Research Explorer

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Researcher

Matthias D'hooghe

Awards & Distinctions

233 Results

2024

Curcumin as a source of inspiration for the development of novel benzothiazepane-based cancer cell cytotoxic agents

Katarina MagdalenicFelien MorlionUlrike RonseSteven De JongheLeentje PersoonsDominique ScholsJulie De MunckCharlotte GrootaertJohn Van CampMatthias D'hooghe

High-yield synthesis of 2-O-α-d-glucosyl-d-glycerate by a bifunctional glycoside phosphorylase

Jorick FranceusManon SteynenYentl AllaertKato BredaelMatthias D'hoogheTom Desmet

A1 Journal Article in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Unlocking the secrets of β-lactams : exploring reactivity and application for the synthesis of bioactive heterocycles

Sari DeketelaereMatthias D'hoogheChristian Stevens

2023

Curcumin as a source of inspiration for the development of novel benzothiazepane-based cancer cell cytotoxic agents

Katarina MagdalenicUlrike RonseFelien MorlionSteven De JongheLeentje PersoonsDominique ScholsJulie De MunckCharlotte GrootaertJohn Van CampMatthias D'hooghe

Curcumin as a source of inspiration for the development of novel benzothiazepane-based cancer cell cytotoxic agents

Katarina MagdalenicUlrike RonseFelien MorlionSteven De JongheLeentje PersoonsDominique ScholsJulie De MunckCharlotte GrootaertJohn Van CampMatthias D'hooghe

Engineering Comamonas testosteroni for the production of 2-pyrone-4,6-dicarboxylic acid as a promising building block

Tom DelmulleStijn BovijnSari DeketelaereMartijn CasteleinTom ErauwMatthias D'hoogheWim Soetaert

A1 Journal Article in MICROBIAL CELL FACTORIES

Exposure of curcumin (analogues) to 2D and 3D intestinal in vitro models

Julie De MunckCharlotte GrootaertElien AlderweireldtKatarina MagdalenicMatthias D'hoogheJohn Van Camp

HDAC6 : one protein, two domains, diverse therapeutic opportunities : inhibitor synthesis and validation in cellular disease models

Silke GeursMatthias D'hoogheKarolien De BosscherDorien Clarisse

Synthesis and cancer cell cytotoxicity of 2-aryl-4-(4-aryl-2-oxobut-3-en-1-ylidene)-substituted benzothiazepanes

Katarina MagdalenicUlrike RonseSteven De JongheLeentje PersoonsDominique ScholsJulie De MunckCharlotte GrootaertJohn Van CampMatthias D'hooghe

A1 Journal Article in PHYTOCHEMISTRY LETTERS

Synthesis of 4‐imidoyl‐, 4‐oxiranyl‐ and 4‐propargyloxyphenyl‐substituted β‐lactam building blocks

Sari DeketelaereGurkirat KaurNicola PiensDaan DeturckRobin DepestelKristof Van HeckeChristian StevensVipan KumarMatthias D'hooghe

A1 Journal Article in JOURNAL OF HETEROCYCLIC CHEMISTRY

Synthesis of the 1,5-benzothiazepane scaffold : established methods and new developments

Ulrike RonseKatarina MagdalenicJohn Van CampMatthias D'hooghe

A1 Journal Article in CHEMISTRYOPEN

The zinc-binding group effect : lessons from non-hydroxamic acid vorinostat analogs

Silke GeursDorien ClarisseKarolien De BosscherMatthias D'hooghe

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

2022

Carboxylic acid bioisosteres in medicinal chemistry : synthesis and properties

Kato BredaelSilke GeursDorien ClarisseKarolien De BosscherMatthias D'hooghe

A1 Journal Article in JOURNAL OF CHEMISTRY

Covalent organic framework supported palladium catalysts

Hadi SalemiMaarten DebruyneVeronique Van SpeybroeckPascal Van Der VoortMatthias D'hoogheChristian Stevens

A1 Journal Article in JOURNAL OF MATERIALS CHEMISTRY A

Curcumin-derived functionalized thiazepanes to selectively target colon cancer cells

Julie De MunckCharlotte GrootaertNathan VanwinsenMatthias D'hoogheJohn Van Camp

Curcumin-derived functionalized thiazepanes to selectively target colon cancer cells

Julie De MunckCharlotte GrootaertNathan VanwinsenMatthias D'hoogheJohn Van Camp

Fight against AMR : synthesis of pyrrolidine-fused azetidin-2-ones as potential antibacterials

Sari DeketelaereCarlos Díez PozaMargot AelbrechtJonas MortierBram Van Den BosscheChristian StevensMatthias D'hooghe

Identification of mercaptoacetamide-based HDAC6 inhibitors via a lean inhibitor strategy : screening, synthesis, and biological evaluation

Silke GeursDorien ClarisseFreya BaeleJorick FranceusTom DesmetKarolien De BosscherMatthias D'hooghe

A1 Journal Article in CHEMICAL COMMUNICATIONS

The natural product curcumin as a source of inspiration for the development of novel benzothiazepane-based cancer cell cytotoxic agents

Katarina MagdalenicUlrike RonseSteven De JongheJohn Van CampMatthias D'hooghe

The natural product curcumin as a source of inspiration for the development of novel benzothiazepane-based cancer cell cytotoxic agents

Katarina MagdalenicUlrike RonseSteven De JongheJohn Van CampMatthias D'hooghe

The ubiquitin binding domain of HDAC6 : a key regulator of aggresomal protein disposal and new therapeutic target to combat multiple myeloma

Silke GeursEleni StaessensDorien ClarisseKarolien De BosscherMatthias D'hooghe

The ubiquitin binding domain of HDAC6 : a key regulator of aggresomal protein disposal and new therapeutic target to combat multiple myeloma

Silke GeursDorien ClarisseEleni StaessensKarolien De BosscherMatthias D'hooghe

Unexpected formation of N-(chloromethyl)acetamides during attempted Staudinger β-lactam synthesis

Sari DeketelaereElias Van Den BroeckLore CoolsDaan DeturckHannes NaeyaertKristof Van HeckeChristian StevensVeronique Van SpeybroeckMatthias D'hooghe

2021

Chemistry in flow motion : leveraging the benefits of microreactors for problematic batch reactions

Reinout Van KerrebroeckChristian StevensMatthias D'hooghe

Evolution of phosphorylases from N-acetylglucosaminide hydrolases in family GH3

Jorick FranceusJolien LormansLore CoolsMatthias D'hoogheTom Desmet

A1 Journal Article in ACS CATALYSIS

Recent contributions of quinolines to antimalarial and anticancer drug discovery research

Tim Van de WalleLore CoolsSven MangelinckxMatthias D'hooghe

A1 Journal Article in EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Unexpected formation of 2,2‐Dichloro‐N‐(chloromethyl)acetamides during attempted Staudinger 2,2‐Dichloro‐β‐lactam synthesis

Sari DeketelaereElias Van Den BroeckLore CoolsDaan DeturckHannes NaeyaertKristof Van HeckeChristian StevensVeronique Van SpeybroeckMatthias D'hooghe

A1 Journal Article in EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

2020

A de novo synthetic method to the access of N-substituted benzazepines

Lamiaa OuchakourMelinda NonnMatthias D'hoogheLorand Kiss

A1 Journal Article in JOURNAL OF FLUORINE CHEMISTRY

Design and synthesis of novel ferrocene-quinoline conjugates and evaluation of their electrochemical and antiplasmodium properties

Aleksandra MinićTim Van de WalleKristof Van HeckeJill CombrinckPeter J. SmithKelly ChibaleMatthias D'hooghe

A1 Journal Article in EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Development of antimalarial quinoline-based conjugates and anticancer nitroxoline derivatives

Tim Van de WalleMatthias D'hoogheSven Mangelinckx

Expedient synthesis of lupulones and their derivatization to 2,8-7H-dihydrochromen-7-ones

Lena DecuyperGurkirat KaurCharlotte VersyckEline BlondeelYves DepetterKristof Van HeckeMatthias D'hooghe

A1 Journal Article in CHEMISTRYOPEN

Synthesis and biological evaluation of novel quinoline-piperidine scaffolds as antiplasmodium agents

Tim Van de WalleMaya BooneJulie Van PuyveldeJill CombrinckPeter J. SmithKelly ChibaleSven MangelinckxMatthias D'hooghe

A1 Journal Article in EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and penicillin‐binding protein inhibitory assessment of dipeptidic 4‐phenyl‐β‐lactams from α‐amino acid‐derived imines

Lena DecuyperMarko JukičIzidor SosičAna Maria AmorosoOlivier VerlaineBernard JorisStanislav GobecMatthias D'hooghe

A1 Journal Article in CHEMISTRY-AN ASIAN JOURNAL

Synthesis of novel nitroxoline analogs with potent cathepsin B exopeptidase inhibitory activity

Tim Van de WalleMarina BriandAna MitrovićIzidor SosičStanislav GobecJanko KosLeentje PersoonsDirk DaelemansSteven De JongheZorica Ubiparip et al.

A1 Journal Article in CHEMMEDCHEM

Synthetic strategies in curcumin chemistry focused on anticancer applications

Mr. Atiruj TheppawongGurkirat KaurVipan KumarJohn Van CampMatthias D'hooghe

A1 Journal Article in ARKIVOC

2019

Deployment of aziridines for the synthesis of alkaloids and their derivatives

Lingamurthy MachaMatthias D'hoogheHyun-Joon Ha

A1 Journal Article in SYNTHESIS-STUTTGART

Design, synthesis and evaluation of monocyclic β-lactams as inhibitors of penicillin-binding proteins of resistant bacteria

Lena DecuyperMatthias D'hooghe

Electrophilic bromination in flow : a safe and sustainable alternative to the use of molecular bromine in batch

Reinout Van KerrebroeckPieter NaertThomas HeugebaertMatthias D'hoogheChristian Stevens

A1 Journal Article in MOLECULES

Reactivity of 3-oxo-β-lactams with respect to primary amines

Sari DeketelaereNicola PiensHannelore GoossensDietmar HertsenLieselotte CrulLotte DemeurisseJelle De MoorElias Van Den BroeckKaren MolletKristof Van Hecke et al.

Reactivity of 3-oxo-β-lactams with respect to primary amines

Sari DeketelaereNicola PiensHannelore GoossensDietmar HertsenLieselotte CrulLotte DemeurisseJelle De MoorElias Van Den BroeckKaren MolletKristof Van Hecke et al.

Selective pharmacological inhibitors of HDAC6 reveal biochemical activity but functional tolerance in cancer models

Yves DepetterSilke GeursRob De VreeseSophie GoethalsElien VandoornAlien LaevensJonas SteenbruggeEvelyne MeyerPascal de TullioMarc Bracke et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF CANCER

Synthesis and cytotoxic evaluation of monocarbonyl curcuminoids and their pyrazoline derivatives

Tim Van de WalleMr. Atiruj TheppawongCharlotte GrootaertSteven De JongheLeentje PersoonsDirk DaelemansKristof Van HeckeJohn Van CampMatthias D'hooghe

A1 Journal Article in MONATSHEFTE FUR CHEMIE

Synthesis and first line in vitro evaluation of novel curcumin derivatives as anti-tumoral agents

Mr. Atiruj TheppawongMatthias D'hoogheJohn Van Camp

Synthesis of 1,4‐thiazepane‐based curcuminoids with promising anticancer activity

Mr. Atiruj TheppawongTim Van de WalleKristof Van HeckeCharlotte GrootaertJohn Van CampMatthias D'hooghe

A1 Journal Article in CHEMISTRY-A EUROPEAN JOURNAL

Synthesis of indoline‐based benzhydroxamic acids as potential HDAC6 inhibitors

Yves DepetterSilke GeursJorick FranceusDamijan KnezTom DesmetKarolien De BosscherOlivier De WeverStanislav GobecMatthias D'hooghe

A1 Journal Article in CHEMISTRYSELECT

Synthesis of non‐symmetrical nitrogen‐containing curcuminoids in the pursuit of new anticancer candidates

Mr. Atiruj TheppawongTim Van de WalleCharlotte GrootaertKristof Van HeckeNathalie CatryTom DesmetJohn Van CampMatthias D'hooghe

A1 Journal Article in CHEMISTRYOPEN

Synthesis of selective HDAC6 inhibitors and their evaluation in cancer models

Yves DepetterMatthias D'hoogheOlivier De Wever

α‐Unsaturated 3‐Amino‐1‐carboxymethyl‐β‐lactams as bacterial PBP inhibitors : synthesis and biochemical assessment

Lena DecuyperKatarina MagdalenicMarie VerstraeteMarko JukičIzidor SosičEric SauvageAna Maria AmorosoOlivier VerlaineBernard JorisStanislav Gobec et al.

A1 Journal Article in CHEMISTRY-A EUROPEAN JOURNAL

2018

An update on the synthesis and reactivity of spiro-fused β-lactams

Hang Dao ThiMatthias D'hooghe

A1 Journal Article in ARKIVOC

Antibacterial and β-lactamase inhibitory activity of monocyclic β-lactams

Lena DecuyperMarko JukičIzidor SosičAleš ŽulaMatthias D'hoogheStanislav Gobec

A1 Journal Article in MEDICINAL RESEARCH REVIEWS

Assessment of the trifluoromethyl ketone functionality as an alternative zinc-binding group for selective HDAC6 inhibition

Yves DepetterSilke GeursFlore Vanden BusscheRob De VreeseJorick FranceusTom DesmetOlivier De WeverMatthias D'hooghe

A1 Journal Article in MEDCHEMCOMM

Chemoenzymatic approach toward the synthesis of 3-O-(α/β)-glucosylated 3-hydroxy-β-lactams

Lena DecuyperJorick FranceusShari DhaeneMaarten DebruyneKevin VandoorneNicola PiensGriet DewitteTom DesmetMatthias D'hooghe

A1 Journal Article in ACS OMEGA

Exploring the sequence diversity in glycoside hydrolase family 13_18 reveals a novel glucosylglycerol phosphorylase

Jorick FranceusLena DecuyperMatthias D'hoogheTom Desmet

A1 Journal Article in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Formation of fluorinated amido esters through unexpected C3-C4 bond fission in 4-trifluoromethyl-3-oxo-β-lactams

Hang Dao ThiHannelore GoossensDietmar HertsenValerie OtteTuyen Van NguyenVeronique Van SpeybroeckMatthias D'hooghe

A1 Journal Article in CHEMISTRY-AN ASIAN JOURNAL

In silico design and enantioselective synthesis of functionalized monocyclic 3-amino-1-carboxymethyl-β-lactams as inhibitors of penicillin-binding proteins of resistant bacteria

Lena DecuyperSari DeketelaereLore VanparysMarko JukičIzidor SosičEric SauvageAna Maria AmorosoOlivier VerlaineBernard JorisStanislav Gobec et al.

A1 Journal Article in CHEMISTRY-A EUROPEAN JOURNAL

Synthesis and reactivity of 4-(trifluoromethyl)azetidin-2-ones

Hang Dao ThiTuyen Van NguyenMatthias D'hooghe

A1 Journal Article in MONATSHEFTE FUR CHEMIE

Synthesis of 4-(trifluoromethyl)azetidin-2-one building blocks and their transformation into novel CF3-substituted amines and heterocyclic systems

Hang Dao ThiMatthias D'hoogheTuyen Van Nguyen

Synthesis of Novel Aza‐aromatic Curcuminoids with Improved Biological Activities towards Various Cancer Cell Lines

Mr. Atiruj TheppawongTim Van de WalleCharlotte GrootaertMargot BultinckTom DesmetJohn Van CampMatthias D'hooghe

A1 Journal Article in CHEMISTRYOPEN

Synthesis of nitrogen-containing curcumin analogues in the pursuit of new anticancer candidates

Mr. Atiruj TheppawongCharlotte GrootaertJohn Van CampMatthias D'hooghe

Synthesis, biology and structure-activity relationships of novel β-enaminone-, aza-aromatic- and thiazepanebased curcuminoids

Mr. Atiruj TheppawongCharlotte GrootaertJohn Van CampMatthias D'hooghe

Theoretical insight into the regioselective ring-expansions of bicyclic aziridinium ions

Esma B BoydasGamze TanriverMatthias D'hoogheHyun-Joon HaVeronique Van SpeybroeckSaron Catak

A1 Journal Article in ORGANIC & BIOMOLECULAR CHEMISTRY

Use of 3-hydroxy-4-(trifluoromethyl)azetidin-2-ones as building blocks for the preparation of trifluoromethyl-containing aminopropanes, 1,3-oxazinan-2-ones, aziridines, and 1,4-dioxan-2-ones

Hang Dao ThiGiang Le Nhat ThuySaron CatakVeronique Van SpeybroeckTuyen Van NguyenMatthias D'hooghe

A1 Journal Article in SYNTHESIS-STUTTGART

2017

Asymmetric Synthesis of 3,4-Disubstituted 2-(Trifluoromethyl)pyrrolidines through Rearrangement of Chiral 2-(2,2,2-Trifluoro-1-hydroxyethyl)azetidines

Jeroen DolfenEsma Birsen BoydasVeronique Van SpeybroeckSaron CatakKristof Van HeckeMatthias D'hooghe

A1 Journal Article in JOURNAL OF ORGANIC CHEMISTRY

Carbonylation of aziridines as a powerful tool for the synthesis of functionalized β-lactams

Nicola PiensMatthias D'hooghe

A1 Journal Article in EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Cobalt carbonyl-catalyzed carbonylation of functionalized aziridines to versatile β-lactam building blocks

Nicola PiensKristof Van HeckeDieter VogtMatthias D'hooghe

A1 Journal Article in ORGANIC & BIOMOLECULAR CHEMISTRY

Concise synthesis of 3-(aminomethyl)pyrrolizidines via an In(OTf)3-mediated ring rearrangement of 2-[2-(1-pyrrolin-2-yl)-alkyl]aziridines

Jeroen DolfenMatthias D'hooghe

A1 Journal Article in SYNTHESIS-STUTTGART

Design and synthesis of functionalized monocyclic 3-amino-1-carboxymethyl-beta-lactams as potential inhibitors of PBPs of resistant bacteria

Sari DeketelaereLena DecuyperLore VanparysMarko JukičIzidor SosičEric SauvagePaulette CharlierBernard JorisStanislav GobecMatthias D'hooghe

Design and synthesis of functionalized monocyclic 3-amino-1-carboxymethyl-beta-lactams as potential inhibitors of penicillin binding proteins of resistant bacteria

Sari DeketelaereLena DecuyperLore VanparysMarko JukičIzidor SosičEric SauvageAna Maria AmorosoOlivier VerlainePaulette CharlierBernard Joris et al.

Design and synthesis of functionalized monocyclic 3-amino-1-carboxymethyl-beta-lactams as potential inhibitors of penicillin-binding proteins of resistant bacteria

Lena DecuyperSari DeketelaereLore VanparysMarko JukicIzidor SosicEric SauvagePaulette CharlierBernard JorisStanislav GobecMatthias D'hooghe

Exploration of thiaheterocyclic hHDAC6 inhibitors as potential antiplasmodial agents

Rob De VreeseCarmen de KockPeter J SmithKelly ChibaleMatthias D'hooghe

A1 Journal Article in FUTURE MEDICINAL CHEMISTRY

LiAlH4-induced thia-aza-Payne rearrangement of functionalized 2-(thiocyanatomethyl)aziridines into 2-(aminomethyl)thiiranes as an entry to 5-(chloromethyl)thiazolidin-2-ones

Jeroen DolfenKristof Van HeckeMatthias D'hooghe

A1 Journal Article in EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

New strategies for the construction of heterocyclic systems through ring transformation of aziridines and azetidines

Jeroen DolfenMatthias D'hooghe

Reactivity of 3-oxo-β-lactams with respect to primary amines : an experimental and computational approach

Nicola PiensHannelore GoossensDietmar HertsenSari DeketelaereLieselotte CrulLotte DemeurisseJelle De MoorElias Van Den BroeckKaren MolletKristof Van Hecke et al.

A1 Journal Article in CHEMISTRY-A EUROPEAN JOURNAL

Synthesis and applications of benzohydroxamic acid-based histone deacetylase inhibitors

Rob De VreeseMatthias D'hooghe

A1 Journal Article in EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of 4-(trifluoromethyl)azetidin-2-one building blocks and transformations into novel CF3-substituted amines and heterocyclic systems

Hang Dao ThiTuyen Nguyen VanMatthias D'hooghe

Synthesis of bis-8-hydroxyquinolines via an imination or a Suzuki-Miyaura coupling approach

Rob De VreeseKoen MuylaertCédric MatonLise DereuFrederique TaillieuThomas HarthRik Van DeunHenk VrielinckChristian StevensMatthias D'hooghe

A1 Journal Article in TETRAHEDRON LETTERS

Synthesis of new β-lactam building blocks and their application in heterocyclic chemistry

Nicola PiensMatthias D'hooghe

Synthesis of novel 4-ferrocenyl-1,2,3,4-tetrahydroquinolines and 4-ferrocenylquinolines via α-ferrocenyl carbenium ions as key intermediates

Aleksandra MinićDragana StevanovićMirjana VukićevićGoran A BogdanovićMatthias D'hoogheNiko S RadulovićRastko D Vukićević

A1 Journal Article in TETRAHEDRON

Synthesis of potent and selective HDAC6 inhibitors bearing a cyclohexane- or cycloheptane-annulated 1,5-benzothiazepine scaffold

Rob De VreeseLisa GalleYves DepetterJorick FranceusTom DesmetKristof Van HeckeVeronick BenoyLudo Van Den BoschMatthias D'hooghe

A1 Journal Article in CHEMISTRY-A EUROPEAN JOURNAL

Synthesis of thiaheterocyclic benzohydroxamic acids and evaluation of their HDAC6 inhibitory activity

Rob De VreeseMatthias D'hooghe

Synthesis, biology and structure-activity relationships of novel β-enaminone-, aza-aromatic- and thiazepane-based curcuminoids

Mr. Atiruj TheppawongTim Van de WalleCharlotte GrootaertJohn Van CampMatthias D'hooghe

Synthetic approaches toward monocyclic 3-amino-β-lactams

Sari DeketelaereTuyen Van NguyenChristian StevensMatthias D'hooghe

A1 Journal Article in CHEMISTRYOPEN

Use of α,ω-dichloroketimine building blocks for the construction of 1-azabicyclo[3.1.0]hexanes, piperidines, pyridines, pyrroles and tetrahydroindoles

Nicola PiensWim AeltermanMatthias D'hoogheNorbert De Kimpe

A1 Journal Article in SYNLETT

2016

A nitrilase-mediated entry to 4-carboxymethyl-β-lactams from chemically prepared 4-(cyanomethyl)azetidin-2-ones

Lena DecuyperNicola PiensJens MinckeJeroen BomonBert De SchrijverKaren MolletKarel De WinterTom DesmetMatthias D'hooghe

A1 Journal Article in RSC ADVANCES

Bicyclic aziridinium ions in azaheterocyclic chemistry : preparation and synthetic application of 1-azoniabicyclo[n.1.0]alkanes

Jeroen DolfenNagendra Nath YadavNorbert De KimpeMatthias D'hoogheHyun-Joon Ha

A1 Journal Article in ADVANCED SYNTHESIS & CATALYSIS

Catalytic carbonylation of aziridines to novel β-lactams as versatile building blocks in heterocyclic chemistry

Nicola PiensDieter VogtMatthias D'hooghe

Converting bulk sugars into prebiotics : semirational design of a transglucosylase with controlled selectivity

Tom VerhaegheKarel De WinterMagali BerlandRob De VreeseMatthias D'hoogheBernard OffmannTom Desmet

A1 Journal Article in CHEMICAL COMMUNICATIONS

Deployment of small-ring azaheterocycles as building blocks for the synthesis of organofluorine compounds

Jeroen DolfenNorbert De KimpeMatthias D'hooghe

A1 Journal Article in SYNLETT

Diastereoselective synthesis of 3-acetoxy-4-(3-aryloxiran-2-yl)azetidin-2-ones and their transformation into 3,4-fused bicyclic β-lactams

Nicola PiensSven De CraeneKaren MolletKristof Van HeckeMatthias D'hooghe

Diastereoselective synthesis of 3-acetoxy-4-(3-aryloxiran-2-yl)azetidin-2-ones and their transformation into 3,4-oxolane-fused bicyclic β-lactams

Nicola PiensSven De CraeneJorick FranceusKaren MolletKristof Van HeckeTom DesmetMatthias D'hooghe

A1 Journal Article in ORGANIC & BIOMOLECULAR CHEMISTRY

Integrating biocatalytical processes into organic synthesis: nitrilase-mediated conversion of 2-aryl-3-(2-cyanoethyl)aziridines and 4-(cyanomethyl)azetidin-2-ones as a sustainable entry to functionalized γ-lactams and β-lactams

Nicola PiensLena DecuyperSaskia Vander MeerenJens MinckeJeroen BomonBert De SchrijverKaren MolletKarel De WinterTom DesmetMatthias D'hooghe

LiAlH4-Induced selective ring rearrangement of 2-(2-cyanoethyl)aziridines toward 2-(aminomethyl)pyrrolidines and 3-aminopiperidines as eligible heterocyclic building blocks

Jeroen DolfenKarel VervischNorbert De KimpeMatthias D'hooghe

A1 Journal Article in CHEMISTRY-A EUROPEAN JOURNAL

Recent progress in the use of functionalized β-lactams as building blocks in heterocyclic chemistry

Nicola PiensNorbert De KimpeMatthias D'hooghe

Bookchapter in Progress in Heterocyclic Chemistry, volume 28

Synthesis and SAR assessment of novel Tubathian analogs in the pursuit of potent and selective HDAC6 inhibitors

Rob De VreeseYves DepetterTom VerhaegheTom DesmetVeronick BenoyWanda HaeckLudo Van Den BoschMatthias D'hooghe

A1 Journal Article in ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis and applications of 3-methylene-4-(trifluoromethyl)azetidin-2-ones as building blocks for the preparation of mono- and spirocyclic 4-CF3-β-lactams

Hang Dao ThiBarbara DanneelsTom DesmetKristof Van HeckeTuyen Van NguyenMatthias D'hooghe

A1 Journal Article in ASIAN JOURNAL OF ORGANIC CHEMISTRY

Synthesis and biological assessment of novel N-(hydroxy/methoxy)alkyl β-enaminone curcuminoids

Mr. Atiruj TheppawongRob De VreeseLore VanneckeCharlotte GrootaertJohn Van CampMatthias D'hooghe

A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and chemical/enzymatic hydrolysis of 2-aryl-3-(2-cyanoethyl)aziridines and 4-(cyanomethyl)azetidin-2-ones

Lena DecuyperNicola PiensSaskia Vander MeerenJens MinckeJeroen BomonBert De SchrijverKaren MolletKarel De WinterTom DesmetMatthias D'hooghe

Synthesis and cytotoxic evaluation of novel indenoisoquinoline-propan-2-ol hybrids

Tham Pham ThiLena DecuyperTan Luc QuangChinh Pham TheTuyet Anh Dang ThiHa Thanh NguyenThuy Giang Le NhatTra Nguyen ThanhPhuong Hoang ThiMatthias D'hooghe et al.

A1 Journal Article in TETRAHEDRON LETTERS

Synthesis of novel curcuminoids accommodating a central β-enaminone motif and their impact on cell growth and oxidative stress

Rob De VreeseCharlotte GrootaertSander D'hooreMr. Atiruj TheppawongSam Van DammeMaarten Van BogaertJohn Van CampMatthias D'hooghe

A1 Journal Article in EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of trifluoromethylated azetidines, aminopropanes, 1,3-oxazinanes, and 1,3-oxazinan-2-ones starting from 4-trifluoromethyl-β-lactam building blocks

Hang Dao ThiLena DecuyperKaren MolletSara KenisNorbert De KimpeTuyen Van NguyenMatthias D'hooghe

A1 Journal Article in SYNLETT

2015

Expedient stereoselective synthesis of new dihydropyrano- and dihydrofuranonaphthoquinones

Tuyet Anh Dang ThiYves DepetterKaren MolletHoang Thi PhuongDoan Vu NgocChinh Pham TheHa Thanh NguyenThu Ha Nguyen ThiHung Huy NguyenMatthias D'hooghe et al.

A1 Journal Article in TETRAHEDRON LETTERS

Quinoline-based antimalarial hybrid compounds

Stephanie VandekerckhoveMatthias D'hooghe

A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and anticancer properties of new (dihydro)pyranonaphthoquinones and their epoxy analogs

Anh Dang Thi TuyetHa Vu Thi ThuThi Phuong HoangHa Nguyen ThanhPham The ChinhVu Duc CuongYves DepetterVan Nguyen TuyenMatthias D'hooghe

A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and antimicrobial/cytotoxic assessment of ferrocenyl oxazinanes, oxazinan-2-ones, and tetrahydropyrimidin-2-ones

Anka PejovićBarbara DanneelsTom DesmetBa Thi ChamTuyen Van NguyenNiko S RadulovićRastko D VukicevićMatthias D'hooghe

A1 Journal Article in SYNLETT

Synthesis and cytotoxic evaluation of novel amide-triazole-linked triterpenoid-AZT conjugates

Hang Dao ThiNguyen Thi Kim TuyetChinh Pham TheHa Thanh NguyenCham Ba ThiHoang Thi PhuongLuu Van BoiTuyen Van NguyenMatthias D'hooghe

A1 Journal Article in TETRAHEDRON LETTERS

Synthesis and cytotoxic evaluation of novel dihydrobenzo[h]cinnoline-5,6-diones

Tuyet Anh Dang ThiLena DecuyperHoang Thi PhuongDoan Vu NgocHa Thanh NguyenTra Thanh NguyenThanh Do HuyHung Huy NguyenMatthias D'hoogheTuyen Van Nguyen

A1 Journal Article in TETRAHEDRON LETTERS

Synthesis of 2-aryl-3-(2-cyanoethyl)aziridines and their chemical and enzymatic hydrolysis towards γ-lactams and γ-lactones

Karen MolletLena DecuyperSaskia Vander MeerenNicola PiensKarel De WinterTom DesmetMatthias D'hooghe

A1 Journal Article in ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis of benzothiophene-based hydroxamic acids as potent and selective HDAC6 inhibitors

Rob De VreeseNicholas Van SteenTom VerhaegheTom DesmetNadia BougarneKarolien De BosscherVeronick BenoyWanda HaeckLudo Van Den BoschMatthias D'hooghe

A1 Journal Article in CHEMICAL COMMUNICATIONS

Synthesis of functionalized 3-, 5-, 6- and 8-aminoquinolines via intermediate (3-pyrrolin-1-yl)- and (2-oxopyrrolidin-1-yl)quinolines and evaluation of their antiplasmodial and antifungal activity

Stephanie VandekerckhoveSofie Van HerrewegheJasmine WillemsBarbara DanneelsTom DesmetCarmen de KockPeter J SmithKelly ChibaleMatthias D'hooghe

A1 Journal Article in EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of novel thymine-β-lactam hybrids and evaluation of their anti-tumor activity

Nicola PiensRob De VreeseNympha De NeveKristof Van HeckeJan BalzariniNorbert De KimpeMatthias D'hooghe

Ϲинтеза нових биолошки активних хетероцикличних једињења која садрже фероцен

Anka PejovićRastko VukićevićMatthias D'hooghe

2014

Application of 3-bromo-3-ethylazetidines and 3-ethylideneazetidines for the synthesis of functionalized azetidines

Sonja StankovićMatthias D'hoogheTim VanderhaegenKourosh Abbaspour TehraniNorbert De Kimpe

A1 Journal Article in SYNLETT

Discovery of anxiolytic 2-ferrocenyl-1,3-thiazolidin-4-ones exerting GABA(A) receptor interaction via the benzodiazepine-binding site

Anka PejovićMarija S DenićDragana StevanovićIvan DarnljanovićMirjana VukićevićKalina KostovaMaya Tavlinova-KirilovaPavle RandjelovićNikola M StojanovićGoran A Bogdanović et al.

A1 Journal Article in EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Engineering the specificity of trehalose phosphorylase as a general strategy for the production of glycosyl phosphates

Chao ChenJef Van der BorghtRob De VreeseMatthias D'hoogheWim SoetaertTom Desmet

A1 Journal Article in CHEMICAL COMMUNICATIONS

New strategies for the synthesis of fluorinated carbo- and heterocyclic compounds

Matthias MoensNorbert De KimpeMatthias D'hooghe

Nucleophile-dependent regio- and stereoselective ring opening of 1-azoniabicyclo[3.1.0]hexane tosylate

Mi-Kyung JiDietmar HertsenDoo-Ha YoonHeesung EumHannelore GoossensMichel WaroquierVeronique Van SpeybroeckMatthias D'hoogheNorbert De KimpeHyun-Joon Ha

A1 Journal Article in CHEMISTRY-AN ASIAN JOURNAL

Reactivity of aziridinium salts in different solvents unraveled by a combined theoretical and experimental approach

Hannelore GoossensDietmar HertsenKaren MolletSaron CatakMatthias D'hoogheFrank De ProftPaul GeerlingsNorbert De KimpeMichel WaroquierVeronique Van Speybroeck

Bookchapter in Structure, bonding and reactivity of heterocyclic compounds

Selective synthesis of cis- and trans-2-(methyl/phenyl)-3-(trifluoromethyl)aziridines and their regio- and stereospecific ring opening

Matthias MoensNorbert De KimpeMatthias D'hooghe

A1 Journal Article in JOURNAL OF ORGANIC CHEMISTRY

Selective synthesis of functionalized trifluoromethylated pyrrolidines, piperidines, and azepanes starting from 1-tosyl-2-(trifluoromethyl)aziridine

Jeroen DolfenSara KenisKristof Van HeckeNorbert De KimpeMatthias D'hooghe

A1 Journal Article in CHEMISTRY-A EUROPEAN JOURNAL

Synthesis and biological evaluation of novel quinoline derivatives

Stephanie VandekerckhoveMatthias D'hooghe

Synthesis and cytotoxic evaluation of novel ester-triazole-linked triterpenoid-AZT conjugates

Hang Dao ThiNguyen Thi Kim TuyetChinh Pham TheHa Thanh NguyenCham Ba ThiTien Doan DuyMatthias D'hoogheTuyen Van Nguyen

A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of 2-aryl-3-(2-cyanoethyl)aziridines and their chemical and enzymatic hydrolysis towards γ-lactams and γ-lactones

Lena DecuyperKaren MolletSaskia Vander MeerenNicola PiensKarel De WinterTom DesmetMatthias D'hooghe

Synthesis of 2-hydroxy-1,4-oxazin-3-ones through ring transformation of 3-hydroxy-4-(1,2-dihydroxyethyl)-β-lactams and study of their reactivity

Nicola PiensKaren MolletHannelore GoossensSaron CatakMichel WaroquierKarl W. TörnroosVeronique Van SpeybroeckNorbert De KimpeMatthias D'hooghe

Synthesis of halogenated 4-quinolones and evaluation of their antiplasmodial activity

Stephanie VandekerckhoveTom DesmetHai Giang TranCarmen de KockPeter J SmithKelly ChibaleMatthias D'hooghe

A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of novel thymine-β-lactam hybrids and evaluation of their anti-tumor activity

Nicola PiensRob De VreeseNympha De NeveKristof Van HeckeJan BalzariniNorbert De KimpeMatthias D'hooghe

A1 Journal Article in SYNTHESIS-STUTTGART

Synthesis of novel thymine-β-lactam hybrids and evaluation of their anti-tumor activity

Nicola PiensRob De VreeseNympha De NeveKristof Van HeckeJan BalzariniNorbert De KimpeMatthias D'hooghe

Synthesis of trifluoromethylated azetidines, aminopropanes, 1,3-oxazinanes, and 1,3-oxazinan-2-ones starting from 4-trifluoromethyl-β-lactam building blocks

Hang Dao ThiLena DecuyperKaren MolletSara KennisNorbert De KimpeTuyen Nguyen VanMatthias D'hooghe

2013

A convenient approach towards the 1-aminomethyl-1-fluorocycloalkane scaffold

Matthias MoensMatthias D'hoogheNorbert De Kimpe

A1 Journal Article in TETRAHEDRON LETTERS

Application of functionalized β-lactams for the selective construction of new aza- and oxaheterocyclic systems

Karen MolletNorbert De KimpeMatthias D'hooghe

Computational rationalization of the ring transformation of 3-hydroxy-4-(1,2-dihydroxyethyl)-β-lactams

Hannelore GoossensSaron CatakKaren MolletNicola PiensMatthias D'hoogheNorbert De KimpeMichel WaroquierVeronique Van Speybroeck

Epihalohydrins in organic synthesis

Girija S SinghKaren MolletMatthias D'hoogheNorbert De Kimpe

A1 Journal Article in CHEMICAL REVIEWS

Evaluation of (4-aminobutyloxy)quinolines as a novel class of antifungal agents

Stephanie VandekerckhoveHai Giang TranTom DesmetMatthias D'hooghe

A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Exploration of aziridine- and β-lactam-based hybrids as both bioactive substances and synthetic intermediates in medicinal chemistry

Stephanie VandekerckhoveMatthias D'hooghe

A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY

Nucleophile-directed selective transformation of cis-1-tosyl-2-toxyloxymethyl-3-(trifluoromethyl)aziridine into aziridines, azetidines, and benzo-fused dithianes, oxathianes, dioxanes, and (thio)morpholines

Sara KenisMatthias D'hoogheGuido VerniestMaaike ReybroeckTuyet Anh Dang ThiChinh Pham TheTham Thi PhamKarl W TörnroosNguyen Van TuyenNorbert De Kimpe

A1 Journal Article in CHEMISTRY-A EUROPEAN JOURNAL

Potent and selective HDAC6 inhibitory activity of N-(4-hydroxycarbamoylbenzyl)-1,2,4,9-tetrahydro-3-thia-9-azafluorenes as novel sulfur analogues of Tubastatin A

Rob De VreeseTom VerhaegheTom DesmetMatthias D'hooghe

A1 Journal Article in CHEMICAL COMMUNICATIONS

Synthesis and antiplasmodial evaluation of aziridine-(iso)quinoline hybrids and their ring-opening products

Stephanie VandekerckhoveSofie De MoorDries SegersCarmen de KockPeter J SmithKelly ChibaleNorbert De KimpeMatthias D'hooghe

A1 Journal Article in MEDCHEMCOMM

Synthesis and antiplasmodial evaluation of novel (4-aminobutyloxy)quinolines

Stephanie VandekerckhoveChristian MüllerDieter VogtCarmen LateganPeter J SmithKelly ChibaleNorbert De KimpeMatthias D'hooghe

A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of 2-aminomethyl-4-phenyl-1-azabicyclo[2.2.1]heptanes via LiAlH4-induced reductive cyclization of 2-(4-chloro-2-cyano-2-phenylbutyl) aziridines and evaluation of their antimalarial activity

Matthias D'hoogheKarel VervischKarl W TörnroosTom VerhaegheTom DesmetCarmen LateganPeter J SmithKelly ChibaleNorbert De Kimpe

A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of 2-hydroxy-1,4-oxazin-3-ones through ring transformation of 3-hydroxy-4-(1,2-dihydroxyethyl)-β-lactams and a study of their reactivity

Karen MolletHannelore GoossensNicola PiensSaron CatakMichel WaroquierKarl W TornroosVeronique Van SpeybroeckMatthias D'hoogheNorbert De Kimpe

A1 Journal Article in CHEMISTRY-A EUROPEAN JOURNAL

Synthesis of 2-hydroxy-1,4-oxazin-3-ones through ring transformation of 3-hydroxy-4-(1,2-dihydroxyethyl)-β-lactams and study of their reactivity

Nicola PiensKaren MolletHannelore GoossensSaron CatakMichel WaroquierKarl W. TörnroosVeronique Van SpeybroeckNorbert De KimpeMatthias D'hooghe

Synthesis of piperidin-4-ones starting from 2-(2-bromo-1,1-dimethylethyl)-azetidines and 2-(2-mesyloxyethyl)azetidines through a ring expansion-oxidation protocol

Karen MolletMatthias D'hoogheLeen BroeckxBarbara DanneelsTom DesmetNorbert De Kimpe

A1 Journal Article in TETRAHEDRON

Synthesis of six-membered azaheterocycles by means of the β-lactam synthon method

Karen MolletMatthias D'hoogheNorbert De Kimpe

A1 Journal Article in MINI-REVIEWS IN ORGANIC CHEMISTRY

Synthesis of α-(trifluoromethyl)aziridines and -azetidines and their transformations into novel CF₃-substituted amines and heterocyclic systems

Sara KenisNorbert De KimpeMatthias D'hooghe

2012

Asymmetric synthesis of 4-formyl-1-(ω-haloalkyl)-β-lactams and their transformation to functionalized piperazines and 1,4-diazepanes

Stijn DekeukeleireMatthias D'hoogheMatthieu VanwalleghemWillem Van BrabandtNorbert De Kimpe

A1 Journal Article in TETRAHEDRON

Biocatalytic production of novel glycolipids with cellodextrin phosphorylase

Hai Giang TranTom DesmetKaren SaerensHendrik WaegemanStephanie VandekerckhoveMatthias D'hoogheInge Van BogaertWim Soetaert

A1 Journal Article in BIORESOURCE TECHNOLOGY

Chemical and enzymatic synthesis of 2-(2-carbamoylethyl)- and 2-(2-carboxyethyl)aziridines and their conversion into δ-lactams and γ-lactones

Karel VervischMatthias D'hoogheFloris PJT RutjesNorbert De Kimpe

A1 Journal Article in ORGANIC LETTERS

Computational study on the formation of N-spiro bis-Aziridinium ions and their Nucleophile-induced ring opening reactions

Dietmar HertsenSaron CatakMichel WaroquierMatthias D'hoogheNorbert De KimpeVeronique Van Speybroeck

DFT calculations on aziridines within the supermolecule approach

Hannelore GoossensSaron CatakSonja StankovićMatthias D'hoogheNorbert De KimpeMichel WaroquierVeronique Van Speybroeck

Design, synthesis and antiviral evaluation of purine-β-lactam and purine-aminopropanol hybrids

Matthias D'hoogheKaren MolletRob De VreeseTim JonckersGéry DamsNorbert De Kimpe

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

N-Heterocyclic carbene/Brønsted acid cooperative catalysis as a powerful tool in organic synthesis

Rob De VreeseMatthias D'hooghe

A1 Journal Article in BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY

Radical-mediated nitrile translocation as the key step in the stereoselective transformation of 2-(4-chloro-2-cyanobutyl)aziridines to methyl cis-(1-arylmethyl-4-phenylpiperidin-2-yl)acetates

Karel VervischMatthias D'hoogheKarl W TörnroosNorbert De Kimpe

A1 Journal Article in ORGANIC & BIOMOLECULAR CHEMISTRY

Regioselectivity in the ring opening of non-activated aziridines

Sonja StankovićMatthias D'hoogheSaron CatakHeesung EumMichel WaroquierVeronique Van SpeybroeckNorbert De KimpeHyun-Joon Ha

A1 Journal Article in CHEMICAL SOCIETY REVIEWS

Solvent-controlled selective transformation of 2-Bromomethyl-2-methylaziridines to functionalized Aziridines and Azetidines

Sonja StankovićHannelore GoossensSaron CatakMeniz TezcanMichel WaroquierVeronique Van SpeybroeckMatthias D'hoogheNorbert De Kimpe

A1 Journal Article in JOURNAL OF ORGANIC CHEMISTRY

Stereoselective synthesis of bicyclic tetrahydrofuran-fused β-lactams and their conversion into methyl cis-3-aminotetrahydrofuran-2-carboxylates

Karen MolletMatthias D'hoogheNorbert De Kimpe

A1 Journal Article in TETRAHEDRON

Study of non-activated 2-(bromomethyl)aziridines and 2-bromomethyl-2-methylaziridines as versatile synthons in heterocyclic chemistry

Sonja StankovićNorbert De KimpeMatthias D'hooghe

Synthesis of 1-alkyl-2-(trifluoromethyl)azetidines and their regiospecific ring opening toward diverse α-(trifluoromethyl)amines via intermediate azetidinium salts

Sara KenisMatthias D'hoogheGuido VerniestAnh Dang Thi TuyetChinh Pham TheTuyen Van NguyenNorbert De Kimpe

A1 Journal Article in JOURNAL OF ORGANIC CHEMISTRY

Synthesis of 3-functionalized 3-methylazetidines

Sonja StankovićMatthias D'hoogheKourosch Abbaspour TehraniNorbert De Kimpe

A1 Journal Article in TETRAHEDRON LETTERS

Synthesis of stereodefined 3,4-disubstituted piperidines through rearrangement of 2-(2-bromo-1,1-dimethylethyl)azetidines

Karen MolletLeen BroeckxMatthias D'hoogheNorbert De Kimpe

A1 Journal Article in HETEROCYCLES

2011

Reactivity of activated versus nonactivated 2-(bromomethyl)aziridines with respect to sodium methoxide: a combined computational and experimental study

Hannelore GoossensKarel VervischSaron CatakSonja StankovićMatthias D'hoogheFrank De ProftPaul GeerlingsNorbert De KimpeMichel WaroquierVeronique Van Speybroeck

A1 Journal Article in JOURNAL OF ORGANIC CHEMISTRY

Ring expansion of cyclobutylmethylcarbenium ions to cyclopentane or cyclopentene derivatives and metal-promoted analogous rearrangements

Erika LeemansMatthias D'hoogheNorbert De Kimpe

A1 Journal Article in CHEMICAL REVIEWS

Selective transformation of 2-halomethyl-2-methylaziridines to functionalized aziridines and azetidines

Sonja StankovićMatthias D'hoogheSaron CatakHannelore GoossensMichel WaroquierVeronique Van SpeybroeckKourosch Abbaspour TehraniNorbert De Kimpe

Stereoselective synthesis of 1- and 4-haloalkyl-beta-lactams and their stereoselective transformation into novel azaheterocyclic compounds

Stijn DekeukeleireNorbert De KimpeMatthias D'hooghe

Stereoselective synthesis of cis-3,4-disubstituted piperidines through ring transformation of 2-(2-mesyloxyethyl)azetidines

Karen MolletSaron CatakMichel WaroquierVeronique Van SpeybroeckMatthias D'hoogheNorbert De Kimpe

A1 Journal Article in JOURNAL OF ORGANIC CHEMISTRY

Straightforward synthesis of 1-alkyl-2-(trifluoromethyl)aziridines starting from 1,1,1-trifluoroacetone

Sara KenisMatthias D'hoogheGuido VerniestVinh Duc NguyenAnh Dang Thi TuyetTuyen Van NguyenNorbert De Kimpe

A1 Journal Article in ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis and reactivity of non-activated 2-(chloromethyl)aziridines

Sonja StankovićMatthias D'hoogheJo DewulfPiet BogaertRobrecht JolieNorbert De Kimpe

A1 Journal Article in TETRAHEDRON LETTERS

Synthesis and reactivity of spiro-fused β-lactams

Girija S SinghMatthias D'hoogheNorbert De Kimpe

A1 Journal Article in TETRAHEDRON

Synthesis of 2-(2-cyanoeyhyl)aziridines and their transformation into a variety of novel cyclic amino nitriles

Karel VervischNorbert De KimpeMatthias D'hooghe

Synthesis of 2-(aminomethyl)aziridines and their microwave-assisted ring opening to 1,2,3-triaminopropanes as novel antimalarial pharmacophores

Matthias D'hoogheSara KenisKarel VervischCarmen LateganPeter SmithKelly ChibaleNorbert De Kimpe

A1 Journal Article in EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of 2-amino-3-arylpropan-1-ols and 1-(2,3-diaminopropyl)-1,2,3-triazoles and evaluation of their antimalarial activity

Matthias D'hoogheStephanie VandekerckhoveKaren MolletKarel VervischStijn DekeukeleireLiesbeth LehoucqCarmen LateganPeter J SmithKelly ChibaleNorbert De Kimpe

A1 Journal Article in BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY

Synthesis of 3-methoxyazetidines via an aziridine to azetidine rearrangement and theoretical rationalization of the reaction mechanism

Sonja StankovićSaron CatakMatthias D'hoogheHannelore GoossensKourosch Abbaspour TehraniPieter BogaertMichel WaroquierVeronique Van SpeybroeckNorbert De Kimpe

A1 Journal Article in JOURNAL OF ORGANIC CHEMISTRY

Transformation of trans-4-aryl-3-chloro-1-(2-chloroethyl)azetidin-2-ones into 3-aryl-2-(ethylamino)propan-1-ols via intermediate 1-(1-aryl-2-chloro-3-hydroxypropyl)aziridines and trans-2-aryl-3-(hydroxymethyl)aziridines

Karen MolletMatthias D'hoogheNorbert De Kimpe

A1 Journal Article in JOURNAL OF ORGANIC CHEMISTRY

2010

Conjugate addition of 2-(bromomethyl)- and 2-(2-bromoethyl)piperidine to alkyl acrylates : application towards the synthesis of 2-(methoxycarbonyl)indolizidine

Matthias D'hoogheKourosch Abbaspour TehraniChristophe BuyckNorbert De Kimpe

A1 Journal Article in ARKIVOC

Intramolecular pi-pi stacking interactions in 2-substituted N,N-dibenzylaziridinium ions and their regioselectivity in nucleophilic ring-opening reactions

Saron CatakMatthias D'hoogheNorbert De KimpeMichel WaroquierVeronique Van Speybroeck

A1 Journal Article in JOURNAL OF ORGANIC CHEMISTRY

Microwave-assisted regioselective ring opening of non-activated aziridines by lithium aluminium hydride

Sonja StankovićMatthias D'hoogheNorbert De Kimpe

A1 Journal Article in ORGANIC & BIOMOLECULAR CHEMISTRY

Opposite regiospecific ring opening of 2-(cyanomethyl)aziridines by hydrogen bromide and benzyl bromide : experimental study and theoretical rationalization

Saron CatakMatthias D'hoogheToon VerstraelenKaren HemelsoetAndries Van NieuwenhoveHyun-Joon HaMichel WaroquierNorbert De KimpeVeronique Van Speybroeck

A1 Journal Article in JOURNAL OF ORGANIC CHEMISTRY

Rhodium-catalysed hydroformylation of N-(2-propenyl)-β-lactams as a key step in the synthesis of functionalised N-[4-(2-oxoazetidin-1-yl)but-1-enyl]acetamides

Stijn DekeukeleireMatthias D'hoogheChristian MüllerDieter VogtNorbert De Kimpe

A1 Journal Article in NEW JOURNAL OF CHEMISTRY

Stereoselective synthesis of chiral 4-(1-chloroalkyl)-β-lactams starting from amino acids and their transformation into functionalized chiral azetidines and pyrrolidines

Stijn DekeukeleireMatthias D'hoogheKarl TörnroosNorbert De Kimpe

A1 Journal Article in JOURNAL OF ORGANIC CHEMISTRY

Stereoselective synthesis of trans- and cis-2-aryl-3-(hydroxymethyl)aziridines through transformation of 4-aryl-3-chloro-β-lactams and study of their ring opening

Matthias D'hoogheKaren MolletStijn DekeukeleireNorbert De Kimpe

A1 Journal Article in ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis of 3,4-fused bicyclic β-lactams and their transformation into methyl cis-3-aminotetrahydrofuran-2-carboxylates

Erika LeemansMatthias D'hoogheYves DejaegherKarl TörnroosNorbert De Kimpe

A1 Journal Article in EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Synthesis of stereodefined piperidines from aziridines and their transformation into conformationally constrained amino acids, amino alcohols and 2,7-diazabicyclo[3.3.1]nonanes

Karel VervischMatthias D'hoogheKarl TörnroosNorbert De Kimpe

A1 Journal Article in JOURNAL OF ORGANIC CHEMISTRY

Systematic study of halide-induced ring opening of 2-substituted aziridinium salts and theoretical rationalization of the reaction pathways

Matthias D'hoogheSaron CatakSonja StankovićMichel WaroquierYongeun KimHyun-Joon HaVeronique Van SpeybroeckNorbert De Kimpe

A1 Journal Article in EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Use of functionalized β-lactams as building blocks in heterocyclic chemistry

Matthias D'hoogheStijn DekeukeleireErika LeemansNorbert De Kimpe

A1 Journal Article in PURE AND APPLIED CHEMISTRY

2009

A new approach towards 1-phenyl and 1-benzyl substituted 2-(aminomethyl)cyclopropanecarboxamides as novel derivatives of the antidepressant Milnacipran

Karel VervischMatthias D'hoogheKarl TörnroosNorbert De Kimpe

A1 Journal Article in ORGANIC & BIOMOLECULAR CHEMISTRY

A new entry into cis-3-amino-2-methylpyrrolidines via ring expansion of 2-(2-hydroxyethyl)-3-methylaziridines

Matthias D'hoogheWim AeltermanNorbert De Kimpe

A1 Journal Article in ORGANIC & BIOMOLECULAR CHEMISTRY

Diastereoselective Synthesis of Bicyclic gamma-Lactams via Ring Expansion of Monocydic beta-Lactams

Stijn DekeukeleireMatthias D'hoogheNorbert De Kimpe

A1 Journal Article in JOURNAL OF ORGANIC CHEMISTRY

Nucleophile-dependent regioselective ring opening of 2-substituted N,N-dibenzylaziridinium ions : bromide versus hydride

Sae Young YunSaron CatakWon Koo LeeMatthias D'hoogheNorbert De KimpeVeronique Van SpeybroeckMichel WaroquierYongeun KimHyun-Joon Ha

A1 Journal Article in CHEMICAL COMMUNICATIONS

One-pot synthesis of 3,3-dimethylpyrrolidine-2-carbonitriles from 4-chloro-2,2-dimethylbutanal in water

Matthias D'hoogheBerten Van DriesscheNorbert De Kimpe

A1 Journal Article in HETEROCYCLES

Synthesis and reactivity of 3-haloazetidines and 3-sulfonyloxyazetidines: a review

Willem Van BrabandtSven MangelinckxMatthias D'hoogheBerten Van DriesscheNorbert De Kimpe

A1 Journal Article in CURRENT ORGANIC CHEMISTRY

Synthesis of 2-(3-hydroxy-2-methyl-1-alkenyl)-1-pyrrolines and 2-(3-hydroxybutyl)-1-pyrroline using alpha-lithiated 2-methyl-1-pyrroline

Matthias D'hoogheKourosch Abbaspour TehraniNorbert De Kimpe

A1 Journal Article in TETRAHEDRON

Synthesis of 2-[(arylmethylene)amino]cyclopropanecarbonitriles via a two-step ring transformation of 2-(cyanomethyl)aziridines

Sven MangelinckxMatthias D'hoogheSietske PeetersNorbert De Kimpe

A1 Journal Article in SYNTHESIS-STUTTGART

Synthesis of novel 2-alkoxy-3-amino-3-arylpropan-1-ols and 5-alkoxy-4-aryl-1,3-oxazinanes with antimalarial activity

Matthias D'hoogheStijn DekeukeleireKaren MolletCarmen LateganPeter SmithKelly ChibaleNorbert De Kimpe

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

2008

Azetidines, Azetines, and Azetes: Monocyclic

G SINGHMatthias D'hoogheNorbert De Kimpe

Bookchapter in Comprehensive Heterocyclic Chemistry III

Coupling of 1-alkyl-2-(bromomethyl)aziridines with heteroatom-centered nucleophiles towards 2-[(heteroatom)methyl]aziridines

Matthias D'hoogheNorbert De Kimpe

A1 Journal Article in ARKIVOC

Electrophile-induced bromocyclization of gamma,delta-unsaturated ketimines to intermediate I-pyrrolinium salts and their selective conversion into novel 5-alkoxymethyl-2-aryl-3-chloropyrroles and 2-aroylpyrroles

Matthias D'hoogheC BUYCKJ CONTRERASNorbert De Kimpe

A1 Journal Article in ORGANIC & BIOMOLECULAR CHEMISTRY

Highly stereoselective synthesis of beta-lactams utilizing alpha-chloroimines as new and powerful chiral inductors

Matthias D'hoogheWillem Van BrabandtStijn DekeukeleireY DEJAEGHERNorbert De Kimpe

A1 Journal Article in CHEMISTRY-A EUROPEAN JOURNAL

Novel diastereoselective synthesis of bicyclic beta-lactams through radical cyclization and their reduction toward 2-(1-alkoxy-2-hydroxyethyl)piperidines and 2-(1-alkoxy-2-hydroxyethyl)azepanes

Erika LeemansMatthias D'hoogheY DEJAEGHERKW TOEMROOSNorbert De Kimpe

A1 Journal Article in JOURNAL OF ORGANIC CHEMISTRY

Novel synthesis of 2-aminopentanedinitriles from 2-(bromomethyl)aziridines and their transformation into 2-imino-5-methoxypyrrolidines and 5-methoxypyrrolidin-2-ones

Matthias D'hoogheAndries Van NieuwenhoveWillem Van BrabandtM ROTTIERSNorbert De Kimpe

A1 Journal Article in TETRAHEDRON

Reactivity of N-(omega-haloalkyl)-beta-lactams with regard to lithium aluminium hydride: novel synthesis of 1-(1-aryl-3-hydroxypropyl)aziridines and 3-aryl-3-(N-propylamino)propan-1-ols

Matthias D'hoogheStijn DekeukeleireNorbert De Kimpe

A1 Journal Article in ORGANIC & BIOMOLECULAR CHEMISTRY

Reduction of 5-(bromomethyl)-1-pyrrolinium bromides to 2-(bromomethyl)pyrrolidines and their transformation into piperidin-3-ones through an unprecedented ring expansion-oxidation protocol

Matthias D'hoogheJ BAELEJ CONTRERASMark BoelensNorbert De Kimpe

A1 Journal Article in TETRAHEDRON LETTERS

Regio- and stereocontrolled synthesis of novel 3-sulfonamido-2,3,4,5-tetrahydro-1,5-benzothiazepines from 2-(bromomethyl)- or 2-(sulfonyloxymethyl)aziridines

M KARIKOMIMatthias D'hoogheGuido VerniestNorbert De Kimpe

A1 Journal Article in ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis and reactivity of novel alpha,alpha,beta- and alpha,alpha,delta-trichlorinated imines

Matthias D'hoogheBruno De MeulenaerNorbert De Kimpe

A1 Journal Article in SYNLETT

Synthesis and synthetic applications of 2-amino-3-halo-1-oxypropanes

Matthias D'hoogheNorbert De Kimpe

A1 Journal Article in TETRAHEDRON

Synthesis of novel 3-oxopiperidin-2-ones from methyl 2-alkoxy-5-amino-2-pentenoates

Y DEJAEGHERMatthias D'hoogheNorbert De Kimpe

A1 Journal Article in SYNLETT

Synthesis of trans-4-aryl-3-(3-chloropropyl)azetidin-2-ones and their transformation into trans- and cis-2-arylpiperidine-3-carboxylates

Matthias D'hoogheY DEJAEGHERNorbert De Kimpe

A1 Journal Article in TETRAHEDRON

2007

Highly unusual conversion of 1-alkyl-2-(bromomethyl) aziridines into 1-alkyl-2-(N-alkyl-N-ethylaminomethyl)aziridines using methyllithium

Matthias D'hoogheNorbert De Kimpe

A1 Journal Article in CHEMICAL COMMUNICATIONS

Novel synthesis of 3,4-diaminobutanenitriles and 4-amino-2-butenenitriles from 2-(cyanomethyl)aziridines through intermediate aziridinium salts: An experimental and theoretical approach

Matthias D'hoogheVeronique Van SpeybroeckA VAN NIEUWENHOVEMichel WaroquierNorbert De Kimpe

A1 Journal Article in JOURNAL OF ORGANIC CHEMISTRY

Reactivity of 1-alkyl-2-(bromomethyl)aziridines towards n-butyllithium

Matthias D'hoogheNorbert De Kimpe

A1 Journal Article in ARKIVOC

Ring opening of 2-(cyanomethyl)aziridines by acid chlorides: synthesis of novel 4-amino-2-butenenitrile derivatives through intermediate aziridinium salts

Matthias D'hoogheKarel VervischAndries Van NieuwenhoveNorbert De Kimpe

A1 Journal Article in TETRAHEDRON LETTERS

Stereospecific aziridination of olefins via electrophile-induced cyclization of gamma,delta-unsaturated imines and subsequent hydrolytic rearrangement

Matthias D'hoogheMark BoelensJ PIQUEURNorbert De Kimpe

A1 Journal Article in CHEMICAL COMMUNICATIONS

Synthesis and reactivity of C-heteroatom-substituted aziridines

GS SINGHMatthias D'hoogheNorbert De Kimpe

A1 Journal Article in CHEMICAL REVIEWS

Synthesis of 1-arylmethyl-2-(2-cyanoethyl)aziridines and their rearrangement into novel 2-(Aminomethyl)cyclopropanecarbonitriles

Matthias D'hoogheKarel VervischNorbert De Kimpe

A1 Journal Article in JOURNAL OF ORGANIC CHEMISTRY

2006

2-(Bromomethyl)aziridines as versatile building blocks in organic chemistry

Matthias D'hoogheNorbert De Kimpe

A new approach towards 2-amino-1-aryloxy-3-methoxypropanes from 1-arylmethyl-2-(bromomethyl)aziridines

Matthias D'hoogheA WATERINCKXTim VanlangendonckNorbert De Kimpe

A1 Journal Article in TETRAHEDRON

Asymmetric synthesis of 1-(2- and 3-haloalkyl)azetidin-2-ones as precursors for novel piperazine, morpholine, and 1,4-diazepane annulated beta-lactams

Willem Van BrabandtMatthieu VanwalleghemMatthias D'hoogheNorbert De Kimpe

A1 Journal Article in JOURNAL OF ORGANIC CHEMISTRY

Novel synthesis of cis-3,5-disubstituted morpholine derivatives

Matthias D'hoogheTim VanlangendonckKW TORNROOSNorbert De Kimpe

A1 Journal Article in JOURNAL OF ORGANIC CHEMISTRY

Opposite regioselectivity in the sequential ring-opening of 2-(alkanoyloxymethyl)aziridinium salts by bromide and fluoride in the synthesis of functionalized p-fluoro amines

Matthias D'hoogheNorbert De Kimpe

A1 Journal Article in SYNLETT

Regio- and stereospecific ring opening of 1,1-dialkyl-2-(aryloxymethyl)aziridinium salts by bromide

Matthias D'hoogheVeronique Van SpeybroeckMichel WaroquierNorbert De Kimpe

A1 Journal Article in CHEMICAL COMMUNICATIONS

Synthesis and reactivity of trans-2-aryl-3-chloroazetidines

Berten Van DriesscheWillem Van BrabandtMatthias D'hoogheY DEJAEGHERN DE-KIMPE

A1 Journal Article in TETRAHEDRON

Synthesis of 1-arylmethyl-2-(cyanomethyl) aziridines and their ring transformation into methyl N-(2-cyanocyclopropyl) benzimidates

Matthias D'hoogheSven MangelinckxE PERSYNWillem Van BrabandtN KIMPE

A1 Journal Article in JOURNAL OF ORGANIC CHEMISTRY

Synthesis of chiral 1,5-disubstituted pyrrolidinones via electrophile-induced cyclization of 2-(3-butenyl)oxazolines derived from (1R,2S)- and (1S,2R)-norephedrine

I KANIZSAIZ SZAKONYIR SILLANPAAMatthias D'hoogheNorbert De KimpeF FULOP

A1 Journal Article in TETRAHEDRON-ASYMMETRY

Synthetic approaches towards 2-iminothiazolidines: an overview

Matthias D'hoogheNorbert De Kimpe

A1 Journal Article in TETRAHEDRON

2005

A novel entry toward 2-imino-1,3-thiazolidines and 2-imino-1,3-thiazolines by ring transformation of 2-(thiocyanomethyl)aziridines

Matthias D'hoogheA. WaterinckxNorbert De Kimpe

A1 Journal Article in JOURNAL OF ORGANIC CHEMISTRY

Coupling of 1-alkyl-2-(bromomethyl)aziridines with lithium dialkylcuprates towards 1,2-dialkylaziridines

Matthias D'hoogheM ROTTIERSR JOLIENorbert De Kimpe

A1 Journal Article in SYNLETT

Ring opening of 2-(bromomethyl)-1-sulfonylaziridines towards 1,3-heteroatom substituted 2-aminopropane derivatives

Matthias D'hoogheM ROTTIERSI KERKAERTNorbert De Kimpe

A1 Journal Article in TETRAHEDRON

Synthesis of bicyclic carbamates as precursors of Sedum alkaloid derivatives

Z SZAKONYIMatthias D'hoogheL KANIZSAIF FULOPNorbert De Kimpe

A1 Journal Article in TETRAHEDRON

2004

New synthesis of propargylic amines from 2-(bromomethyl)aziridines. Intermediacy of 3-bromoazetidinium salts

Matthias D'hoogheWillem Van BrabandtNorbert De Kimpe

A1 Journal Article in JOURNAL OF ORGANIC CHEMISTRY

Ring opening reactions of 1-arenesulfonyl-2-(bromomethyl)aziridines

Matthias D'hoogheI KERKAERTM ROTTIERSNorbert De Kimpe

A1 Journal Article in TETRAHEDRON

Synthesis of functionalized 1,4-dihydro-9,10-anthraquinones and anthraquinones by ring closing metathesis using Grubbs' catalyst

TN VANMatthias D'hoogheS PATTYNNorbert De Kimpe

A1 Journal Article in SYNLETT

The mechanism of nucleophilic substitution of 1-alkyl-2-(tosyloxymethyl)-aziridines

Matthias D'hoogheNorbert De Kimpe

A1 Journal Article in SYNLETT

2003

A new route towards N-(alpha-methoxybenzyl)aziridines

Matthias D'hoogheA HOFKENSNorbert De Kimpe

A1 Journal Article in TETRAHEDRON LETTERS

Novel synthesis of indolizidines and quinolizidines

KA TEHRANIMatthias D'hoogheNorbert De Kimpe

A1 Journal Article in TETRAHEDRON

Synthesis of N-(4-chlorobutyl)butanamide, a chlorinated amide isolated from Aloe sabaea

Matthias D'hoogheZ SZAKONYIF FULOPNorbert De Kimpe

A1 Journal Article in ORGANIC PREPARATIONS AND PROCEDURES INTERNATIONAL

Synthesis of quaternary allylammonium salts via ring opening of 1-benzyl-2-(bromomethyl)aziridines

Matthias D'hoogheWillem Van BrabandtNorbert De Kimpe

A1 Journal Article in TETRAHEDRON