Research Explorer

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Researcher

Mireille Van Gele

Awards & Distinctions

83 Results

2021

Personalized development of antisense oligonucleotides for exon skipping restores type XVII collagen expression in junctional epidermolysis bullosa

Michael AblingerThomas LettnerNicole FriedlHannah PotockiTheresa PalmetzhoferUlrich KollerJulia IllmerBernadette LiembergerStefan HainzlAlfred Klausegger et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

2018

Phase 1 dose escalation trial of ipilimumab and stereotactic body radiation therapy in metastatic melanoma

Nora SundahlKatrien De WolfVibeke KruseAnnabel MeiresonDries ReyndersEls GoetghebeurMireille Van GeleReinhart SpeeckaertBenjamin HennartLieve Brochez et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Towards the development of a RNAi-based topical treatment for psoriasis : proof-of-concept in a 3D psoriasis skin model

Eline DesmetMireille Van GeleLynda GrineKatrien RemautJo Lambert

A1 Journal Article in EXPERIMENTAL DERMATOLOGY

2017

A phase I/II trial of fixed-dose stereotactic body radiotherapy with sequential or concurrent pembrolizumab in metastatic urothelial carcinoma : evaluation of safety and clinical and immunologic response

Nora SundahlKatrien De WolfSylvie RotteyKarel DecaesteckerDaan De MaeseneerAnnabel MeiresonEls GoetghebeurValerie FonteyneSofie VerbekePieter De Visschere et al.

A1 Journal Article in JOURNAL OF TRANSLATIONAL MEDICINE

A phase II trial of stereotactic body radiotherapy with concurrent anti-PD1 treatment in metastatic melanoma : evaluation of clinical and immunologic response

Katrien De WolfVIBEKE KRUSENora SundahlMireille Van GeleINES CHEVOLETReinhart SpeeckaertLieve BrochezPiet Ost

A1 Journal Article in JOURNAL OF TRANSLATIONAL MEDICINE

In vitro psoriasis models with focus on reconstructed skin models as promising tools in psoriasis research

Eline DesmetAnesh RamadhasJo LambertMireille Van Gele

A1 Journal Article in EXPERIMENTAL BIOLOGY AND MEDICINE

RNAi-based topical treatment in psoriasis : crossing the barrier

Eline DesmetJo LambertMireille Van Gele

Topically applied lipid- and surfactant-based nanoparticles in the treatment of skin disorders

Eline DesmetMireille Van GeleJo Lambert

A1 Journal Article in EXPERT OPINION ON DRUG DELIVERY

2016

An elastic liposomal formulation for RNAi-based topical treatment of skin disorders: proof-of-concept in the treatment of psoriasis

Eline DesmetSTEFANIE BRACKEKatrien ForierLien TaevernierMarc StuartBart De SpiegeleerKoen RaemdonckMireille Van GeleJo Lambert

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Characterization data on the topical carrier DDC642

Eline DesmetSTEFANIE BRACKEKatrien ForierLien TaevernierMarc CA StuartBart De SpiegeleerKoen RaemdonckMireille Van GeleJo Lambert

A2 Journal Article in DATA IN BRIEF

Exploring the feasibility of whole blood to identify systemic miRNA biomarkers for patients with moderate-to-severe psoriasis

Mireille Van GeleSTEFANIE BRACKEAna Alves de MedeirosJo Lambert

A1 Journal Article in EUROPEAN JOURNAL OF DERMATOLOGY

JAK3 as an emerging target for topical treatment of inflammatory skin diseases

Ana Alves de MedeirosReinhart SpeeckaertEline DesmetMireille Van GeleSofie De SchepperJo Lambert

A1 Journal Article in PLOS ONE

The many faces of interleukin-17 in inflammatory skin diseases

Reinhart SpeeckaertJo LambertLynda GrineMireille Van GeleSofie De SchepperNanja van Geel

A1 Journal Article in BRITISH JOURNAL OF DERMATOLOGY

2015

A translational exploration of melanoma immunology focused on indoleamine 2,3-dioxygenase : lessons for immunoprofiling and immunotherapy

INES CHEVOLETLieve BrochezMireille Van Gele

Characterization of the in vivo immune network of IDO, tryptophan metabolism, PD-L1, and CTLA-4 in circulating immune cells in melanoma

INES CHEVOLETReinhart SpeeckaertMax SchreuerB NeynsOlga KryskoClaus BachertB HennartD AllorgeNanja van GeelMireille Van Gele et al.

A1 Journal Article in ONCOIMMUNOLOGY

Clinical significance of plasmacytoid dendritic cells and myeloid-derived suppressor cells in melanoma

INES CHEVOLETReinhart SpeeckaertMax SchreuerBart NeynsOlga KryskoClaus BachertMireille Van GeleNanja van GeelLieve Brochez

A1 Journal Article in JOURNAL OF TRANSLATIONAL MEDICINE

Stromal protein expression in breast cancer is differentially regulated by TGF-β1

Mieke Van BockstalKathleen LambeinMireille Van GeleElly De VlieghereRidha LimameGeert Braemsmarc brackeHannelore DenysLouis LibbrechtOlivier De Wever

Systemic immune changes associated with adjuvant interferon-α2b-therapy in stage III melanoma patients: failure at the effector phase?

INES CHEVOLETMax SchreuerReinhart SpeeckaertBart NeynsIsabelle HoorensNanja van GeelVibeke KruseBenjamin HennartDelphine AllorgeMireille Van Gele et al.

A1 Journal Article in MELANOMA RESEARCH

Topical carrier for the delivery of therapeutic RNAi molecules to human (impaired) skin

E DesmetMireille Van GeleJo Lambert

microRNAs in psoriasis: leaders or followers?

Jo LambertLynda GrineMireille Van Gele

Editorial material

2014

Development of an oral mucosa model to study host-microbiome interactions during wound healing

Tine De RyckCharlotte GrootaertLaura JaspaertFrederiek-Maarten KerckhofMireille Van GeleJoachim De SchrijverPieter Van den AbbeeleSimon SwiftMarc BrackeTom Van de Wiele et al.

A1 Journal Article in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Differential regulation of extracellular matrix protein expression in carcinoma-associated fibroblasts by TGF-β1 regulates cancer cell spreading but not adhesion

Mieke Van BockstalKathleen LambeinMireille Van GeleElly De VlieghereRIDHA LIMAMEGeert BraemsRudy Van den BroeckeVeronique CocquytHannelore Denysmarc bracke et al.

A2 Journal Article in ONCOSCIENCE

Identification of a ZEB2-MITF-ZEB1 transcriptional network that controls melanogenesis and melanoma progression

Geertrui DeneckerNiels VandammeOzden AkayD KoludrovicJoachim TaminauKelly LemeireAlexander GheldofBram De CraeneMireille Van GeleLieve Brochez et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Peritumoral indoleamine 2,3-dioxygenase expression in melanoma : an early marker of resistance to immune control?

INES CHEVOLETReinhart SpeeckaertMarc HaspeslaghBart NeynsVIBEKE KRUSEMax SchreuerMireille Van GeleNanja van GeelLieve Brochez

A1 Journal Article in BRITISH JOURNAL OF DERMATOLOGY

The biology of hyperpigmentation syndromes

Reinhart SpeeckaertMireille Van GeleMarijn SpeeckaertJo LambertNanja van Geel

A1 Journal Article in PIGMENT CELL & MELANOMA RESEARCH

2013

Characterization of Staphylococcus and Corynebacterium clusters in the human axillary region

Chris CallewaertFrederiek-Maarten KerckhofMichael S GranitsiotisMireille Van GeleTom Van de WieleNico Boon

A1 Journal Article in PLOS ONE

Identification of miR-145 as a key regulator of the pigmentary process

Peter DynoodtPieter MestdaghGert Van PeerJo VandesompeleKaren GoossensLuc PeelmanBarbara GeusensReinhart SpeeckaertJo LambertMireille Van Gele

A1 Journal Article in JOURNAL OF INVESTIGATIVE DERMATOLOGY

Identifying targets for topical RNAi therapeutics in psoriasis: assessment of a new in vitro psoriasis model

STEFANIE BRACKEEline DesmetSara Guerrero-AspizuaSandra G TjabringaJoost SchalkwijkMireille Van GeleMarta CarreteroJo Lambert

A1 Journal Article in ARCHIVES OF DERMATOLOGICAL RESEARCH

Revealing the role of miR-145 as a key player in melanogenesis and melanoma

Peter DynoodtJo LambertMireille Van Gele

The SCIN simulation: a novel in vitro technique to study microbial colonization in the axillary region

Chris CallewaertBenjamin BuysschaertEls VossenMireille Van GeleTom Van de WieleNico Boon

The effect of CD8+tumor-infiltrating lymphocytes on sentinel lymph node immune status

INES CHEVOLETReinhart SpeeckaertBarbara BooneNanja van GeelMireille Van GeleMarc HaspeslaghLieve Brochez

The need for transparency and good practices in the qPCR literature

Stephen A BustinVladimir BenesJeremy GarsonJan HellemansJim HuggettMikael KubistaReinhold MuellerTania NolanMichael W PfafflGregory Shipley et al.

A1 Journal Article in NATURE METHODS

miR-145 overexpression suppresses the migration and invasion of metastatic melanoma cells

Peter DynoodtReinhart SpeeckaertOlivier De WeverINES CHEVOLETLieve BrochezJo LambertMireille Van Gele

A1 Journal Article in INTERNATIONAL JOURNAL OF ONCOLOGY

2012

Hypomelanoses and hypermelanoses

Hilde LapeereBarbara BooneSofie De SchepperEvelien VerhaegheMireille Van GeleKatia OngenaeNanja van GeelJo LambertLieve Brochez

Bookchapter in Fitzpatrick’s dermatology in general medicine

Immune mediated mechanisms of melanocyte destruction: paving the way for efficient immunotherapeutic strategies against melanoma

Reinhart SpeeckaertNanja van GeelJo LambertBarbara BooneINES CHEVOLETMireille Van GeleMarijn SpeeckaertLieve Brochez

Editorial material

Indoleamine 2,3-dioxygenase, a new prognostic marker in sentinel lymph nodes of melanoma patients

Reinhart SpeeckaertKarim VermaelenNanja van GeelPhilippe AutierJo LambertMarc HaspeslaghMireille Van GeleKris ThielemansBart NeynsNathalie Roche et al.

A1 Journal Article in EUROPEAN JOURNAL OF CANCER

The SCIN simulation: a novel in vitro technique to study the odour generation of microbial colonization on the skin

Chris CallewaertBenjamin BuysschaertMireille Van GeleTom Van de WieleNico Boon

The human axillary environment harbors 2 microbiome ecotypes

Chris CallewaertFrederiek-Maarten KerckhofMS GranitsiotisMireille Van GeleTom Van de WieleNico Boon

The human axillary environment harbors two microbiome ecotypes

Chris CallewaertFrederiek-Maarten KerckhofMireille Van GeleTom Van de WieleNico Boon

2011

Development of a 3D pigmented skin model to evaluate RNAi-induced depigmentation

Mireille Van GeleBarbara GeusensReinhart SpeeckaertPeter DynoodtBarbara VanhoeckeKarolien Van Den BosscheJo Lambert

A1 Journal Article in EXPERIMENTAL DERMATOLOGY

Immune reactions in benign and malignant melanocytic lesions: lessons for immunotherapy

Reinhart SpeeckaertNanja van GeelKarim VermaelenJo LambertMireille Van GeleMarijn SpeeckaertLieve Brochez

A1 Journal Article in PIGMENT CELL & MELANOMA RESEARCH

Lipid-mediated gene delivery to the skin

Barbara GeusensTINE STROBBESTEFANIE BRACKEPeter DynoodtNiek SandersMireille Van GeleJo Lambert

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Melanocyte-specific immune response in a patient with multiple regressing nevi and a history of melanoma

Reinhart SpeeckaertNanja van GeelRosalie M LuitenMireille Van GeleMarijn SpeeckaertJo LambertKarim VermaelenEsther PM TjinLieve Brochez

A1 Journal Article in ANTICANCER RESEARCH

Microbial colonization of an ex vivo skin fragment to simulate the axillary environment: a novel approach

Chris CallewaertMireille Van GeleTom Van de WieleNico Boon

Three-dimensional skin models as tools for transdermal drug delivery: challenges and limitations

Mireille Van GeleBarbara GeusensLieve BrochezReinhart SpeeckaertJo Lambert

A1 Journal Article in EXPERT OPINION ON DRUG DELIVERY

2010

Design, development and characterization of lipid-based nanosomes for siRNA delivery into human skin

Barbara GeusensJo LambertMireille Van Gele

Flexible nanosomes (SECosomes) enable efficient siRNA delivery in cultured primary skin cells and in the viable epidermis of ex vivo human skin

Barbara GeusensMireille Van GeleSien BraatStefaan De SmedtMarc CA StuartTarl W ProwWashington SanchezMichael S RobertsNiek SandersJo Lambert

A1 Journal Article in ADVANCED FUNCTIONAL MATERIALS

P-cadherin counteracts myosin II-B function : implications in melanoma progression

Koen JacobsMireille Van GeleRamses ForsythLieve BrochezBarbara VanhoeckeOlivier De WeverMarc Bracke

A1 Journal Article in MOLECULAR CANCER

The flavonoid tangeretin activates the unfolded protein response and synergizes with imatinib in the erythroleukemia cell line K562

Sofie LustBarbara VanhoeckeMireille Van GeleJan PhilippéMarc BrackeFritz Offner

A1 Journal Article in MOLECULAR NUTRITION & FOOD RESEARCH

2009

Cutaneous short-interfering RNA therapy

Barbara GeusensNiek SandersTarl ProwMireille Van Gele

A1 Journal Article in EXPERT OPINION ON DRUG DELIVERY

Evaluation of ethosomes for delivery of siRNA into cultured primary melanocytes and skin

Barbara GeusensSien BraatM StuartStefaan De SmedtNiek SandersT ProwM RobertsJo LambertMireille Van Gele

Griscelli syndrome: a model system to study vesicular trafficking.

Mireille Van GelePeter DynoodtJo Lambert

A1 Journal Article in Pigment Cell and Melanoma Research

Steroid effects on ZAP-70 and SYK in relation to apoptosis in poor prognosis chronic lymphocytic leukemia

Jerina BoelensSofie LustFEMKE VAN BOCKSTAELEMireille Van GeleAnn JanssensLara DeryckeBarbara VanhoeckeJan PhilippéMarc BrackeFritz Offner

A1 Journal Article in LEUKEMIA RESEARCH

The role of RhoC in growth and metastatic capacity of melanoma

Barbara BooneMireille Van GeleJo LambertMarc HaspeslaghLieve Brochez

A1 Journal Article in JOURNAL OF CUTANEOUS PATHOLOGY

Ultradeformable cationic liposomes for delivery of small interfering RNA (siRNA) into human primary melanocytes

Barbara GeusensJo LambertStefaan De SmedtKevin BuyensNiek SandersMireille Van Gele

A1 Journal Article in Journal of Controlled Release

Xanthohumol activates the proapoptotic arm of the unfolded protein response in chronic lymphocytic leukemia

Sofie LustBarbara VanhoeckeMireille Van GeleJerina BoelensHeleen Van MelckebekeMary KailehWim Vanden BergheGuy HaegemanJan PhilippéMarc Bracke et al.

A1 Journal Article in ANTICANCER RESEARCH

2008

Knockdown of myosin Va isoforms by RNAi as a tool to block melanosome transport in primary human melanocytes

Mireille Van GeleBarbara GeusensAM SCHMITTL AGUILARJo Lambert

A1 Journal Article in JOURNAL OF INVESTIGATIVE DERMATOLOGY

RNA interference of myosin Va exon F isoforms in primary human melanocytes: an alternative to treat hyperpigmentation

Mireille Van GeleBarbara GeusensI LAMBERT

The prenylated chalcone xanthohumol induces unfolded protein response, autophagy, and cell death in breast cancer cells by proteasome inhibition

Barbara VanhoeckeMireille Van GeleWim MartinetAnne-Sophie Vercoutter-EdouartSofie LustDelphine DebruyneDenis De KeukeleireFritz Offnermarc bracke

Ultradeformable liposomes for delivery of small interfering RNA (siRNA) into human primary melanocytes

Barbara GeusensMireille Van GeleS DE SMEDTN SANDERSI LAMBERT

2007

Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds

Bram BaertE DECONINCKMireille Van GeleMarian SlodickaP STOPPIESamuel BodéGuido SlegersY VANDER HEYDENJo LambertJ BEETENS et al.

A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY

Xanthohumol induces in vitro apoptosis in B-CLL cells mediated by non-classical ER stress

Sofie LustBarbara VanhoeckeMireille Van GeleJerina BoelensMary KailehWim Vanden BergheJ PHILLIPESmarc brackeFritz Offner

Xanthohumol: a new potential proteasome inhibitor that activates the pro-apoptotic arm of the unfolded protein response in B-CLL cells

Sofie LustBarbara VanhoeckeMireille Van GeleJerina BoelensJan PhilippéPetra Vinckenmarc brackeMartine PoelmanFritz Offner

2006

RNAi-induced suppression of endogenous neurofibromin does not modulate the cell cycle in cultured primary human epidermal melanocytes

Joachim BoucneauSofie De SchepperMireille Van GeleJean NaeyaertJo Lambert

2004

Proneural and proneuroendocrine transcription factor expression in cutaneous mechanoreceptor (Merkel) cells and Merkel cell carcinoma (vol 101, pg 103, 2002)

JH LEONARDAL COOKMireille Van GeleGM BOYLEKJ INGLISFranki SpelemanRA STURM

2003

Application of laser capture microdissection in genetic analysis of neuroblastoma and neuroblastoma precursor cells

Katleen De PreterJo VandesompelePierre HeimannMark M KockxMireille Van GeleJasmien HoebeeckEls De SmetMartine DemarcheGenevieve LaureysNadine Van Roy et al.

A1 Journal Article in CANCER LETTERS

2002

Combined karyotyping, CGH and M-fish analysis allows detailed characterization of unidentified chromosomal rearrangements in Merkel cell carcinoma.

Mireille Van GeleJH LEONARDNadine Van RoyHeidi Van LimbergenSimon Van BelleVeronique CocquytH SALWENAnne De PaepeFranki Speleman

A1 Journal Article in INTERNATIONAL JOURNAL OF CANCER

Localization of the 17q breakpoint of a constitutional 1;17 translocation in a patient with neuroblastoma within a 25-kb segment located between the ACCN1 and TLK2 genes and near the distal breakpoints of two microdeletions in neurofibromatosis type I patients.

Nadine Van RoyJo VandesompeleGeert BerxK STAESMireille Van GeleEls De SmetAnne De PaepeGenevieve LaureysP VAN DER DRIFTR VERSTEEG et al.

A1 Journal Article in GENES CHROMOSOMES & CANCER

Proneural and proneuroendocrine transcription factor expression in cutaneous mechanoreceptor (Merkel) cells and Merkel cell carcinoma.

JH LEONARDAL COOKMireille Van GeleGM BOYLEKJ INGLISFranki SpelemanRA STURM

A1 Journal Article in INTERNATIONAL JOURNAL OF CANCER

Study of genomic aberrations and gene expression profiling in Merkel cell carcinoma

Mireille Van Gele

2001

Combined M-FISH and CGH analysis allows comprehensive description of genetic alterations in neuroblastoma cell lines.

Nadine Van RoyHeidi Van LimbergenJo VandesompeleMireille Van GeleBruce PoppeH SALWENGenevieve LaureysN MANOELAnne De PaepeFranki Speleman

A1 Journal Article in GENES CHROMOSOMES & CANCER

Frequent allelic loss at 10q23 but low incidence of PTEN mutations in Merkel cell carcinoma

Mireille Van GeleJ Helen LeonardNadine Van RoyAnthony L CookAnne De PaepeFranki Speleman

A1 Journal Article in INTERNATIONAL JOURNAL OF CANCER

Tumor formation and inactivation of RIZ1, an Rb-binding member of a nuclear protein-methyltransferase superfamily.

G STEELE-PERKINSW FANGXH YANGMireille Van GeleT CARLINGJ GUIM BUYSEJA FLETCHERJS LIUR BRONSON et al.

A1 Journal Article in GENES & DEVELOPMENT

2000

Chromosome 2 short arm translocations revealed by M-FISH analysis of neuroblastoma cell lines.

Nadine Van RoyHeidi Van LimbergenJo VandesompeleMireille Van GeleBruce PoppeGenevieve LaureysAnne De PaepeFranki Speleman

A1 Journal Article in MEDICAL AND PEDIATRIC ONCOLOGY

Mutation analysis of P73 and TP53 in Merkel cell carcinoma.

Mireille Van GeleM KAGHADJH LEONARDNadine Van RoyJean NaeyaertMarie GeertsSimon Van BelleVeronique CocquytJ BRIDGER SCIOT et al.

A1 Journal Article in BRITISH JOURNAL OF CANCER

Structure and mutation analysis of the gene encoding DNA fragmentation factor 40 (caspase-activated nuclease), a candidate neuroblastoma tumour suppressor gene.

H JUDSONNadine Van RoyL STRAINJo VandesompeleMireille Van GeleFranki SpelemanDT BONTHRON

A1 Journal Article in HUMAN GENETICS

1999

Mapping of novel regions of DNA gain and loss by comparative genomic hybridization in esophageal carcinoma in the black and colored populations of South Africa.

L DU PLESSISE DIETZSCHMireille Van GeleNadine Van RoyP VAN HELDENMI PARKERDK MUGWANYAM DE GROOTMP MARXMJ KOTZE et al.

A1 Journal Article in CANCER RESEARCH

1998

Characteristic pattern of chromosomal gains and losses in Merkel cell carcinoma detected by comparative genomic hybridization

Mireille Van GeleFranki SpelemanJo VandesompeleNadine Van RoyJH Leonard

A1 Journal Article in CANCER RESEARCH

Genetic heterogeneity of neuroblastoma studied by comparative genomic hybridization.

Jo VandesompeleNadine Van RoyMireille Van GeleGenevieve LaureysP AMBROSP HEIMANNC DEVALCKE SCHUURINGP BROCKJ OTTEN et al.

A1 Journal Article in GENES CHROMOSOMES & CANCER

Molecular analysis of lp36 breakpoints in two Merkel cell carcinomas.

Mireille Van GeleNadine Van RoySG RONANLudwine MessiaenJo VandesompeleMarie GeertsM NAEYAERTE BLENNOWI BAR-AMTK DAS GUPTA et al.

A1 Journal Article in GENES CHROMOSOMES & CANCER

1997

Analysis of 1;17 translocation breakpoints in neuroblastoma: Implications for mapping of neuroblastoma genes.

Nadine Van RoyGenevieve LaureysMireille Van GeleG OPDENAKKERR MIURAP VAN DER DRIFTA CHANR VERSTEEGFranki Speleman

A1 Journal Article in EUROPEAN JOURNAL OF CANCER

Monosomy 22 in a mixed germ cell sex cord stromal tumor of the ovary

Franki SpelemanBart DermautChristian R De PotterMireille Van GeleNadine Van RoyAnne De PaepeGenevieve Laureys

A1 Journal Article in GENES CHROMOSOMES & CANCER

Sensitive and reliable detection of genomic imbalances in human neuroblastomas using comparative genomic hybridisation analysis.

Mireille Van GeleNadine Van RoyA JAUCHGenevieve LaureysYves BenoitVera SchelfhoutChristian De PotterP BROCKA UYTTEBROECKR SCIOT et al.

A1 Journal Article in EUROPEAN JOURNAL OF CANCER