mice

Leonie van RijtNanda VosMonique WillartFemke MuskensPaul P TakCorine van der HorstHenk C HoogstedenBart Lambrecht

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The neuropeptide calcitonin gene-related peptide affects allergic airway inflammation by modulating dendritic cell function

S RochlitzerTZ VeresK KühneF PrenzlerC PilznerS KnotheC WinklerHD LauensteinMonique WillartHamida Hammad et al.

A1 Journal Article in CLINICAL AND EXPERIMENTAL ALLERGY

2010

Diesel exhaust particles stimulate adaptive immunity by acting on pulmonary dendritic cells

Sharen ProvoostTania MaesMonique WillartGuy JoosBart LambrechtKurt Tournoy

A1 Journal Article in Journal of Immunology

Inflammatory dendritic cells - not basophils - are necessary and sufficient for induction of Th2 immunity to inhaled house dust mite allergen

Hamida HammadMaud PlantingaKim DeswartePhilippe PouliotMonique WillartMirjam KoolFemke MuskensBart Lambrecht

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Lentiviral gene therapy of murine hematopoietic stem cells ameliorates the Pompe disease phenotype

Niek P van TilMerel StokFatima SF Aerts KayaMonique C de WaardElnaz FarahbakhshianTrudi P VisserMarian A KroosEdwin H JacobsMonique WillartPascal van der Wegen et al.

A1 Journal Article in BLOOD

Studying the function of dendritic cells in mouse models of asthma

Philippe PouliotMonique WillartHamida HammadBart Lambrecht

Bookchapter in Dendritic cell protocols

United airways: circulating Th2 effector cells in an allergic rhinitis model are responsible for promoting lower airways inflammation

Alex KleinjanMonique WillartMenno van NimwegenKarolina LemanHenk HoogstedenRudy HendriksBart Lambrecht

A1 Journal Article in CLINICAL AND EXPERIMENTAL ALLERGY

2009

An anti-inflammatory role for plasmacytoid dendritic cells in allergic airway inflammation

Mirjam KoolMenno van NimwegenMonique WillartFemke MuskensLouis BoonJoost SmitAnthony CoyleBjörn ClausenHenk HoogstedenBart Lambrecht et al.

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Cholera toxin B suppresses allergic inflammation through induction of secretory IgA

H. SmitsA. GloudemansM. van NimwegenMonique WillartT. SoulliéF. MuskensE. de JongL. BoonC. PiletteF.-E. Johansen et al.

A1 Journal Article in Mucosal Immunology

Chronic airway inflammation promotes de novo sensitisation to inhaled allergens by persistent activation of dendritic cells

L van RijtN VosF MuskensMonique WillartH HoogstedenBart Lambrecht

Chronic airway inflammation promotes de novo sensitization to inhaled allergen by persistent activation of dendritic cells

LS Van RijtN VosMonique WillartF MuskensH HoogstedenBart Lambrecht

De rol van de dendritische cel in astma

Monique WillartBart Lambrecht

A4 Journal Article in TIJDSCHRIFT VAN DE BELGISCHE VERENIGING VAN LABORATORIUM-TECHNOLOGEN = REVUE DE L'ASSOCIATION BELGE DES TECHNOLOGUES DE LABORATOIRE

Dendritic cells are crucial for maintenance of tertiary lymphoid structures in the lung of influenza virus-infected mice

Corine H GeurtsvanKesselMonique WillartIngrid M BergenLeonie S van RijtFemke MuskensDirk ElewautAlbert DLE OsterhausRudi HendriksGuus F RimmelzwaanBart Lambrecht

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells

Hamida HammadMarcello ChieppaFrédèric PerrosMonique WillartRonald GermainBart Lambrecht

A1 Journal Article in Nature Medicine

Immune Suppression Feature of Ursodeoxycholic Acid is DC-mediated as Measured in Eosinophilic Airway Inflammation Model

A. KleinjanMonique WillartHamida HammadM. van NimwegenL. MoonsH.C. HoogstedenBart Lambrecht

Mechanism of action of clinically approved adjuvants

Bart LambrechtMirjam KoolMonique WillartHamida Hammad

A1 Journal Article in Current opinion in Immunology

Sensitization by intratracheally injected dendritic cells is independent of antigen presentation by host antigen-presenting cells

Harmjan KuipersThomas SoullieHamida HammadMonique WillartMirjam KoolDanielle HijdraHenk HoogstedenBart Lambrecht

A1 Journal Article in JOURNAL OF LEUKOCYTE BIOLOGY

The danger within: endogenous danger signals, atopy and asthma

Monique WillartBart Lambrecht

A1 Journal Article in Clinical and Experimental Allergy

The lung vascular filter as a site of immune induction for T cell responses to large embolic antigen

Monique WillartHendrik Jan de HeerHamida HammadThomas SoulliéKim DeswarteBjörn E ClausenLouis BoonHenk C HoogstedenBart Lambrecht

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

2008

'United airways': Allergic rhinitis exacerbates lower airway inflammation is controlled by cellular and neurogenic processes in a mouse model

A KLEINJANMonique WillartK LEMANHC HOOGSTEDENBart Lambrecht

Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells

M KOOLT SOULLIEM VAN NIMWEGENMonique WillartF MUSKENSS JUNGHC HOOGSTEDENHamida HammadBart Lambrecht

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Clearance of influenza virus from the lung depends on migratory langerin(+)CD11b(-) but not plasmacytoid dendritic cells

CH GEURTSVANKESSELMonique WillartLS VAN RIJTF MUSKENSM KOOLC BAASK THIELEMANSC BENNETTBE CLASENHC HOOGSTEDEN et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

De rol van de dendritische cel in astma

Monique WillartBart Lambrecht

A3 Journal Article in Nederlands tijdschrift voor klinische chemie en laboratoriumgeneeskunde

De rol van de dendritische cel in astma

Monique WillartBart Lambrecht

A4 Journal Article in Analyse

Inducible costimulator blockade prolongs airway lumnal patency in a mouse model of obliterative bronchiolitis

Alex KleinJanMonique WillartHarmjan KuipersAnthony J. CoyleHenk C. HoogstedenBart Lambrecht

A1 Journal Article in Transplantation

2007

Extracellular ATP triggers and maintains asthmatic airway inflammation by activating dendritic cells

M IDZKOHamida HammadM VAN NIMWEGENM KOOLMonique WillartF MUSKENSHC HOOGSTEDENW LUTTMANND FERRARIF DI VIRGILIO et al.

A1 Journal Article in NATURE MEDICINE

Protective effect of Schistosoma mansoni infection on allergic airway inflammation depends on the intensity and chronicity of infection

Hermehin H. SmitsHamida HammadMenno van NimwegenThomas SoullieMonique WillartEllen LieversJonathan KadouchMirjam KoolJanneke Kos-van OosterhoudAndre M. Deelder et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

2006

An essential role for dendritic cells in human and experimental allergic rhinitis

A KLEINJANMonique WillartLS VAN RIJTGJ BRAUNSTAHLK LEMANS JUNGHC HOOGSTEDENBart Lambrecht

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Contribution of the PD-1 ligands/PD-1 signaling pathway to dendritic cell-mediated CD4(+) T cell activation

H KUIPERSF MUSKENSMonique WillartD HIJDRAFBJ VAN ASSEMAAJ COYLEHC HOOGSTEDENBart Lambrecht

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function

M IDZKOHamida HammadM VAN NIMWEGENM KOOLT MULLERT SOULLIEMonique WillartD HIJDRAHC HOOGSTEDENBart Lambrecht

A1 Journal Article in JOURNAL OF CLINICAL INVESTIGATION

2005

In vivo depletion of lung CD11c(+) dendritic cells during allergen challenge abrogates the characteristic features of asthma

LS VAN RIJTS JUNGA KLEINJANN VOSMonique WillartC DUEZHC HOOGSTEDENBart Lambrecht

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

2004

Dendritic cells retrovirally overexpressing IL-12 induce strong Th1 responses to inhaled antigen in the lung but fail to revert established Th2 sensitization

H KUIPERSC HEIRMAND HIJDRAF MUSKENSMonique WillartS VAN MEIRVENNEK THIELEMANSHC HOOGSTEDENBart Lambrecht

A1 Journal Article in JOURNAL OF LEUKOCYTE BIOLOGY

Essential role of dendritic cell CD80/86 costimulation in the induction, but not reactivation, of T(H)2 effector responses in a mouse model of asthma

LS VAN RIFTN VOSMonique WillartA KLEINJANAJ COYLEHC HOOGSTEDENBart Lambrecht

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Essential role of lung plasmacytoid dendritic cells in preventing asthmatic reactions to harmless inhaled antigen

HJ DE HEERHamida HammadT SOULLIED HIJDRAN VOSMonique WillartHC HOOGSTEDENBart Lambrecht

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE