Research Explorer

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Researcher

Michael Drennan

Awards & Distinctions

23 Results

2020

ER stress in antigen‐presenting cells promotes NKT cell activation through endogenous neutral lipids

Srinath GovindarajanEveline VerheugenKoen VenkenDjoere GaublommeMargaux MaelegheerEva ClootsFien GysensBruno De GeestTan‐Yun ChengD Branch Moody et al.

A1 Journal Article in EMBO REPORTS

2018

Stabilization of cytokine mRNAs in iNKT cells requires the serine-threonine kinase IRE1alpha

Srinath GovindarajanDjoere GaublommeRenée Van der CruyssenEveline VerheugenSofie Van GassenYvan SaeysSimon TavernierTakao IwawakiYehudi BlochSavvas Savvides et al.

A1 Journal Article in NATURE COMMUNICATIONS

2017

A20 inhibition of STAT1 expression in myeloid cells : a novel endogenous regulatory mechanism preventing development of enthesitis

Katelijne De WildeArne MartensStijn LambrechtPeggy JacquesMichael DrennanKarlijn DebusschereSrinath GovindarajanJulie CoudenysEveline VerheugenFien Windels et al.

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

Leptin receptor antagonism of iNKT cell function : a novel strategy to combat multiple myeloma

Mérédis FavreauE MenuDjoere GaublommeK VanderkerkenS FaictK MaesE De BruyneSrinath GovindarajanMichael DrennanSerge Van Calenbergh et al.

A1 Journal Article in LEUKEMIA

Mechanistic insights into the regulation of iNKT development and cytokine production

Srinath GovindarajanDirk ElewautMichael Drennan

2016

Elevated calprotectin levels reveal bowel inflammation in spondyloarthritis

Heleen CypersGaëlle VarkasSam BeeckmanKarlijn DebusschereT VoglJ RothMichael DrennanM LavricD FoellClaude Cuvelier et al.

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

How the microbiota shapes rheumatic diseases

Tom Van de WieleJens Van PraetMassimo MarzoratiMichael DrennanDirk Elewaut

A1 Journal Article in NATURE REVIEWS RHEUMATOLOGY

NKT sublineage specification and survival requires the ubiquitin-modifying enzyme TNF AIP3/A20

Michael DrennanSrinath GovindarajanEveline VerheugenJonathan CoquetJens StaalConor Mc GuireTom TaghonGeorges LeclercqRudi BeyaertGeert van Loo et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

2015

An optimized method for isolating and expanding invariant natural killer T cells from mouse spleen

Srinath GovindarajanDirk ElewautMichael Drennan

A1 Journal Article in JOVE-JOURNAL OF VISUALIZED EXPERIMENTS

Commensal microbiota influence systemic autoimmune responses

Jens Van PraetErin DonovanInge VanasscheMichael DrennanFien WindelsAmélie DendoovenLiesbeth AllaisClaude CuvelierFons van de LooPaula S Norris et al.

A1 Journal Article in EMBO JOURNAL

2014

A bidirectional crosstalk between iNKT cells and adipocytes mediated by leptin modulates susceptibility for T cell mediated hepatitis

Koen VenkenSylvie SeeuwsLennart ZabeauPeggy JacquesTine DecruyJulie CoudenysEveline VerheugenFien WindelsDominiek CatteeuwMichael Drennan et al.

A1 Journal Article in JOURNAL OF HEPATOLOGY

The thymic microenvironment differentially regulates development and trafficking of invariant NKT cell sublineages

Michael DrennanSrinath GovindarajanKatelijne De WildeSusan M SchlennerCarl WareSergei NedospasovHans-Reimer RodewaldDirk Elewaut

A1 Journal Article in JOURNAL OF IMMUNOLOGY

2011

Galactose modified iNKT cell agonists stabilised by a novel structural modification of CD1D lead to marked TH1 polarisation in vivo

SANDRINE ASPESLAGHYaLi LiEsther Dawen YuNora PauwelsMatthias TrappeniersEnrico GirardiTine DecruyKatrien Van BenedenKoen VenkenMichael Drennan et al.

Galactose-modified iNKT cell agonists stabilized by an induced fit of CD1d prevent tumour metastasis

SANDRINE ASPESLAGHYali LiEsther Dawen YuNora PauwelsMatthias TrappeniersEnrico GirardTine DecruyKatrien Van BenedenKoen VenkenMichael Drennan et al.

A1 Journal Article in EMBO JOURNAL

Regulating the regulators: SOCS3 joins the dance

Michael DrennanDirk Elewaut

Editorial material

2010

A multiparameter approach to monitor disease activity in collagen-induced arthritis

Sylvie SeeuwsPeggy JacquesJens Van PraetMichael DrennanNicky VandeghinsteReginald BrysDirk Elewaut

A multiparameter approach to monitor disease activity in collagen-induced arthritis

Sylvie SeeuwsPeggy JacquesJens Van PraetMichael DrennanJulie CoudenysTine DecruyEllen DeschepperLien LepescheuxPhilippe PujuguetLine Oste et al.

A1 Journal Article in ARTHRITIS RESEARCH & THERAPY

Invariant natural killer T cells are natural regulators of murine spondylarthritis

Peggy JacquesKoen VenkenKatrien Van BenedenHamida HammadSylvie SeeuwsMichael DrennanDieter DeforceAugust VerbruggenMaria ApostolakiGeorge Kollias et al.

A1 Journal Article in ARTHRITIS AND RHEUMATISM

Invariant natural killer T cells in rheumatic disease : a joint dilemma

Michael DrennanSANDRINE ASPESLAGHDirk Elewaut

A1 Journal Article in NATURE REVIEWS RHEUMATOLOGY

Optimizing the iNKT cell dependent antitumor effect using an altered glycolipid

SANDRINE ASPESLAGHYali LiTine DecruyKatrien Van BenedenMichael DrennanKoen VenkenMatthias TrappeniersSerge Van CalenberghDirk ZajoncDirk Elewaut

2009

Cutting Edge: The Chemokine Receptor CXCR3 Retains Invariant NK T Cells in the Thymus

Michael DrennanAnn-Sophie FrankiPieter DewintKatrien Van BenedenSylvie SeeuwsSerge van de PavertEmma ReillyGust VerbruggenThomas LaneReina Mebius et al.

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Reversible changes in serum immunoglobulin galactosylation during the immune response and treatment of inflammatory autoimmune arthritis

Katrien Van BenedenKen CoppietersW LaroyFilip De KeyserIlse HoffmanFilip Van den BoschBert Vander CruyssenMichael DrennanPeggy JacquesP Rottiers et al.

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

Thymic emigration: Sphingosine-1-phosphate receptor-1-dependent models and beyond

Michael DrennanDirk ElewautKristin Hogquist

A1 Journal Article in European Journal of immunology