Research Explorer

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Researcher

Mira Haegman

Awards & Distinctions

27 Results

2023

A20 is a master switch of IL-33 signalling in macrophages and determines IL-33-induced lung immunity

Aurora Holgado MuñozZhuangzhuang LiuAigerim AidarovaChristina MüllerMira HaegmanYasmine DriegeMarja KreikeCharlotte ScottInna AfoninaRudi Beyaert

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Normal lymphocyte homeostasis and function in MALT1 protease-resistant HOIL-1 knock-in mice

Ioannis SkordosYasmine DriegeMira HaegmanMarja KreikeJens StaalAnnelies DemeyerRudi Beyaert

A1 Journal Article in FEBS JOURNAL

2022

CARD14 signalling ensures cell survival and cancer associated gene expression in prostate cancer cells

Domien VannesteJens StaalMira HaegmanYasmine DriegeMarieke CarelsElien Van NuffelPieter De BleserYvan SaeysRudi BeyaertInna Afonina

A1 Journal Article in BIOMEDICINES

2021

Defining the combinatorial space of PKC::CARD-CC signal transduction nodes

Jens StaalYasmine DriegeMira HaegmanMarja KreikeStyliani IliakiDomien VannesteMarie LorkInna AfoninaHarald BraunRudi Beyaert

A1 Journal Article in FEBS JOURNAL

Tailored modulation of cellular pro-inflammatory responses with disaccharide lipid A mimetics

Holger HeineFlorian AdanitschTina Tinkara PeterneljMira HaegmanChristoph KasperSimon IttigRudi BeyaertRoman JeralaAlla Zamyatina

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

2020

MALT1 targeting suppresses CARD14‐induced psoriatic dermatitis in mice

Elien Van NuffelJens StaalGriet BaudeletMira HaegmanYasmine DriegeTino HochepiedInna AfoninaRudi Beyaert

A1 Journal Article in EMBO REPORTS

2019

IL-33trap is a novel IL-33-neutralizing biologic that inhibits allergic airway inflammation

Aurora Holgado MuñozHarald BraunElien Van NuffelSammy DetryMartijn SchuijsKim DeswarteKarl VergoteMira HaegmanGriet BaudeletJurgen Haustraete et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

2018

Ancient origin of the CARD-coiled coil/Bcl10/MALT1-like paracaspase signaling complex indicates unknown critical functions

Jens StaalYasmine DriegeMira HaegmanAlice BorghiPaco HulpiauLaurens LievensIsmail Sahin GülSrividhya Sundararaman IyerAmanda GonçalvesIneke Dhondt et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

The E3 ubiquitin ligases HOIP and cIAP1 are recruited to the TNFR2 signaling complex and mediate TNFR2-induced canonical NF-κB signaling

Alice BorghiMira HaegmanRoman FischerIsabelle CarpentierMathieu BertrandClaude LibertInna AfoninaRudi Beyaert

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

2016

MALT1 cleaves the E3 ubiquitin ligase HOIL-1 in activated T cells, generating a dominant negative inhibitor of LUBAC-induced NF-κB signaling

Lynn EltonIsabelle CarpentierJens StaalYasmine DriegeMira HaegmanRudi Beyaert

A1 Journal Article in FEBS JOURNAL

2015

Anti-endotoxic activity and structural basis for human MD-2∙TLR4 antagonism of tetraacylated lipid A mimetics based on βGlcN(l↔l)αGlcN scaffold

Jose Antonio GarateJohannes StöcklMaría del Carmen Fernández-AlonsoDaniel ArtnerMira HaegmanChris OostenbrinkJesús Jiménez-BarberoRudi BeyaertHolger HeinePaul Kosma et al.

A1 Journal Article in INNATE IMMUNITY

Chemical synthesis of Burkholderia Lipid A modified with glycosyl phosphodiester-linked 4-amino-4-deoxy-beta-L-arabinose and its immunomodulatory potential

Ralph HollausSimon IttigAndreas HofingerMira HaegmanRudi BeyaertPaul KosmaAlla Zamyatina

A1 Journal Article in CHEMISTRY-A EUROPEAN JOURNAL

2014

Development of αGlcN(1 <-> 1)αMan-based Lipid A mimetics as a novel class of potent Toll-like Receptor 4 agonists

Florian AdanitschSimon IttigJohannes StöcklAlja OblakMira HaegmanRoman JeralaRudi BeyaertPaul KosmaAlla Zamyatina

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

2012

The Pseudomonas aeruginosa type III secretion system has an exotoxin S/T/Y independent pathogenic role during acute lung infection

Marlies GalleShouguang JinPieter BogaertMira HaegmanPeter VandenabeeleRudi Beyaert

A1 Journal Article in PLOS ONE

2008

Prolonged exposure to IL-1 beta and IFN gamma induces necrosis of L929 tumor cells via a p38MAPK/NF-kappa B/NO-dependent mechanism

Elisabeth VercammenJens StaalAeke Van Den BroekeMira HaegmanLars VereeckePeter SchotteRudi Beyaert

A1 Journal Article in ONCOGENE

Stimulation of Toll-like receptor 3 and 4 induces interleukin-1β maturation by caspase-8

Jonathan MaelfaitElisabeth VercammenSophie JanssensPeter SchotteMira HaegmanStefan MagezRudi Beyaert

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-kappa B inhibitor A20

Beatrice CoornaertM BAENSKaren HeyninckTine BekaertMira HaegmanJens StaalLJ SUNZJJ CHENP MARYNENRudi Beyaert

A1 Journal Article in NATURE IMMUNOLOGY

The Pseudomonas aeruginosa Type III secretion system plays a dual role in the regulation of caspase-1 mediated IL-1 beta maturation

Marlies GallePeter SchotteMira HaegmanAndy WullaertHJ YANGS JINRudi Beyaert

A1 Journal Article in JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

2007

A role for hnRNP C1/C2 and Unr in internal initiation of translation during mitosis

Bert SchepensSandrine TintonYanik BruynoogheEef ParthoensMira HaegmanRudi BeyaertSigrid Cornelis

A1 Journal Article in EMBO JOURNAL

Immune modulation by the pseudomonas type III secretion system

Rudi BeyaertMarlies GalleMira HaegmanP SCHOTT

LIND/ABIN-3 is a novel lipopolysaccharide-inducible inhibitor of NF-kappa B activation

Andy WullaertLynn VerstrepenSofie Van HuffelM Adib-ConquySigrid CornelisMarja KreikeMira HaegmanKarim El BakkouriMatthew SandersKelly Verhelst et al.

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

2005

Adenoviral gene transfer of the NF-kappa B inhibitory protein ABIN-1 decreases allergic airway inflammation in a murine asthma model

Karim El BakkouriAndy WullaertMira HaegmanKaren HeyninckRudi Beyaert

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

1999

Ethylene signaling : more players in the game

Dominique Van Der StraetenJan SmalleSophie BertrandAnnelies De PaepeI De PauwFilip VandenbusscheMira HaegmanWim Van CaeneghemMarc Van Montagu

The expression pattern of the Arabidopsis ACC synthase gene 1 during rosette leaf development

Jan SmalleMira HaegmanJohan MertensJ VangronsveldMarc Van MontaguDominique Van Der Straeten

A1 Journal Article in JOURNAL OF EXPERIMENTAL BOTANY

1998

The trihelix DNA-binding motif in higher plants is not restricted to the transcription factors GT-1 and GT-2

Jan SmalleJasmina KurepaMira HaegmanJan GielenMarc Van MontaguDominique Van Der Straeten

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

1997

Ethylene and Arabidopsis rosette development

Jan SmalleJasmina KurepaMira HaegmanMarc Van MontaguDominique Van Der Straeten

Ethylene can stimulate Arabidopsis hypocotyl elongation in the light

Jan SmalleMira HaegmanJasmina KurepaMarc Van MontaguDominique Van Der Straeten

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA