Research Explorer

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Researcher

Mathieu Bertrand

Publications & Research Data

Awards & Distinctions

100 Results

2026

TAB2 controls a TAK1-independent cell death checkpoint at the level of TNFR1 complex II in the TNF pathway

Tom DelangheMike VadiAnnelore HaemsLisa WijnsInge BruggemanJon HuygheDario PriemPeter VandenabeeleMathieu Bertrand

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

2025

ATG9A-mediated autophagy prevents inflammatory skin disease by limiting TNFR1-driven STING activation and ZBP1-dependent cell death

Dario PriemJon HuygheBarbara GilbertSimon VerdonckTom DelangheBruno VerstraetenEsther HostePeter VandenabeeleJonathan MaelfaitGeert van Loo et al.

A1 Journal Article in IMMUNITY

Primidone : a clinically promising candidate for the treatment of psoriasis

Theresa RiebelingBenedikt KolbrinkRebecca PhilippsenEileen DahlkeTom DelangheFranziska TheiligAgatha SchwarzRoland SchmittMathieu BertrandUlrich Kunzendorf et al.

A1 Journal Article in CELL DEATH DISCOVERY

Virotrap Reveals <i>Salmonella</i> SopB as A Ubiquitinated Cargo for Host ESCRT-0

Margaux De MeyerAnnick VerheeHanna GrzesikDelphine De SutterJon HuygheLouis DelhayeTessa Van de SteeneIgor FijalkowskiVeronique JonckheereLeander Meuris et al.

2024

RIPK1 is dispensable for cell death regulation in β-cells during hyperglycemia

Onay VeliOyku KayaAna Beatriz VarandaXimena HildebrandtPeng XiaoYann EstornesMatea PoggenbergYuan WangManolis PasparakisMathieu Bertrand et al.

A1 Journal Article in MOLECULAR METABOLISM

The autophagy protein RUBCNL/PACER represses RIPK1 kinase-dependent apoptosis and necroptosis

Diego Rojas RiveraSebastián BeltránFrancisco Muñoz-CarvajalPablo Ahumada-MontalvaLorena AbarzúaLaura GomezFernanda HernandezCristian A BergmannLuis LabradorMelissa Calegaro-Nassif et al.

A1 Journal Article in AUTOPHAGY

2023

Apoptotic cell death in disease : current understanding of the NCCD 2023

Ilio VitaleFederico PietrocolaEmma GuilbaudStuart A AaronsonJohn M AbramsDieter AdamMassimiliano AgostiniPatrizia AgostinisEmad S AlnemriLucia Altucci et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Cell death checkpoints in the TNF pathway

Jon HuygheDario PriemMathieu Bertrand

A1 Journal Article in TRENDS IN IMMUNOLOGY

Death by TNF : a road to inflammation

Geert van LooMathieu Bertrand

A1 Journal Article in NATURE REVIEWS IMMUNOLOGY

Detoxification mechanisms in the TNF pathway

Jon HuygheMathieu BertrandDario Priem

From PERK to RIPK1 : design, synthesis and evaluation of novel potent and selective necroptosis inhibitors

Camilla ScarpelliniSophie ValemboisKenneth GoossensMike VadiCaroline LanthierGreta KlejborowskaPieter Van der VekenHans De WinterMathieu BertrandKoen Augustyns

A1 Journal Article in FRONTIERS IN CHEMISTRY

Inhibition of RIPK1 kinase does not affect diabetes development : beta-cells survive RIPK1 activation

Tatiana TakiishiPeng XiaoMarie FranchimontEduardo H. GilglioniErick N. ArrobaEsteban N. GurzovMathieu BertrandAlessandra K. Cardozo

A1 Journal Article in MOLECULAR METABOLISM

LC3-independent autophagy is vital to prevent TNF cytotoxicity

Dario PriemJon HuygheMathieu Bertrand

A1 Journal Article in AUTOPHAGY

NINJ1 is activated by cell swelling to regulate plasma membrane permeabilization during regulated necrosis

Yves DondelingerDario PriemJon HuygheTom DelanghePeter VandenabeeleMathieu Bertrand

A1 Journal Article in CELL DEATH & DISEASE

RIPK1 kinase-dependent inflammation and cell death contribute to the pathogenesis of COPD

Hannelore Van EeckhoutteChantal DonovanRichard Y. KimThomas M. ConlonMeshal AnsariHaroon KhanRanjith JayaramanNicole G. HansbroYves DondelingerTom Delanghe et al.

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

Tumor endothelial cell autophagy is a key vascular-immune checkpoint in melanoma

Jelle VerhoevenKathryn A. JacobsFrancesca RizzolloFrancesca LodiYichao HuaJoanna PoźniakAdhithya Narayanan SrinivasanDiede HoubaertGautam ShankarSanket More et al.

A1 Journal Article in EMBO MOLECULAR MEDICINE

2022

A20 controls RANK-dependent osteoclast formation and bone physiology

Arne MartensPieter HertensDario PriemVagelis RinotasTheodore MeletakosMeropi GennadiLisette Van HoveEls LouagieJulie CoudenysAmélie De Muynck et al.

A1 Journal Article in EMBO REPORTS

ATG9A prevents TNF cytotoxicity by an unconventional lysosomal targeting pathway.

Jon HuygheDario PriemLisette Van HoveBarbara GilbertJ FritschY UchiyamaEsther HosteGeert van LooMathieu Bertrand

A1 Journal Article in SCIENCE

Endocytic membrane repair by ESCRT-III controls antigen export to the cytosol during antigen cross-presentation

Marine GrosElodie SeguraDerek C. RookhuizenBlandine BaudonSandrine Heurtebise-ChretienNina BurgdorfMathieu MaurinEugene A. KappRichard J. SimpsonPatrycja Kozik et al.

A1 Journal Article in CELL REPORTS

Phosphorylation of RIPK1 serine 25 mediates IKK dependent control of extrinsic cell death in T cells

Sam BlanchettYves DondelingerAlessandro BarbaruloMathieu BertrandBenedict Seddon

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

The Impact of RIPK1 Kinase Inhibition on Atherogenesis: A Genetic and a Pharmacological Approach

Pauline PuylaertIsabelle CoornaertCedric H. G. NeutelYves DondelingerTom DelangheMathieu BertrandPieter-Jan GunsGuido R. Y. De MeyerWim Martinet

A1 Journal Article in BIOMEDICINES

2021

Antioxidant and food additive BHA prevents TNF cytotoxicity by acting as a direct RIPK1 inhibitor

Tom DelangheJon HuygheSeungheon LeeDario PriemSamya Van CoillieBarbara GilbertSze Men ChoiPeter VandenabeeleAlexei DegterevGregory D. Cuny et al.

A1 Journal Article in CELL DEATH & DISEASE

Unraveling the role of RIPK1 phosphorylation in TNF-mediated cell death and inflammation

Tom DelangheMathieu BertrandYves Dondelinger

2020

A20 and cell death-driven inflammation

Dario PriemGeert van LooMathieu Bertrand

A1 Journal Article in TRENDS IN IMMUNOLOGY

Autophosphorylation at serine 166 regulates RIP kinase 1-mediated cell death and inflammation

Lucie LaurienMasahiro NagataHannah SchünkeTom DelangheJanica L. WiedersteinSnehlata KumariRobin SchwarzerTeresa CoronaMarcus KrügerMathieu Bertrand et al.

A1 Journal Article in NATURE COMMUNICATIONS

Immunodominant AH1 antigen-deficient necroptotic, but not apoptotic, murine cancer cells induce antitumor protection

Tania Love AaesHanne VerschuereAgnieszka KaczmarekLiesbeth HeyndrickxBartosz WiernickiIris DelrueBram De CraeneJoachim TaminauTinneke DelvaeyeMathieu Bertrand et al.

A1 Journal Article in JOURNAL OF IMMUNOLOGY

OTULIN prevents liver inflammation and hepatocellular carcinoma by inhibiting FADD- and RIPK1 kinase-mediated hepatocyte apoptosis

Lien VerboomArne MartensDario PriemEsther HosteMozes SzeHanna-Kaisa VikkulaLisette Van HoveSofie VoetJana RoelsJonathan Maelfait et al.

A1 Journal Article in CELL REPORTS

Respiratory Syncytial Virus infection promotes necroptosis and HMGB1 release by airway epithelial cells

Jennifer SimpsonZhixuan LohMd Ashik UllahJason P LynchRhiannon B. WerderNatasha CollinsonVivian ZhangYves DondelingerMathieu BertrandMark L. Everard et al.

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

RIPK1 kinase-dependent death : a symphony of phosphorylation events

Tom DelangheYves DondelingerMathieu Bertrand

A1 Journal Article in TRENDS IN CELL BIOLOGY

The ubiquitin-dependent regulation of the inflammatory response by A20 and MAGED1

Dario PriemMathieu Bertrand

Two distinct ubiquitin-binding motifs in A20 mediate its anti-inflammatory and cell-protective activities

Arne MartensDario PriemEsther HosteJessica VettersSofie RennenLeen CatrysseSofie VoetLaura DeelenMozes SzeHanna-Kaisa Vikkula et al.

A1 Journal Article in NATURE IMMUNOLOGY

2019

A20 protects cells from TNF-induced apoptosis through linear ubiquitin-dependent and -independent mechanisms

Dario PriemMichael DevosSarah DruwéArne MartensKarolina SlowickaAdrian T TingManolis PasparakisWim DeclercqPeter VandenabeeleGeert van Loo et al.

A1 Journal Article in CELL DEATH & DISEASE

Network approach identifies Pacer as an autophagy protein involved in ALS pathogenesis

S. BeltranM. NassifE. VicencioJ. ArcosL. LabradorB. I. CortesC. CortezC. A. BergmannS. EspinozaM. F. Hernandez et al.

A1 Journal Article in MOLECULAR NEURODEGENERATION

Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation

Yves DondelingerTom DelangheDario PriemMeghan A Wynosky-DolfiDaniel SorobeteaDiego Rojas RiveraPiero GiansantiRia RoelandtJulia GropengiesserKlaus Ruckdeschel et al.

A1 Journal Article in NATURE COMMUNICATIONS

2018

MK2 puts an additional brake on RIPK1 cytotoxic potential

Yves DondelingerTom DelangheMathieu Bertrand

Editorial material

Molecular mechanisms of cell death : recommendations of the Nomenclature Committee on Cell Death 2018

Lorenzo GalluzziIlio VitaleStuart A AaronsonJohn M AbramsDieter AdamPatrizia AgostinisEmad S AlnemriLucia AltucciIvano AmelioDavid W. Andrews et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Monitoring RIPK1 phosphorylation in the TNFR1 signaling complex

Dario PriemYves DondelingerMathieu Bertrand

Bookchapter in Programmed necrosis : methods and protocols

N-glycosylation of mouse TRAIL-R restrains TRAIL-induced apoptosis

Yann EstornesYves DondelingerKathrin WeberInge BruggemanAdam PeallMarion MacFarlaneSerge LebecquePeter VandenabeeleMathieu Bertrand

A1 Journal Article in CELL DEATH & DISEASE

The E3 ubiquitin ligases HOIP and cIAP1 are recruited to the TNFR2 signaling complex and mediate TNFR2-induced canonical NF-κB signaling

Alice BorghiMira HaegmanRoman FischerIsabelle CarpentierMathieu BertrandClaude LibertInna AfoninaRudi Beyaert

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

Type III collagen affects dermal and vascular collagen fibrillogenesis and tissue integrity in a mutant Col3a1 transgenic mouse model

Sanne D'hondtBrecht GuillemynDelfien SyxSofie SymoensRiet De RyckeLeen VanhoutteWendy ToussaintBart LambrechtAnne De PaepeDouglas R Keene et al.

A1 Journal Article in MATRIX BIOLOGY

2017

Experimental African trypanosome infection suppresses the development of multiple myeloma in mice by inducing intrinsic apoptosis of malignant plasma cells

Nathan De BeuleEline MenuMathieu BertrandMérédis FavreauElke De BruyneKen MaesKim De VeirmanMagdalena RadwanskaAfshin SamaliStefan Magez et al.

A1 Journal Article in ONCOTARGET

MK2 phosphorylation of RIPK1 regulates TNF-mediated cell death

Yves DondelingerTom DelangheDiego Rojas RiveraDario PriemTinneke DelvaeyeInge BruggemanFranky Van HerreweghePeter VandenabeeleMathieu Bertrand

A1 Journal Article in NATURE CELL BIOLOGY

RIPK1 protects hepatocytes from death in Fas-induced hepatitis

Aveline FilliolMuhammad FarooqClaire Piquet-PellorceValentine GenetMarie-Thérèse Dimanche-BoitrelPeter VandenabeeleMathieu BertrandMichel SamsonJacques Le Seyec

A1 Journal Article in SCIENTIFIC REPORTS

RIPK1 protects hepatocytes from Kupffer cells-mediated TNF-induced apoptosis in mouse models of PAMP-induced hepatitis

Aveline FilliolClaire Piquet-PellorceCéline Raguénès-NicolSarah DionMuhammad FarooqCatherine Lucas-ClercPeter VandenabeeleMathieu BertrandJacques Le SeyecMichel Samson

A1 Journal Article in JOURNAL OF HEPATOLOGY

Type III collagen : a major fibrillar collagen with major issues

Sanne D'hondtFransiska MalfaitMathieu BertrandSophie Janssens

Type III collagen is important for type I collagen fibrillogenesis and for dermal and cardiovascular development

Sanne D'hondtBrecht GuillemynSofie SymoensRiet De RyckeYoshi IshikawaHans Peter BachingerSophie JanssensMathieu BertrandFransiska Malfait

When PERK inhibitors turn out to be new potent RIPK1 inhibitors : critical issues on the specificity and use of GSK2606414 and GSK2656157

Diego Rojas RiveraTinneke DelvaeyeRia RoelandtWim NerinckxKoen AugustynsPeter VandenabeeleMathieu Bertrand

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

2016

A real-time fluorometric method for the simultaneous detection of cell death type and rate

Sasker GrootjansBehrouz HassanniaIris DelrueVera GoossensBartosz WiernickiYves DondelingerMathieu BertrandDmitri KryskoMarnik VuylstekePeter Vandenabeele et al.

A1 Journal Article in NATURE PROTOCOLS

A siRNA screen reveals the prosurvival effect of protein kinase A activation in conditions of unresolved endoplasmic reticulum stress

Miguel AguiletaDiego Rojas RiveraVera GoossensYann EstornesGert Van IsterdaelPeter VandenabeeleMathieu Bertrand

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

An evolutionary perspective on the necroptotic pathway

Yves DondelingerPaco HulpiauYvan SaeysMathieu BertrandPeter Vandenabeele

A1 Journal Article in TRENDS IN CELL BIOLOGY

Characterization of new proteins involved in apoptosis regulation

Miguel AguiletaMathieu BertrandPeter Vandenabeele

Differential expression of type III collagen in male and female mice

Sanne D'hondtBrecht GuillemynSofie SymoensYoshi IshikawaHans Peter BachingerSophie JanssensMathieu BertrandFransiska Malfait

More to life than NF-κB in TNFR1 signaling

Adrian T TingMathieu Bertrand

A1 Journal Article in TRENDS IN IMMUNOLOGY

Poly-ubiquitination in TNFR1-mediated necroptosis

Yves DondelingerMaurice DardingMathieu BertrandHenning Walczak

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

Polyhydramnios, transient antenatal Bartter's syndrome, and MAGED2 mutations

Kamel LaghmaniBodo B BeckSung-Sen YangElie SeaayfanAndrea WenzelBjörn ReuschHelga VitzthumDario PriemSylvie DemaretzKlasien Bergmann et al.

A1 Journal Article in NEW ENGLAND JOURNAL OF MEDICINE

Regulation of RIPK1's cell death function by phosphorylation

Yves DondelingerPeter VandenabeeleMathieu Bertrand

Editorial material

RIPK1 protects from TNF-α-mediated liver damage during hepatitis

Aveline FilliolClaire Piquet-PellorceJacques Le SeyecMuhammad FarooqValentine GenetCatherine Lucas-ClercJohn BertinPeter J GoughMarie-Thérèse Dimanche-BoitrelPeter Vandenabeele et al.

A1 Journal Article in CELL DEATH & DISEASE

The tumor suppressor Hace1 is a critical regulator of TNFR1-mediated cell fate

Luigi TortolaRoberto NitschMathieu BertrandMelanie KoglerYounes RedouaneIvona KozieradzkiIris UribesalgoLilian M FennellMads DaugaardHelene Klug et al.

A1 Journal Article in CELL REPORTS

Type III collagen is important for dermal and cardiovascular development, and type I collagen fibrillogenesis

Sanne D'hondtBrecht GuillemynSofie SymoensRiet De RyckeYoshi IshikawaHans Peter BachingerSophie JanssensMathieu BertrandFransiska Malfait

Type III collagen is important for type I collagen fibrillogenesis and for dermal and cardiovascular development

Sanne D'hondtBrecht GuillemynSofie SymoensRiet De RyckeYoshi IshikawaHans Peter BachingerSophie JanssensMathieu BertrandFransiska Malfait

Vaccination with necroptotic cancer cells induces efficient anti-tumor immunity

Tania Love AaesAgnieszka KaczmarekTinneke DelvaeyeBram De CraeneStefaan De KokerLiesbeth HeyndrickxIris DelrueJoachim TaminauBartosz WiernickiPhilippe De Groote et al.

A1 Journal Article in CELL REPORTS

2015

cIAP2 supports viability of mice lacking cIAP1 and XIAP

Kristen N HeardMathieu BertrandPhilip A Barker

A1 Journal Article in EMBO JOURNAL

Endoplasmic reticulum stress induces ligand-independent TNFR1-mediated necroptosis in L929 cells

S SaveljevaSL Mc LaughlinPeter VandenabeeleA SamaliMathieu Bertrand

A1 Journal Article in CELL DEATH & DISEASE

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015

L GalluzziJM Bravo-San PedroI VitaleSA AaronsonJM AbramsD AdamES AlnemriL AltucciD AndrewsM Annicchiarico-Petruzzelli et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

IAPs, regulators of innate immunity and inflammation

Yann EstornesMathieu Bertrand

A1 Journal Article in SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Molecular crosstalk between apoptosis, necroptosis, and survival signaling

Tom Vanden BergheWilliam J KaiserMathieu BertrandPeter Vandenabeele

A2 Journal Article in MOLECULAR AND CELLULAR ONCOLOGY

NF-κB-independent role of IKKα/IKKβ in preventing RIPK1 kinase-dependent apoptotic and necroptotic cell death during TNF signaling

Yves DondelingerSandrine Jouan-LanhouetTatyana DivertEmilie TheatreJohn BertinPeter J GoughPiero GiansantiAlbert JR HeckEmmanuel DejardinPeter Vandenabeele et al.

A1 Journal Article in MOLECULAR CELL

NIK promotes tissue destruction independently of the alternative NF-κB pathway through TNFR1/RIP1-induced apoptosis

L BoutaffalaMathieu BertrandC RemouchampsG SeleznikF ReisingerM JanasC BénézechMT FernandesS MarchettiF Mair et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Type III collagen is important for collagen fibrillogenesis and for dermal and cardiovascular development

Sanne D'hondtBrecht GuillemynSofie SymoensWendy ToussaintLeen VanhoutteRiet De RyckePaul CouckeBart LambrechtPatrick SegersAnne De Paepe et al.

Type III collagen is important for type I collagen fibrillogenesis and for dermal and cardiovascular development

Sanne D'hondtBrecht GuillemynSofie SymoensWendy ToussaintLeen VanhoutteRiet De RyckePaul CouckePatrick SegersBart LambrechtAnne De Paepe et al.

Unraveling the molecular mechanisms of RIPK1-mediated cell death

Yves DondelingerPeter VandenabeeleMathieu Bertrand

2014

Caspase-3 and RasGAP: a stress-sensing survival/demise switch

Hadi KhalilMathieu BertrandPeter VandenabeeleChristian Widmann

A1 Journal Article in TRENDS IN CELL BIOLOGY

Deficiency in the mitochondrial apoptotic pathway reveals the toxic potential of autophagy under ER stress conditions

Shane DeeganSvetlana SaveljevaSusan E LogueKarolina Pakos-ZebruckaSanjeev GuptaPeter VandenabeeleMathieu BertrandAfshin Samali

A1 Journal Article in AUTOPHAGY

Depletion of RIPK3 or MLKL blocks TNF-driven necroptosis and switches towards a delayed RIPK1 kinase-dependent apoptosis

Quinten RemijsenVera GoossensSasker GrootjansC Van den HauteNele VanlangenakkerYves DondelingerRia RoelandtInge BruggemanAmanda GonçalvesMathieu Bertrand et al.

A1 Journal Article in CELL DEATH & DISEASE

MLKL compromises plasma membrane integrity by binding to phosphatidylinositol phosphates

Yves DondelingerWim DeclercqSylvie MontessuitRia RoelandtAmanda GonçalvesInge BruggemanPaco HulpiauKathrin WeberClark A SehonRobert W Marquis et al.

A1 Journal Article in CELL REPORTS

RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis

Nozomi TakahashiLars VereeckeMathieu BertrandLinde DuprezScott B BergerTatyana DivertAmanda GonçalvesMozes SzeBarbara GilbertStephanie Kourula et al.

A1 Journal Article in NATURE

RIPK1 promotes death receptor-independent caspase-8-mediated apoptosis under unresolved ER stress conditions

Yann EstornesMiguel AguiletaChristel DubuissonJulie De KeyserVera GoossensKristof KersseA SamaliPeter VandenabeeleMathieu Bertrand

A1 Journal Article in CELL DEATH & DISEASE

2013

C-propeptide mutations in procollagen type I and V are associated with endoplasmic reticulum stress-specific unfolded protein responses

Sanne D'hondtSofie SymoensSophie JanssensAnne De PaepeMathieu BertrandFransiska Malfait

RIPK3 contributes to TNFR1-mediated RIPK1 kinase-dependent apoptosis in conditions of cIAP1/2 depletion or TAK1 kinase inhibition

Yves DondelingerMiguel AguiletaVera GoossensChristel DubuissonSasker GrootjansE DejardinPeter VandenabeeleMathieu Bertrand

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

2012

Intermediate domain of receptor-interacting protein kinase 1 (RIPK1) determines switch between necroptosis and RIPK1 kinase-dependent apoptosis

Linde DuprezMathieu BertrandTom Vanden BergheYves DondelingerNele FestjensPeter Vandenabeele

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of Maged1 results in obesity, deficits of social interactions, impaired sexual behavior and severe alteration of mature oxytocin production in the hypothalamus

Carlos DombretTuan NguyenOlivier SchakmanJacques L MichaudHélène Hardin-PouzetMathieu BertrandOlivier De Backer

A1 Journal Article in HUMAN MOLECULAR GENETICS

RIP1 is required for IAP inhibitor-mediated sensitization of childhood acute leukemia cells to chemotherapy-induced apoptosis

S LoederM SchirmerH SchoenebergerS CristofanonJ LeibacherNele VanlangenakkerMathieu BertrandPeter VandenabeeleI JeremiasK-M Debatin et al.

A1 Journal Article in LEUKEMIA

The role of the IAP E3 ubiquitin ligases in regulating pattern-recognition receptor signalling

Peter VandenabeeleMathieu Bertrand

A1 Journal Article in NATURE REVIEWS IMMUNOLOGY

The unfolded protein response at the crossroads of cellular life and death during endoplasmic reticulum stress

Richard JägerMathieu BertrandAdrienne M GormanPeter VandenabeeleAfshin Samali

A1 Journal Article in BIOLOGY OF THE CELL

2011

cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production

Nele VanlangenakkerTom Vanden BerghePieter BogaertBram LaukensK ZobelK DeshayesD VucicS FuldaPeter VandenabeeleMathieu Bertrand

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4)

Mathieu BertrandSaskia LippensAn StaesBarbara GilbertRia RoelandtJelle De MedtsKris GevaertWim DeclercqPeter Vandenabeele

A1 Journal Article in PLOS ONE

Inflammasome modulation and NF-κB activation by caspase-1-related CARD domains

Kristof KerssePeter VandenabeeleTom Vanden BergheMathieu Bertrand

Interaction patches of procaspase-1 caspase recruitment domains (CARDs) are differently involved in procaspase-1 activation and receptor-interacting protein 2 (RIP2)-dependent nuclear factor κB signaling

Kristof KersseMohamed LamkanfiMathieu BertrandTom Vanden BerghePeter Vandenabeele

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

NOD-like receptors and the innate immune system: coping with danger, damage and death

Kristof KersseMathieu BertrandMohamed LamkanfiPeter Vandenabeele

A1 Journal Article in CYTOKINE & GROWTH FACTOR REVIEWS

Smac mimetic bypasses apoptosis resistance in FADD- or caspase-8-deficient cells by priming for tumor necrosis factor α-induced necroptosis

Bram LaukensClaudia JenneweinBarbara SchenkNele VanlangenakkerAlexander SchierSilvia CristofanonKerry ZobelKurt DeshayesDomagoj VucicIrmela Jeremias et al.

A1 Journal Article in NEOPLASIA

The Ripoptosome: death decision in the Cytosol

Mathieu BertrandPeter Vandenabeele

Editorial material

TNF-induced necroptosis in L929 cells is tightly regulated by multiple TNFR1 complex I and II members

Nele VanlangenakkerMathieu BertrandPieter BogaertPeter VandenabeeleTom Vanden Berghe

A1 Journal Article in CELL DEATH & DISEASE

2010

Maged1, a new regulator of skeletal myogenic differentiation and muscle regeneration

Tuan HN NguyenMathieu BertrandChristiane SterpinYounes AchouriOlivier RY De Backer

A1 Journal Article in BMC CELL BIOLOGY

ProNGF induces TNF alpha-dependent death of retinal ganglion cells through a p75(NTR) non-cell-autonomous signaling pathway

Frederic Lebrun-JulienMathieu BertrandOlivier De BackerDavid StellwagenCarlos R. MoralesAdriana Di PoloPhilip A. Barker

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RIP1's function in NF-kappa B activation: from master actor to onlooker

Mathieu BertrandPeter Vandenabeele

Editorial material

2009

Cellular inhibitors of apoptosis cIAP1 and cIAP2 are required for innate immunity signaling by the pattern recognition receptors NOD1 and NOD2

Mathieu BertrandKarine DoironKatherine LabbeRobert G. KornelukPhilip A. BarkerMaya Saleh

A1 Journal Article in IMMUNITY

2008

cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination

Mathieu BertrandSnezana MilutinovicKathleen M. DicksonWai Chi HoAlain BoudreaultJon DurkinJohn W. GillardJames B. JaquithStephen J. MorrisPhilip A. Barker

A1 Journal Article in MOLECULAR CELL

NRAGE, a p75NTR adaptor protein, is required for developmental apoptosis in vivo

Mathieu BertrandR. S. KenchappaD. AndrieuM. Leclercq-SmekensH. N. T. NguyenB. D. CarterF. MuscatelliP. A. BarkerO. De Backer

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

2004

Comparative expression analysis of the MAGED genes during embryogenesis and brain development

Mathieu BertrandI HuijbersP ChomezO De Backer

A1 Journal Article in DEVELOPMENTAL DYNAMICS

2001

An overview of the MAGE gene family with the identification of all human members of the family

Patrick ChomezOlivier De BackerMathieu BertrandEtienne De PlaenThierry BoonSophie Lucas

A1 Journal Article in CANCER RESEARCH