Research Explorer

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Researcher

Melissa Pille

Awards & Distinctions

12 Results

2024

Gene editing-based targeted integration for correction of Wiskott-Aldrich syndrome

Melissa PilleJohn M. AvilaSo Hyun ParkCuong Q. LeHaipeng XueFilomeen HaerynckLavanya SaxenaCiaran LeeElizabeth J. ShpallGang Bao et al.

A1 Journal Article in MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT

2023

Knocking out CD70 rescues CD70-specific nanoCAR T cells from antigen induced exhaustion

Stijn De MunterJuliane BuhlLaurenz De CockAlexander Van ParysWillem DaneelsEva PascalLucas DeseinsJoline IngelsGlenn GoetgelukLore Billiet et al.

Single-cell profiling identifies a novel human polyclonal unconventional T cell lineage

Lore BillietLaurenz De CockGuillem Sanchez SanchezRupert MayerGlenn GoetgelukStijn De MunterMelissa PilleJoline IngelsHanne JansenKarin Weening et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

The Wiskott–Aldrich syndrome protein is required for positive selection during T-cell lineage differentiation

Melissa PilleJohn AvilaGuillem Sanchez SanchezGlenn GoetgelukStijn De MunterHanne JansenLore BillietKarin WeeningHaipeng XueSarah Bonte et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

2022

Small-scale manufacturing of neoantigen-encoding messenger RNA for early-phase clinical trials

Joline IngelsLaurenz De CockRupert MayerPam DevrekerKarin WeeningKelly HeynsNele LootensSaskia De SmetMarieke BrusseelStijn De Munter et al.

A1 Journal Article in CYTOTHERAPY

2021

Cas9 RNP transfection by vapor nanobubble photoporation for ex vivo cell engineering

Laurens RaesMelissa PilleAranit HarizajGlenn GoetgelukJelter Van HoeckStephan StremerschJuan FraireToon BransOlivier Gerrit de JongRoel Maas-Bakker et al.

A1 Journal Article in MOLECULAR THERAPY-NUCLEIC ACIDS

In vitro OP9-DL1 co-culture and subsequent maturation in the presence of IL-21 generates tumor antigen-specific T cells with a favorable less-differentiated phenotype and enhanced functionality

Sarah BonteStijn De MunterLore BillietGlenn GoetgelukJoline IngelsHanne JansenMelissa PilleLaurenz De CockKarin WeeningTom Taghon et al.

A1 Journal Article in ONCOIMMUNOLOGY

Photothermal nanofibres enable safe engineering of therapeutic cells

Ranhua XiongDawei HuaJelter Van HoeckDominika BerdeckaLaurens LégerStijn De MunterJuan FraireLaurens RaesAranit HarizajFélix Sauvage et al.

A1 Journal Article in NATURE NANOTECHNOLOGY

2020

Human thymic CD10+ PD-1+ intraepithelial lymphocyte precursors acquire interleukin-15 responsiveness at the CD1a– CD95+ CD28– CCR7– developmental stage

Lore BillietGlenn GoetgelukSarah BonteStijn De MunterLaurenz De CockMelissa PilleJoline IngelsHanne JansenKarin WeeningFilip Van Nieuwerburgh et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Rapid and effective generation of nanobody based CARs using PCR and Gibson Assembly

Stijn De MunterAlexander Van ParysLayla BralJoline IngelsGlenn GoetgelukSarah BonteMelissa PilleLore BillietKarin WeeningAnnick Verhee et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

T-cells with a single tumor antigen-specific T-cell receptor can be generated in vitro from clinically relevant stem cell sources

Sarah BonteStijn De MunterGlenn GoetgelukJoline IngelsMelissa PilleLore BillietTom TaghonGeorges LeclercqBart VandekerckhoveTessa Kerre

A1 Journal Article in ONCOIMMUNOLOGY

2018

Nanobody based dual specific CARs

Stijn De MunterJoline IngelsGlenn GoetgelukSarah BonteMelissa PilleKarin WeeningTessa KerreHinrich AbkenBart Vandekerckhove

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES