Research Explorer

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Researcher

Matthias Van Gils

Publications & Research Data

Awards & Distinctions

42 Results

2025

Cellular senescence in pseudoxanthoma elasticum

Robbe DerudderDaniela QuaglinoLukas NolletMatthias Van GilsMohammad Jakir HosenJanina TiemannPaul CouckeOlivier Vanakker

2023

Inorganic pyrophosphate plasma levels are decreased in pseudoxanthoma elasticum patients and heterozygous carriers but do not correlate with the genotype or phenotype

Matthias Van GilsJustin DepauwPaul CouckeShari AertsShana VerschuereLukas NolletOlivier Vanakker

A1 Journal Article in JOURNAL OF CLINICAL MEDICINE

Serum calcification propensity T50 associates with disease severity in patients with pseudoxanthoma elasticum

Lukas NolletMatthias Van GilsSuzanne FischerLaurence CampensSwapna KarthikAndreas PaschJulie De ZaeytijdBart LeroyDaniel DevosTine De Backer et al.

The Abcc6a knockout zebrafish model as a novel tool for drug screening for pseudoxanthoma elasticum

Matthias Van GilsAndy WillaertPaul CouckeOlivier Vanakker

The pseudoxanthoma elasticum zebrafish model contributes to novel pathophysiological insights and therapeutic strategies in ectopic mineralization

Lisa DangreauLukas NolletMatthias Van GilsAndy WillaertPaul CouckeOlivier Vanakker

2022

Attenuation of dysfunctional DNA damage response and PARP1 signaling by minocycline reduces ectopic calcification in pseudoxanthoma elasticum

Lukas NolletMatthias Van GilsAndy WillaertPaul CouckeOlivier Vanakker

Minocycline attenuates excessive DNA damage response and reduces ectopic calcification in pseudoxanthoma elasticum

Lukas NolletMatthias Van GilsAndy WillaertPaul CouckeOlivier Vanakker

A1 Journal Article in JOURNAL OF INVESTIGATIVE DERMATOLOGY

Plasma inorganic pyrophosphate levels correlate to specific phenotypes and variant archetypes of ABCC6 in pseudoxanthoma elasticum patients

Matthias Van GilsJustin DepauwShana VerschuereLukas NolletOlivier Vanakker

Serum calcification propensity T50 associates with disease severity in patients with pseudoxanthoma elasticum

Lukas NolletMatthias Van GilsSuzanne FischerLaurence CampensSwapna KarthikAndreas PaschJulie De ZaeytijdBart LeroyDaniel DevosTine De Backer et al.

A1 Journal Article in JOURNAL OF CLINICAL MEDICINE

The Abcc6a knockout zebrafish model as a novel tool for drug screening for pseudoxanthoma elasticum

Matthias Van GilsAndy WillaertPaul CouckeOlivier Vanakker

A1 Journal Article in FRONTIERS IN PHARMACOLOGY

The pseudoxanthoma elasticum zebrafish model contributes to novel pathophysiological insights and therapeutic strategies in ectopic mineralization

Lisa DangreauLukas NolletMatthias Van GilsAndy WillaertPaul CouckeOlivier Vanakker

2021

Genetic deletion of Abcc6 disturbs cholesterol homeostasis in mice

Bettina IboldJanina TiemannIsabel FaustUta CeglarekJullia DittrichTheo GorgelsArthur BergenOlivier VanakkerMatthias Van GilsCornelius Knabbe et al.

A1 Journal Article in SCIENTIFIC REPORTS

Inorganic pyrophosphate plasma levels are decreased in pseudoxanthoma elasticum (PXE) patients and carriers, and correlate with the severity of the vascular phenotype

Matthias Van GilsJustin DepauwPaul CouckeShana VerschuereLukas NolletOlivier Vanakker

Pseudoxanthoma elasticum (PXE) patients and heterozygous carriers have decreased plasma PPi levels which correlate with the cardio(vascular) phenotype

Matthias Van GilsJustin DepauwShana VerschuereLukas NolletOlivier Vanakker

2020

Cellular and molecular biomarkers indicate premature aging in pseudoxanthoma elasticum patients

Janina TiemannThomas WagnerOlivier VanakkerMatthias Van GilsJose-Luis Bueno CabreraBettina IboldIsabel FaustCornelius KnabbeDoris Hendig

A1 Journal Article in AGING AND DISEASE

Chlamydia trachomatis L2c infection in a porcine model produced urogenital pathology and failed to induce protective immune responses against re-infection

Evelien De ClercqMatthias Van GilsKatelijn SchautteetBert DevriendtCelien KiekensKoen ChiersWim Van Den BroeckEric CoxD DeanDaisy Vanrompay

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

From membrane to mineralization : the curious case of the ABCC6 transporter

Shana VerschuereMatthias Van GilsLukas NolletOlivier Vanakker

A1 Journal Article in FEBS LETTERS

Nonlinear optical microscopy is a novel tool for the analysis of cutaneous alterations in pseudoxanthoma elasticum

Norbert KissLuca FésűsSzabolcs BozsányiFlóra SzeriMatthias Van GilsViktória SzabóAnikó Ilona NagyBernadett HidvégiRóbert SzipőcsLudovic Martin et al.

A1 Journal Article in LASERS IN MEDICAL SCIENCE

Pseudoxanthoma elasticum (PXE) patients and heterozygous carriers have decreased plasma PPi levels which correlate with the (cardio)vascular phenotype.

Matthias Van GilsJustin DepauwShana VerschuereLukas NolletOlivier Vanakker

2019

Cellular signaling in pseudoxanthoma elasticum : an update

Matthias Van GilsLukas NolletEwout VerlyNancy DeianovaOlivier Vanakker

A1 Journal Article in CELLULAR SIGNALLING

Compound screening for PXE using a zebrafish abcc6a CRISPR/Cas9 mutant model : a proof-of-concept study

Matthias Van GilsAndy WillaertPaul CouckeOlivier Vanakker

Compound screening for PXE using zebrafish abcc6a mutant models

Matthias Van GilsAndy WillaertPaul CouckeOlivier Vanakker

Compound screening for PXE using zebrafish abcc6a mutant models

Matthias Van GilsAndy WillaertPaul CouckeOlivier Vanakker

Generation and validation of the first complete knockout model of abcc6a in zebrafish

Matthias Van GilsAndy WillaertEva De VilderPaul CouckeOlivier Vanakker

Morpholino-mediated gene knockdown in zebrafish : it is all about dosage and validation

Matthias Van GilsOlivier Vanakker

A1 Journal Article in JOURNAL OF INVESTIGATIVE DERMATOLOGY

Plasma inorganic pyrophosphate and alkaline phosphatase in patients with pseudoxanthoma elasticum

Ana María Sánchez-TévarMaría García-FernándezBelén Murcia-CasasJosé Rioja-VillodresJuan Luis CarrilloMarta CamachoMatthias Van GilsMiguel Angel Sánchez-ChaparroOlivier VanakkerPedro Valdivielso

A1 Journal Article in ANNALS OF TRANSLATIONAL MEDICINE

Targeted compound screening for PXE using CRISPR/Cas9 abcc6a mutant zebrafish model

Matthias Van GilsAndy WillaertPaul CouckeOlivier Vanakker

The role of vitamin K and its related compounds in Mendelian and acquired ectopic mineralization disorders

Lukas NolletMatthias Van GilsShana VerschuereOlivier Vanakker

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

2018

Co-occurrence of Chlamydia suis DNA and Chlamydia suis-specific antibodies in the human eye

Evelien KieckensLaura Van den BroeckMatthias Van GilsServaas MorréDaisy Vanrompay

A1 Journal Article in VECTOR-BORNE AND ZOONOTIC DISEASES

Generation and validation of a complete knockout model of abcc6a in zebrafish

Matthias Van GilsAndy WillaertEva De VilderPaul CouckeOlivier Vanakker

A1 Journal Article in JOURNAL OF INVESTIGATIVE DERMATOLOGY

Generation and validation of a complete knockout model of abcc6a in zebrafish

Matthias Van GilsAndy WillaertEva De VilderPaul CouckeOlivier Vanakker

Generation and validation of the first complete knockout model of abcc6a in zebrafish

Matthias Van GilsAndy WillaertEva De VilderPaul CouckeOlivier Vanakker

Generation and validation of the first complete knockout model of abcc6a in zebrafish

Matthias Van GilsAndy WillaertEva De VilderPaul CouckeOlivier Vanakker

Generation and validation of the first complete knockout model of abcc6a in zebrafish

Matthias Van GilsAndy WillaertEva De VilderPaul CouckeOlivier Vanakker

Generation and validation of the first complete knockout model of ABCC6A in zebrafish

Matthias Van GilsAndy WillaertPaul CouckeOlivier Vanakker

2017

Muscular heterotopic calcification with ulcerating skin lesions : a case report

Matthias Van GilsMohammad Jakir HosenTithi RoySrizon Roy TirthoOlivier Vanakker

Primary infection with Chlamydia trachomatis L2c in a porcine model produced urogenital pathology similar as in humans and failed to induce protective immune responses against re-infection

Daisy VanrompayEvelien De ClercqMatthias Van GilsKatelijn SchautteetBert DevriendtKoen ChiersEric CoxDeborah Dean

2016

Aerosolized non-viral nucleic acid delivery in the vaginal tract of pigs

Katrien RemautEvelien De ClercqOliwia AndriesKoen RomboutsMatthias Van GilsLaetitia CiccheleroIan VandenbusscheSarah Van PraetJuan Manuel BenitoJosé Manuel Garcia Fernandéz et al.

A1 Journal Article in PHARMACEUTICAL RESEARCH

Fibroblasts in soft tissue mineralization display an osteogenic expression pattern but do not transform into mature osteoblasts

Matthias Van GilsEva De VilderMohammad HosenPaul CouckeOlivier Le SauxAnne De PaepeOlivier Vanakker

Fibroblasts in soft tissue mineralization display an osteogenic gene expression pattern but do not transform into mature osteoblasts

Matthias Van GilsEva De VilderMohammad HosenPaul CouckeOlivier LeSauxAnne De PaepeOlivier Vanakker

Fibroblasts in soft tissue mineralization display an osteogenic gene expression pattern but do not transform into mature osteoblasts

Matthias Van GilsEva De VilderMohammad Jakir HosenPaul CouckeOlivier LeSauxAnne De PaepeOlivier Vanakker

2015

Absence of Chlamydia-like organisms in pigs

Matthias Van GilsS AebyDaisy VanrompayGilbert Greub

A2 Journal Article in NEW MICROBES AND NEW INFECTIONS