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Researcher
Matthijs Vynck
Profile
Projects
Publications
Activities
Awards & Distinctions
46
Results
2025
Advances in multiplex digital PCR data analysis : from clustering to uncertainty quantification
Yao Chen
Olivier Thas
Ward De Spiegelaere
Wim Trypsteen
Matthijs Vynck
Dissertation
2025
Automated integration and quality assessment of chromatographic peaks in LC-MS data using TARDIS
Pablo Vangeenderhuysen
Matthijs Vynck
Beata Pomian
Kimberly De Windt
Emile Callemeyn
Ellen De Paepe
Lindsey De Commer
Jeroen Raes
Tim Nawrot
Johannes Rainer
et al.
U
Conference
2025
Automated integration and quality assessment of chromatographic peaks in LC–MS-based metabolomics and lipidomics using TARDIS
Pablo Vangeenderhuysen
Matthijs Vynck
Beata Pomian
Kimberly De Windt
Emile Callemeyn
Ellen De Paepe
Lindsey De Commer
Jeroen Raes
Tim Nawrot
Johannes Rainer
et al.
A1
Journal Article
in
ANALYTICAL CHEMISTRY
2025
Flexible methods for uncertainty estimation of digital PCR data
Yao Chen
Ward De Spiegelaere
Matthijs Vynck
Wim Trypsteen
David Gleerup
Jo Vandesompele
Olivier Thas
A1
Journal Article
in
ISCIENCE
2025
Polytect : an automatic clustering and labeling method for multicolor digital PCR data
Yao Chen
Ward De Spiegelaere
Wim Trypsteen
Jo Vandesompele
Gertjan Wils
David Gleerup
Antoon Lievens
Olivier Thas
Matthijs Vynck
A2
Journal Article
in
NAR GENOMICS AND BIOINFORMATICS
2025
The poly (ADP-ribose) polymerase-1 enzyme is overexpressed in various solid canine tumours : an immunohistochemical study
Shana De Vos
Simone Janssen
Sophie Favril
Hilde De Cock
Matthijs Vynck
Jonas Steenbrugge
Ward De Spiegelaere
Hilde De Rooster
A1
Journal Article
in
VETERINARY AND COMPARATIVE ONCOLOGY
2025
Towards enhanced reproducibility and performance of quality control sample-based normalization: key issues and new ideas
Matthijs Vynck
Pablo Vangeenderhuysen
Ellen De Paepe
Lieselot Hemeryck
Vera Plekhova
Lynn Vanhaecke
U
Conference
2025
2024
Benchmarking digital PCR partition classification methods with empirical and simulated duplex data
Yao Chen
Ward De Spiegelaere
Wim Trypsteen
David Gleerup
Jo Vandesompele
Antoon Lievens
Matthijs Vynck
Olivier Thas
A1
Journal Article
in
BRIEFINGS IN BIOINFORMATICS
2024
Digital PCR threshold robustness analysis and optimization using dipcensR
Matthijs Vynck
Wim Trypsteen
Olivier Thas
Jo Vandesompele
Ward De Spiegelaere
A1
Journal Article
in
BRIEFINGS IN BIOINFORMATICS
2024
Treatment randomisation at animal or pen level? Statistical analysis should follow the randomisation pattern!
Luc Duchateau
Robrecht Dockx
Klara Goethals
Matthijs Vynck
Frédéric Vangroenweghe
Christian Paul G. Burvenich
A1
Journal Article
in
LABORATORY ANIMALS
2024
2023
Bias reduction improves accuracy and informativity of high-throughput sequencing chimerism assays
Matthijs Vynck
Friedel Nollet
Lode Sibbens
Helena Devos
A1
Journal Article
in
CLINICA CHIMICA ACTA
2023
Comparative assessment of survival and clinical outcome between two commercial vitrification kits with different warming protocols after blastocyst culture : potential perspectives toward simplified warming procedures
Jan Gunst
Matthijs Vynck
Katleen Hostens
Valerie Standaert
Sylvie Roggeman
Arne van de Vijver
A1
Journal Article
in
REPRODUCTIVE SCIENCES
2023
Digital PCR partition classification
Matthijs Vynck
Yao Chen
David Gleerup
Jo Vandesompele
Wim Trypsteen
Antoon Lievens
Olivier Thas
Ward De Spiegelaere
A1
Journal Article
in
CLINICAL CHEMISTRY
2023
2022
Chimerism monitoring using biallelic single nucleotide or insertion/deletion polymorphisms : how many markers to screen?
Matthijs Vynck
Friedel Nollet
Lode Sibbens
Helena Devos
A1
Journal Article
in
CLINICA CHIMICA ACTA
2022
Some key considerations regarding the design and evaluation of high-throughput sequencing-based biallelic chimerism assays
Matthijs Vynck
A1
Journal Article
in
INTERNATIONAL JOURNAL OF HEMATOLOGY
2022
2021
Dynamics of the cellular and humoral immune response after BNT162b2 mRNA Covid-19 vaccination in Covid-19 naive nursing home residents
Jens Van Praet
Stefaan Vandecasteele
Anneleen De Roo
Matthijs Vynck
An De Vriese
Marijke Reynders
A1
Journal Article
in
JOURNAL OF INFECTIOUS DISEASES
2021
Performance assessment of the Devyser high-throughput sequencing-based assay for chimerism monitoring in patients after allogeneic hematopoietic stem cell transplantation
Matthijs Vynck
Friedel Nollet
Lode Sibbens
Bernadette Lievens
Astrid Denys
Barbara Cauwelier
Helena Devos
A1
Journal Article
in
JOURNAL OF MOLECULAR DIAGNOSTICS
2021
2020
Malignant progression of donor-engrafted clonal hematopoiesis in sibling recipients after stem cell transplantation
Louis Nevejan
Friedel Nollet
Helena Devos
Matthijs Vynck
Pieter Van Vlierberghe
Mercedeh Tajdar
Tom Lodewyck
Dominik Selleslag
Editorial material
2020
2019
Power Doppler ultrasound and contrast-enhanced ultrasound demonstrate non-invasive tumour vascular response to anti-vascular therapy in canine cancer patients
Eline Abma
Emmelie Stock
Ward De Spiegelaere
Leen Van Brantegem
Katrien Vanderperren
Yicheng Ni
Matthijs Vynck
Sylvie Daminet
Kaat De Clercq
Hilde De Rooster
A1
Journal Article
in
SCIENTIFIC REPORTS
2019
2018
A single dose of intravenous combretastatin A4-phosphate is reasonably well tolerated and significantly reduces tumour vascularization in canine spontaneous cancers
Eline Abma
Ward De Spiegelaere
Katrien Vanderperren
Emmelie Stock
Leen Van Brantegem
Ine Cornelis
Sylvie Daminet
Y Ni
Matthijs Vynck
Glenn Verstraete
et al.
A1
Journal Article
in
VETERINARY AND COMPARATIVE ONCOLOGY
2018
Data analysis methods for digital PCR quantification
Matthijs Vynck
Olivier Thas
Jo Vandesompele
Dissertation
2018
On determining the power of digital PCR experiments
Matthijs Vynck
Jo Vandesompele
Olivier Thas
A1
Journal Article
in
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
2018
Prognostic and therapeutic implications of circulating androgen receptor gene copy number in prostate cancer patients using droplet digital polymerase chain reaction
Sarah Buelens
Tom Claeys
Bert Dhondt
Filip Poelaert
Matthijs Vynck
Nurten Yigit
Olivier Thas
Piet Ost
Jo Vandesompele
Nicolaas Lumen
et al.
A1
Journal Article
in
CLINICAL GENITOURINARY CANCER
2018
Reducing bias in digital PCR experiments by appropriate modelling of volume variability
Matthijs Vynck
Olivier Thas
C3
Conference
2018
Reducing bias in digital PCR quantification experiments : the importance of appropriate modelling of volume variability
Matthijs Vynck
Olivier Thas
A1
Journal Article
in
ANALYTICAL CHEMISTRY
2018
2017
A digital PCR data analysis workflow : from sample to effective result
Matthijs Vynck
Olivier Thas
C3
Conference
2017
A unified censored normal regression model for qPCR differential gene expression analysis
Peter Pipelers
Lieven Clement
Matthijs Vynck
Jan Hellemans
Jo Vandesompele
Olivier Thas
A1
Journal Article
in
PLOS ONE
2017
Androgen receptor gene copy number detection using droplet digital PCR and its therapeutic consequences in prostate cancer patients
Sarah Buelens
Tom Claeys
Candy Kumps
Bert Dhondt
Filip Poelaert
Nurten Yigit
Matthijs Vynck
Olivier Thas
Piet Ost
Jo Vandesompele
et al.
C3
Conference
2017
Breath analysis by gas chromatography-mass spectrometry and electronic nose to screen for pleural mesothelioma : a cross-sectional case-control study
Kevin Lamote
Paul Brinkman
Lore Vandermeersch
Matthijs Vynck
Peter J Sterk
Herman Van Langenhove
Olivier Thas
Joris Van Cleemput
Kristiaan Nackaerts
Jan Van Meerbeeck
A1
Journal Article
in
ONCOTARGET
2017
Exhaled breath analysis allows exclusive screening for malignant pleural mesothelioma
Kevin Lamote
Matthijs Vynck
Olivier Thas
Joris Van Cleemput
Kristiaan Nackaerts
Jan Van Meerbeeck
C3
Conference
2017
Exhaled breath to screen for malignant pleural mesothelioma : a validation study
Kevin Lamote
Matthijs Vynck
Olivier Thas
Joris Van Cleemput
Kristiaan Nackaerts
Jan Van Meerbeeck
A1
Journal Article
in
EUROPEAN RESPIRATORY JOURNAL
2017
Quality control of digital PCR assays and platforms
Matthijs Vynck
Jo Vandesompele
Olivier Thas
A1
Journal Article
in
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
2017
The occurrence and therapeutic consequences of androgen receptor copy number gain in prostate cancer patients using Droplet Digital PCR
Sarah Buelens
Tom Claeys
Candy Kumps
Bert Dhondt
Filip Poelaert
Y Nurten
Matthijs Vynck
Olivier Thas
Piet Ost
Jo Vandesompele
et al.
C3
Conference
2017
2016
Detection of malignant pleural mesothelioma in exhaled breath by multicapillary column/ion mobility spectrometry (MCC/IMS)
Kevin Lamote
Matthijs Vynck
Joris Van Cleemput
Olivier Thas
Kristiaan Nackaerts
Jan Van Meerbeeck
A1
Journal Article
in
JOURNAL OF BREATH RESEARCH
2016
Flexible analysis of digital PCR experiments using generalized linear mixed models
Matthijs Vynck
Jo Vandesompele
Nele Nijs
Björn Menten
Ariane De Ganck
Olivier Thas
A2
Journal Article
in
BIOMOLECULAR DETECTION AND QUANTIFICATION
2016
The future of digital polymerase chain reaction in virology
Matthijs Vynck
Wim Trypsteen
Olivier Thas
Linos Vandekerckhove
Ward De Spiegelaere
A1
Journal Article
in
MOLECULAR DIAGNOSIS & THERAPY
2016
Threshold setting in duplex digital PCR experiments
Matthijs Vynck
Olivier Thas
C3
Conference
2016
2015
Breath analysis by ion mobility spectrometry allows discrimination of pleural mesothelioma patients from controls
Kevin Lamote
Matthijs Vynck
Joris Van Cleemput
Olivier Thas
Kristiaan Nackaerts
Jan Van Meerbeeck
C3
Conference
2015
Data analysis of droplet digital PCR with generalized linear mixed models
Olivier Thas
Matthijs Vynck
Jo Vandesompele
C3
Conference
2015
Extreme value theory for threshold determination in droplet digital PCR experiments
Matthijs Vynck
Wim Trypsteen
Jan De Neve
Pawel Bonczkowski
Maja Kiselinova
Eva Malatinková
KAREN VERVISCH
Olivier Thas
Linos Vandekerckhove
Ward De Spiegelaere
C3
Conference
2015
GLMMs for nucleic acid concentration estimation in digital droplet PCR
Matthijs Vynck
Jo Vandesompele
Olivier Thas
C3
Conference
2015
Improving accuracy and precision of dPCR experiments by relying on multiple reference genes
Matthijs Vynck
Jo Vandesompele
Olivier Thas
C3
Conference
2015
Threshold determination in droplet digital PCR experiments using extreme value theory
Matthijs Vynck
Wim Trypsteen
Jan De Neve
Pawel Bonczkowski
Maja Kiselinova
Eva Malatinková
KAREN VERVISCH
Olivier Thas
Linos Vandekerckhove
Ward De Spiegelaere
C3
Conference
2015
Volatile organic compounds increase the likelihood of detecting malignant pleural mesothelioma
Kevin Lamote
Matthijs Vynck
Joris Van Cleemput
Olivier Thas
Kristiaan Nackaerts
Jan Van Meerbeeck
C3
Conference
2015
ddcRquant: threshold determination for single channel droplet digital PCR experiments
Wim Trypsteen
Matthijs Vynck
Jan De Neve
Pawel Bonczkowski
Maja Kiselinova
Eva Malatinková
KAREN VERVISCH
Olivier Thas
Linos Vandekerckhove
Ward De Spiegelaere
C3
Conference
2015
ddpcRquant: threshold determination for single channel droplet digital PCR experiments
Wim Trypsteen
Matthijs Vynck
Jan De Neve
Pawel Bonczkowski
Maja Kiselinova
Eva Malatinková
KAREN VERVISCH
Olivier Thas
Linos Vandekerckhove
Ward De Spiegelaere
A1
Journal Article
in
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
2015