Research Explorer

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Researcher

Michael Ghijs

Awards & Distinctions

31 Results

2024

Analysis of the effect of formulation properties and process parameters on granule formation in twin-screw wet granulation

Michiel PeetersAna Alejandra Barrera JiménezKensaku MatsunamiMichael GhijsEduardo dos Santos SchultzMina RoudgarTamas VighFanny StaufferIngmar NopensThomas De Beer

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

2023

A colourful way to unravel the important fluidization-related granule size effect on semi-continuous drying

Tuur VandeputteMichael GhijsIngmar NopensThomas De Beer

A1 Journal Article in AAPS PHARMSCITECH

A formulation-generic pharmaceutical fluidized bed drying model including granule segregation as a vital component

Tuur VandeputteIngmar NopensThomas De BeerMichael Ghijs

Analysis of the influence of process and formulation properties on the drying behavior of pharmaceutical granules in a semi-continuous fluid bed drying system

Tuur VandeputteMichael GhijsMichiel PeetersAlexander De ManDaan Van HauwermeirenEduardo Dos Santos SchultzTamas VighFanny StaufferIngmar NopensThomas De Beer

A2 Journal Article in POWDERS

Mechanistic modeling of semicontinuous fluidized bed drying of pharmaceutical granules by incorporating single particle and bulk drying kinetics

Tuur VandeputteMichael GhijsDaan Van HauwermeirenEduardo Dos Santos SchultzElisabeth SchäferFanny StaufferThomas De BeerIngmar Nopens

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Model development and calibration of two-dimensional population balance model for twin-screw wet granulation based on particle size distribution and porosity

Ana Alejandra Barrera JiménezKensaku MatsunamiMichael GhijsDaan Van HauwermeirenMichiel PeetersFanny StaufferThomas De BeerIngmar Nopens

A1 Journal Article in POWDER TECHNOLOGY

Validation of model-based design of experiments for continuous wet granulation and drying

Kensaku MatsunamiTuur VandeputteAna Alejandra Barrera JiménezMichiel PeetersMichael GhijsDaan Van HauwermeirenFanny StaufferEduardo dos Santos SchultzIngmar NopensThomas De Beer

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

2022

Model-based design of experiments in drug product development in continuous manufacturing

Tuur VandeputteAna Alejandra Barrera JiménezKensaku MatsunamiMichiel PeetersMichael GhijsDaan Van HauwermeirenIngmar NopensThomas De Beer

Model-based determination of spatial heterogeneities in a pharmaceutical fluidization process and integration into a mechanistic multi-level drying model

Tuur VandeputteMichael GhijsMiguel DazaThomas De BeerUsman RehmanIngmar Nopens

The fitness–fatigue model : what’s in the numbers?

Kobe VermeireMichael GhijsJan BourgoisJan Boone

A1 Journal Article in INTERNATIONAL JOURNAL OF SPORTS PHYSIOLOGY AND PERFORMANCE

Two-dimensional granule property measurement using hyperspectral imaging in continuous pharmaceutical wet granulation

Michael GhijsTuur VandeputteMichiel PeetersThomas De BeerIngmar Nopens

Two-dimensional population balance model for twin-screw wet granulation : model development and calibration based on particle size distribution and porosity

Kensaku MatsunamiAna Alejandra Barrera JiménezMichiel PeetersMichael GhijsDaan Van HauwermeirenThomas De BeerIngmar Nopens

2021

Analysis of fluidization and particle temperature in semicontinuous fluid bed drying of pharmaceutical granules

Tuur VandeputteMichael GhijsThomas De BeerIngmar Nopens

Can filaments, pellets and powder be used as feedstock to produce highly drug-loaded ethylene-vinyl acetate 3D printed tablets using extrusion-based additive manufacturing?

Aseel SamaroBahaa ShaqourNiloofar Moazami GoudarziMichael GhijsLudwig CardonMatthieu BooneBart VerleijeKoen BeyersValérie VanhoornePaul Cos et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Clarifying the formulation effect on the drying behavior of pharmaceutical granules after wet granulation

Tuur VandeputteMichael GhijsMarie VandrommeSelien Van LangenhoveThomas De BeerIngmar Nopens

Model-based analysis of breakage in fluid bed drying of continuously produced pharmaceutical wet granules

Michael GhijsTuur VandeputteMarie VandrommeSelien Van LangenhoveThomas De BeerIngmar Nopens

The influence of different training load quantification methods on the fitness-fatigue model

Kobe VermeireFreek Van de CasteeleMaxim GosseriesJan BourgoisMichael GhijsJan Boone

A1 Journal Article in INTERNATIONAL JOURNAL OF SPORTS PHYSIOLOGY AND PERFORMANCE

The influence of equipment design and process parameters on granule breakage in a semi-continuous fluid bed dryer after continuous twin-screw wet granulation

Alexander RyckaertMichael GhijsChristoph PortierDejan DjuricAdrian FunkeChris VervaetThomas De Beer

A1 Journal Article in PHARMACEUTICS

Two-dimensional moisture content and size measurement of pharmaceutical granules after fluid bed drying using near-infrared chemical imaging

Michael GhijsBrecht VanbillemontNiels NicolaïThomas De BeerIngmar Nopens

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

2020

Modelling and experimentation on fluid bed drying of granules in the context of pharmaceutical continuous wet granulation

Michael GhijsIngmar NopensThomas De Beer

2019

Dynamic flowsheet model development and sensitivity analysis of a continuous pharmaceutical tablet manufacturing process using the wet granulation route

Nirupaplava MettaMichael GhijsElisabeth SchäferAshish KumarPhilippe CappuynsIvo Van AsscheRavendra SinghRohit RamachandranThomas De BeerMarianthi Ierapetritou et al.

A1 Journal Article in PROCESSES

Flowsheet modeling of the compression step of a continuous wet granulation production line

Brecht VanbillemontMichael GhijsManuel Sebastian Escotet-EspinozaPhilippe CappuynsIvo Van AsscheFernando J MuzzioIngmar NopensThomas De Beer

Modeling of semicontinuous fluid bed drying of pharmaceutical granules with respect to granule size

Michael GhijsElisabeth SchäferAshish KumarPhilippe CappuynsIvo Van AsscheFien De LeersnyderValérie VanhoorneThomas De BeerIngmar Nopens

A1 Journal Article in JOURNAL OF PHARMACEUTICAL SCIENCES

Towards a generic model for twin-screw wet granulation

Daan Van HauwermeirenMaxim VerstraetenMichael GhijsKai LeeNeil TurnbullMary T am EndePankaj DoshiDavid WilsonThomas De BeerIngmar Nopens

Bookchapter in Chemical engineering in the pharmaceutical industry : drug product design, development, and modeling

2018

Breakage and drying behaviour of granules in a continuous fluid bed dryer : influence of process parameters and wet granule transfer

Fien De LeersnyderValérie VanhoorneH BekaertJurgen VercruysseMichael GhijsNils BostijnMaxim VerstraetenP CappuynsI Van AsscheY Vander Heyden et al.

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Model development and prediction of particle size distribution, density and friability of a comilling operation in a continuous pharmaceutical manufacturing process

Nirupaplava MettaMaxim VerstraetenMichael GhijsAshish KumarElisabeth SchaferRavendra SinghThomas De BeerIngmar NopensPhilippe CappuynsIvo Van Assche et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Pure breakage PBM calibration in pharmaceutical wet granulation

Michael GhijsElisabeth SchäferAshish KumarPhilippe CappuynsIvo Van AsscheThomas De BeerIngmar Nopens

2017

Extension of a mechanistic model for drying of single pharmaceutical granules to semi-continuous fluid bed drying

Michael GhijsSéverine MortierPhilippe CappuynsKrist V GernaeyThomas De BeerIngmar Nopens

2016

Methodology and pitfalls when calibrating a PBM : the case of twin-screw wet granulation

Daan Van HauwermeirenThomas De BeerMichael GhijsMaxim VerstraetenAshish KumarKrist V GernaeyKai LeeMary T am EndePankaj DoshiIngmar Nopens

Model-based process analysis in continuous manufacturing of pharmaceuticals : calibration of a fluid bed dryer model

Michael GhijsFien De LeersnyderDaan Van HauwermeirenValérie VanhoorneJurgen VercruyssePhilippe CappuynsSéverine MortierThomas De BeerKrist GernaeyIngmar Nopens

2015

Spatio-temporal modelling of filter cake formation in membrane bioreactors

Wouter NaessensMichael GhijsJan BaetensIngmar Nopens